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Keywords: exacerbation
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Articles

Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD

Open Access
Eduardo I. Cardenas, Kristina Andelid, Nikolaos Pournaras, Ann Ekberg- Jansson, Nicola Orsini, Georgios Stratelis, Tomas Jernberg, Anders Lindén
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (09): 449–462.
https://doi.org/10.1042/CS20255852
Published: 09 May 2025
...Eduardo I. Cardenas; Kristina Andelid; Nikolaos Pournaras; Ann Ekberg- Jansson; Nicola Orsini; Georgios Stratelis; Tomas Jernberg; Anders Lindén During exacerbations, patients with chronic obstructive pulmonary disease (COPD) are at risk for severe cardiovascular disease (CVD). Despite...
View articletitled, Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD
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Includes: Supplementary data
Articles

New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways

Available to Purchase
Brianna Atto, Mathew Suji Eapen, Pawan Sharma, Urs Frey, Alaina J. Ammit, James Markos, Collin Chia, Josie Larby, Greg Haug, Heinrich C. Weber, George Mabeza, Stephen Tristram, Stephen Myers, Dominic P. Geraghty, Katie L. Flanagan, Philip M. Hansbro, Sukhwinder Singh Sohal
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (14): 1663–1703.
https://doi.org/10.1042/CS20181009
Published: 25 July 2019
... diseases are among the leading causes of mortality worldwide, with the major contributor, chronic obstructive pulmonary disease (COPD) accounting for approximately 3 million deaths annually. Frequent acute exacerbations (AEs) of COPD (AECOPD) drive clinical and functional decline in COPD and are associated...
View articletitled, New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways
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Articles

Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis

Available to Purchase
Joao A. Gimenes, Jr, Vikram Srivastava, Hymavathi ReddyVari, Sudhir Kotnala, Rahul Mishra, Mohamed Farazuddin, Wuyan Li, Umadevi S. Sajjan
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (8): 983–996.
https://doi.org/10.1042/CS20181088
Published: 29 April 2019
...Joao A. Gimenes, Jr; Vikram Srivastava; Hymavathi ReddyVari; Sudhir Kotnala; Rahul Mishra; Mohamed Farazuddin; Wuyan Li; Umadevi S. Sajjan Rhinovirus (RV), which is associated with acute exacerbations, also causes persistent lung inflammation in patients with chronic obstructive pulmonary disease...
View articletitled, Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis
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Includes: Supplementary data
Articles

A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD

Open Access
Aran Singanayagam, Nicholas Glanville, Ross P. Walton, Julia Aniscenko, Rebecca M. Pearson, James W. Pinkerton, Jay C. Horvat, Philip M. Hansbro, Nathan W. Bartlett, Sebastian L. Johnston
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (3): 245–258.
https://doi.org/10.1042/CS20140654
Published: 08 May 2015
...Aran Singanayagam; Nicholas Glanville; Ross P. Walton; Julia Aniscenko; Rebecca M. Pearson; James W. Pinkerton; Jay C. Horvat; Philip M. Hansbro; Nathan W. Bartlett; Sebastian L. Johnston Viral exacerbations of chronic obstructive pulmonary disease (COPD), commonly caused by rhinovirus (RV...
View articletitled, A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD
Open the PDF for A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD in another window
Includes: Supplementary data
Articles

No exacerbation but impaired anti-viral mechanisms in a rhinovirus-chronic allergic asthma mouse model

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Sabine Rochlitzer, Heinz-Gerd Hoymann, Meike Müller, Armin Braun
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (1): 55–65.
https://doi.org/10.1042/CS20130174
Published: 03 September 2013
...Sabine Rochlitzer; Heinz-Gerd Hoymann; Meike Müller; Armin Braun Severe asthma and viral-induced asthma exacerbations represent a high unmet medical need as no therapy is currently available for these patients. HRV (human rhinovirus) is prominently associated with asthma exacerbations in humans...
View articletitled, No exacerbation but impaired anti-viral mechanisms in a rhinovirus-chronic allergic asthma mouse model
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