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Keywords: exosome
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Clin Sci (Lond) (2020) 134 (4): 419–434.
Published: 27 February 2020
...He Liu; Yanlong Liu; Ping Sun; Kaiming Leng; Yi Xu; Liqi Mei; Peng Han; Bomiao Zhang; Kefei Yao; Chunbo Li; Junge Bai; Binbin Cui Cancer-derived exosomal miRNAs play an important role in the development of metastasis, but the effects and underlying mechanisms remain unclear. In the present study...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (24): 2463–2479.
Published: 20 December 2019
... verified that inhibition of circFMN2 decreased hTERT expression. Importantly, we demonstrated that circFMN2 was up-regulated in serum exosomes from CRC patients. Conclusion: In conclusion, circFMN2 is a central component linking circRNAs to progression of CRC via an miR-1182/hTERT axis. Correspondence...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (21): 2239–2244.
Published: 15 November 2019
... this work, the expression of circular RNA circ-0000284 (aka circHIPK3) was specifically elevated in CCA cell lines, human tumor tissues and plasma exosomes. Gain and loss of function approaches were performed to better understand the molecular mechanisms regulated by circ-0000284. Notably, the authors...
Clin Sci (Lond) (2019) 133 (18): 1955–1975.
Published: 19 September 2019
...) through cell transplantation. The current study aims to explore the role of bone marrow (BM) MSCs (BMSCs)-derived exosomes carrying microRNA-122-5p (miR-122-5p) in ONFH rabbit models. First, rabbit models with ONFH were established. ONFH-related miRNAs were screened using the Gene Expression Omnibus (GEO...
Clin Sci (Lond) (2019) 133 (17): 1871–1881.
Published: 10 September 2019
... potential molecular mechanisms. Through utilizing clinical samples and high fat diet-fed mice, we investigated the physiological roles of miR-122 in obesity-related cardiomyopathy. Besides, present study explored the mitochondrial function under exosomal miR-122 stimulation in mouse primary cardiomyocytes...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (9): 1053–1066.
Published: 09 May 2019
... inhibition of circRASSF2 decreased IGF-1R expression. Furthermore, silencing circRASSF2 suppressed LSCC growth in vivo . Importantly, we demonstrated that circRASSF2 was up-regulated in serum exosomes from LSCC patients. Altogether, silencing circRASSF2 suppresses progression of LSCC by interacting with miR...
Includes: Supplementary data