... types, cell–cell interactions, and acellular components of the tumour microenvironment (TME). Within this tumour type, autocrine and paracrine activation of the endothelin-1 receptors (ET-1R), expressed in tumour cells and stromal elements, drives metastatic progression. The lack of three-dimensional...

...Phil Ambery; Peter J. Greasley; Robert I. Menzies; Lena Brynne; Spoorthy Kulkarni; Jan Oscarsson; Anthony P. Davenport Endothelin A and B receptors, together with sodium-glucose cotransporter-2 (SGLT-2) channels are important targets in improving endothelial function and intervention...

...Francesca Schinzari; Manfredi Tesauro; Carmine Cardillo The endothelin family of peptides has long been recognized as a physiological regulator of diverse biological functions and mechanistically involved in various disease states, encompassing, among others, the cardiovascular system, the kidney...

... Visser; A.H. Jan Danser; Jorie Versmissen Vascular endothelial growth factor antagonism with angiogenesis inhibitors in cancer patients induces a ‘preeclampsia-like’ syndrome including hypertension, proteinuria and elevated endothelin (ET)-1. Cyclo-oxygenase (COX) inhibition with aspirin is known...

...Osvaldo Rivera-Gonzalez; Natalie A. Wilson; Laura E. Coats; Erin B. Taylor; Joshua S. Speed Endothelin-1 (ET-1) is elevated in patients with obesity; however, its contribution to the pathophysiology related to obesity is not fully understood. We hypothesized that high ET-1 levels cause dyslipidemia...

...Katrina M. Mirabito Colafella In a recent issue of Clinical Science, Stanhewicz et al. investigated persistent microvascular dysfunction in women up to 16 months postpartum. The authors found sensitivity to the pressor effects of endothelin-1 (ET-1) was enhanced when compared with women who had...

... - channels) and (iii) osmoregulated Cl - channels. In this study, we examined comparatively the effects of cyclic stretch and endothelin-1 (ET-1) on Cl - channel activity in primary cultures of neonatal rat ventricular myocytes using an 125 I-efflux assay. About 4min after the start of the 125 I-efflux (mean...

...Felix BÖHM; Gunvor AHLBORG; John PERNOW Several cardiovascular disorders, including atherosclerosis, are associated with endothelial dysfunction and enhanced expression of endothelin-1 (ET-1). The role of ET-1 in the development of endothelial dysfunction in vivo remains unclear. The objective...

...Ole SAETRUM OPGAARD; Sebastian MÖLLER; René DE VRIES; Lars EDVINSSON; Pramod R. SAXENA The aim of the present study was to determine possible inotropic effects mediated by endothelin ET A and ET B receptors in human myocardial trabeculae from the right atrium and the left ventricle. Isolated...

...Claudio FERRI; Giovambattista DESIDERI; Roberta BALDONCINI; Cesare BELLINI; Marco VALENTI; Anna SANTUCCI; Giancarlo DE MATTIA We investigated the effect of angiotensin II on endothelin-1 secretion in vitro and in vivo. In vivo , angiotensin II was given intravenously to 23 essential hypertensive...

...Claudio Ferri; Cesare Bellini; Giovambattista Desideri; Clarita Mazzocchi; Luca De Siati; Anna Santucci 1. The behaviour of the potent vasoconstrictive endothelium-derived peptide endothelin-1 was evaluated in salt-sensitive hypertension. 2. Circulating and urinary endothelin-1 levels were...

...Fiona E. Karet 1. Animal kidneys are exquisitely sensitive to the vasoconstrictor and antinatriuretic effects of the endogenous vascular peptide endothelin. Animal studies have implicated endothelin in cyclosporin A and ischaemia-mediated renal damage. 2. In man, endothelin levels are raised...

.... 2. Radiolabeled endothelin-1 and related peptides were used to identify and isolate endothelin receptors from partially purified membrane extracts of human atrial tissue. 3. Binding analysis using radiolabelled endothelin-1 gave an equilibrium dissociation constant ( K d ) of 2 nmol/l, similar...