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Keywords: endothelins
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Articles
Clin Sci (Lond) (2021) 135 (14): 1773–1789.
Published: 30 July 2021
...Osvaldo Rivera-Gonzalez; Natalie A. Wilson; Laura E. Coats; Erin B. Taylor; Joshua S. Speed Endothelin-1 (ET-1) is elevated in patients with obesity; however, its contribution to the pathophysiology related to obesity is not fully understood. We hypothesized that high ET-1 levels cause dyslipidemia...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (1): 33–36.
Published: 02 January 2018
...Katrina M. Mirabito Colafella In a recent issue of Clinical Science, Stanhewicz et al. investigated persistent microvascular dysfunction in women up to 16 months postpartum. The authors found sensitivity to the pressor effects of endothelin-1 (ET-1) was enhanced when compared with women who had...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 148S–151S.
Published: 01 September 2002
... - channels) and (iii) osmoregulated Cl - channels. In this study, we examined comparatively the effects of cyclic stretch and endothelin-1 (ET-1) on Cl - channel activity in primary cultures of neonatal rat ventricular myocytes using an 125 I-efflux assay. About 4min after the start of the 125 I-efflux (mean...
Articles
Clin Sci (Lond) (2002) 102 (3): 321–327.
Published: 12 February 2002
...Felix BÖHM; Gunvor AHLBORG; John PERNOW Several cardiovascular disorders, including atherosclerosis, are associated with endothelial dysfunction and enhanced expression of endothelin-1 (ET-1). The role of ET-1 in the development of endothelial dysfunction in vivo remains unclear. The objective...
Articles
Clin Sci (Lond) (2000) 99 (3): 161–168.
Published: 02 August 2000
...Ole SAETRUM OPGAARD; Sebastian MÖLLER; René DE VRIES; Lars EDVINSSON; Pramod R. SAXENA The aim of the present study was to determine possible inotropic effects mediated by endothelin ET A and ET B receptors in human myocardial trabeculae from the right atrium and the left ventricle. Isolated...
Articles
Clin Sci (Lond) (1999) 96 (3): 261–270.
Published: 01 March 1999
...Claudio FERRI; Giovambattista DESIDERI; Roberta BALDONCINI; Cesare BELLINI; Marco VALENTI; Anna SANTUCCI; Giancarlo DE MATTIA We investigated the effect of angiotensin II on endothelin-1 secretion in vitro and in vivo. In vivo , angiotensin II was given intravenously to 23 essential hypertensive...
Articles
Clin Sci (Lond) (1997) 93 (1): 35–41.
Published: 01 July 1997
...Claudio Ferri; Cesare Bellini; Giovambattista Desideri; Clarita Mazzocchi; Luca De Siati; Anna Santucci 1. The behaviour of the potent vasoconstrictive endothelium-derived peptide endothelin-1 was evaluated in salt-sensitive hypertension. 2. Circulating and urinary endothelin-1 levels were...
Articles
Clin Sci (Lond) (1996) 91 (3): 267–273.
Published: 01 September 1996
...Fiona E. Karet 1. Animal kidneys are exquisitely sensitive to the vasoconstrictor and antinatriuretic effects of the endogenous vascular peptide endothelin. Animal studies have implicated endothelin in cyclosporin A and ischaemia-mediated renal damage. 2. In man, endothelin levels are raised...
Articles
Clin Sci (Lond) (1993) 85 (2): 169–173.
Published: 01 August 1993
.... 2. Radiolabeled endothelin-1 and related peptides were used to identify and isolate endothelin receptors from partially purified membrane extracts of human atrial tissue. 3. Binding analysis using radiolabelled endothelin-1 gave an equilibrium dissociation constant ( K d ) of 2 nmol/l, similar...