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Keywords: endothelium
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Clin Sci (Lond) (2021) 135 (12): 1487–1503.
Published: 17 June 2021
..., and the initiating mechanisms remain incompletely understood. More recently, circulating inflammatory markers, cardiac biomarkers, microRNAs, and extracellular vesicles (EVs) have been considered as early markers of cardiovascular injury. Concomitantly, the role of the endothelium in regulating cardiac function...
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Clin Sci (Lond) (2017) 131 (11): 1055–1058.
Published: 10 May 2017
... endothelial dysfunction. Correspondence: Joel D. Trinity ( [email protected] ) 14 03 2017 10 04 2017 12 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 blood flow endothelium physical inactivity shear...
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Clin Sci (Lond) (2016) 130 (7): 539–549.
Published: 17 February 2016
... associated with this disease. circulating factors endothelium nitric oxide pre-eclamptic plasma prostaglandin uterine artery Following an overnight incubation in 3% plasma and 1 m-unit/ml of heparin, mesenteric and uterine arteries were mounted on two 40-μm wires and attached to a wire...
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Clin Sci (Lond) (2014) 127 (7): 499–505.
Published: 17 June 2014
... ml/min per m 2 during placebo compared with −63±56 ml/min per m 2 during FA, P =0.57; ΔRPF to vitamin C: +93±118 ml/min per m 2 compared with +94±108 ml/min per m 2 ; P =0.70). In line with the lack of effect on the renal endothelium, albuminuria was not affected by FA treatment (110±179 mg/day...
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Clin Sci (Lond) (2013) 124 (9): 579–587.
Published: 21 January 2013
...) underwent cardiopulmonary exercise tolerance test, and were assessed for their upper- and lower-limb vascular endothelial CVC (cutaneous vascular conductance) using LDF (laser Doppler fluximetry) with endothelium-dependent [ACh (acetylcholine chloride)] and -independent [SNP (sodium nitroprusside...
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Clin Sci (Lond) (2012) 122 (6): 289–299.
Published: 22 November 2011
... of the respiratory chain function with altered oxidative phosphorylation. We tested the hypothesis that the function of vascular endothelium is affected by increased oxidative stress in MDs. A total of 12 patients with MDs and pair-matched controls were studied. Endothelial function was assessed by measuring FMD...
Includes: Supplementary data
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Clin Sci (Lond) (2011) 120 (12): 525–536.
Published: 09 March 2011
.... cardiovascular disease diabetes end-stage renal disease endothelium flow-mediated dilatation nitric oxide resistance artery Despite the rapid progress in dialysis treatment, ESRD (end-stage renal disease) patients still die at a markedly accelerated rate, principally from CVD (cardiovascular...
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Clin Sci (Lond) (2011) 120 (9): 377–402.
Published: 18 January 2011
... stimulus, represented by HIF (hypoxia-inducible factor) synthesis [ 6 ]. Conversely, evidence for the stimulation of IGF-1 by other growth factors is lacking. atherothrombosis chronic renal failure diabetes endothelium insulin-like growth factor-1 (IGF-1) myocardial infarction recombinant human...
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Clin Sci (Lond) (2011) 120 (4): 131–141.
Published: 02 November 2010
... in endothelial cells [ 25 ]. One possible explanation that has been suggested is that Rac1 indirectly mediates ROS production by Nox4 [ 26 ]. endothelium hydrogen peroxide NADPH oxidase (Nox) reactive oxygen species superoxide vascular smooth muscle cell ROS (reactive oxygen species...
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Clin Sci (Lond) (2011) 120 (2): 51–63.
Published: 24 September 2010
.... Correspondence: Professor Massimo Volpe (email [email protected] ). 14 6 2010 19 7 2010 9 8 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 biomarker congestive heart failure (CHF) chronic renal failure (CRF) endothelium erythropoietin (EPO...
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Clin Sci (Lond) (2010) 119 (6): 225–238.
Published: 08 June 2010
... of arteriogenesis, comprising sensing of shear stress, endothelial activation and subsequent vasodilatation. Another possible sensor for shear stress is the glycocalyx. This luminal lining of the endothelium, consisting of membranous glycoproteins, proteoglycans and associated plasma proteins, was proposed...
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Clin Sci (Lond) (2010) 119 (1): 1–17.
Published: 07 April 2010
...Alyson A. Miller; Klaudia Budzyn; Christopher G. Sobey The endothelium plays a crucial role in the control of vascular homoeostasis through maintaining the synthesis of the vasoprotective molecule NO • (nitric oxide). Endothelial dysfunction of cerebral blood vessels, manifested as diminished...
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Clin Sci (Lond) (2010) 119 (1): 19–36.
Published: 07 April 2010
... [email protected] ). 7 12 2009 5 2 2010 9 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cation channel endothelium smooth muscle transient receptor potential (TRP) channel vascular function The TRP (transient receptor potential) channel...
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Clin Sci (Lond) (2010) 118 (10): 633–640.
Published: 23 February 2010
...Ellen A. Dawson; Sudhir Rathore; N. Timothy Cable; D. Jay Wright; John L. Morris; Daniel J. Green The aim of this study was to determine the impact of catheter sheath insertion, a model of endothelium disruption in humans, on the conventional FMD (flow-mediated dilatation) response in vivo...
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Clin Sci (Lond) (2010) 118 (9): 583–592.
Published: 09 February 2010
... or not with rosiglitazone (20 mg·kg −1 of body weight·day −1 ) for 90 days and compared with wild-type mice. Endothelium-dependent relaxation of carotid arteries was significantly impaired (−40%) only in rosiglitazone-treated HCD-fed mthfr +/− mice. Carotid M/L (media-to-lumen ratio) and CSA (cross-sectional area) were...
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Clin Sci (Lond) (2010) 118 (7): 459–461.
Published: 12 January 2010
... ). 28 10 2009 2 11 2009 4 11 2009 4 11 2009 ADP angiotensin II clopidogrel endothelium hypertension mesenteric artery P2Y receptor Platelets, normally circulating in resting form, respond to vascular injury by adhering to the damaged vessel wall. Activation results...
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Clin Sci (Lond) (2009) 117 (10): 355–364.
Published: 07 September 2009
... use, distribution and reproduction in any medium, provided the original work is properly cited. androgen cardiovascular system endothelial progenitor cell endothelium gender oestrogen stem cell Cardiovascular risk gradients are primarily driven by gender: women of a reproductive...
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Clin Sci (Lond) (2009) 117 (4): 139–155.
Published: 16 July 2009
...Michel Félétou; Paul M. Vanhoutte The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also by other pathways causing hyperpolarization of the underlying smooth muscle cells. This characteristic was at the origin of the term ‘endothelium-derived hyperpolarizing...
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Clin Sci (Lond) (2009) 117 (3): 129–138.
Published: 02 July 2009
... by the trapezoidal rule, were detected. Figure 5 Aortic responsiveness in female CON offspring (●) and ODM (■) to KCl (A), 5-HT (B), NA (C), ET-1 (D) and AngII (E) in the presence or absence (rubbed) of vascular endothelium, and to NA (F) and ET-1 (G) in the presence or absence of L -NNA (A–E...
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Clin Sci (Lond) (2007) 113 (2): 47–63.
Published: 13 June 2007
... becomes enzymatically uncoupled and generates superoxide, contributing to vascular oxidative stress and endothelial dysfunction. BH4 bioavailability is determined by a balance of enzymatic de novo synthesis and recycling, versus oxidative degradation in dysfunctional endothelium. Augmenting vascular BH4...
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Clin Sci (Lond) (2007) 112 (1): 1–25.
Published: 01 December 2006
... type and produce IL-1β and TNFα after infection or injury to the CNS. The main cellular target for IL-1β and TNFα produced in the brain (peri)vascular compartment is the endothelium, where these cytokines induce the expression of adhesion molecules and promote leucocyte infiltration. Whether...
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Clin Sci (Lond) (2006) 111 (1): 35–46.
Published: 14 June 2006
... existing cardiac myocytes. This process is intimately linked to the development of coronary vasculature from progenitors originating in the endothelium, the proepicardial organ and neural crest. In this review, we systematically evaluate approx. 90 mouse mutations that impair heart muscle growth during...
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Clin Sci (Lond) (2005) 109 (3): 217–226.
Published: 24 August 2005
..., cell growth, apoptosis and hypertrophy. Furthermore, NADPH oxidase-derived superoxide contributes to the impairment of endothelium-dependent vasodilatation by inactivating nitric oxide; the resultant endothelial dysfunction is implicated in the pathophysiology of diseases such as atherosclerosis...
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Clin Sci (Lond) (2005) 109 (1): 27–37.
Published: 23 June 2005
... 8 3 2005 The Biochemical Society 2005 The endothelium has been shown to play a major regulatory role in the vascular response to injury. Most mechanical or haemodynamic methods of injury damage or remove vascular endothelium as part of the injury process. In fact, the loss...
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Clin Sci (Lond) (2005) 108 (4): 357–363.
Published: 22 March 2005
... of reperfusion. Using a cross-over protocol, the subjects were randomized to oral administration of 500 mg of bosentan or placebo 2 h before ischaemia. Endothelium-dependent and -independent vasodilatation were determined by intra-brachial infusion of acetylcholine (1–10 μg/min) and nitroprusside (0.3–3 μg/min...
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Clin Sci (Lond) (2005) 108 (2): 101–112.
Published: 21 January 2005
... Society 2005 antineutrophil cytoplasm antibody (ANCA) endothelium neutrophil small vessel vasculitis SVV (small vessel vasculitis) is an inflammatory disorder affecting arterioles, capillaries and post-capillary venules and is characterized by focal necrosis of the blood vessels...
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Clin Sci (Lond) (2004) 107 (6): 519–532.
Published: 24 November 2004
...Stuart A. RITCHIE; Marie-Ann EWART; Colin G. PERRY; John M. C. CONNELL; Ian P. SALT Vascular integrity in the healthy endothelium is maintained through the release of a variety of paracrine factors such as NO (nitric oxide). Endothelial dysfunction, characterized by reduced NO bioavailability...
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Clin Sci (Lond) (2004) 107 (5): 513–517.
Published: 26 October 2004
...Roger CORDER; Richard C. WARBURTON; Noorafza Q. KHAN; Ruth E. BROWN; Elizabeth G. WOOD; Delphine M. LEES Reduced endothelium-dependent vasodilator responses with increased synthesis of ET-1 (endothelin-1) are characteristics of endothelial dysfunction in heart failure and are predictive...
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Clin Sci (Lond) (2004) 107 (3): 323–330.
Published: 24 August 2004
...). By contrast, aspirin had no effect on increases in RCF evoked by iontophoretic application of the NO (nitric oxide) donor and endothelium-independent dilator sodium nitroprusside (mean increases in RCF were 73.8±9.8 PU before and 79.1±12.2 PU after aspirin). The ACh-evoked increases in RCF were also...
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Clin Sci (Lond) (2004) 107 (2): 191–196.
Published: 27 July 2004
... for 2.5 min. FMD of the brachial artery, resulting from ischaemia-induced reactive hyperaemia following release of this cuff, provided a measure of endothelium-dependent-mediated vasodilation [ 10 , 11 ]. FMD measures were repeated at 60 and 120 min after the initial baseline measure...
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Clin Sci (Lond) (2003) 105 (3): 251–266.
Published: 01 September 2003
... underlies many of the beneficial actions of the statins on vascular endothelium, which include increased endothelial nitric oxide synthase expression, pro-angiogenic effects, increased fibrinolytic activity, immunomodulatory and anti-inflammatory actions, including increased resistance to complement...
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