... of FK506 employed did not decrease the glomerular filtration rate. FK506 elicited hypomagnesaemia in both sets of experiments, accompanied by inappropriately high fractional excretion of magnesium. There was also evidence of disruption of the normal renal reabsorption of calcium, but this did not result...

... continued to be excreted. 3. As a consequence, retarded bone growth occurred in the protein-deprived rat, leading to bones which were shorter and lighter than those of age-matched control animals, the epiphyseal regions appearing to bear the brunt of the growth retardation. This was not accompanied...

...E. Bourke; A. M. Asatoor; M. D. Milne 1. The excretion of structural analogues of ammonia in acidic and alkaline urine was investigated. The lipid-soluble compounds n -propylamine, n -butylamine and n -amylamine and the water-soluble compounds hydrazine and methylhydrazine resemble ammonia in being...

... distribution and handling of 18 F in the hope that this will shed some light on fluoride physiology in health and disease. 2. Plasma radioactivity at any given time depends on the degree of diffusion of 18 F through the extracellular fluid as well as on the competing effects of renal excretion and tissue...