...Wayne Sunman; Peter S. Sever © 1993 The Biochemical Society and the Medical Research Society 1993 angto-oedema angiotensin II angiotensin-converting enzyme inhibitors bradykinin cough endothelium-derived relaxing factor eicosanoids enkephalin renin-angiotensin system Clinical...

... and main pancreatic duct sphincters were studied simultaneously in anaesthetized cats using a perfusion technique. 2. Naloxone did not affect the activity of these sphincters under basal conditions, indicating that there is no basal enkephalinergic tone. 3. The response to [Leu 5 ]enkephalin (0.015–15 μg...

...L. Jivegård; H. Pollard; J. Moreau; J. C. Schwartz; A. Thune; J. Svanvik 1. Enkephalin immunoreactive nerve fibres have been demonstrated in the gall bladder of various mammals including man. In various tissues, enkephalins are partly degraded by a membrane metallo-endopeptidase, enkephalinase (EC...

...Lennart Jivegård; Joar Svanvik 1. Endogenous opioid peptides are found in the enteric nervous system in the gastrointestinal tract. The opioid peptide enkephalin, which has anti-secretory actions in the small intestine, is also contained in nerves in the gall-bladder wall. 2. In experimental...

...S. L. Lightman; Mary L. Forsling 1. Infusion of the methionine enkephalin analogue DAMME (Sandoz) inhibits the rise in plasma arginine vasopressin after a 65° head-up tilt. 2. DAMME does not significantly affect the blood pressure, pulse rate or plasma volume changes produced by tilt. 9 7...

...R. W. Rockhold; J. T. Crofton; L. Share 1. The cardiovascular effects of an enkephalin analogue were examined in spontaneously hypertensive and normotensive Wistar-Kyoto rats. (D-Ala 2 )-methionine enkephalin caused a biphasic increase in blood pressure and an increase in heart rate after...