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Keywords: endothelial cells
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Articles
Clin Sci (Lond) (2021) 135 (18): 2197–2216.
Published: 21 September 2021
... of the Biochemical Society 2021 Angiotensin-(1-7) ANP Arterial Pressure Brain endothelial cells Transgenic rats The renin–angiotensin system (RAS) is an important systemic, tissue and cellular modulator of the function of basically all organs. Actions of the RAS depend essentially on the balance...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (15): 1845–1858.
Published: 04 August 2021
... are not completely understood. The present study tested the hypothesis that lysophosphatidylcholine (LPC), a proatherogenic component of oxLDL, induces endothelial calcium influx, which drives NOX5-dependent reactive oxygen species (ROS) production, oxidative stress, and endothelial cell dysfunction. Approach: Human...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (2): 387–407.
Published: 29 January 2021
... is important in the vascular system where it is found in arterial and venous endothelial cells and arterial smooth muscle cells in many vascular beds. Among the best characterized functions of ACE2 is its role in regulating vascular tone. ACE2 through its effector peptide Ang-(1-7) and receptor Mas1 induces...
Articles
Clin Sci (Lond) (2020) 134 (1): 39–51.
Published: 06 January 2020
... males and females. Besides the action of estrogen, sex chromosome gene expression and programming effects also provoke this sexual dimorphism. MicroRNAs (miRNAs) have emerged as regulators of endothelial cell function and dysfunction. We here hypothesized distinct miRNA expression patterns in male...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (12): 1353–1365.
Published: 20 June 2019
... translocator (ARNT) is a key mediator of proper placental angiogenesis, and within placental endothelial cells (ECs) from human FGRadv pregnancies, low expression of ARNT leads to decreased vascular endothelial growth factor A (VEGFA) expression and deficient tube formation. Thus, the aim of the present study...
Articles
Clin Sci (Lond) (2019) 133 (9): CS20190008.
Published: 02 May 2019
... in diabetic patients. Endothelial cell-derived small extracellular vesicles (sEVs) are important mediators of intercellular communication in the pathogenesis of several diseases. However, the exact mechanisms of wound healing mediated by endothelial cell-derived sEVs remain unclear. sEVs were isolated from...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (22): 2437–2449.
Published: 22 November 2018
... alter miRNA expression. In adults, the miRNA transcriptome as well as endothelial function differ between the sexes. Here, we hypothesized that metabolic disturbances associated with gestational diabetes (GDM) alter miRNA signatures in feto-placental endothelial cells (fpEC), dependent on fetal sex. We...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (4): 437–447.
Published: 16 February 2018
... protein FKBP12. TGF receptor-type I (TGFRI) spontaneous activation is inhibited by the association with FKBP12. We hypothesized that rapamycin, in addition to inhibition of mTOR signaling, activates TGFRI independent of TGFβ. Human umbilical vein endothelial cells (HUVECs) were treated with rapamycin (10...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 2019–2035.
Published: 17 July 2017
... responsible for endothelial proliferation, a root cause of PAH-associated vascular remodeling. Lung tissue specimens from PAH and non-PAH patients and hypoxia-exposed human pulmonary artery endothelial cells (ECs) (HPAEC) were assessed for mRNA and protein expression. Reactive oxygen species (ROS) were...
Articles
Clin Sci (Lond) (2017) 131 (15): 1763–1780.
Published: 05 July 2017
..., and enhanced migration and proliferation of choroidal endothelial cells (ChEC) in the retina rupturing through the Bruch's membrane. In the active phase, CNV starts to expand, either by remaining beneath the RPE or by entering the sub-retinal space ( Figure 1 ). Ultimately, in the end phase CNV becomes...
Articles
Clin Sci (Lond) (2017) 131 (5): 369–379.
Published: 15 February 2017
...), in the form of WM lesions. Despite this, it is unclear to what extent the key cell types involved–the endothelial cells (ECs) of the vasculature and the oligodendrocytes of the WM–interact. Here, we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes...
Articles
Clin Sci (Lond) (2016) 130 (6): 451–461.
Published: 04 February 2016
... clinical benefit. The adjuvant monophosphoryl lipid A (MPLA) is a weak toll-like receptor 4 (TLR4) agonist that induces negligible inflammation but retains potent immunomodulatory properties. We postulated that pre-treatment with MPLA would inhibit the inflammatory response of endothelial cells...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (12): 1225–1236.
Published: 11 November 2015
... and human kidneys, VEGF-A is constitutively expressed in podocytes [ 11 – 13 ] whereas its receptors VEGFR-1 and VEGFR-2 are predominately localized on the glomerular endothelial cells [ 11 , 14 ]. It is proposed that podocyte VEGF-A binds to its receptors on the endothelium of the capillary lumen...
Articles
Clin Sci (Lond) (2012) 123 (3): 147–159.
Published: 05 April 2012
... pathways. Cilostazol also enhanced proliferation, chemotaxis, NO production and vascular tube formation in HUVECs (human umbilical vein endothelial cells) through activation of multiple signalling pathways downstream of PI3K/Akt/eNOS. Cilostazol up-regulated VEGF (vascular endothelial growth factor)-A 165...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 9S–12S.
Published: 01 September 2002
... in experimental studies. Another potent pro-atherosclerotic risk factor is oxidized low-density lipoprotein (oxLDL). Endothelial cells mediate the uptake of oxLDL by the recently identified lectin-like oxLDL receptor-1 (LOX-1), which accumulates in atherosclerotic lesions. In the present study, we analysed...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 68S–71S.
Published: 01 September 2002
... injury. We also found that FK409 substantially reduced endothelin-1 (ET-1) production in cultured vascular endothelial cells (ECs). Nuclear factor κB (NF-κB) is known to play a key role in the development of ischaemic disorders through regulation of the expression of a variety of genes. In the present...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 76S–80S.
Published: 01 September 2002
... A (CsA)- and tacrolimus-associated nephrotoxicity. This study aimed to investigate whether the new immunosuppressive drug mycophenolic acid (MPA), which in contrast with CsA and tacrolimus lacks nephrotoxic side effects, modulates ET-1 synthesis in endothelial cells and renal epithelial cells. ET-1...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 176S–178S.
Published: 01 September 2002
... of atherosclerosis. We therefore subjected cultured human umbilical vein endothelial cells and coronary artery smooth muscle cells to oxidative stress induced by xanthine oxidase or hydrogen peroxide and observed alterations in ET-1 metabolism. Incubation with oxygen-derived free radicals increased preproET-1...
Articles
Clin Sci (Lond) (1996) 90 (2): 135–141.
Published: 01 February 1996
...M. A. Hidalgo; D. J. Mann; B. J. Fuller; C. J. Green 1. Hypothermic storage of whole organs flushed with a preservation solution is common practice in clinical transplantation. This procedure leaves vascular endothelial cells in direct contact with the preservation solution during the length...
Articles
Clin Sci (Lond) (1995) 88 (2): 135–139.
Published: 01 February 1995
... of nitric oxide. 28 9 1994 5 10 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 l-arginine endothelial cells nitric oxide nitric oxide synthase Clinical Science (1995) 88, 135-139 (Printed in Great Britain) L-Arginine increases exhaled nitric oxide...