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Keywords: endothelial function
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (10): 599–614.
Published: 22 May 2024
... (96 h, 3 weeks after IR) had no impact on kidney fibrosis, capillary density, or endothelial function. Conclusion: In rats, administration of miR-486-5p early after kidney IR prevents injury, and protects against CKD development and systemic endothelial dysfunction. These protective effects...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (20): 2707–2727.
Published: 23 October 2020
...). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cardiovascular disease cyclooxygenase cytochrome p450 eicosanoids endothelial function lipoxygenases LO metabolites contribute importantly to platelet function, inflammation, and vascular function ( Figure 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
... authorship. 24 04 2020 01 06 2020 03 06 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 arterial stiffness endothelial function mitophagy oxidative stress reactive oxygen species Cardiovascular diseases (CVD...
Articles
Silvija Cvitic, Jasmin Strutz, Hannah M. Appel, Elisa Weiß, Waltraud T. Brandl, Andrea Thüringer, Eva M. Bernhart, Luciana Lassance, Christian Wadsack, Carolin Schliefsteiner, Ivana Sreckovic, Karl Kashofer, Ursula Hiden
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (1): 39–51.
Published: 06 January 2020
...Silvija Cvitic; Jasmin Strutz; Hannah M. Appel; Elisa Weiß; Waltraud T. Brandl; Andrea Thüringer; Eva M. Bernhart; Luciana Lassance; Christian Wadsack; Carolin Schliefsteiner; Ivana Sreckovic; Karl Kashofer; Ursula Hiden Endothelial function and the risk for endothelial dysfunction differ between...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (17): 2223–2240.
Published: 10 August 2017
... function. The development of pregnancy complications, specifically pre-eclampsia, is associated with poor placentation (decreased angiogenesis), increased arterial stiffness, and vascular dysfunction (reduced endothelial function). Many of the positive adaptations that occur in healthy pregnancy...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1045–1053.
Published: 10 May 2017
... endothelial dysfunction remains unknown. Herein, we tested the hypothesis that sitting-induced leg endothelial dysfunction would be prevented by prior exercise. We also examined if, in the absence of exercise, standing is an effective alternative strategy to sitting for conserving leg endothelial function...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (21): 1881–1888.
Published: 22 September 2016
...Lauren K. Walsh; Robert M. Restaino; Martha Neuringer; Camila Manrique; Jaume Padilla Postprandial hyperglycaemia leads to a transient impairment in endothelial function; however, the mechanisms remain largely unknown. Previous work in cell culture models demonstrate that high glucose results...
Articles
Leila Kheirandish-Gozal, Yang Wang, Ryan C. Duggan, Sindhuja Harshan Vardhan, Hui-Leng Tan, Helena Molero Ramirez, Abdelnaby Khalyfa, Rakesh Bhattacharjee, Hari P.R. Bandla, David Gozal
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (5): 323–330.
Published: 15 May 2014
... with OSA with abnormal endothelial function (OSAab) and with normal endothelial function (OSAn), and controls (CO) were recruited. Peripheral blood mononuclear cells were subtyped into CD14 + and CD16 + cells, and NO production was assessed using flow cytometry. Endothelial dysfunction was defined as T max...
Articles
Victoria S. Sprung, Helen Jones, Christopher J. A. Pugh, Nabil F. Aziz, Christina Daousi, Graham J. Kemp, Daniel J. Green, N. Timothy Cable, Daniel J. Cuthbertson
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (1): 67–74.
Published: 03 September 2013
...) pools in liver and skeletal muscle. A total of 19 women with PCOS (means±S.D.; 26±6 years, 36±5 kg/m 2 ) and 16 control women (31±8 years, 30±6 kg/m 2 ) were recruited. Endothelial function was assessed in the brachial artery using FMD (flow-mediated dilation). VAT (visceral AT) and abdominal SAT...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (5): 247–255.
Published: 10 May 2013
..., diltiazem or placebo were administered to eight healthy subjects for 2 days before each study day. On the study days, the following were assessed before and after the infusion of lipid and heparin to raise serum NEFAs: endothelial function, by measuring FBF (forearm blood flow) responses to ACh...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (7): 329–336.
Published: 07 December 2011
...) and greater than FMD at the same time point without preceding I/R ( P <0.01). Increases in CD133 + /CD34 + /VEGFR2 + cells after darbepoetin did not differ according to the presence or absence of preceding I/R. Preceding I/R is required for darbepoetin to enhance endothelial function, possibly...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (2): 53–61.
Published: 20 September 2011
... J. Kennedy Cruickshank (email [email protected] ). 21 1 2011 27 6 2011 11 7 2011 11 7 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 adiposity endothelial function gestational diabetes pregnancy small artery women...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (11): 485–491.
Published: 15 February 2011
... ). 23 9 2010 2 12 2010 10 12 2010 10 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging blood flow endothelial function endothelin forearm blood flow vasodilatation The incidence and prevalence of cardiovascular diseases...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (8): 313–322.
Published: 06 July 2010
... to nutritional stimuli. This response is impaired in obesity, suggesting parallels with endothelial function. In the present study, we assessed whether regulation of ATBF is related to the regulation of endothelial function, assessed by FMD (flow-mediated vasodilatation) of the brachial artery. Impaired FMD...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (10): 761–770.
Published: 15 April 2009
... dysfunction. The present study aimed to assess a range of circulating markers of endothelial function in overweight women with and without PCOS. Overweight and obese age- and BMI (body mass index)-matched women with ( n =80) and without ( n =27) PCOS were assessed in a cross-sectional study. End-point...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (4): 315–316.
Published: 15 January 2009
... Society 2009 adolescent aerobic interval training blood pressure cardiovascular risk factor endothelial function obesity In the present issue of Clinical Science , Tjønna et al. [ 1 ] report the findings of an intriguing study in which they have shown the dramatic ability of AIT (aerobic...
Articles
Arnt E. Tjønna, Tomas O. Stølen, Anja Bye, Marte Volden, Stig A. Slørdahl, Rønnaug Ødegård, Eirik Skogvoll, Ulrik Wisløff
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (4): 317–326.
Published: 15 January 2009
... months (11 compared with 0%; P <0.01) and 12 months (12 compared with −1%; P <0.01). AIT enhanced endothelial function compared with MTG at both 3 months (absolute change, 5.1 compared with 3.9%; P <0.01) and 12 months (absolute change, 6.3 compared with 1.0%; P <0.01). AIT was favourable...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (4): 283–299.
Published: 15 January 2009
... atherosclerosis endothelial function endothelial progenitor cell smooth muscle progenitor cell translational research Another circulating progenitor cell population in the adult, which has received less attention than the EPC, is the putative SMPC (smooth muscle progenitor cell). Various studies...
Articles
Inga E. Schjerve, Gjertrud A. Tyldum, Arnt E. Tjønna, Tomas Stølen, Jan P. Loennechen, Harald E. M. Hansen, Per M. Haram, Garreth Heinrich, Anja Bye, Sonia M. Najjar, Godfrey L. Smith, Stig A. Slørdahl, Ole J. Kemi, Ulrik Wisløff
Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (9): 283–293.
Published: 01 October 2008
... work capacity, endothelial function and the cardiovascular risk profile in obesity, but it is unknown which of high-intensity aerobic exercise, moderate-intensity aerobic exercise or strength training is the optimal mode of exercise. In the present study, a total of 40 subjects were randomized to high...
Articles
John Lekakis, Sotirios Tsiodras, Ignatios Ikonomidis, John Palios, Garyfalia Poulakou, Loukianos Rallidis, Anastasia Antoniadou, Periklis Panagopoulos, Antonios Papadopoulos, Helen Giamarellou, Dimitrios T. Kremastinos
Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (6): 189–196.
Published: 12 August 2008
... on super VHS videotape for off-line analysis. coronary artery disease endothelial function flow-mediated vasodilation (FMD) HIV highly active antiretroviral therapy (HAART) intima-media thickness The introduction of HAART (highly active antiretroviral therapy) dramatically reduced HIV...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2007) 112 (7): 403–409.
Published: 01 March 2007
...Cheri L. Mcgowan; Andrew S. Levy; Neil Mccartney; Maureen J. Macdonald Isometric HG (handgrip) training lowers resting arterial BP (blood pressure), yet the mechanisms are elusive. In the present study, we investigated improved systemic endothelial function as a mechanism of arterial BP...
Articles
Iftikhar J. Kullo, A. Rauoof Malik, Lawrence F. Bielak, Patrick F. Sheedy, II, Stephen T. Turner, Patricia A. Peyser
Journal:
Clinical Science
Clin Sci (Lond) (2007) 112 (3): 175–182.
Published: 03 January 2007
... 9 2006 The Biochemical Society 2007 brachial artery diameter coronary artery calcium endothelial function flow-mediated dilatation nitroglycerine-mediated dilatation The predictive value of conventional risk factors for CHD (coronary heart disease) events in individual...
Articles
Giulia Dell'omo, Giuseppe Penno, Laura Pucci, Daniela Lucchesi, Carmen Fotino, Stefano Del Prato, Roberto Pedrinelli
Journal:
Clinical Science
Clin Sci (Lond) (2006) 111 (6): 357–364.
Published: 14 November 2006
... was measured by immunonephelometry (interassay variation co-efficient, 5.2%; Laser Nephelometer System; Behring). ACE gene polymorphism albuminuria capillary permeability endothelial function hypertension transcapillary escape rate of albumin Consistent evidence supports the role...
Articles
Michael R. Skilton, Alison K. Gosby, Ben J. Wu, Lisa M. L. Ho, Roland Stocker, Ian D. Caterson, David S. Celermajer
Journal:
Clinical Science
Clin Sci (Lond) (2006) 111 (4): 281–287.
Published: 13 September 2006
... 2006 The Biochemical Society 2006 cardiovascular disease elastin endothelial function fetal growth prenatal nutrition wall thickness Recent research has suggested a significant association between impaired fetal growth and increased rates of adult cardiovascular disease [ 1 – 5...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2006) 111 (1): 87–91.
Published: 14 June 2006
...Stefan Agewall; Åsa Hernberg Endothelial function is known to predict cardiovascular disease. The aim of the present study was to examine whether endothelial function in smokers with normal cholesterol levels could be normalized by treatment with 80 mg of atorvastatin in comparison with a control...
Articles
Mikko J. Järvisalo, Laura Jartti, Jukka Marniemi, Tapani Rönnemaa, Jorma S. A. Viikari, Terho Lehtimäki, Olli T. Raitakari
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (4): 475–482.
Published: 15 March 2006
...Mikko J. Järvisalo; Laura Jartti; Jukka Marniemi; Tapani Rönnemaa; Jorma S. A. Viikari; Terho Lehtimäki; Olli T. Raitakari Brachial artery FMD (flow-mediated dilatation) is widely used as a marker of systemic arterial endothelial function. FMD, however, shows considerable 25% day-to-day variation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (3): 353–360.
Published: 10 February 2006
... ). coronary disease endothelial function fibrinolysis inflammation tumour necrosis factor-α (TNF-α) vasodilation In epidemiologic studies of patients with CHD (coronary heart disease) [ 1 ] and in prospective studies in healthy populations [ 2 ], higher plasma concentrations of the pro...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (3): 387–392.
Published: 10 February 2006
...Jaume Padilla; Ryan A. Harris; Alyce D. Fly; Lawrence D. Rink; Janet P. Wallace The measurement of brachial artery vasodilation in response to a hyperaemic stimulus has been used extensively to assess changes in endothelial function. However, whether or not similar changes occur in response...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (3): 327–328.
Published: 10 February 2006
... the pathophysiology of atherothrombosis. Correspondence: Professor Gordon D. O. Lowe (email [email protected] ). 5 1 2006 6 1 2006 6 1 2006 The Biochemical Society 2006 atherothrombosis coronary heart disease endothelial function inflammation tissue plasminogen activator...
Articles
Irene J. Andersson, Maria E. Johansson, Anna Wickman, Mohammad Bohlooly-Y, Natalia Klintland, Kenneth Caidahl, Maria Gustafsson, Jan Borén, Li-ming Gan, Göran Bergström
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (2): 217–225.
Published: 17 January 2006
... (bovine GH) develop hypertension and hypercholesterolaemia and could be a model for cardiovascular disease in acromegaly. The aims of the present study were to investigate the effects of excess GH on vascular function and to test whether oxidative stress affects endothelial function in bGH transgenic mice...
Articles
Andrzej Wykretowicz, Przemysław Guzik, Grzegorz Bartkowiak, Tomasz Krauze, Ryszard Kąsinowski, Mieczysław Dziarmaga, Karel H. Wesseling, Henryk Wysocki
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (4): 397–403.
Published: 23 September 2005
... glucose level does not exclude abnormal glucose metabolism in patients with CAD. The aim of present study was to evaluate endothelial function and BRS according to glucose metabolism in patients with normal fasting plasma glucose and stable CAD subjected to PTCA (percutaneous transluminal coronary...
Articles
Chris M. PAPAMICHAEL, Konstantinos A. AZNAOURIDIS, Emmanouil N. KARATZIS, Kalliopi N. KARATZI, Kimon S. STAMATELOPOULOS, Georgia VAMVAKOU, John P. LEKAKIS, Myron E. MAVRIKAKIS
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (1): 55–60.
Published: 23 June 2005
... the acute effect of coffee ingestion on endothelial function in healthy individuals, and the potential role of caffeine. We studied 17 healthy young adults (28.9±3.0 years old; nine men), who were regular non-heavy coffee drinkers. The endothelial performance was estimated by endothelium-dependent FMD (flow...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (6): 531–538.
Published: 24 May 2005
... −/− (apolipoprotein E-deficient) mice fed a standard or high-cholesterol diet. Endothelial function in the proximal and mid-descending aortic regions was studied using a myograph technique. Flow velocity at the aortic root of cholesterol-fed ApoE −/− mice was significantly increased as a result of lumen narrowing...
Articles
Jenny MYERS, Rachel IRVINE, Joanna GILLHAM, Maureen MACLEOD, Gary MIRES, Michael TAGGART, Philip BAKER
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (5): 457–462.
Published: 22 April 2005
... endothelial-dependent relaxation in human myometrial arteries, is also capable of inducing altered endothelial function in mouse vessels. Human vessels were isolated from myometrial biopsies taken from women with uncomplicated pregnancies ( n =6). Mesenteric and uterine arteries were isolated from male...
Articles
Ulrika HÄGG, Irene ANDERSSON, Andrew S. NAYLOR, Julia GRÖNROS, Ingibjörg H. JONSDOTTIR, Göran BERGSTRÖM, Li-ming GAN
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (6): 571–581.
Published: 24 November 2004
..., Institute of Physiology and Pharmacology, Göteborg, Sweden (email [email protected] ). 15 6 2004 13 7 2004 6 8 2004 6 8 2004 The Biochemical Society 2004 endothelial function haemodynamics oxygen radical nitric oxide ultrasound Epidemiological data suggest...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (5): 443–445.
Published: 01 May 2004
...Naveed SATTAR There is increasing evidence to implicate inflammation as an important precursor of endothelial dysfunction. This mechanistic link is apparent across the entire spectrum of inflammatory status, i.e. endothelial function is apparent following acute infection, and in subjects...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (5): 447–448.
Published: 01 May 2004
...-inspired diet on endothelial function and lipid fractions. diet cardiovascular disease endothelial function lipid fraction oxidative stress © 2004 The Biochemical Society 2004 21 1 2004 26 1 2004 26 1 2004 Correspondence: Dr Aroon Hingorani (e-mail a.hingorani...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (5): 511–517.
Published: 01 May 2004
... The Biochemical Society 2004 coronary artery disease C-reactive protein (CRP) endothelial function forearm blood flow inflammation secretory non-pancreatic type II phospholipase A2 (sPLA2) Clinical Science (2004) 106, 511 517 (Printed in Great Britain) 511 Elevated secretory non-pancreatic type II...
Articles
Anneli AMBRING, Peter FRIBERG, Mette AXELSEN, Magdalena LAFFRENZEN, Marja-Riitta TASKINEN, Samar BASU, Mats JOHANSSON
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (5): 519–525.
Published: 01 May 2004
... of the present study are to improve endothelial function by dietary intervention in healthy subjects with lipid levels representative of a Western population. Twenty-two healthy subjects (mean total cholesterol, 5.6 mmol/l) were given a Mediterranean-inspired diet rich in ω-3 fatty acids and sterol esters...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (4): 353–358.
Published: 01 April 2004
...Richard J. WOODMAN; David E. CELERMAJER; Peter L. THOMPSON; Joseph HUNG Folic acid supplementation lowers total plasma homocysteine (tHcy) and improves endothelial function in individuals with coronary artery disease (CAD) and in those with additional CAD risk factors. In the present study, we...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (4): 345–346.
Published: 01 April 2004
... blood vessels. This comment discusses the study of Woodman and colleagues in this issue of Clinical Science in which they investigate the effects of hyperhomocysteinaemia on endothelial function. Correspondence: Professor Coen Stehouwer (e-mail [email protected] ). 27 11 2003 4 12...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (3): 239–240.
Published: 01 March 2004
... function nitric oxide (NO) physical exercise Clinical Science (2004) 106, 239 240 (Printed in Great Britain) 239 C O M M E N T Aging, physical fitness and endothelial function: are all ultracentenarians marathon runners? Guido GRASSI Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (3): 315–319.
Published: 01 March 2004
...-Hong Chen (e-mail [email protected] ). 8 7 2003 15 10 2003 16 10 2003 16 10 2003 © 2004 The Biochemical Society 2004 endothelial function flow-mediated vasodilatation glutathione peroxidase high-fat meal oxidative stress postprandial hypertriglyceridaemia...
Articles
Ferdinando FRANZONI, Fabio GALETTA, Carmela MORIZZO, Valter LUBRANO, Carlo PALOMBO, Gino SANTORO, Eleuterio FERRANNINI, Alfredo QUIÑONES-GALVAN
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (3): 329–335.
Published: 01 March 2004
... compared with trained subjects. NOx concentrations were positively correlated with V O 2 max ( r =0.46, P <0.001). Stimulated SBFs were correlated with NOx ( r >0.30, P <0.05). These findings show that chronic exercise may improve endothelial function in older (and young) men, probably...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (6): 699–707.
Published: 01 December 2003
... glucose and homocysteine levels, a lower low-density lipoprotein–cholesterol and a rise in the concentration of von Willebrand factor, indicating a prothrombotic endothelial function. The severity of the heart failure, measured as the plasma level of brain natriuretic peptide, correlated...
Articles
M. Pilar OUBIÑA, Natalia de las HERAS, Eva CEDIEL, David SANZ-ROSA, Paloma ARAGONCILLO, Cristina DÍAZ, Gonzalo HERNÁNDEZ, Vicente LAHERA, Victoria CACHOFEIRO
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (6): 655–662.
Published: 01 December 2003
... or in combination on inflammatory markers, endothelial function, intimal thickening and fibrinolytic balance in rabbits fed with either a control diet or a diet containing 1% (v/v) cholesterol for 12 weeks. Atorvastatin alone or in combination partially prevented the increase in cholesterol plasma levels observed...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 363–371.
Published: 01 September 2003
.... Correspondence: Dr Jonathan Elliott (e-mail [email protected] ). 27 1 2003 16 4 2003 21 5 2003 21 5 2003 © 2003 The Biochemical Society 2003 atherosclerosis chylomicron remnants endothelial function nitric oxide (NO) vasoconstriction/dilation Clinical Science (2003...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (1): 67–71.
Published: 01 July 2003
...) atherosclerosis cardiovascular disease endothelial function oestrogen nitric oxide Clinical Science (2003) 105, 67 71 (Printed in Great Britain) 67 Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women T. TEERLINK , S. J. M. NEELE , S. DE JONG...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (1): 113–118.
Published: 01 July 2003
... reactivity C-peptide endothelial function glucagon test homoeostasis model assessment (HOMA) index Type II diabetes mellitus Clinical Science (2003) 105, 113 118 (Printed in Great Britain) 113 Residual C-peptide secretion and endothelial function in patients with Type II diabetes Daniela MANZELLA...
Articles
Paul L. van HAELST, Jasper J. van DOORMAAL, Folkert W. ASSELBERGS, Arie M. van ROON, Nic J. G. M. VEEGER, Maureen M. HENNEMAN, Andries J. SMIT, Jan Willem COHEN TERVAERT, Johan F. MAY, Rijk O. B. GANS
Journal:
Clinical Science
Clin Sci (Lond) (2003) 104 (6): 627–632.
Published: 01 June 2003
... conclude that endothelial function, as reflected by FMD, does not seem to be related to markers of inflammation in familial hypercholesterolaemia subjects at high risk of, but without clinically overt signs of, atherosclerosis. Moreover, aggressive lipid-lowering therapy with simvastatin does not result...
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