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Keywords: endothelial function
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Articles
Clin Sci (Lond) (2024) 138 (10): 599–614.
Published: 22 May 2024
... (96 h, 3 weeks after IR) had no impact on kidney fibrosis, capillary density, or endothelial function. Conclusion: In rats, administration of miR-486-5p early after kidney IR prevents injury, and protects against CKD development and systemic endothelial dysfunction. These protective effects...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (20): 2707–2727.
Published: 23 October 2020
..., and vascular smooth muscle cells [ 12 , 71 , 73 ]. cardiovascular disease cyclooxygenase cytochrome p450 eicosanoids endothelial function lipoxygenases Blood vessels are the transportation and delivery system essential for maintaining organ function and life. Arteries and arterioles...
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Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
... authorship. 24 04 2020 01 06 2020 03 06 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 arterial stiffness endothelial function mitophagy oxidative stress reactive oxygen species Cardiovascular diseases (CVD...
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Clin Sci (Lond) (2017) 131 (17): 2223–2240.
Published: 10 August 2017
... function. The development of pregnancy complications, specifically pre-eclampsia, is associated with poor placentation (decreased angiogenesis), increased arterial stiffness, and vascular dysfunction (reduced endothelial function). Many of the positive adaptations that occur in healthy pregnancy...
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Clin Sci (Lond) (2017) 131 (11): 1045–1053.
Published: 10 May 2017
... endothelial dysfunction remains unknown. Herein, we tested the hypothesis that sitting-induced leg endothelial dysfunction would be prevented by prior exercise. We also examined if, in the absence of exercise, standing is an effective alternative strategy to sitting for conserving leg endothelial function...
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Clin Sci (Lond) (2016) 130 (21): 1881–1888.
Published: 22 September 2016
...Lauren K. Walsh; Robert M. Restaino; Martha Neuringer; Camila Manrique; Jaume Padilla Postprandial hyperglycaemia leads to a transient impairment in endothelial function; however, the mechanisms remain largely unknown. Previous work in cell culture models demonstrate that high glucose results...
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Clin Sci (Lond) (2014) 127 (5): 323–330.
Published: 15 May 2014
... with OSA with abnormal endothelial function (OSAab) and with normal endothelial function (OSAn), and controls (CO) were recruited. Peripheral blood mononuclear cells were subtyped into CD14 + and CD16 + cells, and NO production was assessed using flow cytometry. Endothelial dysfunction was defined as T max...
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Clin Sci (Lond) (2013) 125 (5): 247–255.
Published: 10 May 2013
..., diltiazem or placebo were administered to eight healthy subjects for 2 days before each study day. On the study days, the following were assessed before and after the infusion of lipid and heparin to raise serum NEFAs: endothelial function, by measuring FBF (forearm blood flow) responses to ACh...
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Clin Sci (Lond) (2012) 122 (2): 53–61.
Published: 20 September 2011
... 6 2011 11 7 2011 11 7 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 adiposity endothelial function gestational diabetes pregnancy small artery women T2DM (Type 2 diabetes mellitus) is characterized by a 3–4-fold excess of cardiovascular...
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Clin Sci (Lond) (2011) 120 (11): 485–491.
Published: 15 February 2011
... causes premature aging of endothelial function in humans Hypertension 1997 29 736 743 5 DeSouza C.A. Shapiro L.F. Clevenger C.M. Dinenno F.A. Monahan K.D. Tanaka H. Seals D.R. Regular aerobic exercise prevents and restores age-related declines in endothelium...
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Clin Sci (Lond) (2010) 119 (8): 313–322.
Published: 06 July 2010
... to nutritional stimuli. This response is impaired in obesity, suggesting parallels with endothelial function. In the present study, we assessed whether regulation of ATBF is related to the regulation of endothelial function, assessed by FMD (flow-mediated vasodilatation) of the brachial artery. Impaired FMD...
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Clin Sci (Lond) (2009) 116 (10): 761–770.
Published: 15 April 2009
... dysfunction. The present study aimed to assess a range of circulating markers of endothelial function in overweight women with and without PCOS. Overweight and obese age- and BMI (body mass index)-matched women with ( n =80) and without ( n =27) PCOS were assessed in a cross-sectional study. End-point...
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Clin Sci (Lond) (2009) 116 (4): 315–316.
Published: 15 January 2009
... interval training blood pressure cardiovascular risk factor endothelial function obesity In the present issue of Clinical Science , Tjønna et al. [ 1 ] report the findings of an intriguing study in which they have shown the dramatic ability of AIT (aerobic interval training) to decrease...
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Clin Sci (Lond) (2009) 116 (4): 317–326.
Published: 15 January 2009
... months (11 compared with 0%; P <0.01) and 12 months (12 compared with −1%; P <0.01). AIT enhanced endothelial function compared with MTG at both 3 months (absolute change, 5.1 compared with 3.9%; P <0.01) and 12 months (absolute change, 6.3 compared with 1.0%; P <0.01). AIT was favourable...
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Clin Sci (Lond) (2008) 115 (9): 283–293.
Published: 01 October 2008
... work capacity, endothelial function and the cardiovascular risk profile in obesity, but it is unknown which of high-intensity aerobic exercise, moderate-intensity aerobic exercise or strength training is the optimal mode of exercise. In the present study, a total of 40 subjects were randomized to high...
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Clin Sci (Lond) (2007) 112 (7): 403–409.
Published: 01 March 2007
...Cheri L. Mcgowan; Andrew S. Levy; Neil Mccartney; Maureen J. Macdonald Isometric HG (handgrip) training lowers resting arterial BP (blood pressure), yet the mechanisms are elusive. In the present study, we investigated improved systemic endothelial function as a mechanism of arterial BP...
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Clin Sci (Lond) (2006) 111 (6): 357–364.
Published: 14 November 2006
... albuminuria capillary permeability endothelial function hypertension transcapillary escape rate of albumin Urinary albumin was measured by nephelometry using a commercially available kit (0.1 mg/dl detection limit; Roche). Intra- and inter-assay variation co-efficients at different concentrations...
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Clin Sci (Lond) (2006) 111 (1): 87–91.
Published: 14 June 2006
...Stefan Agewall; Åsa Hernberg Endothelial function is known to predict cardiovascular disease. The aim of the present study was to examine whether endothelial function in smokers with normal cholesterol levels could be normalized by treatment with 80 mg of atorvastatin in comparison with a control...
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Clin Sci (Lond) (2006) 110 (4): 475–482.
Published: 15 March 2006
...Mikko J. Järvisalo; Laura Jartti; Jukka Marniemi; Tapani Rönnemaa; Jorma S. A. Viikari; Terho Lehtimäki; Olli T. Raitakari Brachial artery FMD (flow-mediated dilatation) is widely used as a marker of systemic arterial endothelial function. FMD, however, shows considerable 25% day-to-day variation...
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Clin Sci (Lond) (2006) 110 (3): 327–328.
Published: 10 February 2006
...)] in which they studied the effects of TNF-α on endothelial cell release of t-PA and its inhibitor PAI-1, as well as endothelial function (acetylcholine- and nitroprusside-induced vasodilation, and bradykinin-induced release of t-PA). In a saline-controlled randomized double-blind crossover study in 12 males...
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Clin Sci (Lond) (2006) 110 (3): 353–360.
Published: 10 February 2006
... in both forearms by venous occlusion plethysmography using mercury in silastic strain gauges as described previously [ 16 ]. BP and HR (heart rate) were measured using a semi-automated non-invasive sphygmomanometer (Omron 705 IT). coronary disease endothelial function fibrinolysis inflammation...
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Clin Sci (Lond) (2006) 110 (3): 387–392.
Published: 10 February 2006
...Jaume Padilla; Ryan A. Harris; Alyce D. Fly; Lawrence D. Rink; Janet P. Wallace The measurement of brachial artery vasodilation in response to a hyperaemic stimulus has been used extensively to assess changes in endothelial function. However, whether or not similar changes occur in response...
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Clin Sci (Lond) (2006) 110 (2): 217–225.
Published: 17 January 2006
... (bovine GH) develop hypertension and hypercholesterolaemia and could be a model for cardiovascular disease in acromegaly. The aims of the present study were to investigate the effects of excess GH on vascular function and to test whether oxidative stress affects endothelial function in bGH transgenic mice...
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Clin Sci (Lond) (2005) 109 (1): 55–60.
Published: 23 June 2005
... the acute effect of coffee ingestion on endothelial function in healthy individuals, and the potential role of caffeine. We studied 17 healthy young adults (28.9±3.0 years old; nine men), who were regular non-heavy coffee drinkers. The endothelial performance was estimated by endothelium-dependent FMD (flow...
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Clin Sci (Lond) (2005) 108 (6): 531–538.
Published: 24 May 2005
... −/− (apolipoprotein E-deficient) mice fed a standard or high-cholesterol diet. Endothelial function in the proximal and mid-descending aortic regions was studied using a myograph technique. Flow velocity at the aortic root of cholesterol-fed ApoE −/− mice was significantly increased as a result of lumen narrowing...
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Clin Sci (Lond) (2004) 107 (6): 571–581.
Published: 24 November 2004
... on large and small vessel function using the voluntary running exercise model. Possible involvement of the NO pathway was explored. An ex vivo approach was used to assess the endothelial function in resistance and conduit vessel segments to dissect out the specific underlying mechanisms. In vivo...
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Clin Sci (Lond) (2004) 106 (5): 443–445.
Published: 01 May 2004
...Naveed SATTAR There is increasing evidence to implicate inflammation as an important precursor of endothelial dysfunction. This mechanistic link is apparent across the entire spectrum of inflammatory status, i.e. endothelial function is apparent following acute infection, and in subjects...
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Clin Sci (Lond) (2004) 106 (5): 447–448.
Published: 01 May 2004
...-inspired diet on endothelial function and lipid fractions. Correspondence: Dr Aroon Hingorani (e-mail [email protected] ). 21 1 2004 26 1 2004 26 1 2004 © 2004 The Biochemical Society 2004 diet cardiovascular disease endothelial function lipid fraction oxidative...
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Clin Sci (Lond) (2004) 106 (5): 519–525.
Published: 01 May 2004
... of the present study are to improve endothelial function by dietary intervention in healthy subjects with lipid levels representative of a Western population. Twenty-two healthy subjects (mean total cholesterol, 5.6 mmol/l) were given a Mediterranean-inspired diet rich in ω-3 fatty acids and sterol esters...
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Clin Sci (Lond) (2004) 106 (4): 353–358.
Published: 01 April 2004
...Richard J. WOODMAN; David E. CELERMAJER; Peter L. THOMPSON; Joseph HUNG Folic acid supplementation lowers total plasma homocysteine (tHcy) and improves endothelial function in individuals with coronary artery disease (CAD) and in those with additional CAD risk factors. In the present study, we...
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Clin Sci (Lond) (2004) 106 (3): 239–240.
Published: 01 March 2004
... function nitric oxide (NO) physical exercise Clinical Science (2004) 106, 239 240 (Printed in Great Britain) 239 C O M M E N T Aging, physical fitness and endothelial function: are all ultracentenarians marathon runners? Guido GRASSI Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e...
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Clin Sci (Lond) (2004) 106 (3): 315–319.
Published: 01 March 2004
...-Hong Chen (e-mail [email protected] ). 8 7 2003 15 10 2003 16 10 2003 16 10 2003 © 2004 The Biochemical Society 2004 endothelial function flow-mediated vasodilatation glutathione peroxidase high-fat meal oxidative stress postprandial hypertriglyceridaemia...
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Clin Sci (Lond) (2004) 106 (3): 329–335.
Published: 01 March 2004
... compared with trained subjects. NOx concentrations were positively correlated with V O 2 max ( r =0.46, P <0.001). Stimulated SBFs were correlated with NOx ( r >0.30, P <0.05). These findings show that chronic exercise may improve endothelial function in older (and young) men, probably...
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Clin Sci (Lond) (2003) 105 (6): 699–707.
Published: 01 December 2003
... glucose and homocysteine levels, a lower low-density lipoprotein–cholesterol and a rise in the concentration of von Willebrand factor, indicating a prothrombotic endothelial function. The severity of the heart failure, measured as the plasma level of brain natriuretic peptide, correlated...
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Clin Sci (Lond) (2003) 105 (1): 67–71.
Published: 01 July 2003
...) atherosclerosis cardiovascular disease endothelial function oestrogen nitric oxide Clinical Science (2003) 105, 67 71 (Printed in Great Britain) 67 Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women T. TEERLINK , S. J. M. NEELE , S. DE JONG...
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Clin Sci (Lond) (2003) 105 (1): 113–118.
Published: 01 July 2003
... reactivity C-peptide endothelial function glucagon test homoeostasis model assessment (HOMA) index Type II diabetes mellitus Clinical Science (2003) 105, 113 118 (Printed in Great Britain) 113 Residual C-peptide secretion and endothelial function in patients with Type II diabetes Daniela MANZELLA...
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