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1-23 of 23
Keywords: endotoxin
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Articles
Endothelial cell tolerance to lipopolysaccharide challenge is induced by monophosphoryl lipid A
Available to PurchaseRyan J. Stark, Hyehun Choi, Stephen R. Koch, Benjamin A. Fensterheim, Fred S. Lamb, Edward R. Sherwood
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (6): 451–461.
Published: 04 February 2016
... endotoxin tolerance in endothelial cells. Most importantly, MPLA, a vaccine adjuvant with a wide therapeutic window, induced tolerance to LPS in endothelial cells. Primary human umbilical vein endothelial cells (HUVECs) were purchased from Lonza and grown in Endothelial Growth Media-2 (Lonza...
Includes: Supplementary data
Articles
Does endotoxaemia contribute to osteoarthritis in obese patients?
Available to PurchaseDavid Metcalfe, Alison L. Harte, Mina Olga Aletrari, Nasser M. Al Daghri, Dara Al Disi, Gyanendra Tripathi, Philip G. McTernan
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (11): 627–634.
Published: 01 August 2012
... 2012 25 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 endotoxaemia endotoxin lipopolysaccharide obesity osteoarthritis However, the biomechanical model is undermined by the propensity for obese patients to develop OA in non-weight-bearing joints...
Articles
Protein metabolism in leg muscle following an endotoxin injection in healthy volunteers
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Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (6): 421–427.
Published: 14 December 2009
...Rokhsareh F. Vesali; Norbert Cibicek; Towe Jakobsson; Maria Klaude; Jan Wernerman; Olav Rooyackers The human endotoxin model has been used to study the early phase of sepsis. The aim of the present study was to assess leg muscle protein kinetics after an endotoxin challenge given to healthy human...
Articles
Acute Escherichia coli endotoxaemia decreases the plasma l-arginine/asymmetrical dimethylarginine ratio in humans
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Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (6): 577–581.
Published: 01 June 2004
... endotoxin [LPS (lipopolysaccharide), 20 units/kg of body mass; n =8] or placebo ( n =9) in healthy males. L -Arginine and dimethylarginines were quantified after solid-phase extraction by reversed-phase HPLC. Body temperature, heart rate and leucocyte count increased after LPS administration ( P <0.01...
Articles
Glucan phosphate potentiates endotoxin-induced interferon-γ expression in immunocompetent mice, but attenuates induction of endotoxin tolerance
Available to PurchaseEdward R. SHERWOOD, Tushar K. VARMA, Ricki Y. FRAM, Cheng Y. LIN, Aristides P. KOUTROUVELIS, Tracy E. TOLIVER-KINSKY
Journal:
Clinical Science
Clin Sci (Lond) (2001) 101 (6): 541–550.
Published: 24 October 2001
... expression in normal mice and endotoxin [lipopolysaccharide (LPS)]-tolerant mice. The model of LPS tolerance was used because it results in patterns of cytokine expression similar to those commonly observed following severe trauma or sepsis. Glucan treatment potentiated LPS-induced IFN-γ expression...
Articles
Effects of extracellular pH on tumour necrosis factor-α production by resident alveolar macrophages
Available to PurchaseThomas A. HEMING, Sanat K. DAVÉ, Divina M. TUAZON, Ashok K. CHOPRA, Johnny W. PETERSON, Akhil BIDANI
Journal:
Clinical Science
Clin Sci (Lond) (2001) 101 (3): 267–274.
Published: 03 August 2001
..., TX 77555–0876, U.S.A. (e-mail [email protected] ). 20 4 2001 18 5 2001 The Biochemical Society and the Medical Research Society © 2001 2001 acidbase cytokine endotoxin leucocyte tumour necrosis factor- 267Clinical Science (2001) 101, 267 274 (Printed in Great Britain...
Articles
Regional transcapillary albumin exchange in rodent endotoxaemia: effects of fluid resuscitation and inhibition of nitric oxide synthase
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Journal:
Clinical Science
Clin Sci (Lond) (2001) 100 (1): 81–89.
Published: 08 December 2000
... The Biochemical Society and the Medical Research Society © 2001 2001 capillary density endotoxin microvascular permeability sepsis 81Clinical Science (2001) 100, 81 89 (Printed in Great Britain) Regional transcapillary albumin exchange in rodent endotoxaemia: effects of fluid resuscitation...
Articles
Sequential changes in plasma cytokine and endotoxin levels in cirrhotic patients with bacterial infection
Available to PurchaseSun-Sang WANG, Fa-Yauh LEE, Che-Chang CHAN, Rei-Hwa LU, Yee CHAO, Han-Chieh LIN, Shwu-Ling WU, Yang-Te TSAI, Shou-Dong LEE
Journal:
Clinical Science
Clin Sci (Lond) (2000) 98 (4): 419–425.
Published: 08 March 2000
...Sun-Sang WANG; Fa-Yauh LEE; Che-Chang CHAN; Rei-Hwa LU; Yee CHAO; Han-Chieh LIN; Shwu-Ling WU; Yang-Te TSAI; Shou-Dong LEE To delineate the clinical roles of plasma cytokine or endotoxin levels in the natural course of infection in patients with decompensated cirrhosis, 66 cirrhotic patients were...
Articles
Hyperdynamic Circulation of Cirrhotic Rats with Ascites: Role of Endotoxin, Tumour Necrosis Factor-α and Nitric Oxide
Available to PurchaseChi-Jen Chu, Fa-Yauh Lee, Sun-Sang Wang, LU Rei-Hwa, Yang-Te Tsai, Han-Chieh Lin, Ming-Chih Hou, Che-Chang Chan, Shou-Dong Lee
Journal:
Clinical Science
Clin Sci (Lond) (1997) 93 (3): 219–225.
Published: 01 September 1997
... and regional blood flows. Endotoxin, tumour necrosis factor-alpha (TNF-α) and nitric oxide (NO) have been reported to be involved in the pathogenesis of hyperdynamic circulation, but the interactions between endotoxin, TNF-α and NO in cirrhotic rats with ascites have never been specifically addressed. 2...
Articles
Mild Endotoxaemia and the Inflammatory Response Induced by a Marathon Race
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Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (4): 415–422.
Published: 01 April 1997
... of the inflammatory response to exercise were measured: polymorphonuclear myeloperoxidase (MPO), anaphylatoxin C5a (C5a), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Plasma endotoxin was measured by a sensitive and rapid chromogenic Limulus assay. All inflammatory markers were significantly increased...
Articles
Dietary Sulphur Amino Acid Adequacy Influences Glutathione Synthesis and Glutathione-Dependent Enzymes during the Inflammatory Response to Endotoxin and Tumour Necrosis Factor-α in Rats
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Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (3): 297–305.
Published: 01 March 1997
... an inflammatory challenge by intraperitoneal injection of tumour necrosis factor-α or endotoxin (lipopolysaccharide). 3. Diets containing 200 g of casein and 8 g of l-cysteine/kg (normal-protein diet), or 80 g of casein and 8 g of l-cysteine, or isonitrogenous amounts of l-methionine or l-alanine (low-protein...
Articles
Beneficial Effects of L-Canavanine, a Selective Inhibitor of Inducible Nitric Oxide Synthase, during Rodent Endotoxaemia
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Journal:
Clinical Science
Clin Sci (Lond) (1996) 90 (5): 369–377.
Published: 01 May 1996
... contrast to the deleterious consequences of nitro-l-arginine methyl ester, a non-selective nitric oxide synthase inhibitor, in similar conditions. 7 9 1995 8 1 1996 16 1 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 l-canavanine endotoxin mouse...
Articles
Comparison of the Modulatory Influence of Maize and Olive Oils and Butter on Metabolic Responses to Endotoxin in Rats
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (1): 59–66.
Published: 01 January 1995
...H. T. Besler; R. F. Grimble 1. n -3 polyunsaturated fatty acids decrease responses to cytokines and inflammatory agents. The present study examines how different intakes of n -6 and n -9 fatty acids influence the metabolic response to endotoxin in Wistar rats. 2. Weanling male rats were, for 4...
Articles
Model for Whole Body Production of Tumour Necrosis Factor-α in Experimental Endotoxaemia in Healthy Subjects
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Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (4): 459–465.
Published: 01 October 1994
... behaviour of an intravenously injected bolus of recombinant human tumour necrosis factor-α (50 μg/m 2 ) in another group of six normal subjects. We then calculated the total amount of tumour necrosis factor-α produced after intravenous injection of endotoxin (2 ng/kg) as the product of the systemic...
Articles
Cellular Localization of Inducible Nitric Oxide Synthase in Experimental Endotoxic Shock in the Rat
Available to PurchaseH. Terence Cook, Alison J. Bune, Albertine S. Jansen, G. Michael Taylor, Rashpal K. Loi, Victoria Cattell
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (2): 179–186.
Published: 01 August 1994
...H. Terence Cook; Alison J. Bune; Albertine S. Jansen; G. Michael Taylor; Rashpal K. Loi; Victoria Cattell 1. Endotoxin induces a shock-like syndrome with increased nitric oxide synthesis. To clarify the cellular source of NO in endotoxic shock we used immunohistochemistry and in situ hybridization...
Articles
Tumour necrosis factor- α : Its role in the metabolic response to sepsis
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Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (3): 247–256.
Published: 01 March 1993
...Tom van der Poll; Hans P. Sauerwein © 1993 The Biochemical Society and the Medical Research Society 1993 cytokines endotoxin fat glucose metabolism sepsis stress hormones tumor necrosis factor-α Clinical Science (1993) 84, 247-256 (Printed in Great Britain) Editorial Review...
Articles
Time course of plasma and pulmonary lymph endothelin-like immunoreactivity during sustained endotoxaemia in chronically instrumented sheep
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (3): 357–365.
Published: 01 September 1991
... failure syndrome and death within 42 h of a continuous intravenous infusion of Escherichia coli endotoxin (40 ng min −1 kg −1 ). 2. Plasma and pulmonary lymph endothelin-like immunoreactivity were measured by r.i.a. using a specific antiserum raised in rabbits against porcine endothelin-1. Endothelin-like...
Articles
Endothelin Immunoreactivity in Mice with Gram-Negative Bacteraemia: Relationship to Tumour Necrosis Factor-α
Available to PurchaseKazuhiro Takahashi, Ayona Silva, Jonathan Cohen, Hing-Chung Lam, Mohammad A. Ghatei, Stephen R. Bloom
Journal:
Clinical Science
Clin Sci (Lond) (1990) 79 (6): 619–623.
Published: 01 December 1990
... endotoxin Escherichia coli Gram-negative bacteraemia lipopolysaccharide tumour necrosis factor-α Clinical Science (1 990) 79, 6 19-623 619 Endothelin immunoreactivity in mice with Gram-negative bacteraemia: relationship to tumour necrosis factor- a KAZUHIRO TAKAHASHI, AYONA SILVA*, JONATHAN COHEN...
Articles
Effects of Insulin on Glucose Metabolism in Skeletal Muscle from Septic and Endotoxaemic Rats
Available to PurchaseBrendan Leighton, George D. Dimitriadis, Mark Parry-Billings, Jane Bond, Paulo R. L. de Vasconcelos, Eric A. Newsholme
Journal:
Clinical Science
Clin Sci (Lond) (1989) 77 (1): 61–67.
Published: 01 July 1989
... of glycolysis to insulin. 4. Endotoxaemia decreased the rates of glycogen synthesis at all concentrations of insulin both at 24 h (∼ 39%) and 48 h (∼ 23%). 5. The increase in the rate of glycolysis was related in a dose-dependent manner to the amount of endotoxin given to the animals. 6. Endotoxaemia decreased...
Articles
Effects of Plasma, Tumour Necrosis Factor, Endotoxin and Dexamethasone on Extracellular Proteolysis by Neutrophils from Healthy Subjects and Patients with Emphysema
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Journal:
Clinical Science
Clin Sci (Lond) (1989) 77 (1): 35–41.
Published: 01 July 1989
... with the polymorphonuclear leucocytes in suspension. Bacterial endotoxin in concentrations above 6 μg/ml significantly increased fibronectin digestion by neutrophils, but leukotriene B 4 , interferon-μ and interleukin-1α had no significant effects. 3. Dexamethasone inhibited fibronectin digestion by neutrophils in a dose...
Articles
Effect of parenteral nutrition on protein turnover in endotoxaemic rats
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Journal:
Clinical Science
Clin Sci (Lond) (1989) 76 (6): 659–666.
Published: 01 June 1989
...S. A. Ash; G. E. Griffin 1. Intravenous infusion of endotoxin into rats over 18 h caused a reduction in food intake to 20% of normal levels, weight loss, hypoalbuminaemia and a fall in rates of protein synthesis in vivo in heart and skeletal muscle. 2. Measurements of protein turnover in vitro...
Articles
Inhibition of Partially Purified Rat Brain Na + , K + - Dependent Atpase by Bile Acids, Phenolic Acids and Endotoxin
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Journal:
Clinical Science
Clin Sci (Lond) (1984) 66 (4): 415–420.
Published: 01 April 1984
... toxic substances present in the serum of patients with FHF. 3. Chenodeoxycholic acid, p -hydroxyphenyllactic acid, p -hydroxyphenylpyruvic acid and endotoxin caused 30–45% inhibition of partially purified rat brain Na + ,K + -ATPase at concentrations known to occur in the serum of patients with FHF...
Articles
Role of Endotoxin in Glycerol-Induced Renal Failure in the Rat
Available to Purchase
Journal:
Clinical Science
Clin Sci Mol Med (1978) 54 (6): 615–620.
Published: 01 June 1978
...J. P. Nolan; R. C. Venuto; Gwendolyn S. Goldmann 1. A relationship between bacterial endotoxin absorbed from the gut and acute renal failure has been postulated. Experiments employing either the endotoxin-tolerant state or the enhancement of endotoxin injury were undertaken to test...