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Keywords: endothelin
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Articles
Clin Sci (Lond) (2019) 133 (12): 1341–1352.
Published: 20 June 2019
... treatment. Activation of the endothelin system has emerged as an important pathway in PE pathophysiology based on experimental PE models where endothelin receptor antagonists (ERAs) prevented or attenuated hypertension and proteinuria. Hence, ERAs have been suggested as potential therapy for PE. However...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (20): 2261–2267.
Published: 29 October 2018
... (SMCs) is regulated by hypoxia and through the endothelin A (ET A ) receptor. SMCs from fibroids (fSMC) and the adjacent myometrium smooth muscle cells (mSMCs) were extracted from ten women undergoing hysterectomy for uterine fibroids and cultured with or without 1.0 µM of an ET A receptor antagonist...
Articles
Clin Sci (Lond) (2014) 126 (4): 267–274.
Published: 14 October 2013
... 8 2013 4 9 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 aldosterone blood pressure endothelin inflammation innate and adaptive immunity interleukin renin–angiotensin system (RAS) target organ damage regulatory T-cell (T reg -cell) vascular...
Articles
Clin Sci (Lond) (2013) 125 (7): 311–318.
Published: 07 June 2013
... Society 2013 androgen endothelin menopause obesity oestrogen renin–angiotensin system sympathetic nervous system The roles played by sex and gender in controlling blood pressure have not been completely elucidated, and studies have shown that these mechanisms are not as easily...
Articles
Clin Sci (Lond) (2011) 120 (11): 485–491.
Published: 15 February 2011
...Christian M. Westby; Brian R. Weil; Jared J. Greiner; Brian L. Stauffer; Christopher A. Desouza ET (endothelin)-1, a potent vasoconstrictor peptide released by the endothelium, plays an important role in vasomotor regulation and has been linked to diminished endothelial vasodilator capacity...
Articles
Clin Sci (Lond) (2010) 119 (11): 453–463.
Published: 17 August 2010
...Marc Iglarz; Martine Clozel ET (endothelin)-1 was first described as a potent vasoconstrictor. Since then, many other deleterious properties mediated via its two receptors, ET A and ET B , have been described, such as inflammation, fibrosis and hyperplasia. These effects, combined with a wide...
Articles
Clin Sci (Lond) (2010) 119 (9): 361–372.
Published: 23 July 2010
...Nathan R. Tykocki; Stephanie W. Watts The 21-amino-acid peptide ET-1 (endothelin-1) regulates a diverse array of physiological processes, including vasoconstriction, angiogenesis, nociception and cell proliferation. Most of the effects of ET-1 are associated with an increase in intracellular...
Articles
Clin Sci (Lond) (2008) 114 (4): 289–291.
Published: 15 January 2008
... from several randomized phase II trials in acute MI are eagerly awaited. BNP B-type natriuretic peptide EPO erythropoietin ET-1 endothelin-1 MI myocardial infarction References 1 Yellon D. M. Hausenloy D. J. Myocardial reperfusion injury N. Engl. J. Med...
Articles
Clin Sci (Lond) (2008) 114 (4): 293–304.
Published: 15 January 2008
... unit/ml EPO; P <0.005 compared with vehicle). Perfusate ET-1 (endothelin-1) increased transiently during EPO infusion, and the ET A/ ET B antagonist bosentan abolished the inotropic response to EPO. BNP (B-type natriuretic peptide) secretion (28±8%; P <0.05) and nuclear transcription factor GATA...
Articles
Clin Sci (Lond) (2008) 114 (2): 85–97.
Published: 11 December 2007
...Rita C. Tostes; Zuleica B. Fortes; Glaucia E. Callera; Augusto C. Montezano; Rhian M. Touyz; R. Clinton Webb; Maria Helena C. Carvalho The ETs (endothelins) comprise a family of three 21-amino-acid peptides (ET-1, ET-2 and ET-3) and 31-amino-acid ETs (ET-1 1–31 , ET-2 1–31 and ET-3 1–31 ). ET-1...
Articles
Clin Sci (Lond) (2007) 112 (9): 485–491.
Published: 02 April 2007
... to nitroprusside-induced hypotension. However, compared with the rise observed on the control day, plasma ANP (atrial natriuretic peptide; P =0.043), BNP (brain natriuretic peptide; P =0.038) and endothelin-1 ( P =0.011) levels were reduced following Ucn1 administration. Associated with this significant reduction...
Articles
Clin Sci (Lond) (2006) 110 (2): 205–206.
Published: 17 January 2006
...David M. Pollock Endothelin and reactive oxygen species have been identified as important mediators in the pathogenesis of hypertension and associated end-organ damage. In the present issue of Clinical Science , Callera and co-workers have provided new evidence that endothelin stimulates...
Articles
Clin Sci (Lond) (2004) 107 (5): 467–475.
Published: 26 October 2004
...Martin E. BEYER; Tobias HÖVELBORN; Ursula DELABAR; Hans Martin HOFFMEISTER The main aim of the present study was to investigate the direct inotropic effects of stimulation of the endothelin (ET) receptor ET A under in vivo conditions. It is well known that ET A receptor stimulation causes...
Articles
Clin Sci (Lond) (2004) 106 (6): 569–576.
Published: 01 June 2004
...Miriam T. RADEMAKER; Chris J. CHARLES; Eric A. ESPINER; Chris M. FRAMPTON; M. Gary NICHOLLS; A. Mark RICHARDS Blockade of AngII (angiotensin II) and ET (endothelin)-1, established and potential therapeutic strategies respectively, for heart failure, may have an adverse effect on the cardiac...
Articles
Clin Sci (Lond) (2003) 105 (6): 647–653.
Published: 01 December 2003
...Jean-François JASMIN; Peter CERNACEK; Jocelyn DUPUIS Although activation of the endothelin (ET) system contributes to pulmonary hypertension, modifications of the cardiopulmonary ET system and its responses to chronic ET receptor blockade are not well known. To investigate this, rats were injected...
Articles
Clin Sci (Lond) (2003) 104 (2): 143–151.
Published: 17 January 2003
...Felix BÖHM; John PERNOW; Jonas LINDSTRÖM; Gunvor AHLBORG The contribution of the endothelin (ET) receptors ET A and ET B to basal vascular tone and ET-1-induced vasoconstriction in the renal and splanchnic vasculature was investigated in six healthy humans. ET-1 was infused alone and in combination...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 179S–183S.
Published: 01 September 2002
...Zenon S. KYRIAKIDES; Dimitrios Th. KREMASTINOS; Fotis KOLOKATHIS; Anna KOSTOPOULOU; Michael GEORGIADIS; David J. WEBB Endothelin (ET) exerts a tonic, stiffening effect on the common carotid artery in rats in vitro . This effect is mediated via the ET A receptor. The aim of this study was to examine...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 396S–398S.
Published: 01 September 2002
...Torsten SLOWINSKI; Thomas SUBKOWSKI; Petra DIEHR; Daniela BACHERT; Lutz FRITSCHE; Hans.-H. NEUMAYER; Berthold HOCHER Plasma endothelin (ET)-1 concentrations have been shown to be elevated in patients receiving calcineurin-inhibitors (CI). We investigated urinary and plasma ET-1 (uET-1, pET-1...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 267S–271S.
Published: 01 September 2002
... Trypanosoma cruzi , is an important cause of cardiomyopathy. Microvascular spasm and matrix dissolution, modulated by endothelin-1 (ET-1), is implicated in the pathogenesis of chagasic heart disease. To further elucidate the role of ET-1 in murine chagasic heart disease, C57BL/6×129sv mice were infected...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 132S–136S.
Published: 01 September 2002
...Andrey SOROKIN; Marco FOSCHI; Michael J. DUNN The molecular mechanisms of endothelin (ET)-dependent activation of extracellular signal-regulated kinase (ERK)and p38 mitogen-activated protein (MAP) kinase were studied in rat and human renal glomerular mesangial cells. ET-1 induced a rapid...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 228S–232S.
Published: 01 September 2002
...Li LIN; Wen-Jun YUAN This study aims to investigate the role of endothelin-1 (ET-1) in the genesis of acute ischaemic arrhythmias. In anaesthetized cats and rats receiving continuous monitor of electrocardiogram and arterial blood pressure, the ischaemic arrhythmias during 60-min myocardial...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 1S–3S.
Published: 01 September 2002
...Anthony P. DAVENPORT; Bruno BATTISTINI The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr A.P. Davenport (e-mail Apd10@medschl.cam.ac.uk ) or Dr B. Battistini (e-mail Bruno.battistini@med.ulaval.ca ). © 2002...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 314S–317S.
Published: 01 September 2002
...Badar A. USMANI; Ben HARDEN; Norman J. MAITLAND; Anthony J. TURNER Neutral endopeptidase-24.11 (neprilysin; NEP/CD10) is a cell surface metallopeptidase expressed by prostatic epithelial cells that degrades various bioactive peptides including endothelin. Endothelin-converting enzyme (ECE), the key...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 399S–403S.
Published: 01 September 2002
...David K. MENON; Diana DAY; Rhoda E. KUC; Andrew J. DOWNIE; Doris A. CHATFIELD; Anthony P. DAVENPORT Plasma endothelin (ET) is elevated in patients with vasospasm following subarachnoid haemorrhage (SAH). However, systemic levels provide no indication regarding local production in the brain...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 404S–407S.
Published: 01 September 2002
...Andrzej LOESCH; Geoffrey BURNSTOCK Novel data is presented from this electron-immunocytochemical study that demonstrates endothelin-containing cerebrovascular nerves in the human middle cerebral artery. The Seventh International Conference on Endothelin was held at the University of Edinburgh...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 189S–193S.
Published: 01 September 2002
...Andrew T. GOODWIN; Mohamed AMRANI; Caroline C. GRAY; Jay JAYAKUMAR; Adrian J. MARCHBANK; Magdi H. YACOUB Endothelin (ET) may have both detrimental (reduced coronary flow) and beneficial effects (positive inotrope, reduced arrhythmogenesis) following ischaemia. We examined the effects of ET...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 233S–236S.
Published: 01 September 2002
... compared with that in control periods. Since endothelin-1 (ET-1) has been proven to be an endogenous arrhythmogenic substance, we investigated the changes in serum ET-1 and big-ET levels in patients undergoing ICD implantation. Serum concentrations of ET-1 and big-ET were measured in 14 patients...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 48S–52S.
Published: 01 September 2002
...Tomoyuki KUWAKI; Toru ISHII; Kihwan JU; Masashi YANAGISAWA; Yasuichiro FUKUDA Blood pressure (BP) and heart rate (HR) in endothelin-3 (ET-3) null (-/-) knockout mice and ET A receptor (-/-) mice were measured using the servo null pressure measuring technique under halothane anaesthesia. In infant...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 237S–240S.
Published: 01 September 2002
...Henning MORAWIETZ; Winfried GOETTSCH; Marten SZIBOR; Matthias BARTON; Sidney SHAW; Kavous HAKIM; Hans-Reinhard ZERKOWSKI; Juergen HOLTZ Endothelin-1 (ET-1) is considered to be involved in the development and progression of heart failure. Therefore, we analysed the expression of endothelin...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 9S–12S.
Published: 01 September 2002
...Henning MORAWIETZ; Nicole DUERRSCHMIDT; Bernd NIEMANN; Jan GALLE; Tatsuya SAWAMURA; Juergen HOLTZ Endothelin-1 (ET-1) may be involved in the development and progression of atherosclerosis. Furthermore, endothelin receptor blockade was shown to reduce the formation of atherosclerotic lesions...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 241S–244S.
Published: 01 September 2002
...Masato OHNISHI; Atsuyuki WADA; Takayoshi TSUTAMOTO; Masanori FUJII; Takehiro MATSUMOTO; Takashi YAMAMOTO; Tomoyuki TAKAYAMA; Xinwen WANG; Masahiko KINOSHITA Congestive heart failure (CHF) is characterized by increased peripheral vascular resistance. Endothelin-1 (ET-1), a potent endothelium-derived...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 53S–58S.
Published: 01 September 2002
...Charles J. FERRO; William G. HAYNES; Malcolm F. HAND; David J. WEBB The importance of endothelin-1 (ET-1) in the pathophysiology of essential hypertension is unclear. We therefore compared the effects of endothelin ET A receptor blockade and the stimulation of ET A and ET B receptors...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 371S–375S.
Published: 01 September 2002
...Bilal AYACH; John TSANG; Arco Y. JENG; André BLOUIN; Mélanie GOSSELIN; Fu-Hou WANG; Jinshyun R. WU-WONG; Jerry WESSALE; Terry J. OPGENORTH; Bruno BATTISTINI Acute pulmonary air embolism (APAE) injures the vascular endothelium in the lung and results in pulmonary hypertension (PH). Endothelins (ETs...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 418S–423S.
Published: 01 September 2002
...Jinshyun R. WU-WONG; Cathleen E. BERG; Brian D. DAYTON Endothelin-1 (ET-1) is a 21-amino-acid peptide that binds to G-protein-coupled receptors to evoke biological responses. Previously we have shown that ET-1 stimulates glucose uptake in 3T3-L1 adipocytes and neonatal rat cardiomyocytes...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 107S–111S.
Published: 01 September 2002
...J. Ruth WU-WONG; Douglas B. DIXON; William J. CHIOU; Brian K. SORENSEN; Gang LIU; H.-S. JAE; Andrew TASKER; Thomas W. Von GELDERN; Martin WINN; Terry J. OPGENORTH Endothelins (ETs), 21-amino-acid peptides involved in the pathogenesis of various diseases, bind to ET A and ET B receptors to initiate...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 424S–429S.
Published: 01 September 2002
... to determine the effect of diabetes mellitus on endothelin (ET)-1, ET-3, vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8)-mediated angiogenesis. In an initial group of experiments, streptozotocin-induced diabetes resulted in impairment of ET-1-mediated angiogenesis from 69% to 32...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 249S–253S.
Published: 01 September 2002
... International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr R. Willenbrock (e-mail willenbrock@fvk-berlin.de ). © 2002 The Biochemical Society and the Medical Research Society 2002 atrial natriuretic peptide brain natriuretic peptide congestive...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 21S–24S.
Published: 01 September 2002
... and prevented an increase in mean pulmonary artery pressure, without significant systemic effects, when compared with controls. Our results indicate the occurrence of selective pulmonary vasodilation in both treatment groups. The Seventh International Conference on Endothelin was held at the University...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 162S–166S.
Published: 01 September 2002
...Noreen F. ROSSI; Haiping CHEN The endothelins (ETs) stimulate the secretion of arginine-vasopressin (AVP) in vivo and in vitro . The activation of hypothalamic ET B receptors increases AVP release, but the neurotransmitters mediating these responses are not known. In the compartmentalized...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 112S–117S.
Published: 01 September 2002
...Jerry L. WESSALE; Andrew L. ADLER; Eugene I. NOVOSAD; Samuel V. CALZADILLA; Brian D. DAYTON; Kennan C. MARSH; Martin WINN; Hwan-Soo JAE; Thomas W.von GELDERN; Terry J. OPGENORTH; J. Ruth WU-WONG Endothelins (ETs), 21-amino-acid peptides involved in the pathogenesis of various diseases, bind to ET...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 442S–445S.
Published: 01 September 2002
...Robert J. PADLEY; Douglas B. DIXON; J. Ruth WU-WONG Endothelin (ET) plays a pivotal role in the pathogenesis of cell growth disorders such as cancer. Atrasentan (ABT-627), a selective antagonist for the ET receptor A (ET A ), has shown benefit in controlling disease progression in men with hormone...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 446S–449S.
Published: 01 September 2002
...Torsten SLOWINSKI; Hans-H. NEUMAYER; Thomas STOLZE; Gabriele GOSSING; Horst HALLE; Berthold HOCHER Pre-eclampsia complicates approximately 5–7% of pregnancies and it may be deleterious to both maternal and fetal health. In a prospective study, we investigated plasma endothelin (ET)-1 concentration...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 455S–458S.
Published: 01 September 2002
...Takaharu KOZAKAI; Hong ZHAO; Mitsue SAKATE; Yoshinori MASUO; Tsuyoshi UCHIDE; Kaname SAIDA To elucidate the physiological roles of endothelin-1 (ET-1) and endothelin-2 (ET-2)/vasoactive intestinal contractor (VIC) in gastric injury of mice, we measured the gene expression rates of ET-1 and ET-2/VIC...
Articles
Clin Sci (Lond) (2002) 102 (6): 661–666.
Published: 14 May 2002
...R.C. WIMALASUNDERA; S.A.McG. THOM; L. REGAN; A.D. HUGHES Endothelin-1 (ET-1) has been proposed to contribute to the regulation of vascular tone in humans. BQ-123, an ET A receptor antagonist, has also been reported to increase forearm blood flow (FBF) in vivo ; however, the efficacy of BQ-123...
Articles
Clin Sci (Lond) (2001) 101 (1): 45–51.
Published: 24 May 2001
...Chris HILLIER; Mark C. PETRIE; Michael P. LOVE; Fiona JOHNSTON; Margaret R. MACLEAN; John J. V. MCMURRAY Endothelin-1 (ET-1) and adrenomedullin (ADM) are both produced in the arterial wall, but have opposing biological actions. Evidence from experimental animals suggests a functional interaction...
Articles
Clin Sci (Lond) (2000) 99 (3): 175–179.
Published: 02 August 2000
...Daniel F. MCAULEY; Ailish G. NUGENT; Colm MCGURK; Suzanne MAGUIRE; J. Randal HAYES; G. Dennis JOHNSTON Endothelin-1 has potent vasoconstrictor and vasopressor actions contributing to basal vascular tone and maintenance of blood pressure acting predominantly through endothelin-A receptors...
Articles
Clin Sci (Lond) (1999) 97 (2): 149–156.
Published: 16 June 1999
...Flemming WOLLESEN; Lars BERGLUND; Christian BERNE Insulin stimulates endothelin-1 (ET-1) expression in a dose-response relationship, and ET-1 effects on vascular wall structure are similar to the long-term complications of diabetes. We therefore determined whether the plasma ET-1 concentration...
Articles
Clin Sci (Lond) (1999) 96 (6): 577–588.
Published: 04 May 1999
... disease for the response to mild cool stimuli, and whether the cutaneous response is accompanied by the release of endothelin-1 (ET-1). In nine subjects with primary Raynaud's disease and in nine matched controls, the left hand was placed in cool water at 16 °C for 2 min five times on each of three...
Articles
Clin Sci (Lond) (1999) 96 (4): 397–402.
Published: 01 April 1999
...Takako OKAMOTO-KOIZUMI; Masayuki TAKEDA; Takeshi KOMEYAMA; Akihiko HATANO; Makoto TAMAKI; Takaki MIZUSAWA; Toshiki TSUTSUI; Kenji OBARA; Yoshihiko TOMITA; Kei ARAI; Kota TAKAHASHI The aim of this study was to characterize endothelin receptor subtypes of the detrusor muscle of the human urinary...
Articles
Clin Sci (Lond) (1998) 95 (5): 595–602.
Published: 01 November 1998
...Giorgio LA VILLA; Massimo MANNELLI; Chiara LAZZERI; Sabrina VECCHIARINO; Maria Laura DE FEO; Cristina TOSTI GUERRA; Renzo BANDINELLI; Marco FOSCHI; Franco FRANCHI 1. Following the observation that brain natriuretic peptide enhances the urinary excretion rate of endothelin-1, the relationship...