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Keywords: endothelin-1
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Articles

Enhanced vasoconstriction in sickle cell disease is dependent on ET A receptor activation

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Endothelin XVIII Conference Collection
John Miller Allan, Brandon M. Fox, Malgorzata Kasztan, Gillian C. Kelly, Patrick A. Molina, McKenzi A. King, Jackson Colson, Leigh Wells, Latanya Bowman, Marsha Blackburn, Abdullah Kutlar, Ryan A. Harris, David M. Pollock, Jennifer S. Pollock
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (23): 1505–1520.
https://doi.org/10.1042/CS20240625
Published: 26 November 2024
... for poor vascular health and vascular dysfunction. High levels of vascular reactive oxygen species (ROS) as well as elevated plasma endothelin-1 (ET-1), a potent vasoconstrictor with actions via the ET A receptor, are both common phenotypes in SCD. Alpha-1 adrenergic receptor activation is a major mediator...
View articletitled, Enhanced vasoconstriction in sickle cell disease is dependent on ET A receptor activation
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Includes: Supplementary data
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Complex regulation of tau phosphorylation by the endothelin system in brain microvascular endothelial cells (BMVECs): link to barrier function

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Endothelin XVIII Conference Collection
Eda Karakaya, Yasir Abdul, Jazlyn Edwards, Sarah Jamil, Onder Albayram, Adviye Ergul
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (21): 1329–1341.
https://doi.org/10.1042/CS20240616
Published: 24 October 2024
...Eda Karakaya; Yasir Abdul; Jazlyn Edwards; Sarah Jamil; Onder Albayram; Adviye Ergul Endothelin-1 (ET-1), the most potent vasoconstrictor identified to date, contributes to cerebrovascular dysfunction. ET-1 levels in postmortem brain specimens from individuals diagnosed with Alzheimer’s disease (AD...
View articletitled, Complex regulation of tau phosphorylation by the endothelin system in brain microvascular endothelial cells (BMVECs): link to barrier function
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Includes: Supplementary data
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Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity

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Endothelin XVIII Conference Collection
Anna Flavia R. Lima, Daniel Rodrigues, Mirele R. Machado, José Teles Oliveira-Neto, Alecsander F. M. Bressan, Carina A. Pedersoli, Juliano V. Alves, Júlio A. Silva-Neto, Paula R. Barros, Thiago B. Dias, Luis V. Garcia, Ariane Bruder-Nascimento, Thiago Bruder-Nascimento, Fernando S. Carneiro, Luiz Osório S. Leiria, Rita C. Tostes, Rafael M. Costa
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (17): 1071–1087.
https://doi.org/10.1042/CS20240624
Published: 30 August 2024
... is the peptide endothelin-1 (ET-1), which induces oxidative stress and disrupts vascular function. The present study postulates that obesity augments ET-1 production in the PVAT, decreases the function of the nuclear factor erythroid 2-related factor-2 (Nrf2) transcription factor, further increasing reactive...
View articletitled, Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity
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Articles

Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions

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Endothelin XVIII Conference Collection
Mia Edgerton-Fulton, Yasir Abdul, Sarah Jamil, Adviye Ergul
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (16): 1009–1022.
https://doi.org/10.1042/CS20240328
Published: 21 August 2024
... endothelin-1 pericytes senescence Veterans Affairs (VA) Merit Review BX000347 VA Senior Research Career Scientist Award IK6 BX004471 National Institute of Health (NIH) RF1 NS083559 National Institute of Health (NIH) R01 NS104573 NINDS-Diversity Supplement RF1...
View articletitled, Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions
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Includes: Supplementary data
Articles

Mechanism of protective actions of sparsentan in the kidney: lessons from studies in models of chronic kidney disease

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Donald E. Kohan, Patricia W. Bedard, Celia Jenkinson, Bruce Hendry, Radko Komers
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (11): 645–662.
https://doi.org/10.1042/CS20240249
Published: 29 May 2024
... Endothelin-1 FSGS IgA nephropathy Sparsentan Travere Therapeutics, Inc. Evidence collected over three decades supports the use of dual inhibition of the renin–angiotensin–aldosterone (RAAS) and endothelin (ET) systems in the treatment of proteinuric chronic kidney disease (CKD...
View articletitled, Mechanism of protective actions of sparsentan in the kidney: lessons from studies in models of chronic kidney disease
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Pre-clinical effects of highly potent MEK1/2 inhibitors on rat cerebral vasculature after organ culture and subarachnoid haemorrhage

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Clinical and translational research highlights
Simon T. Christensen, Kristian A. Haanes, Stine Spray, Anne-Sofie Grell, Karin Warfvinge, Lars Edvinsson, Sara E. Johansson
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (16): 1797–1811.
https://doi.org/10.1042/CS20190636
Published: 20 August 2019
.... In both regimens, trametinib treatment caused significant reductions in the endothelin-1 induced contractility after SAH, which is believed to be associated with endothelin B receptor up-regulation. Trametinib treated rats showed improved neurological scores, evaluated by the ability to traverse...
View articletitled, Pre-clinical effects of highly potent MEK1/2 inhibitors on rat cerebral vasculature after organ culture and subarachnoid haemorrhage
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Includes: Supplementary data
Articles

Impact of ET-1 and sex in glomerular hyperfiltration in humanized sickle cell mice

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Malgorzata Kasztan, David M. Pollock
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (13): 1475–1486.
https://doi.org/10.1042/CS20190215
Published: 15 July 2019
... ). Previous studies have demonstrated that endothelin-1 (ET-1) contributes to P alb changes in models of diabetes and SCD. Thus, we performed longitudinal studies of renal function to determine the relationship between ET-1 and glomerular size and P alb that may contribute to hyperfiltration in humanized...
View articletitled, Impact of ET-1 and sex in glomerular hyperfiltration in humanized sickle cell mice
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Articles

TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury

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Junhui Shen, Zhong-Kai Cui, Fang Yao, Kai Li, Yue Zhang, Zhenguo Chen, Yuxia Zhou, Song Xu, Yuwei Zhang, Wenqing Jiang, Hanbin Zhang, Kaifen Tan, Anling Liu, Xiaochun Bai
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (19): 2087–2101.
https://doi.org/10.1042/CS20180348
Published: 02 October 2018
... of serum creatinine and blood urea nitrogen in AKI compared with that in TSC1 fl/fl control mice. Endothelin-1 (EDN1) and phospho-Jun-amino-terminal kinase (p-JNK) were up-regulated in Fibro-TSC1 −/− renal fibroblasts after LPS challenge. Rapamycin, an mTORC1 inhibitor, and bosentan, an EDN1 antagonist...
View articletitled, TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury
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Includes: Supplementary data
Articles

Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia

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Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2777–2789.
https://doi.org/10.1042/CS20171292
Published: 23 November 2017
... vasoconstrictor sensitivity to endothelin-1 (ET-1), mediated by alterations in ET-1 receptor type-B (ET B R). We evaluated ET-1 sensitivity, ET A R, and ET B R contributions to ET-1-mediated constriction, and the mechanistic role of ET B R in endothelium-dependent dilation in vivo in the microvasculature...
View articletitled, Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia
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Consequences of postnatal vascular smooth muscle EGFR deletion on acute angiotensin II action

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Barbara Schreier, Mirja Hünerberg, Sindy Rabe, Sigrid Mildenberger, Daniel Bethmann, Christian Heise, Maria Sibilia, Stefan Offermanns, Michael Gekle
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (1): 19–33.
https://doi.org/10.1042/CS20150503
Published: 30 November 2015
... development and extracellular-signal-regulated kinase 1 and 2 (ERK1/2) phosphorylation in aortic rings from KO animals. By contrast, we observed no difference in force development during application of serotonin, KCl, endothelin-1 or endothelin-1-induced pressure load in KO animals. In addition, nitric oxide...
View articletitled, Consequences of postnatal vascular smooth muscle EGFR deletion on acute angiotensin II action
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Includes: Supplementary data
Articles

Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase

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Rocío López-Sepúlveda, Manuel Gómez-Guzmán, Maria José Zarzuelo, Miguel Romero, Manuel Sánchez, Ana María Quintela, Pilar Galindo, Francisco O'Valle, Juan Tamargo, Francisco Pérez-Vizcaíno, Juan Duarte, Rosario Jiménez
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (8): 321–333.
https://doi.org/10.1042/CS20100311
Published: 22 December 2010
... endothelial function by reducing the plasma levels of ET-1 (endothelin-1) and the subsequent vascular production of O 2 •− (superoxide anion). Our present study was designed to evaluate whether RWPs act directly in the vascular wall improving endothelial dysfunction and O 2 •− production induced by ET-1...
View articletitled, Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase
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Articles

Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms

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Glaucia E. Callera, Rita C. Tostes, Alvaro Yogi, Augusto C. I. Montezano, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (2): 243–253.
https://doi.org/10.1042/CS20050307
Published: 17 January 2006
...)-salt hypertension endothelin-1 ET A receptor NADPH oxidase oxidative stress The study protocol was approved by the Animal Care Committees of the University of Sao Paulo and the Clinical Research Institute of Montreal. Rats were housed under conditions of constant humidity...
View articletitled, Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms
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Articles

The endothelin-1 receptor antagonist bosentan protects against ischaemia/reperfusion-induced endothelial dysfunction in humans

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Felix BÖHM, Magnus SETTERGREN, Adrian T. GONON, John PERNOW
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (4): 357–363.
https://doi.org/10.1042/CS20040317
Published: 22 March 2005
...Felix BÖHM; Magnus SETTERGREN; Adrian T. GONON; John PERNOW Endothelial dysfunction may contribute to the extent of ischaemia/reperfusion injury. ET (endothelin)-1 receptor antagonism protects against myocardial ischaemia/reperfusion injury in animal models. The present study investigated whether...
View articletitled, The endothelin-1 receptor antagonist bosentan protects against ischaemia/reperfusion-induced endothelial dysfunction in humans
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Effects of a dual endothelin-1 receptor antagonist on airway obstruction and acute lung injury in sheep following smoke inhalation and burn injury

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Robert A. COX, Perenlei ENKHABAATAR, Ann S. BURKE, Jiro KATAHIRA, Katahiro SHIMODA, Abhijit CHANDRA, Lillian D. TRABER, David N. HERNDON, Hal K. HAWKINS, Daniel L. TRABER
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (3): 265–272.
https://doi.org/10.1042/CS20040191
Published: 18 February 2005
...Robert A. COX; Perenlei ENKHABAATAR; Ann S. BURKE; Jiro KATAHIRA; Katahiro SHIMODA; Abhijit CHANDRA; Lillian D. TRABER; David N. HERNDON; Hal K. HAWKINS; Daniel L. TRABER Studies have suggested that ET-1 (endothelin-1) is associated with lung injury, airway inflammation and increased vascular...
View articletitled, Effects of a dual endothelin-1 receptor antagonist on airway obstruction and acute lung injury in sheep following smoke inhalation and burn injury
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The procyanidin-induced pseudo laminar shear stress response: a new concept for the reversal of endothelial dysfunction

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Roger CORDER, Richard C. WARBURTON, Noorafza Q. KHAN, Ruth E. BROWN, Elizabeth G. WOOD, Delphine M. LEES
Journal: Clinical Science
Clin Sci (Lond) (2004) 107 (5): 513–517.
https://doi.org/10.1042/CS20040189
Published: 26 October 2004
...Roger CORDER; Richard C. WARBURTON; Noorafza Q. KHAN; Ruth E. BROWN; Elizabeth G. WOOD; Delphine M. LEES Reduced endothelium-dependent vasodilator responses with increased synthesis of ET-1 (endothelin-1) are characteristics of endothelial dysfunction in heart failure and are predictive...
View articletitled, The procyanidin-induced pseudo laminar shear stress response: a new concept for the reversal of endothelial dysfunction
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Pattern of prepro-endothelin-1 expression revealed by reporter-gene activity in kidneys of erythropoietin-overexpressing mice

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Torsten SLOWINSKI, Norma SCHULZ, Frank T. RUSCHITZKA, Thomas QUASCHNING, Christian BAUER, Franz THEURING, Hans-H. NEUMAYER, Max GASSMANN, Berthold HOCHER
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 44S–47S.
https://doi.org/10.1042/CS103S044S
Published: 01 September 2002
... viscosity and volume. As a consequence, renal tissue endothelin-1 (ET-1) concentrations are significantly elevated in erythropoietin-overexpressing (Epo+) mice (mean±S.E.M; Epo+, 798±71; Epo-, 400±25pg/g tissue; P <0.01). To investigate the pattern of expression of the primary translation product...
View articletitled, Pattern of prepro-endothelin-1 expression revealed by reporter-gene activity in kidneys of erythropoietin-overexpressing mice
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Articles

Chronic elevated endothelin-1 concentrations regulate mitogen-activated protein kinases ERK 1 and ERK 2 in vascular smooth muscle cells

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Bernhard R. BREHM, Martina KLAUSSNER, Sabine C. WOLF
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 137S–140S.
https://doi.org/10.1042/CS103S137S
Published: 01 September 2002
...Bernhard R. BREHM; Martina KLAUSSNER; Sabine C. WOLF Increased endothelin-1 (ET-1) levels are found in patients with atherosclerosis. ET-1 is known to increase the mitotic response of different growth factors already at threshold concentrations. The aim of this study was to investigate...
View articletitled, Chronic elevated endothelin-1 concentrations regulate mitogen-activated protein kinases ERK 1 and ERK 2 in vascular smooth muscle cells
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Influence of endothelin receptor antagonists on myocardial protein kinase C isoforms in uraemic cardiomyopathy

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Sabine C. WOLF, Thorsten AMEND, Teut RISLER, Kerstin AMANN, Bernhard R. BREHM
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 276S–279S.
https://doi.org/10.1042/CS103S276S
Published: 01 September 2002
...Sabine C. WOLF; Thorsten AMEND; Teut RISLER; Kerstin AMANN; Bernhard R. BREHM Increased endothelin-1 (ET-1) levels were found in patients with chronic renal failure and these correlate with the severity of renal failure. Increased mortality due to cardiovascular problems is observed in patients...
View articletitled, Influence of endothelin receptor antagonists on myocardial protein kinase C isoforms in uraemic cardiomyopathy
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Role of endothelin-1 receptors in the sarcolemma membrane and the nuclear membrane in the modulation of basal cytosolic and nuclear calcium levels in heart cells

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Ghassan BKAILY, Danie MASSAAD, Sanaa CHOUFANI, Danielle JACQUES, Pedro D'ORLÉANS-JUSTE
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 141S–147S.
https://doi.org/10.1042/CS103S141S
Published: 01 September 2002
... and the confocal microscopy technique, our present results show that stimulation of endothelin-1 (ET-1) receptors at the sarcolemma membrane induced a dose-dependent sustained increase in basal cytosolic and nuclear calcium levels that was insensitive to the ET A and ET B receptor antagonists BQ123 and BQ788...
View articletitled, Role of endothelin-1 receptors in the sarcolemma membrane and the nuclear membrane in the modulation of basal cytosolic and nuclear calcium levels in heart cells
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Coronary responses to endothelin-1 and acetylcholine during partial coronary ischaemia and reperfusion in anaesthetized goats

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Maria Angeles MARTÍNEZ, Nuria FERNÁNDEZ, Luis MONGE, Angel Luis GARCÍA-VILLALÓN, Elena SANZ, Godofredo DIÉGUEZ
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 194S–197S.
https://doi.org/10.1042/CS103S194S
Published: 01 September 2002
...Maria Angeles MARTÍNEZ; Nuria FERNÁNDEZ; Luis MONGE; Angel Luis GARCÍA-VILLALÓN; Elena SANZ; Godofredo DIÉGUEZ To examine coronary reactivity to acetylcholine and endothelin-1 (ET-1) during partial ischaemia and reperfusion, flow in the left circumflex coronary artery was measured...
View articletitled, Coronary responses to endothelin-1 and acetylcholine during partial coronary ischaemia and reperfusion in anaesthetized goats
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Effect of the novel endothelin(A) receptor antagonist LU 208075 on contraction and relaxation of isolated rat basilar artery

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Hartmut VATTER, Michael ZIMMERMANN, Carla JUNG, Edda WEYRAUCH, Josef LANG, Volker SEIFERT
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 408S–413S.
https://doi.org/10.1042/CS103S408S
Published: 01 September 2002
... (e-mail [email protected] ). © 2002 The Biochemical Society and the Medical Research Society 2002 endothelin-1 big endothelin-1 ET(A) receptor antagonist rat basilar artery LU 208075 ...
View articletitled, Effect of the novel endothelin(A) receptor antagonist LU 208075 on contraction and relaxation of isolated rat basilar artery
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Stimulation of peroxisome-proliferator-activated receptor α (PPAR α) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts

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Takehiro OGATA, Takashi MIYAUCHI, Satoshi SAKAI, Yoko IRUKAYAMA-TOMOBE, Katsutoshi GOTO, Iwao YAMAGUCHI
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 284S–288S.
https://doi.org/10.1042/CS103S284S
Published: 01 September 2002
...Takehiro OGATA; Takashi MIYAUCHI; Satoshi SAKAI; Yoko IRUKAYAMA-TOMOBE; Katsutoshi GOTO; Iwao YAMAGUCHI Endothelin-1 (ET-1) production is increased in hypertrophied hearts accompanied with fibrosis. ET-1 is a potent mitogen of fibroblasts and ET receptor antagonists are reported to inhibit...
View articletitled, Stimulation of peroxisome-proliferator-activated receptor α (PPAR α) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts
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Pericardial concentrations of adenosine, inosine and hypoxanthine in an experimental canine model of spastic ischaemia

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Violetta KÉKESI, Endre ZIMA, Erzsébet BARÁT, Éva HUSZÁR, Andrea NAGY, László LOSONCZI, Béla MERKELY, Ferenc HORKAY, Alexander Juhász-Nagy
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 198S–201S.
https://doi.org/10.1042/CS103S198S
Published: 01 September 2002
... the intrapericardial concentrations of adenosine, inosine and hypoxanthine during coronary spasm provoked by intracoronary administration of endothelin-1 (ET-1; 0.08±0.02nmol/g of myocardial tissue). In the in situ dog heart ( n = 10), adenosine, inosine and hypoxanthine concentrations were determined by HPLC in fluid...
View articletitled, Pericardial concentrations of adenosine, inosine and hypoxanthine in an experimental canine model of spastic ischaemia
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Effects of periodontopathic bacteria on the expression of endothelin-1 in gingival epithelial cells in adult periodontitis

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Toshihiro ANSAI, Eri YAMAMOTO, Shuji AWANO, Weixian YU, Anthony J. TURNER, Tadamichi TAKEHARA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 327S–331S.
https://doi.org/10.1042/CS103S327S
Published: 01 September 2002
... gingivalis . Our aims in the present study were to examine the expression of endothelin-1 (ET-1) in cultured HEp-2 epithelial cells after infection with P. gingivalis , and in gingival tissue from adult periodontitis patients. The cell lines were infected with the strains P. gingivalis 33277 and 381...
View articletitled, Effects of periodontopathic bacteria on the expression of endothelin-1 in gingival epithelial cells in adult periodontitis
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Effects of increased pulmonary flow on the expression of endothelial nitric oxide synthase and endothelin-1 in the rat

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Zen-Kong DAI, Mian-Shin TAN, Chee-Yin CHAI, Ing-Jun CHEN, Arco Y. JENG, Jiunn-Ren WU
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 289S–293S.
https://doi.org/10.1042/CS103S289S
Published: 01 September 2002
...) and endothelin-1 (ET-1) in the rat lung. Nine 42-day-old Wistar rats underwent abdominal aortocaval shunt to increase pulmonary blood flow for 12 weeks. The shunt resulted in significant medial hypertrophy of pulmonary artery without significant alterations in pulmonary or systemic blood pressure. Using...
View articletitled, Effects of increased pulmonary flow on the expression of endothelial nitric oxide synthase and endothelin-1 in the rat
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Peroxisome proliferator-activated receptor-γ activators inhibit endothelin-1-related cardiac hypertrophy in rats

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Satoshi SAKAI, Takashi MIYAUCHI, Yoko IRUKAYAMA-TOMOBE, Takehiro OGATA, Katsutoshi GOTO, Iwao YAMAGUCHI
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 16S–20S.
https://doi.org/10.1042/CS103S016S
Published: 01 September 2002
...Satoshi SAKAI; Takashi MIYAUCHI; Yoko IRUKAYAMA-TOMOBE; Takehiro OGATA; Katsutoshi GOTO; Iwao YAMAGUCHI Endothelin-1 (ET-1) causes cardiac hypertrophy, and ET receptor antagonists inhibit the development of cardiac hypertrophy in vitro and in vivo . Peroxisome proliferator-activated receptor γ...
View articletitled, Peroxisome proliferator-activated receptor-γ activators inhibit endothelin-1-related cardiac hypertrophy in rats
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Effects of endothelin receptors ET A and ET B blockade on renal haemodynamics in normal rats and in rats with experimental congestive heart failure

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Zaid ABASSI, Bahaa FRANCIS, Jerry WESSALE, Elena OVCHARENKO, Joseph WINAVER, Aaron HOFFMAN
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 245S–248S.
https://doi.org/10.1042/CS103S245S
Published: 01 September 2002
...Zaid ABASSI; Bahaa FRANCIS; Jerry WESSALE; Elena OVCHARENKO; Joseph WINAVER; Aaron HOFFMAN The present study examined the effects of two highly selective endothelin-1 (ET-1) receptor antagonists, ABT-627 (ET A blocker) and A-192621 (ET B blocker), on the systemic and renal haemodynamic effects...
View articletitled, Effects of endothelin receptors ET A and ET B blockade on renal haemodynamics in normal rats and in rats with experimental congestive heart failure
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Endothelin-1-induced elevations in purine metabolite concentrations — autoregulatory protection in the canine pericardium?

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Endre ZIMA, Violetta KÉKESI, Andrea NAGY, László LOSONCZI, Ildikó TOMA, Pál SOÓS, Erzsébet Barát, Éva HUSZÁR, Béla MERKELY, Ferenc HORKAY, Alexander Juhász-Nagy
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 202S–205S.
https://doi.org/10.1042/CS103S202S
Published: 01 September 2002
...Endre ZIMA; Violetta KÉKESI; Andrea NAGY; László LOSONCZI; Ildikó TOMA; Pál SOÓS; Erzsébet Barát; Éva HUSZÁR; Béla MERKELY; Ferenc HORKAY; Alexander Juhász-Nagy Pericardial fluid accumulates the cardioprotective purine metabolites, as well as the endogenous vasoconstrictor agent endothelin-1 (ET-1...
View articletitled, Endothelin-1-induced elevations in purine metabolite concentrations — autoregulatory protection in the canine pericardium?
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Articles

Nitric oxide inhibits endothelin-1 production through the suppression of nuclear factor κB

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Mamoru OHKITA, Masanori TAKAOKA, Yasuko SHIOTA, Rumi NOJIRI, Yasuo MATSUMURA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 68S–71S.
https://doi.org/10.1042/CS103S068S
Published: 01 September 2002
... injury. We also found that FK409 substantially reduced endothelin-1 (ET-1) production in cultured vascular endothelial cells (ECs). Nuclear factor κB (NF-κB) is known to play a key role in the development of ischaemic disorders through regulation of the expression of a variety of genes. In the present...
View articletitled, Nitric oxide inhibits endothelin-1 production through the suppression of nuclear factor κB
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Articles

Endothelin A-receptor blockade in experimental diabetes improves glucose balance and gastrointestinal function

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Bruno BALSIGER, Andreas RICKENBACHER, Penelope Jane BODEN, Erwin BIECKER, Janice TSUI, Michael DASHWOOD, Jürg REICHEN, Sidney George SHAW
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 430S–433S.
https://doi.org/10.1042/CS103S430S
Published: 01 September 2002
.... Endothelin-1 (ET-1) and NO represent key homoeostatic mechanisms reciprocally involved in several disease processes, including the regulation of vascular tone, neurotransmission and endoneural and retinal blood flow. Effects are mediated in an autocrine Key words : endothelin-1, receptors, nitric oxide...
View articletitled, Endothelin A-receptor blockade in experimental diabetes improves glucose balance and gastrointestinal function
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Articles

Comparison of red wine extract and polyphenol constituents on endothelin-1 synthesis by cultured endothelial cells

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Noorafza Q. KHAN, Delphine M. LEES, Julie A. DOUTHWAITE, Martin J. CARRIER, Roger CORDER
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 72S–75S.
https://doi.org/10.1042/CS103S072S
Published: 01 September 2002
... compounds present in red wine. Here we show that an extract of red wine polyphenols causes a concentration-dependent inhibition of endothelin-1 synthesis in cultured bovine aortic endothelial cells. This action was associated with modifications in phosphotyrosine staining, indicating that the active...
View articletitled, Comparison of red wine extract and polyphenol constituents on endothelin-1 synthesis by cultured endothelial cells
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Articles

Pathophysiological roles of Ca 2+ overload via the Na + /Ca 2+ exchanger and endothelin-1 overproduction in ischaemia/reperfusion-induced acute renal failure

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Yasuo MATSUMURA, Junji YAMASHITA, Satomi KITA, Takahiro IWAMOTO, Masaya OGATA, Masanori TAKAOKA, Koji WAKIMOTO, Munekazu SHIGEKAWA, Issei KOMURO
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 389S–392S.
https://doi.org/10.1042/CS103S389S
Published: 01 September 2002
... overproduction, plays an important role in the pathogenesis of ischaemia/reperfusion-induced acute renal failure. 389SClinical Science (2002) 103 (Suppl. 48), 389S 392S (Printed in Great Britain) Pathophysiological roles of Ca2+ overload via the Na+/Ca2+ exchanger and endothelin-1 overproduction in ischaemia...
View articletitled, Pathophysiological roles of Ca 2+ overload via the Na + /Ca 2+ exchanger and endothelin-1 overproduction in ischaemia/reperfusion-induced acute renal failure
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Articles

Oestrogen protects against ischaemic acute renal failure in rats by suppressing renal endothelin-1 overproduction

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Masanori TAKAOKA, Mikihiro YUBA, Toshihide FUJII, Mamoru OHKITA, Yasuo MATSUMURA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 434S–437S.
https://doi.org/10.1042/CS103S434S
Published: 01 September 2002
... by suppression of enhanced endothelin-1 production in postischaemic kidneys. Ischaemic ARF was induced by clamping the left renal artery and vein for 45min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal function parameters such as blood urea nitrogen, plasma creatinine and creatinine...
View articletitled, Oestrogen protects against ischaemic acute renal failure in rats by suppressing renal endothelin-1 overproduction
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Articles

Effects of exercise training on expression of endothelin-1 mRNA in the aorta of aged rats

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Seiji MAEDA, Takashi MIYAUCHI, Motoyuki IEMITSU, Takumi TANABE, Tomoko YOKOTA, Katsutoshi GOTO, Iwao YAMAGUCHI, Mitsuo MATSUDA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 118S–123S.
https://doi.org/10.1042/CS103S118S
Published: 01 September 2002
...Seiji MAEDA; Takashi MIYAUCHI; Motoyuki IEMITSU; Takumi TANABE; Tomoko YOKOTA; Katsutoshi GOTO; Iwao YAMAGUCHI; Mitsuo MATSUDA Aging impairs endothelial function and the vascular tone regulation, although the precise mechanism remains unclear. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide...
View articletitled, Effects of exercise training on expression of endothelin-1 mRNA in the aorta of aged rats
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Articles

Expression of endothelin-1 and vasoactive intestinal contractor genes in mouse organs during the perinatal period

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Tsuyoshi UCHIDE, Yuki FUJIMORI, Takushi SASAKI, Kyosuke TEMMA, Javier ADUR, Yoshinori MASUO, Takaharu KOZAKAI, Yun-Sik LEE, Kaname SAIDA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 167S–170S.
https://doi.org/10.1042/CS103S167S
Published: 01 September 2002
...Tsuyoshi UCHIDE; Yuki FUJIMORI; Takushi SASAKI; Kyosuke TEMMA; Javier ADUR; Yoshinori MASUO; Takaharu KOZAKAI; Yun-Sik LEE; Kaname SAIDA In an attempt to understand the significance of endothelin-1 (ET-1) and vasoactive intestinal contractor (VIC)/ET-2 peptides in organs during perinatal...
View articletitled, Expression of endothelin-1 and vasoactive intestinal contractor genes in mouse organs during the perinatal period
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Articles

ET A receptor blockade improves post-ischaemic functional recovery in ‘hibernating’ rat myocardium

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Martin E. BEYER, Marcus FISCHER, Tobias HÖVELBORN, Hans Martin HOFFMEISTER
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 215S–218S.
https://doi.org/10.1042/CS103S215S
Published: 01 September 2002
...Martin E. BEYER; Marcus FISCHER; Tobias HÖVELBORN; Hans Martin HOFFMEISTER Endothelin-1 (ET-1) is a potent vasoconstrictor, and ET A receptors mainly mediate this effect. Elevated plasma levels of ET-1 are observed in patients with coronary heart disease. The release of this peptide from...
View articletitled, ET A receptor blockade improves post-ischaemic functional recovery in ‘hibernating’ rat myocardium
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Articles

Chronic administration of phosphodiesterase type 5 inhibitor suppresses renal production of endothelin-1 in dogs with congestive heart failure

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Takashi YAMAMOTO, Atsuyuki WADA, Masato OHNISHI, Takayoshi TSUTAMOTO, Masanori FUJII, Takehiro MATSUMOTO, Tomoyuki TAKAYAMA, Xinwen WANG, Kiyoshi KUROKAWA, Masahiko KINOSHITA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 258S–262S.
https://doi.org/10.1042/CS103S258S
Published: 01 September 2002
...Takashi YAMAMOTO; Atsuyuki WADA; Masato OHNISHI; Takayoshi TSUTAMOTO; Masanori FUJII; Takehiro MATSUMOTO; Tomoyuki TAKAYAMA; Xinwen WANG; Kiyoshi KUROKAWA; Masahiko KINOSHITA Endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) play important roles in the regulation of body fluid balance...
View articletitled, Chronic administration of phosphodiesterase type 5 inhibitor suppresses renal production of endothelin-1 in dogs with congestive heart failure
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Articles

The immunosuppressive drug mycophenolic acid reduces endothelin-1 synthesis in endothelial cells and renal epithelial cells

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Cornelia HAUG, Alexandra SCHMID-KOTSAS, Theresia LINDER, Peter M. JEHLE, Max G. BACHEM, Adolf GRUENERT, Eva ROZDZINSKI
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 76S–80S.
https://doi.org/10.1042/CS103S076S
Published: 01 September 2002
...Cornelia HAUG; Alexandra SCHMID-KOTSAS; Theresia LINDER; Peter M. JEHLE; Max G. BACHEM; Adolf GRUENERT; Eva ROZDZINSKI Several studies have demonstrated that endothelin-1 (ET-1) plays an important pathophysiological role in ischaemic renal failure and drug-induced renal injury, such as cyclosporine...
View articletitled, The immunosuppressive drug mycophenolic acid reduces endothelin-1 synthesis in endothelial cells and renal epithelial cells
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Articles

Activity of the endothelin system in kidney allograft recipients is not associated with progression of chronic graft dysfunction

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Torsten SLOWINSKI, Thomas SUBKOWSKI, Petra DIEHR, Daniela BACHERT, Lutz FRITSCHE, Hans.-H. NEUMAYER, Berthold HOCHER
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 393S–395S.
https://doi.org/10.1042/CS103S393S
Published: 01 September 2002
... of impaired kidney function. However, the actual concentration of ET-1, soluble ECE, and BigET-1 in urine and plasma in our study is not associated with parameters for progression of chronic graft dysfunction. chronic graft dysfunction endothelin-1 endothelin-converting enzyme kidney transplantation...
View articletitled, Activity of the endothelin system in kidney allograft recipients is not associated with progression of chronic graft dysfunction
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Articles

Comparison of the effects of atherosclerosis and nitrate therapy on responses to nitric oxide and endothelin-1 in human arteries in vitro

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Katherine E. WILEY, Anthony P. DAVENPORT
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 124S–127S.
https://doi.org/10.1042/CS103S124S
Published: 01 September 2002
...Katherine E. WILEY; Anthony P. DAVENPORT The effect of previous nitrate therapy on vascular responses to endothelin-1 (ET-1) and NO was investigated in human internal mammary artery (IMA) in vitro. Cumulative concentration–response curves to ET-1 were constructed in rings of IMA and the data...
View articletitled, Comparison of the effects of atherosclerosis and nitrate therapy on responses to nitric oxide and endothelin-1 in human arteries in vitro
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Articles

G-protein-coupled receptors in human atherosclerosis: comparison of vasoconstrictors (endothelin and thromboxane) with recently de-orphanized (urotensin-II, apelin and ghrelin) receptors

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Sidath D. KATUGAMPOLA, Rhoda E. KUC, Janet J. MAGUIRE, Anthony P. DAVENPORT
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 171S–175S.
https://doi.org/10.1042/CS103S171S
Published: 01 September 2002
.... The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr A. P. Davenport (e-mail [email protected] ). © 2002 The Biochemical Society and the Medical Research Society 2002 apelin atherosclerosis coronary artery endothelin-1...
View articletitled, G-protein-coupled receptors in human atherosclerosis: comparison of vasoconstrictors (endothelin and thromboxane) with recently de-orphanized (urotensin-II, apelin and ghrelin) receptors
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Articles

Three vasoactive peptides, endothelin-1, adrenomedullin and urotensin-II, in human tumour cell lines of different origin: expression and effects on proliferation

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Kazuhiro TAKAHASHI, Kazuhito TOTSUNE, Tomomi KITAMURO, Masahiko SONE, Osamu MURAKAMI, Shigeki SHIBAHARA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 35S–38S.
https://doi.org/10.1042/CS103S035S
Published: 01 September 2002
...Kazuhiro TAKAHASHI; Kazuhito TOTSUNE; Tomomi KITAMURO; Masahiko SONE; Osamu MURAKAMI; Shigeki SHIBAHARA Evidence has accumulated showing that vasoactive peptides, such as endothelin-1, adrenomedullin and urotensin-II, are expressed in various kinds of tumour cells. In the present study...
View articletitled, Three vasoactive peptides, endothelin-1, adrenomedullin and urotensin-II, in human tumour cell lines of different origin: expression and effects on proliferation
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Articles

Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence

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Huan HUANG, Masashi YANAGISAWA, Yaz Y. KISANUKI, Linda A. JELICKS, Madhulika CHANDRA, Stephen M. FACTOR, Murray WITTNER, Louis M. WEISS, Richard G. PESTELL, Vitaliy SHTUTIN, Jamshid SHIRANI, Herbert B. TANOWITZ
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 263S–266S.
https://doi.org/10.1042/CS103S263S
Published: 01 September 2002
... of chronic cardiomyopathy. We previously demonstrated a role for endothelin-1 (ET-1) in the pathogenesis of chagasic heart disease. In order to explore further the significance of ET-1 in chagasic heart disease, we infected ET-1 (flox/flox); α-MHC-Cre(+) (ET-1KO) mice, in which the ET-1 gene has been deleted...
View articletitled, Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence
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Articles

HMG-CoA reductase inhibition and PPAR-alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells

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Abdelmejid KANDOUSSI, François MARTIN, Marc HAZZAN, Christian NOËL, Jean-Charles FRUCHART, Bart STAELS, Patrick DURIEZ
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 81S–83S.
https://doi.org/10.1042/CS103S081S
Published: 01 September 2002
... The Biochemical Society and the Medical Research Society 2002 endothelin-1 cyclosporin A PPAR-alpha activators ciprofibric acid HMG-CoA inhibitors compactin 81SClinical Science (2002) 103 (Suppl. 48), 81S 83S (Printed in Great Britain) HMG-CoA reductase inhibition and PPAR- alpha activation both...
View articletitled, HMG-CoA reductase inhibition and PPAR-alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells
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Articles

Endothelin-1 mRNA and protein in vascular wall cells is increased by reactive oxygen species

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Jan KAEHLER, Bjoern SILL, Ralf KOESTER, Clemens MITTMANN, Hans-Dieter ORZECHOWSKI, Thomas MUENZEL, Thomas MEINERTZ
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 176S–178S.
https://doi.org/10.1042/CS103S176S
Published: 01 September 2002
...Jan KAEHLER; Bjoern SILL; Ralf KOESTER; Clemens MITTMANN; Hans-Dieter ORZECHOWSKI; Thomas MUENZEL; Thomas MEINERTZ A dysregulated metabolism of oxygen-derived free radicals, nitric oxide and endothelin-1(ET-1) in conditions such as hypercholesterolaemia or hypertension may promote the development...
View articletitled, Endothelin-1 mRNA and protein in vascular wall cells is increased by reactive oxygen species
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Articles

Roles of angiogenic factors and endothelin-1 in gastric ulcer healing

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Masumi AKIMOTO, Hiroshi HASHIMOTO, Atsushi MAEDA, Mutsuo SHIGEMOTO, Katsuko YAMASHITA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 450S–454S.
https://doi.org/10.1042/CS103S450S
Published: 01 September 2002
... angiogenesis. The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr M. Akimoto (e-mail [email protected] ). © 2002 The Biochemical Society and the Medical Research Society 2002 gastric ulcer angiogenesis endothelin-1 ETA...
View articletitled, Roles of angiogenic factors and endothelin-1 in gastric ulcer healing
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Articles

Reduction of endothelin-1 binding and inhibition of endothelin-1-mediated detrusor contraction by naftidrofuryl

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Robert C. CALVERT, Faiz H. MUMTAZ, Mick R. DASHWOOD, Masood A. KHAN, Robert J. MORGAN, Dimitri P. MIKHAILIDIS, Cecil S. THOMPSON
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 459S–463S.
https://doi.org/10.1042/CS103S459S
Published: 01 September 2002
...Robert C. CALVERT; Faiz H. MUMTAZ; Mick R. DASHWOOD; Masood A. KHAN; Robert J. MORGAN; Dimitri P. MIKHAILIDIS; Cecil S. THOMPSON Endothelin-1 (ET-1) causes urinary bladder smooth muscle contraction and the endothelin receptors A and B (ET A and ET B ) are both known to be present in the rabbit...
View articletitled, Reduction of endothelin-1 binding and inhibition of endothelin-1-mediated detrusor contraction by naftidrofuryl
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Articles

Endothelin-1 production by a microvascular endothelial cell line treated with Plasmodium falciparum parasitized red blood cells

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Nicoletta BASILICO, Livianna SPECIALE, Silvia PARAPINI, Pasquale FERRANTE, Donatella TARAMELLI
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 464S–466S.
https://doi.org/10.1042/CS103S464S
Published: 01 September 2002
...Nicoletta BASILICO; Livianna SPECIALE; Silvia PARAPINI; Pasquale FERRANTE; Donatella TARAMELLI In this study, we investigated the production of endothelin 1 (ET-1) by a human microvascular endothelial cell line, HMEC-1, co-cultured with Plasmodium falciparum -parasitized red blood cells (pRBCs...
View articletitled, Endothelin-1 production by a microvascular endothelial cell line treated with Plasmodium falciparum parasitized red blood cells
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Articles

Circadian variation in vascular tone and endothelial cell function in normal males

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Khalid ELHERIK, Faisel KHAN, Margaret MCLAREN, Gwen KENNEDY, Jill J.F. BELCH
Journal: Clinical Science
Clin Sci (Lond) (2002) 102 (5): 547–552.
https://doi.org/10.1042/cs1020547
Published: 18 April 2002
... (NO) and endothelin-1 (ET-1) levels, and endothelium-dependent and -independent vasodilation in normal males. Plasma ET-1 and NO were measured every 4h in nine subjects (20-41 years old) over a 24h period. Endothelium-dependent and -independent vascular responses were measured in the forearm skin every 4h using laser...
View articletitled, Circadian variation in vascular tone and endothelial cell function in normal males
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Articles

Endothelin-1 plus oxidized low-density lipoprotein, but neither alone, increase human monocyte adhesion to endothelial cells

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M.R. LANGENFELD, S. NAKHLA, A.K. DEATH, W. JESSUP, D.S. CELERMAJER
Journal: Clinical Science
Clin Sci (Lond) (2001) 101 (6): 731–738.
https://doi.org/10.1042/cs1010731
Published: 21 November 2001
...M.R. LANGENFELD; S. NAKHLA; A.K. DEATH; W. JESSUP; D.S. CELERMAJER Endothelin-1 is a potent vasoconstrictor and mitogenic peptide that is implicated in the atherosclerosis of apolipoprotein E-deficient mice and may promote atherogenesis in humans. We hypothesized that endothelin-1 might promote...
View articletitled, Endothelin-1 plus oxidized low-density lipoprotein, but neither alone, increase human monocyte adhesion to endothelial cells
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