... kidney injury (AKI) has not been shown. mTORC1 activation (p-S6) in renal fibroblasts was increased in a mouse AKI model induced by 1.5 mg/kg lipopolysaccharide (LPS). Deletion of tuberous sclerosis complex 1 (TSC1), an mTORC1 negative regulator, in fibroblasts (Fibro-TSC1 −/− ) inhibited the elevation...

...Iona C. Evans; Josephine L. Barnes; Ian M. Garner; David R. Pearce; Toby M. Maher; Xu Shiwen; Elisabetta A. Renzoni; Athol U. Wells; Christopher P. Denton; Geoffrey J. Laurent; David J. Abraham; Robin J. McAnulty Fibroblasts derived from the lungs of patients with idiopathic pulmonary fibrosis (IPF...

... fibroblasts do not exhibit any endogenous activity. As fibroblasts are the major cell type found in an infarct zone following a myocardial infarction, we examined the effects of ACE2 gene delivery to cultured cardiac fibroblasts after acute hypoxic exposure. Cardiac fibroblasts from 5-day-old Sprague–Dawley...

.... We determined whether human airway epithelial cells are capable of producing polypeptide mediators that could induce fibroblast proliferative activity, in particular insulin-like growth factor I. 2. We examined 12 primary cultures of human airway epithelial cells grown to confluence on collagen gel...

... and cultured skin fibroblast homogenates. The pH profile of leucocyte and fibroblast iduronidase activity was dependent on substrate structure and concentration, the ionic strength and the nature of the buffer ion used in the assay mixture. 2. NaCl, KBr and Na 2 SO 4 were shown to be parabolic competitive...