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Keywords: fibroblasts
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Clin Sci (Lond) (2022) 136 (16): 1229–1240.
Published: 31 August 2022
... and hypoxemia. Current concepts of IPF pathogenesis posit that aberrant repair of the aging lung is driven by the altered differentiation states and corrupted cell–cell signaling involving multiple cell populations, notably epithelial cells, mesenchymal stromal cells (MSCs)/fibroblasts, and immune cells [ 1 , 2...
Clin Sci (Lond) (2022) 136 (1): 29–44.
Published: 05 January 2022
...) and kidney fibroblasts proliferating in response to TNFα, which both involved NF-κB signaling. Kidney expression of WISP1 was found to be increased in mouse models of progressive kidney inflammation-unilateral ureter obstruction (UUO) and streptozotocin (STZ)-induced diabetic nephropathy (DN). Treatment...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (3): 429–446.
Published: 01 February 2021
... in the kidney, and depletion of endogenous kallistatin by antibody injection resulted in aggravated renal fibrosis, which was accompanied by enhanced Wnt/β-catenin activation. Conversely, overexpression of kallistatin attenuated renal inflammation, interstitial fibroblast activation and tubular injury in UUO...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (14): 1537–1548.
Published: 17 July 2019
...: Soluble ST2 (interleukin 1 receptor-like 1) (sST2) is involved in inflammatory diseases and increased in heart failure (HF). We herein investigated sST2 effects on oxidative stress and inflammation in human cardiac fibroblasts and its pathological role in human aortic stenosis (AS). Methods and results...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (9): CS20190008.
Published: 02 May 2019
... human umbilical vein endothelial cells (HUVECs) pretreated with or without advanced glycation end products (AGEs). The roles of HUVEC-derived sEVs on the biological characteristics of skin fibroblasts were investigated both in vitro and in vivo . We demonstrate that sEVs derived from AGEs-pretreated...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (2): 231–242.
Published: 19 January 2018
... by fibroblast activation and fibrosis of the skin and internal organs. Alterations in cell–integrin interaction are sufficient to initiate profibrotic processes. SSc fibroblasts express both αvβ3 and αvβ5 integrins and their activation induces myofibroblasts differentiation. The aim of the present study...
Clin Sci (Lond) (1995) 89 (1): 69–73.
Published: 01 July 1995
...Andrew E. Pocock; Martin J. O. Francis; Roger Smith 1. Skin fibroblast lines were cultured from nine patients who had the features of idiopathic juvenile osteoporosis, six relatives, five unrelated control subjects and three unrelated patients with osteogenesis imperfecta type I. Some patients...
Clin Sci Mol Med (1975) 49 (6): 543–550.
Published: 01 December 1975
...R. B. Ellis; P. Willcox; A. D. Patrick 1. In a patient with I-cell disease the activities of several acid hydrolases were elevated in plasma and reduced in cultured fibroblasts when compared with normal values. Normal activities for the enzymes were found in leucocytes. These findings agree...
Clin Sci Mol Med (1974) 47 (1): 43–61.
Published: 01 July 1974
... megaloblastic anaemia homocysteine metabolism mental deficiency fibroblasts Clinical Science and Molecular Medicine (1974) 47,43-61. MENTAL RETARDATION, MEGALOBLASTIC ANAEMIA, METHYLMALONIC ACIDURIA A N D ABNORMAL HOMOCYSTEINE METABOLISM DUE TO A N ERROR I N VITAMIN B i z METABOLISM M. J . DILLON J . M...