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Clin Sci (Lond) (2021) 135 (14): 1773–1789.
Published: 30 July 2021
...Osvaldo Rivera-Gonzalez; Natalie A. Wilson; Laura E. Coats; Erin B. Taylor; Joshua S. Speed Endothelin-1 (ET-1) is elevated in patients with obesity; however, its contribution to the pathophysiology related to obesity is not fully understood. We hypothesized that high ET-1 levels cause dyslipidemia...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (1): 33–36.
Published: 02 January 2018
...Katrina M. Mirabito Colafella In a recent issue of Clinical Science, Stanhewicz et al. investigated persistent microvascular dysfunction in women up to 16 months postpartum. The authors found sensitivity to the pressor effects of endothelin-1 (ET-1) was enhanced when compared with women who had...
Clin Sci (Lond) (2002) 103 (s2002): 148S–151S.
Published: 01 September 2002
... - channels) and (iii) osmoregulated Cl - channels. In this study, we examined comparatively the effects of cyclic stretch and endothelin-1 (ET-1) on Cl - channel activity in primary cultures of neonatal rat ventricular myocytes using an 125 I-efflux assay. About 4min after the start of the 125 I-efflux (mean...
Clin Sci (Lond) (2002) 102 (3): 321–327.
Published: 12 February 2002
...Felix BÖHM; Gunvor AHLBORG; John PERNOW Several cardiovascular disorders, including atherosclerosis, are associated with endothelial dysfunction and enhanced expression of endothelin-1 (ET-1). The role of ET-1 in the development of endothelial dysfunction in vivo remains unclear. The objective...
Clin Sci (Lond) (2000) 99 (3): 161–168.
Published: 02 August 2000
...Ole SAETRUM OPGAARD; Sebastian MÖLLER; René DE VRIES; Lars EDVINSSON; Pramod R. SAXENA The aim of the present study was to determine possible inotropic effects mediated by endothelin ET A and ET B receptors in human myocardial trabeculae from the right atrium and the left ventricle. Isolated...
Claudio FERRI, Giovambattista DESIDERI, Roberta BALDONCINI, Cesare BELLINI, Marco VALENTI, Anna SANTUCCI, Giancarlo DE MATTIA
Clin Sci (Lond) (1999) 96 (3): 261–270.
Published: 01 March 1999
...Claudio FERRI; Giovambattista DESIDERI; Roberta BALDONCINI; Cesare BELLINI; Marco VALENTI; Anna SANTUCCI; Giancarlo DE MATTIA We investigated the effect of angiotensin II on endothelin-1 secretion in vitro and in vivo. In vivo , angiotensin II was given intravenously to 23 essential hypertensive...
Claudio Ferri, Cesare Bellini, Giovambattista Desideri, Clarita Mazzocchi, Luca De Siati, Anna Santucci
Clin Sci (Lond) (1997) 93 (1): 35–41.
Published: 01 July 1997
...Claudio Ferri; Cesare Bellini; Giovambattista Desideri; Clarita Mazzocchi; Luca De Siati; Anna Santucci 1. The behaviour of the potent vasoconstrictive endothelium-derived peptide endothelin-1 was evaluated in salt-sensitive hypertension. 2. Circulating and urinary endothelin-1 levels were...
Clin Sci (Lond) (1996) 91 (3): 267–273.
Published: 01 September 1996
...Fiona E. Karet 1. Animal kidneys are exquisitely sensitive to the vasoconstrictor and antinatriuretic effects of the endogenous vascular peptide endothelin. Animal studies have implicated endothelin in cyclosporin A and ischaemia-mediated renal damage. 2. In man, endothelin levels are raised...
Clin Sci (Lond) (1993) 85 (2): 169–173.
Published: 01 August 1993
.... 2. Radiolabeled endothelin-1 and related peptides were used to identify and isolate endothelin receptors from partially purified membrane extracts of human atrial tissue. 3. Binding analysis using radiolabelled endothelin-1 gave an equilibrium dissociation constant ( K d ) of 2 nmol/l, similar...