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Keywords: epileptogenesis
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Articles

Candesartan restores blood–brain barrier dysfunction, mitigates aberrant gene expression, and extends lifespan in a knockin mouse model of epileptogenesis

Michael F. Hammer, Erfan Bahramnejad, Joseph C. Watkins, Patrick T. Ronaldson
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (17): 1089–1110.
https://doi.org/10.1042/CS20240771
Published: 03 September 2024
...Michael F. Hammer; Erfan Bahramnejad; Joseph C. Watkins; Patrick T. Ronaldson Blockade of Angiotensin type 1 receptor (AT1R) has potential therapeutic utility in the treatment of numerous detrimental consequences of epileptogenesis, including oxidative stress, neuroinflammation, and blood–brain...
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Includes: Supplementary data
Articles

Participation of the spleen in the neuroinflammation after pilocarpine-induced status epilepticus: implications for epileptogenesis and epilepsy

Paula Virginia Sarchi, Dante Gomez Cuautle, Alicia Rossi, Alberto Javier Ramos
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (9): 555–572.
https://doi.org/10.1042/CS20231621
Published: 29 April 2024
...Paula Virginia Sarchi; Dante Gomez Cuautle; Alicia Rossi; Alberto Javier Ramos Epilepsy, a chronic neurological disorder characterized by recurrent seizures, affects millions of individuals worldwide. Despite extensive research, the underlying mechanisms leading to epileptogenesis, the process...
View article titled, Participation of the spleen in the neuroinflammation after pilocarpine-induced status epilepticus: implications for <span class="search-highlight">epileptogenesis</span> and epilepsy
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Articles

Brain angiotensin system: a new promise in the management of epilepsy?

Alberto Javier Ramos
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 725–730.
https://doi.org/10.1042/CS20201296
Published: 17 March 2021
... 10.1007/s40263-019-00678-4 31680223 31. Nozaki T. , Ura H. , Takumi I. , Kobayashi S. , Maru E. and Morita A. ( 2018 ) The angiotensin II type I receptor antagonist losartan retards amygdala kindling-induced epileptogenesis . Brain Res. 1694 , 121 – 128...
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