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Keywords: fetal programmingClose
Clin Sci (Lond) (2021) 135 (19): 2307–2327.
Published: 13 October 2021
... 08 09 2021 29 09 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Epigentics Fetal Programming IUGR Placenta Preeclampsia Preeclampsia (PE), the leading cause of maternal and fetal morbidity and mortality, affects...
Clin Sci (Lond) (2020) 134 (23): 3123–3136.
Published: 07 December 2020
... fetal development Fetal programming neurodevelopmental disorders pregnancy serotonin (5-HT) trophoblast It is well established that a suboptimal intrauterine environment results in fetal adaptations with adverse consequences persisting after birth, throughout the lifespan and in future...
Includes: Supplementary data
Andrew M. South, Hossam A. Shaltout, Lisa K. Washburn, Alexa S. Hendricks, Debra I. Diz, Mark C. Chappell
Clin Sci (Lond) (2019) 133 (1): 55–74.
Published: 08 January 2019
... an unknown etiology, considerable research efforts in both experimental models and human cohorts has focused on the premise that alterations in the fetal and perinatal environment are key factors in the development of hypertension in children and adults. The exact mechanisms of how fetal programming events...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (17): 1953–1962.
Published: 14 September 2018
... with chronic cardiovascular consequences. In a sheep model of fetal programming, in utero BM-exposed (BMX) offspring as adults exhibit elevated mean arterial pressure (MAP), decreased baroreflex sensitivity (BRS) for the control of heart rate and insulin resistance accompanied by dysregulation of the brain...
Jeanie B. Tryggestad, Anu Vishwanath, Shaoning Jiang, Ashwini Mallappa, April M. Teague, Yusuke Takahashi, David M. Thompson, Steven D. Chernausek
Clin Sci (Lond) (2016) 130 (21): 1955–1967.
Published: 22 September 2016
... metabolic disease. fetal programming gestational diabetes human umbilical vein endothelial cell (HUVEC) miRNA The impact of maternal diabetes on future metabolic health of the offspring is well described [ 1 – 3 ]. The risk of a child developing Type 2 diabetes mellitus (T2DM) is several...
Daniela F. Pinheiro, Patricia F. F. Pinheiro, José Buratini, JR, Anthony C. S. Castilho, Paula F. Lima, Luiza A. Trinca, Maria de Lourdes M. Vicentini-Paulino
Clin Sci (Lond) (2013) 125 (6): 281–289.
Published: 22 May 2013
... as fetal programming. The present study evaluated mRNA abundance and immunolocalization of nutrient transporters as well as enterocytes proliferation in the proximal, median and distal segments of small intestine of rats born to protein-restricted dams. Pregnant rats were fed hypoproteic (6% protein...
Heather L. Blackmore, Ana V. Piekarz, Denise S. Fernandez-Twinn, John R. Mercer, Nichola Figg, Martin Bennett, Susan E. Ozanne
Clin Sci (Lond) (2012) 123 (4): 251–257.
Published: 30 April 2012
... and reproduction in any medium, provided the original work is properly cited. apolipoprotein atherosclerosis cholesterol fetal programming low-protein diet maternal nutrition offspring Although many insults can arise during development, maternal under-nutrition is one of the best...
Robert D. Roghair, John A. Wemmie, Kenneth A. Volk, Thomas D. Scholz, Fred S. Lamb, Jeffrey L. Segar
Clin Sci (Lond) (2011) 121 (10): 427–436.
Published: 25 July 2011
... effects on control offspring ( P =0.16 for effect of tempol on context conditioned fear and P =0.06 for effect of tempol on cue-conditioned fear). antioxidant cardiovascular response carbenoxolone fetal programming 11β-hydroxysteroid dehydrogenase stress In addition to its association...
Emily M. Segar, Andrew W. Norris, Jian-Rong Yao, Shanming Hu, Stacia L. Koppenhafer, Robert D. Roghair, Jeffrey L. Segar, Thomas D. Scholz
Clin Sci (Lond) (2009) 117 (3): 129–138.
Published: 02 July 2009
... 2009 Biochemical Society 2009 cardiovascular disease fetal programming endothelium gestational diabetes glucose vascular smooth muscle There is increasing evidence that adverse factors in the perinatal environment predispose an individual to disease later in life. This concept...
Clin Sci (Lond) (2009) 117 (2): 75–84.
Published: 15 June 2009
... ). 11 7 2008 19 12 2008 7 1 2009 7 1 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 fetal programming kidney Na + /K + /2Cl − co-transporter (NKCC2) pressure–natriuresis relationship sodium pump An adverse environment during key stages...
Clin Sci (Lond) (2007) 113 (5): 219–232.
Published: 01 August 2007
... to the concept of ‘fetal programming’. The molecular mechanisms that underlie this relationship remain unclear, but are being extensively investigated using a number of experimental models. One major hypothesis for early life physiological programming implicates fetal overexposure to stress (glucocorticoid...
Clin Sci (Lond) (2005) 109 (1): 1–11.
Published: 23 June 2005
... in satiety and meal termination [ 41 ]. To identify the underlying mechanisms it is necessary to understand the normal regulation of mammalian appetite. 20 12 2004 16 2 2004 23 2 2005 The Biochemical Society 2005 appetite cardiovascular disease diabetes fetal programming...
Clin Sci (Lond) (1996) 91 (5): 607–615.
Published: 01 November 1996
... independently or in concert. 1 7 1996 19 7 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 fetal programming glucocorticoids hypertension kidney maternal nutrition rats Clinical Science (1996) 91,607-615 (Printed in Great Britain) 607 Weanling rats...