... targets [ 64 ]. Correspondence: Barbara T. Alexander ( balexander@umc.edu ) 30 06 2021 08 09 2021 29 09 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Epigentics Fetal Programming IUGR Placenta Preeclampsia...

... fetal development Fetal programming neurodevelopmental disorders pregnancy serotonin (5-HT) trophoblast It is well established that a suboptimal intrauterine environment results in fetal adaptations with adverse consequences persisting after birth, throughout the lifespan and in future...

... an unknown etiology, considerable research efforts in both experimental models and human cohorts has focused on the premise that alterations in the fetal and perinatal environment are key factors in the development of hypertension in children and adults. The exact mechanisms of how fetal programming events...

... with chronic cardiovascular consequences. In a sheep model of fetal programming, in utero BM-exposed (BMX) offspring as adults exhibit elevated mean arterial pressure (MAP), decreased baroreflex sensitivity (BRS) for the control of heart rate and insulin resistance accompanied by dysregulation of the brain...

... results in changes in miRNA expression. These changes affect target proteins known to function in energy homoeostasis and may predispose the children to future metabolic disease. fetal programming gestational diabetes human umbilical vein endothelial cell (HUVEC) miRNA • The chance...

... as fetal programming. The present study evaluated mRNA abundance and immunolocalization of nutrient transporters as well as enterocytes proliferation in the proximal, median and distal segments of small intestine of rats born to protein-restricted dams. Pregnant rats were fed hypoproteic (6% protein...

.... apolipoprotein atherosclerosis cholesterol fetal programming low-protein diet maternal nutrition offspring The DOHaD (Developmental Origins of Health and Disease) hypothesis proposes that insults acting during critical periods of growth and development may have a long-term effect on susceptibility...

...: Dr Robert D. Roghair (email robert-roghair@uiowa.edu ). 22 3 2011 11 5 2011 26 5 2011 26 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 antioxidant cardiovascular response carbenoxolone fetal programming 11β-hydroxysteroid dehydrogenase...

... 2009 Biochemical Society 2009 cardiovascular disease fetal programming endothelium gestational diabetes glucose vascular smooth muscle There is increasing evidence that adverse factors in the perinatal environment predispose an individual to disease later in life. This concept...

.... Correspondence: Dr Nick Ashton (email nick.ashton@manchester.ac.uk ). 11 7 2008 19 12 2008 7 1 2009 7 1 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 fetal programming kidney Na + /K + /2Cl − co-transporter (NKCC2) pressure–natriuresis relationship...

... to the concept of ‘fetal programming’. The molecular mechanisms that underlie this relationship remain unclear, but are being extensively investigated using a number of experimental models. One major hypothesis for early life physiological programming implicates fetal overexposure to stress (glucocorticoid...

... The Biochemical Society 2005 appetite cardiovascular disease diabetes fetal programming metabolic syndrome obesity perinatal programming Obesity is a key risk factor in the development of Type II diabetes, high blood pressure, cardiovascular disease and cancers such as breast cancer [ 1...

... independently or in concert. 1 7 1996 19 7 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 fetal programming glucocorticoids hypertension kidney maternal nutrition rats Clinical Science (1996) 91,607-615 (Printed in Great Britain) 607 Weanling rats...