...- L -arginine)], after a single oral administration of telmisartan (80 mg) or placebo, using a randomized double-blind cross-over design. In six volunteers, we also assessed the roles of prostacyclin and EDHF (endothelium-derived hyperpolarizing factor) during radial FMD after AT 1 receptor blockade...

...Amrita AHLUWALIA Since the discovery of endothelium-derived hyperpolarizing factor (EDHF), several different candidates and pathways have been proposed as mediators of endothelium-dependent hyperpolarization of vascular smooth muscle. In particular, there has been considerable support for a role...

... ). 27 3 2003 4 6 2003 24 6 2003 26 6 2003 © 2003 The Biochemical Society 2003 bradykinin cytochrome P450 endothelium-derived hyperpolarizing factor forearm sulphaphenazole vasodilatation Clinical Science (2003) 105, 513 518 (Printed in Great Britain) 513 Baseline...

... and endothelium-derived hyperpolarizing factor. When the former was abolished during nitric oxide synthase inhibition, an 80% diabetic deficit in the remaining relaxation was noted. LY333531 treatment attenuated the development of these defects by 64% and 53% respectively. Thus protein kinase Cβ contributes...

... not to do so in significant amounts. Thirty per cent of the relaxation induced by acetylcholine in human small arteries is mediated by release of endothelium-derived nitric oxide, whereas more than 60% is the result of release of another agent, perhaps the putative endothelium-derived hyperpolarizing factor...