... they undergo AKI (acute kidney injury). An incomplete repair of renal tubules can result in progressive fibrotic CKD (chronic kidney disease). Studies have revealed the relationship between tubular epithelial cells and kidney fibrogenesis. However, the underlying mechanism remains unclear. Hippo pathway...

... fibrotic rat and human samples. Nevertheless, we found that miR-31 was particularly up-regulated in HSCs but not in hepatocytes during fibrogenesis. Thus, we hypothesized that miR-31 may mediate liver fibrosis. In the present study, we found that inhibition of miR-31 expression significantly inhibited HSC...

...) or transiently elevated expression (MMP-9, -11 and -13). The first group closely correlated to the parameters of fibrogenesis. Hepatic MMP-3 expression was unrelated to disease stage, but was determined by the MMP-3(-1171) promoter polymorphism. In conclusion, MMP expression during the course of chronic...

...Jordi Camps; Teresa Bargallo; America Gimenez; Silvia Alie; Joan Caballeria; Albert Pares; Jorge Joven; Lluis Masana; Joan Rodes 1. Lipid peroxidation and hepatic fibrogenesis were investigated in 25 carbon tetrachloride-treated rats and in 25 control animals. Rats were further divided into two...

... the cholesterol diet for another 4 weeks. With continuing feeding for 24 weeks these abnormalities were sustained. 3. In the absence of available evidence that cholesterol is ‘toxic’ to the liver, it is concluded that lipid loading alone increases hepatic fibrogenesis. 6 10 1980 16 3 1981 © 1981...