... muscle. acute mountain sickness acetazolamide fatigue hypoxia isolated muscle exercise metabolic acidosis ventilation Five men and one woman (20±1 years, 78±2 kg and 173±2 cm; values are means±S.E.M.) voluntarily provided verbal and written consent to participate after being fully...

... longer than 6 months. Orthostatic intolerance was defined by the presence of lightheadedness, migraine-like headache, chronic fatigue, neurocognitive deficits, palpitations, nausea, blurred vision, abnormal sweating and dyspnoea or sensation of heat while upright. POTS was defined by signs and symptoms...

... femoris muscle fatigue was evaluated using voluntary and electrically stimulated contractions during 20min of repetitive voluntary isometric contractions at 40% of maximal force-generating capacity (MFGC). After 5min of exercise, MFGC had declined significantly to 70.6±4.1% (mean±S.E.M.) and 87.2±1.6...

...Mark G. SWAIN Fatigue is an extremely common complaint among patients with chronic disease. However, because of the subjective nature of fatigue, and the lack of effective therapeutics with which to treat fatigue, this symptom is often ignored by clinicians, who instead focus on hard, objective...

...Gerald P. MCCANN; Helen CAHILL; Stephen KNIPE; Douglas F. MUIR; Paul D. MACINTYRE; W. Stewart HILLS 5-Hydroxytryptamine (5-HT; serotonin) has been implicated in the perception of exercise-induced fatigue. Sumatriptan is a selective 5-HT 1B/D receptor agonist which does not cross the blood–brain...

... to 34.2±5.4% and 33.3±6.3% (means±S.D.) of the values for unfatigued muscle in the control and MAD-deficient subjects respectively ( P > 0.05; n = 7). Maximal isometric forces and shortening velocities did not differ between groups in unfatigued, fatigued or recovered muscle. None of the subjects...

... less fused, but the maximal rate of increase in force remained unchanged. Heating had no effect upon either force decline or slowing of relaxation during fatiguing contractions. The force–frequency relationship of the paralysed quadriceps muscle was shifted to the right after the muscle was heated...

... 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 CO 2 responsiveness fatigue inspiratory effort sensation sustained loading Clinical Science (1996) 91, 513-518 (Printed in Great Britain) 513 Effect of sustained inspiratory loading on respiratory sensation...

... and the Medical Research Society 1993 creatine energy metabolism fatigue phosphocreatine Clinical Science (1993) 84, 565-571 (Printed in Great Britain) 565 Influence of oral creatine supplementation of muscle torque during repeated bouts- of maximal voluntary exercise in man Paul L. GREENHAFF, Anna...

... to that produced at 50 Hz, the 20:50 ratio) before and after fatiguing exercise of the sternomastoid muscle in 10 normal subjects. The mean (±) fresh state twitch maximum relaxation rate was 9.51 (± 0.64)% force loss/10 ms and the mean (± sem ) 20:50 ratio was 73.4 (± 2.6)%. 2. The mean twitch maximum relaxation...

...D. J. Newham; D. A. Jones; G. Ghosh; P. Aurora 1. The effect of muscle length on the development of muscle pain and fatigue has been studied. 2. Eight normal young adults performed maximal eccentric contractions of the elbow flexors. The muscles of one arm were exercised at short length...

... ( r = 0.86) was also found that accounted statistically for the combined effects of age and height. 3. The percentage decline in power during 30 s (fatigue index) was lower in subjects reporting greater leisure activity. 4. A close relationship was found between total work in 30 s and Vo 2 max. ( r...

...D. A. Jones; S. Howell; C. Roussos; R. H. T. Edwards 1. A form of skeletal muscle fatigue was examined with isolated animal and human muscle preparations. The possibility that methylxanthines could overcome this was investigated. 2. Prolonged contractile activity resulted in a long-lasting...

...S. C. Gandevia; K. J. Killian; E. J. M. Campbell 1. Eight subjects maintained maximal inspiratory pressure as long as possible. The subjects accurately judged the pressure developed, but considered that the sense of effort or motor command increased progressively during the contraction as fatigue...

...B. Bigland-Ritchie; D. A. Jones; G. P. Hosking; R. H. T. Edwards 1. The fatigue of force that occurs during the first 60 s of a maximum voluntary contraction of the human quadriceps has been examined by comparing the voluntary force with that obtained by brief tetanic stimulation at 50 Hz in nine...

...P. T. Macklem; C. S. Roussos 1. The question whether respiratory muscle fatigue ever causes respiratory failure is over 40 years old, but we still have no definitive answer to this question. Skeletal muscle fatigue occurs when the rate of energy consumption of themu scle is greater than the energy...

...% of their maximal voluntary force could be maintained without fatigue, and without any post-exercise increase in blood flow. More powerful contractions produced both fatigue and a large post-exercise hyperaemia, even though blood flow had reached a plateau during the exercise. 3. An attempt to show that the post...