1-16 of 16
Keyword: extracellular matrix
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Clin Sci (Lond) (2019) 133 (6): 739-740.
Published: 19 March 2019
... Portland Press Limited on behalf of the Biochemical Society 2019 Extracellular Matrix Sodium Tonicity I read with great interest the hypothesis paper by Rossitto et al [ 1 ]. The authors should be commended for a thoughtful analysis of the interpretation of changes in tissue [Na...
Articles
Clin Sci (Lond) (2019) 133 (1): 83-99.
Published: 11 January 2019
... diagnostic potential of ADAM8. Current knowledge of substrates and interaction partners gave rise to the hypothesis that ADAM8 dysregulation affects diverse processes in tumor biology, attributable to different functional cores of the multidomain enzyme. Proteolytic degradation of extracellular matrix (ECM...
Articles
Clin Sci (Lond) (2017) 131 (12): 1261-1281.
Published: 07 June 2017
... wall. Thrombospondin-1 (TSP-1; gene Thbs1) is a member of the matricellular protein family important in the control of extracellular matrix (ECM) remodelling. In the present study, the association of serum TSP-1 concentration with AAA progression was assessed in 276 men that underwent repeated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (12): 1301-1315.
Published: 07 June 2017
... confirmed in patients with diabetes, thereby facilitating extracellular matrix (ECM) stabilization. Correspondence: Paola Dongiovanni ( paola.dongiovanni@policlinico.mi.it ) or Luca Valenti ( luca.valenti@unimi.it ) * These authors contributed equally to this work. 26 02 2017 10 04...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (7): 515-531.
Published: 17 March 2017
... extracellular matrix (ECM) function. In addition, genetic studies in ‘sporadic’ SVD have also shown that the disease is highly heritable, particularly among young-onset stroke patients, and that common variants in monogenic disease genes may contribute to disease processes in some SVD subtypes. Genetic studies...
Articles
Clin Sci (Lond) (2017) 131 (6): 425-437.
Published: 06 March 2017
... factor for SVD is brain hypoperfusion from cerebral blood vessel narrowing due to chronic hypertension. The hypoperfusion leads to activation and degeneration of astrocytes with the resulting fibrosis of the extracellular matrix (ECM). Elasticity is lost in fibrotic cerebral vessels, reducing the...
Articles
Clin Sci (Lond) (2016) 130 (14): 1221-1236.
Published: 01 June 2016
... with the extracellular matrix (ECM), which are mediated by anchoring filaments (AFs). The ECM protein EMILIN1 is a component of AFs and is involved in the regulation of lymphatic vessel functions: accordingly, Emilin1 −/− mice display lymphatic vascular morphological alterations, leading to functional...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (12): 1107-1113.
Published: 22 October 2015
...-like 1)] are associated with this phenotype, and experimental evidence suggests that intestinal fibrosis results from an altered balance between deposition of ECM (extracellular matrix) and degradation of ECM by proteases. Studies have also contributed to identify the main phenotypic and functional...
Articles
Clin Sci (Lond) (2015) 129 (12): 1077-1081.
Published: 13 October 2015
... called ‘synthetic’, phenotype. Synthetic VSMCs are able to proliferate, migrate and secrete ECM (extracellular matrix) proteinases and ECM proteins. In addition, they produce pro-inflammatory molecules, providing an inflammatory microenvironment for leucocyte penetration, accumulation and activation. The...
Articles
Clin Sci (Lond) (2014) 126 (4): 275-288.
Published: 14 October 2013
... Authors Journal compilation © 2014 Biochemical Society 2014 angiotensin II (AngII) autoinduction cardiac hypertrophy extracellular matrix signalling transforming growth factor-β (TGF- β) • Excessive activation of the AngII/TGF-β axis is thought to play a central role in the...
Articles
Clin Sci (Lond) (2013) 124 (3): 123-137.
Published: 02 October 2012
... on the development of atherosclerosis; and (iv) the role of FXIIIa on matrix deposition and tissue repair, including cross-linking of extracellular matrix proteins, such as fibronectin, collagen and von Willebrand factor, and the effects on matrix deposition and cell–matrix interactions. The review...
Articles
Clin Sci (Lond) (2007) 112 (4): 229-239.
Published: 17 January 2007
..., TIMP-2 and TIMP-3). An imbalance of extracellular matrix production/degradation was thus observed in veins as well as in the skin of the patients with varicose veins and, taken together, these findings show that remodelling is present in different organs, confirming systemic alterations of connective...
Articles
Clin Sci (Lond) (2004) 106 (3): 301-306.
Published: 01 March 2004
... aortic aneurysm cytokine extracellular matrix integrin metalloproteinase Clinical Science (2004) 106, 301 306 (Printed in Great Britain) 301 Expression and localization of tumour necrosis factor- and its converting enzyme in human abdominal aortic aneurysm Hidetoshi SATOH , Motoyuki NAKAMURA...
Articles
Clin Sci (Lond) (1997) 93 (2): 97-108.
Published: 01 August 1997
... acid receptors); (iv) factors which regulate detachment from the extracellular matrix (e.g. urokinase-type plasminogen activator, matrix metalloproteinases); and (iv) molecules which regulate cytoskeletal function (e.g. Rac), which allows the formation of specialized cellular processes termed...
Articles
Clin Sci (Lond) (1997) 92 (2): 113-122.
Published: 01 February 1997
... future therapeutic strategy aimed at transplanting genetically modified oligodendrocyte precursors to repair widespread demyelinated lesions. © 1997 The Biochemical Society and the Medical Research Society 1997 demyelination extracellular matrix integrin migration multiple sclerosis...
Articles
Clin Sci (Lond) (1993) 85 (3): 295-301.
Published: 01 September 1993
... were suppressed by treatment with methylprednisolone. 8. These data suggest that abnormal regulation of the genes for metalloproteinases and tissue inhibitor of metalloproteinases contribute to the accumulation of extracellular matrix components in lupus nephritis and that the beneficial effect of...