... direction, and some of the actions ascribed to Ang II are actually mediated by Ang-(1-7) formation. The redundancy of both RAS axes seems to be important to guarantee the success of the female reproductive process. ACE2 Angiotensin-(1-7) erectile dysfunction Mas receptor ovulation reproduction...

... dissociation inhibitors and GTPase-activating proteins. We also summarize the current knowledge about the physiological roles of RhoA/Rho-kinase in both male and female erectile tissues and its aberrations contributing to erectile dysfunction in several disease states. Understanding the RhoA/Rho-kinase...

...Simon F. CAMPBELL The research programme that started in 1985 led to the approval of Sildenafil (Viagra ® ), in 1998, as the first oral treatment for male erectile dysfunction. The initial project objective was the design and synthesis of novel inhibitors of phosphodiesterase that would increase...