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Keyword: endothelium
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Articles
Clin Sci (Lond) (2017) 131 (11): 1055-1058.
Published: 10 May 2017
... caused by excessive sitting. Correspondence: Joel D. Trinity ( joel.trinity@utah.edu ) 14 03 2017 10 04 2017 12 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 blood flow endothelium physical inactivity...
Articles
Clin Sci (Lond) (2016) 130 (11): 881-893.
Published: 22 April 2016
...-2 endothelium energy expenditure inflammation Ptp1b • Current pharmacotherapies aiming to decrease body weight and prevent the development of obesity and diabetes have a history of cardiovascular safety risk. Ptp1b emerges as a potential avenue for the treatment and prevention of...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (7): 539-549.
Published: 17 February 2016
...-dependent vasoconstrictors. circulating factors endothelium nitric oxide pre-eclamptic plasma prostaglandin uterine artery • The multifactorial nature of the pathophysiology seen in PE has contributed to the difficulty in finding an effective treatment. Endothelial dysfunction is one...
Articles
Clin Sci (Lond) (2015) 129 (12): 1195-1206.
Published: 11 November 2015
... vessels. Alzheimer's disease blood–brain barrier endothelium lipids statins • We have explored why patients who have been prescribed lipid-lowering drugs in mid-life are at a lower risk of dementia. We identified a novel anti-inflammatory effect for statins in patients with...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (8): 527-537.
Published: 30 June 2014
... characterize the effects of a new recombinant form of human manganese superoxide dismutase (rMnSOD) on hepatic CS+WR injury. After CS+WR, the liver endothelium exhibited accumulation of superoxide anion (O 2 − ) and diminished levels of nitric oxide (NO); these detrimental effects were prevented by rMnSOD. CS...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (7): 499-505.
Published: 17 June 2014
... ml/min per m 2 during placebo compared with −63±56 ml/min per m 2 during FA, P =0.57; ΔRPF to vitamin C: +93±118 ml/min per m 2 compared with +94±108 ml/min per m 2 ; P =0.70). In line with the lack of effect on the renal endothelium, albuminuria was not affected by FA treatment (110±179 mg/day...
Articles
Clin Sci (Lond) (2013) 124 (9): 579-587.
Published: 21 January 2013
... years) underwent cardiopulmonary exercise tolerance test, and were assessed for their upper- and lower-limb vascular endothelial CVC (cutaneous vascular conductance) using LDF (laser Doppler fluximetry) with endothelium-dependent [ACh (acetylcholine chloride)] and -independent [SNP (sodium nitroprusside...
Articles
Clin Sci (Lond) (2013) 124 (6): 403-411.
Published: 27 November 2012
... (coronary artery disease) and T2D (Type 2 diabetes mellitus) is concomitant with elevated mtROS (mitochondrial reactive oxygen species) production in the endothelium and establish if this, in turn, regulates the activity of endothelial AMPK (AMP-activated protein kinase). We investigated endothelial...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (8): 499-507.
Published: 27 June 2012
... endothelium nitric oxide prostaglandin reactive oxygen species red wine polyphenol Aging is an independent and important risk factor for CVD (cardiovascular disease) [ 1 ]. Senescence of the vascular wall may be on the causal path to age-related endothelial dysfunction and atherogenesis, as it...
Articles
Clin Sci (Lond) (2012) 122 (6): 289-299.
Published: 22 November 2011
... the respiratory chain function with altered oxidative phosphorylation. We tested the hypothesis that the function of vascular endothelium is affected by increased oxidative stress in MDs. A total of 12 patients with MDs and pair-matched controls were studied. Endothelial function was assessed by...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2011) 120 (12): 525-536.
Published: 09 March 2011
... cardiovascular disease diabetes end-stage renal disease endothelium flow-mediated dilatation nitric oxide resistance artery Despite the rapid progress in dialysis treatment, ESRD (end-stage renal disease) patients still die at a markedly accelerated rate, principally from CVD (cardiovascular...
Articles
Clin Sci (Lond) (2011) 120 (9): 377-402.
Published: 18 January 2011
... 2011 atherothrombosis chronic renal failure diabetes endothelium insulin-like growth factor-1 (IGF-1) myocardial infarction recombinant human insulin-like growth factor-1 (rh-IGF-1) Two peptide hormones, namely IGF (insulin-like growth factor)-1 and IGF-2, two types of cell-surface...
Articles
Clin Sci (Lond) (2011) 120 (4): 131-141.
Published: 02 November 2010
... vascular biology. Correspondence: Dr Augusto C. Montezano (email amonteza@uottawa.ca ). 20 7 2010 1 9 2010 14 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 endothelium hydrogen peroxide NADPH oxidase (Nox) reactive oxygen species superoxide...
Articles
Clin Sci (Lond) (2011) 120 (2): 51-63.
Published: 24 September 2010
.... Correspondence: Professor Massimo Volpe (email massimo.volpe@uniroma1.it ). 14 6 2010 19 7 2010 9 8 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 biomarker congestive heart failure (CHF) chronic renal failure (CRF) endothelium erythropoietin (EPO...
Articles
Clin Sci (Lond) (2010) 119 (6): 225-238.
Published: 08 June 2010
... Biochemical Society 2010 arteriogenesis collateral circulation diabetes mellitus endothelium peripheral arterial disease vascular smooth muscle DM is recognized as a major cardiovascular risk factor. PAD is a common vascular complication in the diabetic population, as diabetes increases the...
Articles
Clin Sci (Lond) (2010) 119 (1): 1-17.
Published: 07 April 2010
...Alyson A. Miller; Klaudia Budzyn; Christopher G. Sobey The endothelium plays a crucial role in the control of vascular homoeostasis through maintaining the synthesis of the vasoprotective molecule NO • (nitric oxide). Endothelial dysfunction of cerebral blood vessels, manifested as diminished NO...
Articles
Clin Sci (Lond) (2010) 119 (1): 19-36.
Published: 07 April 2010
... joe.brayden@uvm.edu ). 7 12 2009 5 2 2010 9 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cation channel endothelium smooth muscle transient receptor potential (TRP) channel vascular function The TRP (transient receptor potential) channel...
Articles
Clin Sci (Lond) (2010) 118 (10): 633-640.
Published: 23 February 2010
...Ellen A. Dawson; Ellen A. Dawson; Sudhir Rathore; N. Timothy Cable; D. Jay Wright; John L. Morris; Daniel J. Green The aim of this study was to determine the impact of catheter sheath insertion, a model of endothelium disruption in humans, on the conventional FMD (flow-mediated dilatation) response...
Articles
Clin Sci (Lond) (2010) 118 (9): 583-592.
Published: 09 February 2010
... or not with rosiglitazone (20 mg·kg −1 of body weight·day −1 ) for 90 days and compared with wild-type mice. Endothelium-dependent relaxation of carotid arteries was significantly impaired (−40%) only in rosiglitazone-treated HCD-fed mthfr +/− mice. Carotid M/L (media-to-lumen ratio) and CSA (cross...
Articles
Clin Sci (Lond) (2010) 118 (7): 459-461.
Published: 12 January 2010
... ). 28 10 2009 2 11 2009 4 11 2009 4 11 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 ADP angiotensin II clopidogrel endothelium hypertension mesenteric artery P2Y receptor Platelets, normally circulating in resting form, respond to...
Articles
Clin Sci (Lond) (2010) 118 (7): 463-471.
Published: 12 January 2010
...]. Although 2-MeS-ADP induced endothelium-dependent relaxation [(Emax %)=71±12%) as well as contractile vascular responses (Emax %=83±12%), these actions are not mediated by P2Y 12 receptor activation. 2-MeS-ADP produced similar vascular responses in control and AngII rats. These results indicate potential...
Articles
Clin Sci (Lond) (2009) 117 (10): 355-364.
Published: 07 September 2009
.... androgen cardiovascular system endothelial progenitor cell endothelium gender oestrogen stem cell In the last decade, our knowledge on vascular homoeostasis has significantly changed thanks to the discovery of EPCs (endothelial progenitor cells) in adult human blood [ 1 ]. EPCs originally...
Articles
Clin Sci (Lond) (2009) 117 (4): 165-172.
Published: 16 July 2009
... © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiopulmonary exercise test chronic heart failure endothelial progenitor cell endothelium migration Type D personality Type D personality, a joint tendency toward negative affectivity and social inhibition, is...
Articles
Clin Sci (Lond) (2009) 117 (4): 139-155.
Published: 16 July 2009
...Michel Félétou; Paul M. Vanhoutte The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also by other pathways causing hyperpolarization of the underlying smooth muscle cells. This characteristic was at the origin of the term ‘endothelium-derived hyperpolarizing...
Articles
Clin Sci (Lond) (2009) 117 (3): 129-138.
Published: 02 July 2009
... compilation © 2009 Biochemical Society 2009 cardiovascular disease fetal programming endothelium gestational diabetes glucose vascular smooth muscle There is increasing evidence that adverse factors in the perinatal environment predispose an individual to disease later in life. This concept...
Articles
Clin Sci (Lond) (2007) 113 (2): 47-63.
Published: 13 June 2007
... becomes enzymatically uncoupled and generates superoxide, contributing to vascular oxidative stress and endothelial dysfunction. BH4 bioavailability is determined by a balance of enzymatic de novo synthesis and recycling, versus oxidative degradation in dysfunctional endothelium. Augmenting vascular BH4...
Articles
Clin Sci (Lond) (2007) 112 (1): 1-25.
Published: 01 December 2006
... type and produce IL-1β and TNFα after infection or injury to the CNS. The main cellular target for IL-1β and TNFα produced in the brain (peri)vascular compartment is the endothelium, where these cytokines induce the expression of adhesion molecules and promote leucocyte infiltration. Whether this and...
Articles
Clin Sci (Lond) (2006) 111 (6): 381-387.
Published: 14 November 2006
... 2006 The Biochemical Society 2006 adrenomedullin angiogenesis bone-marrow-derived cell collateral development endothelium ischaemia AM (adrenomedullin) was isolated as a vasodilatory peptide from pheochromocytoma [ 1 ]. The major source of circulating AM is the vascular wall...
Articles
Clin Sci (Lond) (2006) 111 (1): 71-80.
Published: 14 June 2006
... 2 2006 22 3 2006 22 3 2006 The Biochemical Society 2006 blood flow coronary disease diet endothelium flavonoid Cocoa and chocolate are plant foods derived from the cacao bean ( Theobroma cacao ), which are rich in flavonoids. The main subclasses of flavonoids found...
Articles
Clin Sci (Lond) (2006) 111 (1): 35-46.
Published: 14 June 2006
... existing cardiac myocytes. This process is intimately linked to the development of coronary vasculature from progenitors originating in the endothelium, the proepicardial organ and neural crest. In this review, we systematically evaluate approx. 90 mouse mutations that impair heart muscle growth during...
Articles
Clin Sci (Lond) (2005) 109 (6): 523-530.
Published: 23 November 2005
... amino acid transport endothelium exercise training nitric oxide The systemic vasoconstriction observed in CHF (congestive heart failure) represents the combined effect of activation of neurohormonal systems, such as the sympathetic nervous system [ 1 ] and renin–angiotensin system [ 2 ], as...
Articles
Clin Sci (Lond) (2005) 109 (3): 217-226.
Published: 24 August 2005
..., cell growth, apoptosis and hypertrophy. Furthermore, NADPH oxidase-derived superoxide contributes to the impairment of endothelium-dependent vasodilatation by inactivating nitric oxide; the resultant endothelial dysfunction is implicated in the pathophysiology of diseases such as atherosclerosis...
Articles
Clin Sci (Lond) (2005) 109 (2): 171-176.
Published: 25 July 2005
... coronary heart disease CRP (C-reactive protein) cytokine endothelium inflammation There is substantial interest in the concept of inflammatory-driven atherogenesis in the general cardiovascular arena and, more specifically, in the autoimmune field, perhaps best exemplified by work in RA...
Articles
Clin Sci (Lond) (2005) 109 (1): 45-54.
Published: 23 June 2005
...-menopausal controls (277±124 pu; P <0.05), but had no effect in pre-menopausal controls (225±92 pu). These results suggest that vasoconstrictor COX products limit ACh-evoked endothelium-dependent cutaneous dilatation in the digits in pre- and post-menopausal women with PR and in post-menopausal, but not...
Articles
Clin Sci (Lond) (2005) 109 (1): 27-37.
Published: 23 June 2005
... 8 3 2005 The Biochemical Society 2005 atherosclerosis culture-modified mononuclear cell (CMMC) endothelial cell endothelium restenosis vascular disease The endothelium plays a privileged role in cardiovascular biology. Previously conceived as a static barrier between...
Articles
Clin Sci (Lond) (2005) 108 (4): 357-363.
Published: 22 March 2005
... of reperfusion. Using a cross-over protocol, the subjects were randomized to oral administration of 500 mg of bosentan or placebo 2 h before ischaemia. Endothelium-dependent and -independent vasodilatation were determined by intra-brachial infusion of acetylcholine (1–10 μg/min) and nitroprusside...
Articles
Clin Sci (Lond) (2005) 108 (4): 331-338.
Published: 22 March 2005
... ACE and PDE5 inhibition on endothelial function are warranted. Correspondence: Dr Stuart D. Katz (email stuart.katz@yale.edu ). 2 9 2004 23 11 2004 2 12 2004 2 12 2004 The Biochemical Society 2005 angiotensin-converting enzyme (ACE) heart failure endothelium...
Articles
Clin Sci (Lond) (2005) 108 (2): 101-112.
Published: 21 January 2005
... ). 6 8 2004 16 9 2004 25 10 2004 25 10 2004 The Biochemical Society 2005 antineutrophil cytoplasm antibody (ANCA) endothelium neutrophil small vessel vasculitis SVV (small vessel vasculitis) is an inflammatory disorder affecting arterioles, capillaries and...
Articles
Clin Sci (Lond) (2005) 108 (1): 85-91.
Published: 15 December 2004
... TNF-α. Correspondence: Dr Juan Carlos Porres Cubero (email jcporres@fjd.es ). 23 7 2004 22 9 2004 24 9 2004 24 9 2004 The Biochemical Society 2005 CD32 receptor C-reactive protein (CRP) endothelium endothelial nitric oxide synthase (eNOS) inflammation...
Articles
Clin Sci (Lond) (2004) 107 (6): 519-532.
Published: 24 November 2004
...Stuart A. RITCHIE; Marie-Ann EWART; Colin G. PERRY; John M. C. CONNELL; Ian P. SALT Vascular integrity in the healthy endothelium is maintained through the release of a variety of paracrine factors such as NO (nitric oxide). Endothelial dysfunction, characterized by reduced NO bioavailability, is...
Articles
Clin Sci (Lond) (2004) 107 (5): 513-517.
Published: 26 October 2004
...Roger CORDER; Richard C. WARBURTON; Noorafza Q. KHAN; Ruth E. BROWN; Elizabeth G. WOOD; Delphine M. LEES Reduced endothelium-dependent vasodilator responses with increased synthesis of ET-1 (endothelin-1) are characteristics of endothelial dysfunction in heart failure and are predictive of...
Articles
Clin Sci (Lond) (2004) 107 (3): 323-330.
Published: 24 August 2004
...). By contrast, aspirin had no effect on increases in RCF evoked by iontophoretic application of the NO (nitric oxide) donor and endothelium-independent dilator sodium nitroprusside (mean increases in RCF were 73.8±9.8 PU before and 79.1±12.2 PU after aspirin). The ACh-evoked increases in RCF were also...
Articles
Clin Sci (Lond) (2004) 107 (2): 191-196.
Published: 27 July 2004
... brevis@cyllene.uwa.edu.au ). 7 1 2004 29 3 2004 7 4 2004 7 4 2004 The Biochemical Society 2004 endothelium glucose high-resolution ultrasound insulin nitric oxide The importance of the endothelium in maintaining a healthy vasculature has been increasingly...
Articles
Clin Sci (Lond) (2004) 106 (5): 541-546.
Published: 01 May 2004
...Chia-Hung YEN; Ying-Tung LAU 17β-Oestradiol (E 2 ; oestrogen) is known to increase endothelium-dependent vasodilatation and NO (nitric oxide) production. It is also known to decrease the response of VSMCs (vascular smooth muscle cells) to vasoconstrictors in vitro . E 2 induces a decrease in age...
Articles
Clin Sci (Lond) (2004) 106 (2): 115-120.
Published: 01 February 2004
... vasomotor dysfunction is not solely restricted to the endothelium. Correspondence: Dr Folkert W. Asselbergs (e-mail f.w.asselbergs@thorax.azg.nl ). 1 Both authors contributed equally to this paper. 24 6 2003 22 8 2003 4 9 2003 4 9 2003 © 2004 The Biochemical...
Articles
Clin Sci (Lond) (2003) 105 (3): 251-266.
Published: 01 September 2003
... underlies many of the beneficial actions of the statins on vascular endothelium, which include increased endothelial nitric oxide synthase expression, pro-angiogenic effects, increased fibrinolytic activity, immunomodulatory and anti-inflammatory actions, including increased resistance to complement. This...
Articles
Clin Sci (Lond) (2003) 105 (2): 173-180.
Published: 01 August 2003
.... Correspondence: Dr W. H. M. Peters (e-mail w.peters@mdl.umcn.nl ). 31 1 2003 17 4 2003 23 4 2003 23 4 2003 © 2003 The Biochemical Society 2003 antioxidant endothelium free radical homocysteine redox balance Clinical Science (2003) 105, 173 180 (Printed in Great Britain...
Articles
Clin Sci (Lond) (2003) 105 (2): 227-234.
Published: 01 August 2003
.... This relates to the severity of cirrhosis and may contribute to the increase in circulating ET-1 levels. Correspondence: Dr Jocelyn Dupuis (e-mail dupuisj@icm.umontreal.ca ). 21 1 2003 21 3 2003 23 4 2003 23 4 2003 © 2003 The Biochemical Society 2003 endothelium...
Articles
Clin Sci (Lond) (2003) 105 (1): 81-87.
Published: 01 July 2003
... endothelium fatty acid insulin meal Clinical Science (2003) 105, 81 87 (Printed in Great Britain) 81 The effect of a mixed meal on endothelium- dependent vasodilation is dependent on fat content in healthy humans Peter STEER*, Dennis M. SARABI*, Brita KARLSTRO¨M , Samar BASU , Christian BERNE*, Bengt...
Articles
Clin Sci (Lond) (2003) 105 (1): 73-79.
Published: 01 July 2003
... Society 2003 endothelium nifedipine-sensitive Ca2+ channel oligostilbene rabbit thoracic aorta vitisin C Clinical Science (2003) 105, 73 79 (Printed in Great Britain) 73 Endothelium-dependent vasodilatory effect of vitisin C, a novel plant oligostilbene from Vitis plants (Vitaceae), in rabbit...