1-50 of 145
Keywords: essential hypertension
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles

A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension

Ying Xin, Xiaodong Song, Hao Xue, Zhe Liu, Xiaojian Wang, Hu Wang, Kai Sun, Yongyi Bai, Junhao Liu, Rutai Hui
Journal: Clinical Science
Clin Sci (Lond) (2009) 117 (2): 67–73.
https://doi.org/10.1042/CS20080476
Published: 15 June 2009
... common variants in NOS3 (the eNOS gene) are associated with the risk of LVH [LV (left ventricular) hypertrophy] in patients with essential hypertension. Three NOS3 genetic variants, −T786C (rs2070744), eNOS4a/b and +G894T (rs1799983), were genotyped in two independent case-control studies: the first...
View articletitled, A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension
Open the PDF for A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension in another window
Articles

The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension

Gorka San José, Ana Fortuño, María U. Moreno, Pablo A. Robador, Julen Bidegain, Nerea Varo, Oscar Beloqui, Javier Díez, Guillermo Zalba
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (3): 233–240.
https://doi.org/10.1042/CS20080057
Published: 08 January 2009
... on NADPH oxidase activity. As a second aim we also analysed the impact of this polymorphism on the cardiovascular profile of patients with essential hypertension. The study population consisted of 223 hypertensive subjects and 189 non-hypertensive healthy subjects consecutively referred...
View articletitled, The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension
Open the PDF for The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension in another window
Articles

A functional intronic variant in the tyrosine hydroxylase (TH) gene confers risk of essential hypertension in the Northern Chinese Han population

Laiyuan Wang, Biao Li, Xiangfeng Lu, Qi Zhao, Yun Li, Dongliang Ge, Hongfan Li, Penghua Zhang, Shufeng Chen, Runsheng Chen, Boqin Qiang, Dongfeng Gu
Journal: Clinical Science
Clin Sci (Lond) (2008) 115 (5): 151–158.
https://doi.org/10.1042/CS20070335
Published: 01 August 2008
... of binding by unidentified transcriptional repressor(s). These results provide evidence for an association of the functional intronic rs2070762 with essential hypertension. A single copy human TH gene is located on chromosome 11 p15.5 and consists of 13 primary exons [ 10 ]. Several variants within...
View articletitled, A functional intronic variant in the tyrosine hydroxylase (TH) gene confers risk of essential hypertension in the Northern Chinese Han population
Open the PDF for A functional intronic variant in the tyrosine hydroxylase (TH) gene confers risk of essential hypertension in the Northern Chinese Han population in another window
Articles

Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension

Ramón Rodrigo, Hernán Prat, Walter Passalacqua, Julia Araya, Jean P. Bächler
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (10): 625–634.
https://doi.org/10.1042/CS20070343
Published: 14 April 2008
...Ramón Rodrigo; Hernán Prat; Walter Passalacqua; Julia Araya; Jean P. Bächler Oxidative stress has been associated with mechanisms of EH (essential hypertension). The aim of the present study was to test the hypothesis that the antioxidant properties of vitamins C and E are associated...
View articletitled, Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension
Open the PDF for Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension in another window
Articles

Sodium–lithium countertransport and the Gly 460 →Trp α-adducin polymorphism in essential hypertension

Paul A. MEAD, John N. HARVEY, Peter A. RUTHERFORD, Helen LEITCH, Trevor H. THOMAS
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (3): 231–236.
https://doi.org/10.1042/CS20040267
Published: 18 February 2005
...Paul A. MEAD; John N. HARVEY; Peter A. RUTHERFORD; Helen LEITCH; Trevor H. THOMAS A polymorphism of the α-subunit of adducin, Gly 460 →Trp, may affect membrane ion transport and be associated with human EH (essential hypertension). The α-adducin Gly 460 →Trp polymorphism was determined in 242 NC...
View articletitled, Sodium–lithium countertransport and the Gly 460 →Trp α-adducin polymorphism in essential hypertension
Open the PDF for Sodium–lithium countertransport and the Gly 460 →Trp α-adducin polymorphism in essential hypertension in another window
Articles

Angiotensinogen gene M235T polymorphism and reduction in wall thickness in response to antihypertensive treatment

Erwan BOZEC, Céline FASSOT, Anne-Isabelle TROPEANO, Pierre BOUTOUYRIE, Xavier JEUNEMAITRE, Patrick LACOLLEY, Hubert DABIRE, Stéphane LAURENT
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (5): 637–644.
https://doi.org/10.1042/CS20030156
Published: 01 November 2003
... of atherosclerosis. The objectives of the present study were to determine in previously untreated essential hypertensive patients whether carotid IMT was associated with the M235T polymorphism, and to determine whether the M235T polymorphism could influence the reduction of carotid IMT by antihypertensive treatment...
View articletitled, Angiotensinogen gene M235T polymorphism and reduction in wall thickness in response to antihypertensive treatment
Open the PDF for Angiotensinogen gene M235T polymorphism and reduction in wall thickness in response to antihypertensive treatment in another window
Articles

Short-term blood pressure variability in renovascular hypertension and in severe and mild essential hypertension

Hanna MUSSALO, Esko VANNINEN, Risto IKÄHEIMO, Tomi LAITINEN, Juha HARTIKAINEN
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (5): 609–614.
https://doi.org/10.1042/CS20020268
Published: 01 November 2003
... continuous finger blood pressure (Finapres) recordings. Ten patients with renovascular hypertension (RVHT), 34 with severe essential hypertension (SEHT) and 29 with mild essential hypertension (MEHT) as well as healthy age- and sex-matched control subjects were studied. The RVHT group was characterized...
View articletitled, Short-term blood pressure variability in renovascular hypertension and in severe and mild essential hypertension
Open the PDF for Short-term blood pressure variability in renovascular hypertension and in severe and mild essential hypertension in another window
Articles

Forearm vasoconstriction to endothelin-1 is impaired, but constriction to sarafotoxin 6c and vasodilatation to BQ-123 unaltered, in patients with essential hypertension

Charles J. FERRO, William G. HAYNES, Malcolm F. HAND, David J. WEBB
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 53S–58S.
https://doi.org/10.1042/CS103S053S
Published: 01 September 2002
...Charles J. FERRO; William G. HAYNES; Malcolm F. HAND; David J. WEBB The importance of endothelin-1 (ET-1) in the pathophysiology of essential hypertension is unclear. We therefore compared the effects of endothelin ET A receptor blockade and the stimulation of ET A and ET B receptors...
View articletitled, Forearm vasoconstriction to endothelin-1 is impaired, but constriction to sarafotoxin 6c and vasodilatation to BQ-123 unaltered, in patients with essential hypertension
Open the PDF for Forearm vasoconstriction to endothelin-1 is impaired, but constriction to sarafotoxin 6c and vasodilatation to BQ-123 unaltered, in patients with essential hypertension in another window
Articles

Forearm vasoconstriction in response to noradrenaline and NG-monomethyl-L-arginine in essential hypertension

Barry J. KNEALE, Philip J. CHOWIENCZYK, Sally E. BRETT, JohnR. COCKCROFT, James M. RITTER
Journal: Clinical Science
Clin Sci (Lond) (1999) 97 (3): 277–282.
https://doi.org/10.1042/cs0970277
Published: 15 July 1999
...Barry J. KNEALE; Philip J. CHOWIENCZYK; Sally E. BRETT; JohnR. COCKCROFT; James M. RITTER A role for abnormal NO production in essential hypertension remains controversial. Blunted vasoconstriction of forearm resistance vasculature in response to N G -monomethyl-⌊-arginine (⌊-NMMA; an inhibitor...
View articletitled, Forearm vasoconstriction in response to noradrenaline and NG-monomethyl-L-arginine in essential hypertension
Open the PDF for Forearm vasoconstriction in response to noradrenaline and NG-monomethyl-L-arginine in essential hypertension in another window
Articles

Erythrocyte Na+/Li+ countertransport and Na+/K+–2Cl− co-transport measurement in essential hypertension: useful diagnostic tools or failure? A meta-analysis of 17 years of literature

T. Tepper, W. J. Sluiter, R. M. Huisman, D. de Zeeuw
Journal: Clinical Science
Clin Sci (Lond) (1998) 95 (6): 649–657.
https://doi.org/10.1042/cs0950649
Published: 01 December 1998
...T. Tepper; W. J. Sluiter; R. M. Huisman; D. de Zeeuw 1. A meta-analysis of 17 years of literature on erythrocyte Na + /Li + countertransport (NLCT) and Na + /K + co-transport (COT) measurements in relation to essential hypertension is presented. The analysis aimed to answer two questions: (i) Which...
View articletitled, Erythrocyte Na+/Li+ countertransport and Na+/K+–2Cl− co-transport measurement in essential hypertension: useful diagnostic tools or failure? A meta-analysis of 17 years of literature
Open the PDF for Erythrocyte Na+/Li+ countertransport and Na+/K+–2Cl− co-transport measurement in essential hypertension: useful diagnostic tools or failure? A meta-analysis of 17 years of literature in another window
Includes: Supplementary data
Articles

Suppression of Post-Glucose Hyperinsulinaemia Does Not Affect Blood Pressure in Either Normotensive or Hypertensive Subjects

Mark W. Savage, Vidya Mohamed-Ali, Gareth Williams
Journal: Clinical Science
Clin Sci (Lond) (1998) 94 (6): 609–614.
https://doi.org/10.1042/cs0940609
Published: 01 June 1998
... pressure in either group when post-glucose hyper- insulinaemia was suppressed. This argues against insulin playing a direct role in the short-term regulation of blood pressure. INTRODUCTION Several studies have shown that patients with essential hypertension have significantly increased insulin levels...
View articletitled, Suppression of Post-Glucose Hyperinsulinaemia Does Not Affect Blood Pressure in Either Normotensive or Hypertensive Subjects
Open the PDF for Suppression of Post-Glucose Hyperinsulinaemia Does Not Affect Blood Pressure in Either Normotensive or Hypertensive Subjects in another window
Articles

Change in Blood Pressure during Altered Sodium Intake is not Associated with Calciotropic Hormone Level

Ryoji Ozono, Tetsuya Oshima, Hideo Matsuura, Katsuhiko Ishibashi, Mitsuaki Watanabe, Mitsuisa Yoshimura, Goro Kajiyama, Masayuki Kambe
Journal: Clinical Science
Clin Sci (Lond) (1997) 93 (2): 153–157.
https://doi.org/10.1042/cs0930153
Published: 01 August 1997
... concentration in the mechanism of sodium sensitivity. 17 2 1997 13 3 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 calciotropic hormone calcium essential hypertension sodium sensitivity Clinical Science (I 997) 93, 153- I57 (Printed in Great Britain) I53...
View articletitled, Change in Blood Pressure during Altered Sodium Intake is not Associated with Calciotropic Hormone Level
Open the PDF for Change in Blood Pressure during Altered Sodium Intake is not Associated with Calciotropic Hormone Level in another window
Articles

Blood Pressure Parameters as Determinants of Small Artery Structure in Human Essential Hypertension

Anne Cooper, Anthony M. Heagerty
Journal: Clinical Science
Clin Sci (Lond) (1997) 92 (6): 551–557.
https://doi.org/10.1042/cs0920551
Published: 01 June 1997
...Anne Cooper; Anthony M. Heagerty 1. Adaptive changes in small arteries may be more closely correlated with pulse pressure than with systolic, diastolic or mean blood pressures in human essential hypertension. 2. An analysis was performed on the structure of small arteries, age and blood pressure...
View articletitled, Blood Pressure Parameters as Determinants of Small Artery Structure in Human Essential Hypertension
Open the PDF for Blood Pressure Parameters as Determinants of Small Artery Structure in Human Essential Hypertension in another window
Articles

Raised Affinity for Extracellular Sodium of the Sodium-Lithium Countertransporter is Associated with a Family History of Hypertension and Uraemia in Patients with Renal Disease

Susan J. Carr, Debbie Moore, Kulvinder Sikand, Robert I. Norman
Journal: Clinical Science
Clin Sci (Lond) (1997) 92 (5): 497–503.
https://doi.org/10.1042/cs0920497
Published: 01 May 1997
...Susan J. Carr; Debbie Moore; Kulvinder Sikand; Robert I. Norman 1. Increased affinity for sodium ( K m ) at an external site of the sodium—lithium countertransporter and altered membrane microviscosity in the surface regions of the lipid bilayer identifies a group of essential hypertensive patients...
View articletitled, Raised Affinity for Extracellular Sodium of the Sodium-Lithium Countertransporter is Associated with a Family History of Hypertension and Uraemia in Patients with Renal Disease
Open the PDF for Raised Affinity for Extracellular Sodium of the Sodium-Lithium Countertransporter is Associated with a Family History of Hypertension and Uraemia in Patients with Renal Disease in another window
Articles

Urinary Albumin Excretion and Atherosclerosis in Essential Hypertension

Roberto Pedrinelli, Klaus Undpaintner, Giulia Dell'omo, Vinicio Napoli, Vitantonio Di Bello, Raffaele De Caterina, Roberto Petrucci
Journal: Clinical Science
Clin Sci (Lond) (1997) 92 (1): 45–50.
https://doi.org/10.1042/cs0920045
Published: 01 January 1997
...Roberto Pedrinelli; Klaus Undpaintner; Giulia Dell'omo; Vinicio Napoli; Vitantonio Di Bello; Raffaele De Caterina; Roberto Petrucci 1. Increased urinary albumin excretion is common in patients with essential hypertension and is at least to some extent correlated with prevailing blood pressure...
View articletitled, Urinary Albumin Excretion and Atherosclerosis in Essential Hypertension
Open the PDF for Urinary Albumin Excretion and Atherosclerosis in Essential Hypertension in another window
Articles

Behaviour of Adrenomedullin during Acute and Chronic Salt Loading in Normotensive and Hypertensive Subjects

Toshihiko Ishimitsu, Toshio Nishikimi, Hiroaki Matsuoka, Kenji Kangawa, Kazuo Kitamura, Jun-Ichi Minami, Hisayuki Matsuo, Tanenao Eto
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (3): 293–298.
https://doi.org/10.1042/cs0910293
Published: 01 September 1996
... saline (50 ml/kg for 1 h) was intravenously infused into nine normotensive subjects and 11 patients with essential hypertension. Plasma adrenomedullin was higher in hypertensive than in normotensive subjects but was unchanged by saline infusion in either the normotensive (before infusion, 2.4 ± 0.2 fmol...
View articletitled, Behaviour of Adrenomedullin during Acute and Chronic Salt Loading in Normotensive and Hypertensive Subjects
Open the PDF for Behaviour of Adrenomedullin during Acute and Chronic Salt Loading in Normotensive and Hypertensive Subjects in another window
Articles

Impaired Left Ventricular Relaxation and Arterial Stiffness in Patients with Essential Hypertension

K.-C. Chang, Y. Z. Tseng, T. S. Kuo, H. I. Chen
Journal: Clinical Science
Clin Sci (Lond) (1994) 87 (6): 641–647.
https://doi.org/10.1042/cs0870641
Published: 01 December 1994
...K.-C. Chang; Y. Z. Tseng; T. S. Kuo; H. I. Chen 1. This study was designed to determine how left ventricular relaxation function in patients with essential hypertension is impaired by arterial haemodynamic load that is increased in early ejection phase. These patients did not suffer from cardiac...
View articletitled, Impaired Left Ventricular Relaxation and Arterial Stiffness in Patients with Essential Hypertension
Open the PDF for Impaired Left Ventricular Relaxation and Arterial Stiffness in Patients with Essential Hypertension in another window
Articles

N-Terminal Atrial Natriuretic Peptide and Atrial Natriuretic Peptide in Human Plasma: Investigation of Plasma Levels and Molecular Circulating Form(s) Using Radioimmunoassays for Pro-Atrial Natriuretic Peptide (31–67), Pro-Atrial Natriuretic Peptide (1–30) and Atrial Natriuretic Peptide (99–126)

M. G. Buckley, N. D. Markandu, G. A. Sagnella, G. A. MacGregor
Journal: Clinical Science
Clin Sci (Lond) (1994) 87 (3): 311–317.
https://doi.org/10.1042/cs0870311
Published: 01 September 1994
...M. G. Buckley; N. D. Markandu; G. A. Sagnella; G. A. MacGregor 1. The aim of this study was to determine plasma levels of N-terminal atrial natriuretic peptide and atrial natriuretic peptide in normal subjects and in patients with essential hypertension, cardiac transplant and chronic renal failure...
View articletitled, N-Terminal Atrial Natriuretic Peptide and Atrial Natriuretic Peptide in Human Plasma: Investigation of Plasma Levels and Molecular Circulating Form(s) Using Radioimmunoassays for Pro-Atrial Natriuretic Peptide (31–67), Pro-Atrial Natriuretic Peptide (1–30) and Atrial Natriuretic Peptide (99–126)
Open the PDF for N-Terminal Atrial Natriuretic Peptide and Atrial Natriuretic Peptide in Human Plasma: Investigation of Plasma Levels and Molecular Circulating Form(s) Using Radioimmunoassays for Pro-Atrial Natriuretic Peptide (31–67), Pro-Atrial Natriuretic Peptide (1–30) and Atrial Natriuretic Peptide (99–126) in another window
Articles

Plasma Levels of Brain Natriuretic Peptide in Healthy Subjects and Patients with Essential Hypertension: Response to Posture

Giorgio La Villa, Silvio Vena, Alberto Conti, Caterina Fronzaroli, Aldo Brat, Chiara Lazzeri, Cristina Tosti Guerra, Stefania Madiai, Nazzareno Marra, Franco Franchi
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (4): 411–416.
https://doi.org/10.1042/cs0850411
Published: 01 October 1993
... brain natriuretic peptide-32-like immunoreactivity (hBNP-32-li) were measured by radioimmunoassay in 11 healthy subjects and 20 patients with essential hypertension after 15 min supine, 15 min sitting and 15 min with the legs raised at 60°, together with plasma atrial natriuretic peptide concentration...
View articletitled, Plasma Levels of Brain Natriuretic Peptide in Healthy Subjects and Patients with Essential Hypertension: Response to Posture
Open the PDF for Plasma Levels of Brain Natriuretic Peptide in Healthy Subjects and Patients with Essential Hypertension: Response to Posture in another window
Articles

Aggregation of erythrocyte sodium/lithium countertransport activity in families of patients with immunoglobulin A nephropathy

A. Fabbri, R. Boero, E. Degli Esposti, C. Guarena, A. Lucatello, A. Sturani, G. Piccoli, M. Fusaroli
Journal: Clinical Science
Clin Sci (Lond) (1992) 83 (2): 241–245.
https://doi.org/10.1042/cs0830241
Published: 01 August 1992
... patients. 5. In IgA nephropathy the inheritance of erythrocyte Na + /Li + countertransport activity was preserved. Therefore genetic factors could play a role in the non-immunological progression of IgA nephropathy. erythrocytes essential hypertension immunoglobulin A nephropathy proteinuria sodium...
View articletitled, Aggregation of erythrocyte sodium/lithium countertransport activity in families of patients with immunoglobulin A nephropathy
Open the PDF for Aggregation of erythrocyte sodium/lithium countertransport activity in families of patients with immunoglobulin A nephropathy in another window
Articles

Altered renal response to enhanced endogenous 5-hydroxytryptamine after tryptophan administration in essential hypertension

Fumihiro Tomoda, Masanobu Takata, Shinya Oh-Hashi, Hitoshi Ueno, Kotaro Yasumoto, Hiroyuki Iida, Shigetake Sasayama
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (5): 551–557.
https://doi.org/10.1042/cs0820551
Published: 01 May 1992
...Fumihiro Tomoda; Masanobu Takata; Shinya Oh-Hashi; Hitoshi Ueno; Kotaro Yasumoto; Hiroyuki Iida; Shigetake Sasayama 1. To examine the pathophysiological significance of 5-hydroxytryptamine (serotonin) in essential hypertension, we compared the renal response to intrarenally formed 5...
View articletitled, Altered renal response to enhanced endogenous 5-hydroxytryptamine after tryptophan administration in essential hypertension
Open the PDF for Altered renal response to enhanced endogenous 5-hydroxytryptamine after tryptophan administration in essential hypertension in another window
Articles

Coronary haemodynamic effects of angiotensin II in mild essential hypertension in man

Fabio Magrini, Paolo Reggiani, Michele Ciulla, Roberto Meazza, Gerardina Fratianni
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (2): 133–137.
https://doi.org/10.1042/cs0820133
Published: 01 February 1992
...Fabio Magrini; Paolo Reggiani; Michele Ciulla; Roberto Meazza; Gerardina Fratianni 1. The present investigation was carried out to elucidate the possible role of the renin-angiotensin system in modulating coronary vasomotor responses in eight patients with uncomplicated mild essential hypertension...
View articletitled, Coronary haemodynamic effects of angiotensin II in mild essential hypertension in man
Open the PDF for Coronary haemodynamic effects of angiotensin II in mild essential hypertension in man in another window
Articles

Alterations of Platelet Membrane Microviscosity in Essential Hypertension

Kim-Hanh Le Quan Sang, Thérèse Montenay-Garestier, Marie-Aude Devynck
Journal: Clinical Science
Clin Sci (Lond) (1991) 80 (3): 205–211.
https://doi.org/10.1042/cs0800205
Published: 01 March 1991
... and the Medical Research Society 1991 cytosolic Ca 2+ essential hypertension fluorescence depolarization membrane fluidity platelets thrombin Clinical Science (1991) 80, 205-21 1 205 Alterations of platelet membrane microviscosity in essential hypertension KIM-HANH LE QUAN SANG, TISE MONTENAY...
View articletitled, Alterations of Platelet Membrane Microviscosity in Essential Hypertension
Open the PDF for Alterations of Platelet Membrane Microviscosity in Essential Hypertension in another window
Articles

Effect of plasma from patients with essential hypertension on vascular resistance in the isolated perfused rat kidney

Jürgen Bachmann, Hartmut Schlüter, Walter Storkebaum, Herbert Witzel, Franz Wessels, Walter Zidek
Journal: Clinical Science
Clin Sci (Lond) (1991) 80 (1): 17–23.
https://doi.org/10.1042/cs0800017
Published: 01 January 1991
...Jürgen Bachmann; Hartmut Schlüter; Walter Storkebaum; Herbert Witzel; Franz Wessels; Walter Zidek 1. Isolated perfused rat kidneys were used to study the effects of plasma fractions obtained by gel filtration from essential hypertensive patients ( n = 40) and from normotensive subjects ( n = 36...
View articletitled, Effect of plasma from patients with essential hypertension on vascular resistance in the isolated perfused rat kidney
Open the PDF for Effect of plasma from patients with essential hypertension on vascular resistance in the isolated perfused rat kidney in another window
Articles

Increased Erythrocyte Sodium-Lithium Countertransport Activity in essential Hypertension is Due to an Increased Affinity for Extracellular Sodium

P. A. Rutherford, T. H. Thomas, R. Wilkinson
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (4): 365–369.
https://doi.org/10.1042/cs0790365
Published: 01 October 1990
...P. A. Rutherford; T. H. Thomas; R. Wilkinson 1. Sodium-lithium countertransport activity in a standard assay, its sodium affinity constant and maximum velocity were measured in erythrocytes from normal subjects and from essential hypertensive patients with and without a family history...
View articletitled, Increased Erythrocyte Sodium-Lithium Countertransport Activity in essential Hypertension is Due to an Increased Affinity for Extracellular Sodium
Open the PDF for Increased Erythrocyte Sodium-Lithium Countertransport Activity in essential Hypertension is Due to an Increased Affinity for Extracellular Sodium in another window
Articles

Renal functional reserve in patients with essential hypertension: Effect of inhibition of the renin-angiotensin system

Enrico Valvo, Patrizia Casagrande, Valeria Bedogna, Francesca Dal Santo, Daniele Alberti, Cristina Fontanarosa, Paolo Braggio, Giuseppe Maschio
Journal: Clinical Science
Clin Sci (Lond) (1990) 78 (6): 585–590.
https://doi.org/10.1042/cs0780585
Published: 01 June 1990
... evaluated in 15 essential hypertensive patients with preserved renal function and compared with 12 normal subjects. 2. Seven patients had microalbuminuria (>30 mg/day) that was not correlated with blood pressure values. 3. After an oral protein load, an average increase of 20% in glomerular filtration...
View articletitled, Renal functional reserve in patients with essential hypertension: Effect of inhibition of the renin-angiotensin system
Open the PDF for Renal functional reserve in patients with essential hypertension: Effect of inhibition of the renin-angiotensin system in another window
Articles

Influences of propranolol and atenolol on the circadian rhythm of heart rate in elderly patients with essential hypertension

Hiroyuki Shimamoto, Yoriko Shimamoto, Shogo Sakata
Journal: Clinical Science
Clin Sci (Lond) (1990) 78 (4): 403–407.
https://doi.org/10.1042/cs0780403
Published: 01 April 1990
...Hiroyuki Shimamoto; Yoriko Shimamoto; Shogo Sakata 1. The influence of long-acting propranolol and of atenolol on the circadian rhythm of heart rate was assessed using 24 h electrocardiographic recordings in elderly patients with essential hypertension. Eighteen elderly patients were investigated...
View articletitled, Influences of propranolol and atenolol on the circadian rhythm of heart rate in elderly patients with essential hypertension
Open the PDF for Influences of propranolol and atenolol on the circadian rhythm of heart rate in elderly patients with essential hypertension in another window
Articles

Immunoreactive N -terminal Pro-Atrial Natriuretic Peptide in Human Plasma: Plasma Levels and Comparisons with α-Human Atrial Natriuretic Peptide in Normal Subjects, Patients with Essential Hypertension, Cardiac Transplant and Chronic Renal Failure

M. G. Buckley, G. A. Sagnella, N. D. Markandu, D. R. J. Singer, G. A. MacGregor
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (5): 573–579.
https://doi.org/10.1042/cs0770573
Published: 01 November 1989
...M. G. Buckley; G. A. Sagnella; N. D. Markandu; D. R. J. Singer; G. A. MacGregor 1. Plasma levels of immunoreactive N -terminal pro-atrial natriuretic peptide ( N -terminal ANP) have been measured in 25 normal subjects, 29 patients with essential hypertension, six cardiac transplant recipients...
View articletitled, Immunoreactive N -terminal Pro-Atrial Natriuretic Peptide in Human Plasma: Plasma Levels and Comparisons with α-Human Atrial Natriuretic Peptide in Normal Subjects, Patients with Essential Hypertension, Cardiac Transplant and Chronic Renal Failure
Open the PDF for Immunoreactive N -terminal Pro-Atrial Natriuretic Peptide in Human Plasma: Plasma Levels and Comparisons with α-Human Atrial Natriuretic Peptide in Normal Subjects, Patients with Essential Hypertension, Cardiac Transplant and Chronic Renal Failure in another window
Articles

Alterations in Cerebrospinal Fluid Angiotensin II by Sodium Intake in Patients with Essential Hypertension

Minoru Kawamura, Yuhei Kawano, Kaoru Yoshida, Masahito Imanishi, Satoshi Akabane, Yohkazu Matsushima, Morio Kuramochi, Kazuaki Shimamoto, Keiichi Ito, Teruo Omae
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (4): 389–394.
https://doi.org/10.1042/cs0770389
Published: 01 October 1989
...Minoru Kawamura; Yuhei Kawano; Kaoru Yoshida; Masahito Imanishi; Satoshi Akabane; Yohkazu Matsushima; Morio Kuramochi; Kazuaki Shimamoto; Keiichi Ito; Teruo Omae 1. Angiotensin (ANG) levels were measured in the cerebrospinal fluid of 15 patients with essential hypertension on a high sodium diet...
View articletitled, Alterations in Cerebrospinal Fluid Angiotensin II by Sodium Intake in Patients with Essential Hypertension
Open the PDF for Alterations in Cerebrospinal Fluid Angiotensin II by Sodium Intake in Patients with Essential Hypertension in another window
Articles

Prolonged Decrease in Blood Pressure after Atrial Natriuretic Peptide Infusion in Essential Hypertension: A New Anti-Pressor Mechanism?

D. R. J. Singer, N. D. Markandu, M. G. Buckley, M. A. Miller, A. L. Sugden, G. A. Sagnella, G. A. MacGregor
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (3): 253–258.
https://doi.org/10.1042/cs0770253
Published: 01 September 1989
...D. R. J. Singer; N. D. Markandu; M. G. Buckley; M. A. Miller; A. L. Sugden; G. A. Sagnella; G. A. MacGregor 1. To study the anti-hypertensive effects of atrial natriuretic peptide (ANP), eight patients with mild to moderate essential hypertension, on no treatment, were infused with α-human ANP (102...
View articletitled, Prolonged Decrease in Blood Pressure after Atrial Natriuretic Peptide Infusion in Essential Hypertension: A New Anti-Pressor Mechanism?
Open the PDF for Prolonged Decrease in Blood Pressure after Atrial Natriuretic Peptide Infusion in Essential Hypertension: A New Anti-Pressor Mechanism? in another window
Articles

Platelet Cytosolic Free Calcium in Essential Hypertension: Responses to Vasopressin

A. F. Dominiczak, J. J. Morton, G. Murray, P. F. Semple
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (2): 183–188.
https://doi.org/10.1042/cs0770183
Published: 01 August 1989
...A. F. Dominiczak; J. J. Morton; G. Murray; P. F. Semple 1. Resting and stimulated free calcium concentrations have been measured in platelets loaded with the fluorescent probe quin2 from 30 patients with essential hypertension and from 30 age-matched controls. 2. Cytosolic free calcium...
View articletitled, Platelet Cytosolic Free Calcium in Essential Hypertension: Responses to Vasopressin
Open the PDF for Platelet Cytosolic Free Calcium in Essential Hypertension: Responses to Vasopressin in another window
Articles

Changes in calcium metabolic indices during long-term treatment of patients with essential hypertension

Andreas Hvarfner, Reinhold Bergström, Hans Lithell, Claes Mörlin, Leif Wide, Sverker Ljunghall
Journal: Clinical Science
Clin Sci (Lond) (1988) 75 (5): 543–549.
https://doi.org/10.1042/cs0750543
Published: 01 November 1988
...Andreas Hvarfner; Reinhold Bergström; Hans Lithell; Claes Mörlin; Leif Wide; Sverker Ljunghall 1. Disturbances of calcium metabolism, mimicking mild, compensated secondary hyperparathyroidism, accompany essential hypertension, but it is not known whether these alterations are primary or only...
View articletitled, Changes in calcium metabolic indices during long-term treatment of patients with essential hypertension
Open the PDF for Changes in calcium metabolic indices during long-term treatment of patients with essential hypertension in another window
Articles

The ratio between ankle and brachial systolic pressure in patients with sustained uncomplicated essential hypertension

Ch. J. Hugue, M. E. Safar, M. Ch. Aliefierakis, R. G. Asmar, G. M. London
Journal: Clinical Science
Clin Sci (Lond) (1988) 74 (2): 179–182.
https://doi.org/10.1042/cs0740179
Published: 01 February 1988
...Ch. J. Hugue; M. E. Safar; M. Ch. Aliefierakis; R. G. Asmar; G. M. London 1. The ratio between ankle (ASP) and brachial (BSP) systolic pressures was studied using Doppler ultrasound in 66 male subjects, 33 with sustained uncomplicated essential hypertension and 33 age-matched normal controls. 2...
View articletitled, The ratio between ankle and brachial systolic pressure in patients with sustained uncomplicated essential hypertension
Open the PDF for The ratio between ankle and brachial systolic pressure in patients with sustained uncomplicated essential hypertension in another window
Articles

Effect of plasma from hypertensive subjects on Ca 2+ transport in permeabilized human neutrophils

Walter Zidek, Agapios Sachinidis, Claus Spieker, Walter Storkebaum
Journal: Clinical Science
Clin Sci (Lond) (1988) 74 (1): 53–56.
https://doi.org/10.1042/cs0740053
Published: 01 January 1988
...Walter Zidek; Agapios Sachinidis; Claus Spieker; Walter Storkebaum 1. The effects of plasma fractions from essential hypertensive subjects ( n = 14) and normotensive subjects ( n = 14) on Ca 2+ transport in permeabilized human neutrophils was studied using an ion-selective electrode. 2. Plasma...
View articletitled, Effect of plasma from hypertensive subjects on Ca 2+ transport in permeabilized human neutrophils
Open the PDF for Effect of plasma from hypertensive subjects on Ca 2+ transport in permeabilized human neutrophils in another window
Articles

Peripheral vascular responses during carotid baroreceptor stimulation in normotensive and hypertensive subjects

D. Duprez, N. De Pue, D. L. Clement
Journal: Clinical Science
Clin Sci (Lond) (1987) 73 (6): 635–640.
https://doi.org/10.1042/cs0730635
Published: 01 December 1987
...D. Duprez; N. De Pue; D. L. Clement 1. The carotid baroreceptors were stimulated for 2 min by neck suction at −30 and −60 mmHg in 19 normotensive subjects and 12 patients with moderate essential hypertension. 2. Blood pressure was measured with a mercury sphygmomanometer and heart rate was derived...
View articletitled, Peripheral vascular responses during carotid baroreceptor stimulation in normotensive and hypertensive subjects
Open the PDF for Peripheral vascular responses during carotid baroreceptor stimulation in normotensive and hypertensive subjects in another window
Articles

Multifactorial evaluation of blood pressure fall upon hospitalization in essential hypertensive patients

Hikaru Nishimura, Akinori Nishioka, Shinichiro Kubo, Michihiro Suwa, Masaya Kino, Keishiro Kawamura
Journal: Clinical Science
Clin Sci (Lond) (1987) 73 (2): 135–141.
https://doi.org/10.1042/cs0730135
Published: 01 August 1987
...Hikaru Nishimura; Akinori Nishioka; Shinichiro Kubo; Michihiro Suwa; Masaya Kino; Keishiro Kawamura 1. Studies were prospectively performed on 72 hospitalized patients with essential hypertension. Blood pressure was normalized within 1 week of admission in 33 patients (group I), but did...
View articletitled, Multifactorial evaluation of blood pressure fall upon hospitalization in essential hypertensive patients
Open the PDF for Multifactorial evaluation of blood pressure fall upon hospitalization in essential hypertensive patients in another window
Articles

Corticosteroid binding globulin in normotensive and hypertensive human pregnancy

Julia M. Potter, Utz W. Mueller, Peter E. Hickman, Con A. Michael
Journal: Clinical Science
Clin Sci (Lond) (1987) 72 (6): 725–735.
https://doi.org/10.1042/cs0720725
Published: 01 June 1987
... with hypertension in pregnancy, and that it can be used as a marker to identify and monitor those patients at risk. 29 10 1986 7 1 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 albumin corticosteroid binding globulin Cortisol essential hypertension oestriol...
View articletitled, Corticosteroid binding globulin in normotensive and hypertensive human pregnancy
Open the PDF for Corticosteroid binding globulin in normotensive and hypertensive human pregnancy in another window
Articles

Altered extracellular calcium homoeostasis in essential hypertension: A consequence of abnormal cell calcium handling

P. Strazzullo, F. Galletti, M. Cirillo, A. Siani, V. Nunziata, R. Giannattasio, M. Mancini
Journal: Clinical Science
Clin Sci (Lond) (1986) 71 (3): 239–244.
https://doi.org/10.1042/cs0710239
Published: 01 September 1986
... of an altered cell calcium handling in hypertension. Clinical Science (1986) 71, 239-244 239 Altered extracellular calcium homoeostasis in essential hypertension: a consequence of abnormal cell calcium handling P. STRAZZULLO, F. GALLETTI, M. CIRILLO, A. SIANI, V. "ZIATA, R. GIANNATTASIO AND M. MANCINI Institute...
View articletitled, Altered extracellular calcium homoeostasis in essential hypertension: A consequence of abnormal cell calcium handling
Open the PDF for Altered extracellular calcium homoeostasis in essential hypertension: A consequence of abnormal cell calcium handling in another window
Articles

Effect of serum from patients with essential hypertension on sodium transport in normal leucocytes

H. H. Gray, P. J. Hilton, P. J. Richardson
Journal: Clinical Science
Clin Sci (Lond) (1986) 70 (6): 583–586.
https://doi.org/10.1042/cs0700583
Published: 01 June 1986
...H. H. Gray; P. J. Hilton; P. J. Richardson 1. This study has confirmed that serum from patients with essential hypertension inhibits sodium transport and elevates intracellular sodium in normal human leucocytes in vitro when compared with that of well matched normotensive controls. 2. The magnitude...
View articletitled, Effect of serum from patients with essential hypertension on sodium transport in normal leucocytes
Open the PDF for Effect of serum from patients with essential hypertension on sodium transport in normal leucocytes in another window
Articles

Cation transport abnormalities in vivo in untreated essential hypertension

Nicholas A. Boon, Jeffrey K. Aronson, Keith F. Hallis, David G. Grahame-Smith
Journal: Clinical Science
Clin Sci (Lond) (1986) 70 (6): 611–616.
https://doi.org/10.1042/cs0700611
Published: 01 June 1986
... findings in 22 patients with untreated essential hypertension, compared with the findings in 22 carefully matched control subjects. Our findings in patients receiving short-term digoxin therapy and in patients with chronic renal failure are also included for comparison. 3. Whereas the findings in patients...
View articletitled, Cation transport abnormalities in vivo in untreated essential hypertension
Open the PDF for Cation transport abnormalities in vivo in untreated essential hypertension in another window
Articles

Differential effects of sulindac and indomethacin on blood pressure in treated essential hypertensive subjects

I. B. Puddey, L. J. Beilin, R. Vandongen, R. Banks, I. Rouse
Journal: Clinical Science
Clin Sci (Lond) (1985) 69 (3): 327–336.
https://doi.org/10.1042/cs0690327
Published: 01 September 1985
... on blood pressure may make it a safer therapeutic option if NSAI drug therapy is necessary in the hypertensive patient. blood pressure essential hypertension indomethacin sulindac Clinical Science (1985) 69, 321-336 327 Differential effects of sulindac and indomethacin on blood pressure in treated...
View articletitled, Differential effects of sulindac and indomethacin on blood pressure in treated essential hypertensive subjects
Open the PDF for Differential effects of sulindac and indomethacin on blood pressure in treated essential hypertensive subjects in another window
Articles

Cation transport functions in vitro in patients with untreated essential hypertension: a comparison of erythrocytes and leucocytes

N. A. Boon, C. Harper, J. K. Aronson, D. G. Grahame-Smith
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (5): 511–515.
https://doi.org/10.1042/cs0680511
Published: 01 May 1985
...N. A. Boon; C. Harper; J. K. Aronson; D. G. Grahame-Smith 1. We have measured intracellular sodium concentrations and specific 3 H-labelled glycoside binding characteristics in the erythrocytes and leucocytes of patients with untreated essential hypertension, and have compared the results...
View articletitled, Cation transport functions in vitro in patients with untreated essential hypertension: a comparison of erythrocytes and leucocytes
Open the PDF for Cation transport functions in vitro in patients with untreated essential hypertension: a comparison of erythrocytes and leucocytes in another window
Articles

Cytoplasmic Free [Ca 2+ ] is Increased in the Platelets of Spontaneously Hypertensive Rats and Essential Hypertensive Patients

Giacomo Bruschi, Maria E. Bruschi, Maurizio Caroppo, Guido Orlandini, Marco Spaggiari, Angelo Cavatorta
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (2): 179–184.
https://doi.org/10.1042/cs0680179
Published: 01 February 1985
...—Kyoto rats (WKY), essential hypertensive patients (EHP) and normotensive human control subjects (NCS). 2. [Ca 2+ ] i was significantly higher in the platelets of 8- and 20-week-old SHR in comparison with WKY. However, no difference was evident after weaning. Changes of cellular calcium in hypertensive...
View articletitled, Cytoplasmic Free [Ca 2+ ] is Increased in the Platelets of Spontaneously Hypertensive Rats and Essential Hypertensive Patients
Open the PDF for Cytoplasmic Free [Ca 2+ ] is Increased in the Platelets of Spontaneously Hypertensive Rats and Essential Hypertensive Patients in another window
Articles

Intracellular Chloride in Essential Hypertension

W. Zidek, H. Losse, H. Lange-Asschenfeldt, H. Vetter
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (1): 45–47.
https://doi.org/10.1042/cs0680045
Published: 01 January 1985
...W. Zidek; H. Losse; H. Lange-Asschenfeldt; H. Vetter 1. In 25 patients with untreated essential hypertension and 25 healthy controls, erythrocyte intracellular Cl − concentration and activity as well as Na + activity were measured. 2. Intracellular Cl − concentration in essential hypertensive...
View articletitled, Intracellular Chloride in Essential Hypertension
Open the PDF for Intracellular Chloride in Essential Hypertension in another window
Articles

The adrenaline -α 2 -adrenoceptor-mediated vasoconstrictor axis

Peter Bolli, Paul Erne, Wolfgang Kiowski, Franz W. Amman, Fritz R. Bühler
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (s10): 141s–146s.
https://doi.org/10.1042/cs068s141
Published: 01 January 1985
...Peter Bolli; Paul Erne; Wolfgang Kiowski; Franz W. Amman; Fritz R. Bühler 1. In patients with essential hypertension plasma adrenaline concentrations have been found to be higher than in normotensive subjects and this may represent increased adrenergic activity. Adrenaline released...
View articletitled, The adrenaline -α 2 -adrenoceptor-mediated vasoconstrictor axis
Open the PDF for The adrenaline -α 2 -adrenoceptor-mediated vasoconstrictor axis in another window
Articles

Ouabain-Resistant, Frusemide-Sensitive Sodium Efflux in Human Lymphocytes: A Comparison of Normotensive and Hypertensive Subjects

A. Montanari, Isabella Simoni, E. Sani, P. Schianchi, A. Borghetti, A. Novarini
Journal: Clinical Science
Clin Sci (Lond) (1984) 67 (4): 407–411.
https://doi.org/10.1042/cs0670407
Published: 01 October 1984
...A. Montanari; Isabella Simoni; E. Sani; P. Schianchi; A. Borghetti; A. Novarini 1. Peripheral blood lymphocytes were isolated at room temperature in a low sodium medium in 17 normotensive control subjects (NC) and 13 patients with essential hypertension (EHP). 2. Lymphocyte sodium content...
View articletitled, Ouabain-Resistant, Frusemide-Sensitive Sodium Efflux in Human Lymphocytes: A Comparison of Normotensive and Hypertensive Subjects
Open the PDF for Ouabain-Resistant, Frusemide-Sensitive Sodium Efflux in Human Lymphocytes: A Comparison of Normotensive and Hypertensive Subjects in another window
Articles

Cardiac Output, Oxygen Consumption and Renal Blood Flow in Essential Hypertension

G. M. London, M. E. Safar, J. L. Bouthier, R. M. Gitelman
Journal: Clinical Science
Clin Sci (Lond) (1984) 67 (3): 313–319.
https://doi.org/10.1042/cs0670313
Published: 01 September 1984
...G. M. London; M. E. Safar; J. L. Bouthier; R. M. Gitelman 1. Cardiac output, oxygen consumption, total blood volume and mean circulatory transit time were investigated at rest in men with sustained essential hypertension in comparison with normal subjects of the same age and sex. 2. In normal...
View articletitled, Cardiac Output, Oxygen Consumption and Renal Blood Flow in Essential Hypertension
Open the PDF for Cardiac Output, Oxygen Consumption and Renal Blood Flow in Essential Hypertension in another window
Articles

A Paradoxical Fall in Urine Dopamine Output When Patients with Essential Hypertension Are Given Added Dietary Salt

J. N. Harvey, I. F. Casson, A. D. Clayden, G. F. Cope, C. M. Perkins, M. R. Lee
Journal: Clinical Science
Clin Sci (Lond) (1984) 67 (1): 83–88.
https://doi.org/10.1042/cs0670083
Published: 01 July 1984
... be important in relation to renal sodium handling by patients with essential hypertension. 22 12 1983 18 1 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 dopamine essential hypertension kidney sodium load Clinical Science (1984) 67, 83-88 83 A paradoxical...
View articletitled, A Paradoxical Fall in Urine Dopamine Output When Patients with Essential Hypertension Are Given Added Dietary Salt
Open the PDF for A Paradoxical Fall in Urine Dopamine Output When Patients with Essential Hypertension Are Given Added Dietary Salt in another window
Articles

Calmodulin Distribution and Ca 2+ Transport in the Erythrocytes of Patients with Essential Hypertension

Yu. V. Postnov, S. N. Orlov, M. B. Reznikova, G. G. Rjazhsky, N. I. Pokudin
Journal: Clinical Science
Clin Sci (Lond) (1984) 66 (4): 459–463.
https://doi.org/10.1042/cs0660459
Published: 01 April 1984
...Yu. V. Postnov; S. N. Orlov; M. B. Reznikova; G. G. Rjazhsky; N. I. Pokudin 1. The rate of calcium transport and calmodulin distribution in the erythrocytes of patients with essential hypertension were studied. In erythrocyte membranes subjected to calmodulin depletion by treatment with EGTA, both...
View articletitled, Calmodulin Distribution and Ca 2+ Transport in the Erythrocytes of Patients with Essential Hypertension
Open the PDF for Calmodulin Distribution and Ca 2+ Transport in the Erythrocytes of Patients with Essential Hypertension in another window
Articles

Captopril Enhances Vascular and Adrenal Responsiveness to Angiotensin II in Essential Hypertension

Richard J. Koletsky, Murray B. Gordon, Meryl S. Leboff, Thomas J. Moore, Robert G. Dluhy, Norman K. Hollenberg, Gordon H. Williams
Journal: Clinical Science
Clin Sci (Lond) (1984) 66 (3): 299–305.
https://doi.org/10.1042/cs0660299
Published: 01 March 1984
... in sodium balance in 11 patients with normal renin essential hypertension on 10 mmol of sodium/day intake. Pressor, renal vascular and adrenal responses to graded infusions of ANG II (0.3, 1 and 3 pmol kg −1 min −1 ) were measured before and after captopril administration. Systemic vascular responses were...
View articletitled, Captopril Enhances Vascular and Adrenal Responsiveness to Angiotensin II in Essential Hypertension
Open the PDF for Captopril Enhances Vascular and Adrenal Responsiveness to Angiotensin II in Essential Hypertension in another window