... of renal function including reductions in both glomerular filtration rate (GFR) and tubular handling of water and solutes. Although obstruction can be released by surgical operation, the child will suffer from diuresis for sometime. It has been reported that erythropoietin (EPO) could prevent the down...

...Lindsey Tilling; Joanne Hunt; Ann Donald; Brian Clapp; Phil Chowienczyk Vasoprotective effects of erythropoietin in animal models are mediated by endothelium-derived NO and/or mobilization of EPCs (endothelial progenitor cells) and may be enhanced by ischaemia: whether they are present in humans...

...Torsten SLOWINSKI; Norma SCHULZ; Frank T. RUSCHITZKA; Thomas QUASCHNING; Christian BAUER; Franz THEURING; Hans-H. NEUMAYER; Max GASSMANN; Berthold HOCHER Transgenic overexpression of erythropoietin (Epo) in mice increases haematocrit to a mean of 80% in adult mice, leading to an increase in blood...

...M. BUEMI; E. CAVALLARO; F. FLOCCARI; A. STURIALE; C. ALOISI; M. TRIMARCHI; G. GRASSO; F. CORICA; N. FRISINA It is now widely known that erythropoietin (Epo) does not only affect the haematopoietic system, but it can be considered a multifunctional trophic factor with an effect on the general...

...Xiao Chun WU; Nicholas T. RICHARDS; Edward J. JOHNS This study investigated potential reasons why erythropoietin (EPO) given therapeutically to patients with renal failure may increase peripheral, but not renal, vascular resistance. This was done by comparing the effects of EPO on resting tension...

...Xiao Chun WU; Edward J. JOHNS; Nicholas T. RICHARDS We have investigated the effects of recombinant human erythropoietin (EPO) on the responses of rat renal arcuate arteries to dopamine, noradrenaline and acetylcholine and on the release of NO from human umbilical vein endothelial cells (HUVEC...

...Felix Stockenhuber; Michaela Keil; Christian Wurnig; Robert W. Kurz; Michael Gottsauner-Wolf; Peter Balcke 1. Serum levels of erythropoietin and the immune parameters tumour necrosis factor-α, soluble interleukin-2 receptor, interleukin-2, interleukin-6 and interferon-γ were measured in patients...

...Peter Báaráany; Ulla Freyschuss; Erna Pettersson; Jonas Bergström 1. The effects of correcting anaemia on exercise capacity were evaluated in 21 haemodialysis patients (aged 39 ± 12 years) before starting treatment with recombinant human erythropoietin (Hb concentration, 73 ± 10 g/l; total Hb, 59...

...Michael F. Fitzpatrick; Tom MacKay; Kenneth F. Whyte; Martin Allen; Robert C. Tam; Caroline J. Dore; Michael Henley; P. Mary Cotes; Neil J. Douglas 1. To clarify the relationship between nocturnal oxygen desaturation and erythropoietin production in patients with chronic obstructive pulmonary...

...Kazuhiro Takahashi; Kazuhito Totsune; Yutaka Imai; Masahiko Sone; Mitsuru Nozuki; Osamu Murakami; Hiroshi Sekino; Toraichi Mouri 1. Elevation of blood pressure is one of the major side effects of recombinant human erythropoietin therapy in haemodialysis patients. 2. We investigated the possible...

...Chunlong Huang; Gerard Davis; Edward J. Johns 1. Studies were undertaken to examine the effect of acute and chronic administration of human recombinant erythropoietin on kidney cortical and papillary perfusion in the anaesthetized rat using laser-Doppler flowmetry. 2. Thirty minutes after...

... concentrations, plasma renin activity and serum erythropoietin concentration remained unchanged. 4. The sensitivity of the renal allograft to plasma atrial natriuretic factor concentrations in the high physiological range suggests a role for endogenous atrial natriuretic factor in the modulation of graft...

...Peter Bárány; Rolf Wibom; Eric Hultman; Jonas Bergström 1. The ATP production rate in isolated skeletal muscle mitochondria was measured with a bioluminescence method, before and during erythropoietin treatment, in 21 anaemic haemodialysis patients. In addition, the concentrations of ATP...

...Sergio De Marchi; Emanuela Cecchin 1. A randomized, partial-crossover study was conducted in uraemic patients with dialysis-associated anaemia and transfusional iron overload to evaluate the effects of desferrioxamine chelation therapy and of recombinant human erythropoietin treatment on hepatic...

... is usually performed for excessive secondary polycythaemia in man. Our results suggest a possible therapeutic role for verapamil in such individuals. 01 4 1987 12 6 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 erythropoietin hypoxia polycythaemia...

... with chronic airflow obstruction and polycythaemia and 19 normal controls. 2. Estimates of serum immunoreactive erythropoietin (siEp) in those without polycythaemia were 19 m-i.u./ml (geometric mean) with 95% confidence range 11–35 m-i.u./ml and stable during 3 months. In those with polycythaemia they were...