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Keywords: exercise intolerance
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Articles

Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression

Grainne S. Gorman, Emma L. Blakely, Hue-Tran Hornig-Do, Helen A.L. Tuppen, Laura C. Greaves, Langping He, Angela Baker, Gavin Falkous, Jane Newman, Michael I. Trenell, Bryan Lecky, Richard K. Petty, Doug M. Turnbull, Robert McFarland, Robert W. Taylor
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (12): 895–904.
https://doi.org/10.1042/CS20140705
Published: 27 March 2015
... and molecular characterization of two adults with progressive exercise intolerance and severe isolated mitochondrial complex I (CI) deficiency due to novel MTND1 mutations. We demonstrate compensatory CI assembly factor up-regulation probably partially rescuing the clinical phenotype. 1 These authors...
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Articles

Effect of training on the response of plasma vascular endothelial growth factor to exercise in patients with peripheral arterial disease

Rachel E. Wood, Brad E. Sanderson, Christopher D. Askew, Philip J. Walker, Simon Green, Ian B. Stewart
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (6): 401–409.
https://doi.org/10.1042/CS20060151
Published: 14 November 2006
... (the third test overall) served as the baseline test. angiogenesis exercise intolerance growth factor intermittent claudication peripheral arterial disease vascular endothelial growth factor (VEGF) In healthy individuals expansion of the capillary network with exercise training is well...
View article titled, Effect of training on the response of plasma vascular endothelial growth factor to exercise in patients with peripheral arterial disease
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Articles

Walking performance, oxygen uptake kinetics and resting muscle pyruvate dehydrogenase complex activity in peripheral arterial disease

Glenn A. BARKER, Simon GREEN, Anita A. GREEN, Philip J. WALKER
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (3): 241–249.
https://doi.org/10.1042/CS20030244
Published: 01 March 2004
... 2004 The Biochemical Society 2004 exercise intolerance intermittent claudication oxygen uptake skeletal muscle Clinical Science (2004) 106, 241 249 (Printed in Great Britain) 241 Walking performance, oxygen uptake kinetics and resting muscle pyruvate dehydrogenase complex activity...
View article titled, Walking performance, oxygen uptake kinetics and resting muscle pyruvate dehydrogenase complex activity in peripheral arterial disease
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