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Keywords: endothelial cells
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Clin Sci (Lond) (2024) 138 (21): 1395–1419.
Published: 04 November 2024
...Doris M.T. Adao; Crizza Ching; Jason E. Fish; Craig A. Simmons; Filio Billia To maintain homeostasis in the heart, endothelial cells and cardiomyocytes engage in dynamic cross-talk through paracrine signals that regulate both cardiac development and function. Here, we review the paracrine signals...
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Clin Sci (Lond) (2023) 137 (18): 1451–1476.
Published: 21 September 2023
... of endothelial cells and do not have supporting mural cells or a basement membrane, making them very permeable to proteins and chylomicrons [ 16–18 ]. The mechanism of lymph formation is thought to involve transient pressure gradients across the lymphatic wall that favor entry of interstitial fluid...
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Clin Sci (Lond) (2023) 137 (8): 597–601.
Published: 19 April 2023
... Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with Individual. endothelial cells hypertension lymphangiogenesis renal physiology Hypertension is a multifactorial syndrome that affects about 46% of the adult population...
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Clin Sci (Lond) (2022) 136 (17): 1281–1301.
Published: 05 September 2022
... and quantified rat ASC-exosome miRNAs and used bioinformatics to select uncharacterized miRNAs down-regulated in post-MI related to cardiac repair. We selected and validated miR-196a-5p and miR-425-5p as candidates for the concerted response in neonatal cardiomyocytes, cardiac fibroblasts, endothelial cells...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (2): 387–407.
Published: 29 January 2021
... is important in the vascular system where it is found in arterial and venous endothelial cells and arterial smooth muscle cells in many vascular beds. Among the best characterized functions of ACE2 is its role in regulating vascular tone. ACE2 through its effector peptide Ang-(1-7) and receptor Mas1 induces...
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Clin Sci (Lond) (2019) 133 (12): 1353–1365.
Published: 20 June 2019
... translocator (ARNT) is a key mediator of proper placental angiogenesis, and within placental endothelial cells (ECs) from human FGRadv pregnancies, low expression of ARNT leads to decreased vascular endothelial growth factor A (VEGFA) expression and deficient tube formation. Thus, the aim of the present study...
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Clin Sci (Lond) (2018) 132 (22): 2437–2449.
Published: 22 November 2018
... alter miRNA expression. In adults, the miRNA transcriptome as well as endothelial function differ between the sexes. Here, we hypothesized that metabolic disturbances associated with gestational diabetes (GDM) alter miRNA signatures in feto-placental endothelial cells (fpEC), dependent on fetal sex. We...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (4): 437–447.
Published: 16 February 2018
... protein FKBP12. TGF receptor-type I (TGFRI) spontaneous activation is inhibited by the association with FKBP12. We hypothesized that rapamycin, in addition to inhibition of mTOR signaling, activates TGFRI independent of TGFβ. Human umbilical vein endothelial cells (HUVECs) were treated with rapamycin (10...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (15): 1763–1780.
Published: 05 July 2017
... homeostasis and vision. It functions to dissipate heat and nourish the RPE and outer retinal photoreceptor cells through their fenestrated capillary endothelial cells (EC). Choroidal vascular dysfunction is now recognized as a critical early event in the development and progression of AMD and CNV. The choroid...
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Clin Sci (Lond) (2017) 131 (5): 369–379.
Published: 15 February 2017
...), in the form of WM lesions. Despite this, it is unclear to what extent the key cell types involved–the endothelial cells (ECs) of the vasculature and the oligodendrocytes of the WM–interact. Here, we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes...
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Clin Sci (Lond) (2016) 130 (6): 451–461.
Published: 04 February 2016
... clinical benefit. The adjuvant monophosphoryl lipid A (MPLA) is a weak toll-like receptor 4 (TLR4) agonist that induces negligible inflammation but retains potent immunomodulatory properties. We postulated that pre-treatment with MPLA would inhibit the inflammatory response of endothelial cells...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 129 (12): 1225–1236.
Published: 11 November 2015
... [ 52 ]. The loss of glomerular capillaries is associated with a reduction in podocyte VEGF-A expression as evaluated by immunohistochemistry [ 53 ]. Administration of recombinant VEGF-A in this model at a time-point when glomerular lesions have already formed leads to glomerular endothelial cell...
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Clin Sci (Lond) (2002) 103 (s2002): 9S–12S.
Published: 01 September 2002
... in experimental studies. Another potent pro-atherosclerotic risk factor is oxidized low-density lipoprotein (oxLDL). Endothelial cells mediate the uptake of oxLDL by the recently identified lectin-like oxLDL receptor-1 (LOX-1), which accumulates in atherosclerotic lesions. In the present study, we analysed...
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Clin Sci (Lond) (2002) 103 (s2002): 68S–71S.
Published: 01 September 2002
... injury. We also found that FK409 substantially reduced endothelin-1 (ET-1) production in cultured vascular endothelial cells (ECs). Nuclear factor κB (NF-κB) is known to play a key role in the development of ischaemic disorders through regulation of the expression of a variety of genes. In the present...
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Clin Sci (Lond) (2002) 103 (s2002): 176S–178S.
Published: 01 September 2002
... of atherosclerosis. We therefore subjected cultured human umbilical vein endothelial cells and coronary artery smooth muscle cells to oxidative stress induced by xanthine oxidase or hydrogen peroxide and observed alterations in ET-1 metabolism. Incubation with oxygen-derived free radicals increased preproET-1...
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Clin Sci (Lond) (2002) 103 (s2002): 76S–80S.
Published: 01 September 2002
... A (CsA)- and tacrolimus-associated nephrotoxicity. This study aimed to investigate whether the new immunosuppressive drug mycophenolic acid (MPA), which in contrast with CsA and tacrolimus lacks nephrotoxic side effects, modulates ET-1 synthesis in endothelial cells and renal epithelial cells. ET-1...
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Clin Sci (Lond) (1996) 90 (2): 135–141.
Published: 01 February 1996
...M. A. Hidalgo; D. J. Mann; B. J. Fuller; C. J. Green 1. Hypothermic storage of whole organs flushed with a preservation solution is common practice in clinical transplantation. This procedure leaves vascular endothelial cells in direct contact with the preservation solution during the length...
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Clin Sci (Lond) (1995) 88 (2): 135–139.
Published: 01 February 1995
... pathophysiology [ 1, 21. Endogenous NO is formed from the semiessential amino acid L-arginine by NO synthase (NOS), of which three main iso- forms have been described. Constitutive forms of NOS (cNOS) are found in endothelial cells and produce NO that is responsible for endothelium- dependent vasodilatation...