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Keywords: fatty acid
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Articles
Clin Sci (Lond) (2015) 128 (6): 349–355.
Published: 28 November 2014
...Michael F. Oliver Plasma free fatty acids (non-esterified fatty acids) increase in the first hour of the onset of acute myocardial ischaemia. This results from catecholamine stimulation of adipose tissue lipolysis. It can lead to a metabolic crisis in the injured myocardium with the development of...
Articles
Clin Sci (Lond) (2010) 118 (5): 351–358.
Published: 23 November 2009
... α-tocopherol, NEFAs (non-esterified fatty acids), and palmitic, palmitoleic, γ-linolenic and arachidonic acids were higher in women with IUGR pregnancies than in AGA-35wk controls, whereas stearic and α-linolenic acids were lower. Smaller differences were found when comparing these variables for...
Articles
Clin Sci (Lond) (2010) 118 (1): 43–45.
Published: 02 October 2009
...Markus Schlaich Sympathetic nervous system activation is a hallmark of several conditions associated with an adverse prognosis, including hypertension and the metabolic syndrome. Proposed mediators of increased sympathetic drive include hyperinsulinaemia, leptin, NEFAs (non-esterified fatty acids...
Articles
Clin Sci (Lond) (2010) 118 (1): 61–69.
Published: 02 October 2009
...John P. Florian; James A. Pawelczyk Previous studies have shown that acute increases in plasma NEFAs (non-esterified fatty acids) raise SVR (systemic vascular resistance) and BP (blood pressure). However, these studies have failed to distinguish between CNS (central nervous system) mechanisms that...
Articles
Clin Sci (Lond) (2009) 116 (4): 327–334.
Published: 15 January 2009
... (lipoprotein lipase) activity. To test our hypothesis, we measured basal VLDL-TAG and VLDL-apoB-100 (apolipoprotein B-100), and plasma NEFA [non-esterified fatty acid (‘free fatty acid’)] kinetics, by using stable isotope-labelled tracer techniques, on the morning after a single session of evening exercise of...
Articles
Clin Sci (Lond) (2009) 116 (3): 205–218.
Published: 08 January 2009
... we describe the rationale behind drug design strategies targeting PPARγ, based on current knowledge regarding the effects of such drugs in experimental animal models, as well as in clinical practice. Regarding endogenous PPARγ ligands, several fatty acid derivatives bind PPARγ with different...
Articles
Clin Sci (Lond) (2009) 116 (2): 113–123.
Published: 15 December 2008
.... Correspondence: Mrs Margaret J. Hill (email margaret.hill@warwick.ac.uk ). 19 2 2008 14 5 2008 5 6 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiovascular disease fatty acid obesity triacylglycerol Type 2 diabetes Obesity, diabetes and CVD...
Articles
Clin Sci (Lond) (2008) 115 (1): 1–12.
Published: 02 June 2008
... Society 2008 atherosclerosis cardiovascular disease energy homoeostasis fatty acid metabolic syndrome non-alcoholic fatty liver disease (NAFLD) NAFLD (non-alcoholic fatty liver disease) encompasses the spectrum of fatty liver diseases seen in individuals with the MS (metabolic syndrome...
Articles
Clin Sci (Lond) (2007) 113 (4): 205–212.
Published: 13 July 2007
...Christian J. F. Holubarsch; Martin Rohrbach; Matthias Karrasch; Erich Boehm; Lech Polonski; Piotr Ponikowski; Siegfried Rhein Etomoxir is an inhibitor of mitochondrial CPT1 (carnitine palmitoyltransferase 1) and thereby switches energy metabolism from fatty acids to glucose oxidation. Such a...
Articles
Clin Sci (Lond) (2007) 113 (2): 65–77.
Published: 13 June 2007
...Thais Martins de Lima; Renata Gorjão; Elaine Hatanaka; Maria Fernanda Cury-Boaventura; Erica Paula Portioli Silva; Joaquim Procopio; Rui Curi Fatty acids (FAs) have been shown to alter leucocyte function and thus to modulate inflammatory and immune responses. In this review, the effects of FAs on...
Articles
Clin Sci (Lond) (2007) 112 (12): 617–624.
Published: 14 May 2007
... cardiac energy substrate switches from FAs (fatty acids) to glucose. LPL (lipoprotein lipase) is the key enzyme in triacylglycerol (triglyceride) hydrolysis and supplies FAs to the heart. To investigate whether substrate utilization influences cardiac growth and CHD risk, we examined the association...
Articles
Clin Sci (Lond) (2007) 112 (1): 59–67.
Published: 01 December 2006
... lymphocyte death were evaluated by flow cytometry. Plasma levels of glucose, NEFAs (non-esterified fatty acids) and ketone bodies (acetoacetate and β-hydroxybutyrate) were determined in rats fasted for 24 and 48 h. Lymphocytes obtained from fasted rats had an increase in DNA fragmentation and...
Articles
Clin Sci (Lond) (2006) 111 (5): 307–317.
Published: 13 October 2006
... mechanisms involved were examined by measuring mitochondrial depolarization, lipid accumulation and PPARγ (peroxisome-proliferator-activated receptor γ) activation. The results demonstrate that fatty acids induce apoptosis and necrosis of J774 cells. At high concentrations, fatty acids cause macrophage death...
Articles
Clin Sci (Lond) (2005) 109 (2): 177–182.
Published: 25 July 2005
...Giovanna Priante; Estella Musacchio; Elisa Pagnin; Lorenzo A. Calò; Bruno Baggio A specific modulatory effect of PUFAs (polyunsaturated fatty acids) on gene expression of some cytokines involved in bone remodelling has been reported previously. In particular, although a direct action of AA...
Articles
Clin Sci (Lond) (2004) 106 (2): 191–199.
Published: 01 February 2004
... of β-cell mass is not indefinite and may well decrease with time. Changes in circulating concentrations of nutritional factors, such as fatty acids and/or glucose, may lead to a reduction in β-cell mass in vivo . Few previous studies have attempted to explore the interplay between glucose, amino...
Articles
Clin Sci (Lond) (2003) 105 (1): 81–87.
Published: 01 July 2003
... endothelium fatty acid insulin meal Clinical Science (2003) 105, 81 87 (Printed in Great Britain) 81 The effect of a mixed meal on endothelium- dependent vasodilation is dependent on fat content in healthy humans Peter STEER*, Dennis M. SARABI*, Brita KARLSTRO¨M , Samar BASU , Christian BERNE*, Bengt...
Articles
Clin Sci (Lond) (2003) 104 (2): 171–179.
Published: 17 January 2003
...Declan A. HEALY; R. William G. WATSON; Philip NEWSHOLME We report here that monounsaturated fatty acids and polyunsaturated fatty acids (PUFAs) provoke the accumulation of neutral lipids and apoptosis in retinoic acid-treated HL-60 cells in a concentration- and time-dependent manner. The PUFAs...