...Doris M.T. Adao; Crizza Ching; Jason E. Fish; Craig A. Simmons; Filio Billia To maintain homeostasis in the heart, endothelial cells and cardiomyocytes engage in dynamic cross-talk through paracrine signals that regulate both cardiac development and function. Here, we review the paracrine signals...

... A. London; Jacob D. Jaffe; Jenica N. Upshaw; Vicky K. Yang; Iris Z. Jaffe Vascular endothelial growth factor receptor inhibitors (VEGFRis) improve cancer survival but are associated with treatment-limiting hypertension, often attributed to endothelial cell (EC) dysfunction. Using phosphoproteomic profiling...

... 01 2024 31 01 2024 01 02 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 cholesterol endothelial cells preeclampsia pregnancy toll-like receptors Alberta Innovates (AI) 501100009192 N/A Canadian...

... of endothelial cells and do not have supporting mural cells or a basement membrane, making them very permeable to proteins and chylomicrons [ 16–18 ]. The mechanism of lymph formation is thought to involve transient pressure gradients across the lymphatic wall that favor entry of interstitial fluid...

... Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with Individual. endothelial cells hypertension lymphangiogenesis renal physiology Hypertension is a multifactorial syndrome that affects about 46% of the adult population...

... and quantified rat ASC-exosome miRNAs and used bioinformatics to select uncharacterized miRNAs down-regulated in post-MI related to cardiac repair. We selected and validated miR-196a-5p and miR-425-5p as candidates for the concerted response in neonatal cardiomyocytes, cardiac fibroblasts, endothelial cells...

... determined by qPCR, we chose to examine aorta, heart, lung, kidney and brain. Transgene expression was detectable preferentially in endothelial cells in aorta, heart, lung and kidney ( Figure 2 A). Low expression was also observed in aortic smooth muscle cells and Bowman capsule ( Figure 2 A). In the brain...

... are not completely understood. The present study tested the hypothesis that lysophosphatidylcholine (LPC), a proatherogenic component of oxLDL, induces endothelial calcium influx, which drives NOX5-dependent reactive oxygen species (ROS) production, oxidative stress, and endothelial cell dysfunction. Approach: Human...

... is important in the vascular system where it is found in arterial and venous endothelial cells and arterial smooth muscle cells in many vascular beds. Among the best characterized functions of ACE2 is its role in regulating vascular tone. ACE2 through its effector peptide Ang-(1-7) and receptor Mas1 induces...

... males and females. Besides the action of estrogen, sex chromosome gene expression and programming effects also provoke this sexual dimorphism. MicroRNAs (miRNAs) have emerged as regulators of endothelial cell function and dysfunction. We here hypothesized distinct miRNA expression patterns in male...

... translocator (ARNT) is a key mediator of proper placental angiogenesis, and within placental endothelial cells (ECs) from human FGRadv pregnancies, low expression of ARNT leads to decreased vascular endothelial growth factor A (VEGFA) expression and deficient tube formation. Thus, the aim of the present study...

... in diabetic patients. Endothelial cell-derived small extracellular vesicles (sEVs) are important mediators of intercellular communication in the pathogenesis of several diseases. However, the exact mechanisms of wound healing mediated by endothelial cell-derived sEVs remain unclear. sEVs were isolated from...

... alter miRNA expression. In adults, the miRNA transcriptome as well as endothelial function differ between the sexes. Here, we hypothesized that metabolic disturbances associated with gestational diabetes (GDM) alter miRNA signatures in feto-placental endothelial cells (fpEC), dependent on fetal sex. We...

... protein FKBP12. TGF receptor-type I (TGFRI) spontaneous activation is inhibited by the association with FKBP12. We hypothesized that rapamycin, in addition to inhibition of mTOR signaling, activates TGFRI independent of TGFβ. Human umbilical vein endothelial cells (HUVECs) were treated with rapamycin (10...

... responsible for endothelial proliferation, a root cause of PAH-associated vascular remodeling. Lung tissue specimens from PAH and non-PAH patients and hypoxia-exposed human pulmonary artery endothelial cells (ECs) (HPAEC) were assessed for mRNA and protein expression. Reactive oxygen species (ROS) were...

... homeostasis and vision. It functions to dissipate heat and nourish the RPE and outer retinal photoreceptor cells through their fenestrated capillary endothelial cells (EC). Choroidal vascular dysfunction is now recognized as a critical early event in the development and progression of AMD and CNV. The choroid...

...), in the form of WM lesions. Despite this, it is unclear to what extent the key cell types involved–the endothelial cells (ECs) of the vasculature and the oligodendrocytes of the WM–interact. Here, we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes...

... clinical benefit. The adjuvant monophosphoryl lipid A (MPLA) is a weak toll-like receptor 4 (TLR4) agonist that induces negligible inflammation but retains potent immunomodulatory properties. We postulated that pre-treatment with MPLA would inhibit the inflammatory response of endothelial cells...

... [ 52 ]. The loss of glomerular capillaries is associated with a reduction in podocyte VEGF-A expression as evaluated by immunohistochemistry [ 53 ]. Administration of recombinant VEGF-A in this model at a time-point when glomerular lesions have already formed leads to glomerular endothelial cell...

... pathways. Cilostazol also enhanced proliferation, chemotaxis, NO production and vascular tube formation in HUVECs (human umbilical vein endothelial cells) through activation of multiple signalling pathways downstream of PI3K/Akt/eNOS. Cilostazol up-regulated VEGF (vascular endothelial growth factor)-A 165...

... in experimental studies. Another potent pro-atherosclerotic risk factor is oxidized low-density lipoprotein (oxLDL). Endothelial cells mediate the uptake of oxLDL by the recently identified lectin-like oxLDL receptor-1 (LOX-1), which accumulates in atherosclerotic lesions. In the present study, we analysed...

... injury. We also found that FK409 substantially reduced endothelin-1 (ET-1) production in cultured vascular endothelial cells (ECs). Nuclear factor κB (NF-κB) is known to play a key role in the development of ischaemic disorders through regulation of the expression of a variety of genes. In the present...

... of atherosclerosis. We therefore subjected cultured human umbilical vein endothelial cells and coronary artery smooth muscle cells to oxidative stress induced by xanthine oxidase or hydrogen peroxide and observed alterations in ET-1 metabolism. Incubation with oxygen-derived free radicals increased preproET-1...

... A (CsA)- and tacrolimus-associated nephrotoxicity. This study aimed to investigate whether the new immunosuppressive drug mycophenolic acid (MPA), which in contrast with CsA and tacrolimus lacks nephrotoxic side effects, modulates ET-1 synthesis in endothelial cells and renal epithelial cells. ET-1...

...M. A. Hidalgo; D. J. Mann; B. J. Fuller; C. J. Green 1. Hypothermic storage of whole organs flushed with a preservation solution is common practice in clinical transplantation. This procedure leaves vascular endothelial cells in direct contact with the preservation solution during the length...

... pathophysiology [ 1, 21. Endogenous NO is formed from the semiessential amino acid L-arginine by NO synthase (NOS), of which three main iso- forms have been described. Constitutive forms of NOS (cNOS) are found in endothelial cells and produce NO that is responsible for endothelium- dependent vasodilatation...