... of resistance artery endothelium-dependent relaxation in the pathophysiology of hypertension in the elderly. 26 9 1996 4 10 1996 © 1997 The Biochemical Society and the Medical Research Society 1997 endothelium endothelium-derived relaxing factor nitric oxide resistance arteries aged...

... slightly but significantly less, indicating that generation of endothelium-derived relaxing factor (endothelium-derived nitric oxide) was only minimally reduced or that production of minor amounts of endothelium-derived contracting factor occurred in small arteries from these hypertensive subjects...

... with this condition. Nitric oxide generation, however, may be inappropriately low in pregnant women developing pre-eclampsia, thus leading to an enhanced vasoconstriction. © 1995 The Biochemical Society and the Medical Research Society 1995 endothelium-derived relaxing factor pre-eclampsia pregnancy...

... nitroprusside. 4. These results suggest that there may be a defect in the endothelial cell acetylcholine receptor excitation-coupling in diabetes mellitus rather than a decreased ability to synthesize and release endothelium-derived relaxing factor. Impaired contraction and endothelium-dependent relaxation...

...Wayne Sunman; Peter S. Sever © 1993 The Biochemical Society and the Medical Research Society 1993 angto-oedema angiotensin II angiotensin-converting enzyme inhibitors bradykinin cough endothelium-derived relaxing factor eicosanoids enkephalin renin-angiotensin system Clinical...

...Hiromichi SUZUKI; Hideki IKENAGA; Keiichi HISHIKAWA; Toshio NAKAKI; Ryuichi KATO; Takao SARUTA 1. Under hormonally constant conditions, the effects of a sudden increase in blood pressure on the release of endothelium-derived relaxing factor were evaluated by measuring urinary excretion of NO 2...

... (58 ± 3 versus 56 ± 4 ml/min, P > 0.05). 6. These results suggest that intravenously administered l -arginine produces an elevation of renal blood flow, which may be mediated by facilitation of endogenous acetylcholine-induced release of endothelium-derived relaxing factor and vasodilatory...

... the provision of excess substrate. arginine endothelium-derived relaxing factor nitric oxide resistance vessels veins Clinical Science (1991) 81,695-700 695 Dilator actions of arginine in human peripheral vasculature ALISON CALVER, JOE COLLIER AND PATRICK VALLANCE Department of Pharmacology...

...G. A. Burton; J. Haylor; A. de Jonge 1. The sensitivity of the kidney to endothelium-derived-relaxing-factor-mediated vasodilatation has been investigated in the spontaneously hypertensive rat and the Wistar-Kyoto normotensive rat using an isolated perfused rat kidney model. 2. No difference...

... that vehicles used for commercial preparations of cyclosporin A interfere with the synthesis of endothelium-derived relaxing factor at an early stage during which l-arginine is made available for enzymatic degradation. 6 12 1989 26 2 1990 8 3 1990 © 1990 The Biochemical Society...

.... Abbreviations: ACh, acetylcholine; EDRF, endothelium- derived relaxing factor; NA, noradrenaline. INTRODUCTION It is now recognized that the response of blood vessels to exogenous acetylcholine (ACh) depends on a balance between a direct vasoconstrictor action and an indirect, endothelium-dependent, vasodilator...

... Research Society 1990 age endothelium-derived relaxing factor forearm resistance vessel Clinical Science (1990) 78, 89-93 89 Age-independent forearm vasodilatation by acetylcholine and adenosine 5 -triphosphate in humans TSUTOMU IMAIZUMI, AKIRA TAKESHITA, SATOSHI SUZUKI, MEGUMU YOSHIDA, SHINICHI...

... unaltered by the presence of 10 −5 mol/l indomethacin, suggesting that prostacyclin is not a significant vasodilator in this system 5. Reduced production of endothelium-derived relaxant factor rather than production of a constrictor factor, or a direct effect on the smooth muscle, may be involved...

... cyclase. In these respects the endothelium-dependent responses of human arteries to acetylcholine and A23187 resemble those described in other species. 9 4 1987 21 5 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 endothelium-derived relaxing factor...