... chain amino acids or individual amino acids in the diet, as well as ketogenic diets, can elicit similar effects. In addition, it is becoming clear that fasting protocols, such as time-restricted-feeding or every-other-day feeding, without changes in overall energy intake can also profoundly affect...

... Critical Illness Fasting Hypercortisolemia Ketogenesis Sepsis Tight glucose control © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License...

.... In the last decades, preclinical and clinical research has revealed a biphasic pattern in the (neuro-)endocrine responses to sepsis as to other forms of critical illness, contributing to development of severe metabolic alterations. Immediately after the critical illness-inducing insult, fasting- and stress...

...Alaa Alkhalefah; Warwick B. Dunn; James W. Allwood; Kate L. Parry; Franchesca D. Houghton; Nick Ashton; Jocelyn D. Glazier During Ramadan, many pregnant Muslim women fast between dawn and sunset. Although the impacts of prolonged maternal intermittent fasting (IF) on fetal growth and placental...

... Science , Moller and co-workers show that, in humans, IHL (intrahepatic lipid) content, measured using 1 H-magnetic resonance spectroscopy, increases following 36 h of fasting, with a direct association with plasma levels of 3-hydroxybutyrate. The observation raises interesting questions as to how IHL...

...Louise Moller; Hans Stodkilde-Jorgensen; Finn T. Jensen; Jens O. L. Jorgensen The impact of fasting on IHL (intrahepatic lipid) content in human subjects has not been investigated previously, but results indicate that it may change rapidly in response to metabolic cues. The aim of the present study...

... acid and glucose metabolism in a porcine model of compensated hyperdynamic sepsis. Fasting catheterized pigs received endotoxin ( Escherichia coli lipopolysaccharide; 3 µ g·h -1 ·kg -1 ; intravenous) or saline (controls) and volume resuscitation over 24h to reproduce hyperdynamic sepsis. Primed...

...Mads RASMUSSEN; Thomas ALMDAL; Palle BRATHOLM; Niels Juel CHRISTENSEN The aim of the present study was to quantify β 2 -adrenoceptor protein content in adipose tissue during fasting, and to study the relationships between β 2 -adrenoceptor protein and mRNA levels and changes in metabolites related...

... and after a similar period of bed rest and hypocaloric nutrition (fast/bed rest group) to delineate the effects of surgery per se. 3. Basal endogenous glucose production and whole-body glucose disposal was higher after surgery ( P < 0.001), whereas no change was found after fast/bed rest. During glucose...

...D. Joe Millward; Paul J. Pacy © 1995 The Biochemical Society and the Medical Research Society 1995 diurnal cycling fasting feeding indispensable amino acid requirements leucine nitrogen balance protein turnover stable isotopes Clinical Science (1995) 88, 5 9 7 4 6 (Printed...

...J. Webber; J. Taylor; H. Greathead; J. Dawson; P. J. Buttery; I. A. Macdonald 1. The effects of fasting for 12, 36 and 72 h were examined in 19 normal subjects. Each subject was studied before and during a euglycaemic (4 mmol/l) hyperinsulinaemic (100 m-units min −1 m −2 ) clamp. Measurements were...

...Paul J. Pacy; Gill M. Price; David Halliday; Marcello R. Quevedo; D. Joe Millward 1. The diurnal changes in whole body protein turnover associated with the increasing fasting body nitrogen (N) losses and feeding gains with increasing protein intake were investigated in normal adults. [ 13 C]Leucine...

... continuous infusions of [3- 3 H]glucose and [ 14 C]palmitate. 2. Studies were performed in the post-absorptive state (16 h of overnight fasting) and again after 22 h of overnight fasting. 3. In the post-absorptive state, net fat oxidation and triacylglycerol (‘triglyceride’) concentrations were significantly...

...I. A. MacDonald; T. Bennett; R. Sainsbury 1. The thermoregulatory responses to graded cooling were measured in 11 healthy male subjects after a 12 h fast and after a 48 h fast. The cooling stimulus was produced by changing the temperature of the skin of the trunk and legs with a water-perfused suit...

...David McR. Russell; Harold L. Atwood; J. Scott Whittaker; Takeo Itakura; Paul M. Walker; Donald A. G. Mickle; Khursheed N. Jeejeebhoy 1. Previous observations have shown that in human subjects with malnutrition and after prolonged fasting, there are characteristic changes in the force-frequency...

...T. Bennett; I. A. MacDonald; R. Sainsbury 1. The cardiovascular responses to lower body subatmospheric pressure or to standing were measured in the same nine normal male subjects after a 12 h and after a 48 h fast. 2. After the 48 h fast there was a significant reduction in diastolic blood pressure...

...R. E. Cowan; R. P. H. Thompson; J. P. Kaye; Gillian M. Clark 1. The concentrations of plasma total and unconjugated bilirubin and of serum non-esterified fatty acids (NEFA) have been measured in two healthy subjects during fasts of up to 21 h. 2. Fasting was either continuous or interrupted...

...M. A. Page; D. J. Galton 1. Glucose 6-phosphate, fructose 6-phosphate, fructose diphosphate, glycerol phosphate and uridine diphosphate glucose have been measured in human adipose tissue and blood from obese subjects under fed and fasting conditions and in obese diabetic and non-diabetic subjects...

...K. A. K. North; D. Lascelles; Pandora Coates 1. The excretion of electrolytes was studied in six obese subjects before, during and after a 7 day fast. 2. Despite a constant sodium intake throughout the study, there was a marked but transient increase in sodium excretion during the fast, and a sharp...

...P. F. Semple; A. R. Henderson; J. A. Boyle 1. The effect of an 18, 30 or 40 h fast on the rate of purine biosynthesis de novo as measured by the incorporation of [ 14 C]formate into formylglycinamide ribonucleotide during azaserine block has been examined in the rat spleen. 2...