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Keywords: fibrosis
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Articles
Clin Sci (Lond) (2022) 136 (12): 1005–1017.
Published: 29 June 2022
... acetate-salt challenge in rats, finerenone treatment prevented cardiac and renal hypertrophy, proteinuria, and structural injury, which was associated with the reduction of the mRNA levels of some fibrosis and inflammatory markers including plasminogen activator inhibitor-1 (PAI-1), monocyte...
Articles
Clin Sci (Lond) (2022) 136 (3): 239–256.
Published: 07 February 2022
..., leading to extensive investigation to unravel key pathophysiological mechanisms underlying irreversible functional loss and structural damage in the chronically ischemic kidney. Research studies identified complex interactions among various players, including inflammation, fibrosis, mitochondrial injury...
Articles
Clin Sci (Lond) (2021) 135 (16): 1999–2029.
Published: 24 August 2021
... in renal structures. Tubulointerstitial fibrosis is observed in glomerular diseases as well as in the regeneration failure of acute kidney injury (AKI). Therefore, finding antifibrotic therapies comprises an intensive research field in Nephrology. Nowadays, ECM is not only considered as a cellular scaffold...
Articles
Clin Sci (Lond) (2021) 135 (14): 1631–1647.
Published: 23 July 2021
..., raising the question of whether dabrafenib is cardiotoxic. In the heart, ERK1/2 signalling promotes not only cardiomyocyte hypertrophy and is cardioprotective but also promotes fibrosis. Our hypothesis is that ERK1/2 signalling is not required in a non-stressed heart but is required for cardiac...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (23): 3175–3193.
Published: 09 December 2020
...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (20): 2681–2706.
Published: 21 October 2020
... leading to tissue dysfunction, and is a risk factor in many diseases including cardiovascular disease, diabetes, cancer, dementia, glaucoma, chronic obstructive pulmonary disease (COPD) and fibrosis. ECM changes are recognised as a major driver of aberrant cell responses. Mesenchymal cells in aged tissue...
Articles
Clin Sci (Lond) (2020) 134 (18): 2435–2445.
Published: 25 September 2020
... health issues worldwide. GDM increases the risks of macrosomia, premature infants, and preeclampsia. Although placental dysfunction, including fibrosis is associated with the development of GDM, factors that link these observations remain unknown. Prothymosin α (ProTα) is expressed in the placenta...
Articles
Clin Sci (Lond) (2020) 134 (16): 2189–2201.
Published: 26 August 2020
...Jessica P.E. Davis; Stephen H. Caldwell Fibrosis results from a disordered wound healing response within the liver with activated hepatic stellate cells laying down dense, collagen-rich extracellular matrix that eventually restricts liver hepatic synthetic function and causes increased sinusoidal...
Articles
Clin Sci (Lond) (2019) 133 (21): 2217–2220.
Published: 13 November 2019
...Mark Chandy Cardiac fibrosis is important for wound healing, regeneration and producing the extracellular matrix (ECM) that provides the scaffold for cells. In pathological situations, fibroblasts are activated and remodel the ECM. In volume 133, issue 17 of Clinical Science , Yang et al...
Articles
Clin Sci (Lond) (2019) 133 (15): 1721–1744.
Published: 05 August 2019
...Chenzhu Zhang; Caleb C.Y. Chan; Kwok Fan Cheung; Mel K.M. Chau; Desmond Y.H. Yap; Maggie K.M. Ma; Kwok Wah Chan; Susan Yung; Tak Mao Chan Lupus nephritis (LN) leads to chronic kidney disease (CKD) through progressive fibrosis. Mycophenolate inhibits inosine monophosphate dehydrogenase...
Articles
Clin Sci (Lond) (2019) 133 (1): 41–54.
Published: 03 January 2019
... may act simultaneously on glomerular hyperfiltration, tubular inflammation, fibrosis development and tubular hypertrophy. Yousif et al. [ 40 ] have demonstrated, in an ex-vivo perfused kidney model, that exogenous histamine-induced vasodilation in diabetic rat-derived kidneys is mediated by both...
Articles
Clin Sci (Lond) (2018) 132 (19): 2117–2120.
Published: 05 October 2018
... promoting fibrosis. Here, we will discuss the background, significance of the study, alternative mechanisms, and future directions. epidermal growth factor receptor fibrosis paracrine signalling proteomics Hypertension is a well-known contributor to the development of cardiovascular diseases...
Articles
Clin Sci (Lond) (2018) 132 (17): 1977–1994.
Published: 14 September 2018
... are limiting the translation of hydrogel-based stem cell therapy for CKD. Correspondence: Sharon D. Ricardo ( Sharon.ricardo@monash.edu ) 24 05 2018 01 08 2018 17 08 2018 Fibrosis and loss of renal function is a common end point of most forms of progressive kidney disease [ 8...
Articles
Clin Sci (Lond) (2018) 132 (16): 1855–1874.
Published: 30 August 2018
...-dependent manner. Exogenous β2M showed pro-fibrotic effects in cultured cardiac fibroblasts but few effects in cardiomyocytes. Adeno-associated virus 9 (AAV9)-mediated knockdown of β2M significantly reduced cardiac β2M level and inhibited myocardial fibrosis and cardiac dysfunction but not cardiac...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (12): 1341–1343.
Published: 28 June 2018
... Mauro E. , Crespo G. , Montironi C. , Londoño M.-C. , Hernández-Gea V. , Ruiz P. ( 2017 ) Portal pressure and liver stiffness measurements in the prediction of fibrosis regression after sustained virological response in recurrent hepatitis C . Hepatology 10.1002/hep...
Articles
Clin Sci (Lond) (2018) 132 (9): 909–923.
Published: 08 May 2018
... Cardiovascular fibrosis inflammation MR NGAL renal Correspondence: Frédéric Jaisser ( frederic.jaisser@inserm.fr ) 21 12 2017 05 03 2018 04 04 2018 NGAL has proinflammatory and chemotactic properties. Treatment of neutrophils in culture with recombinant NGAL...
Articles
Clin Sci (Lond) (2018) 132 (3): 375–379.
Published: 08 February 2018
... to the fibroblast population [ 30 , 31 ] in chronic lung disease, especially in the small airways fibrosis seen in COPD, wherein tissue remodelling and scarring occurs, i.e. reorganization of the extracellular matrix (ECM) [ 32 , 33 ]. The changes to the ECM have profound effects on lung physiology and pathology...
Articles
Clin Sci (Lond) (2018) 132 (2): 231–242.
Published: 19 January 2018
... by fibroblast activation and fibrosis of the skin and internal organs. Alterations in cell–integrin interaction are sufficient to initiate profibrotic processes. SSc fibroblasts express both αvβ3 and αvβ5 integrins and their activation induces myofibroblasts differentiation. The aim of the present study...
Articles
Clin Sci (Lond) (2017) 131 (10): 935–949.
Published: 04 May 2017
...Vanessa Arrieta; Ernesto Martinez-Martinez; Jaime Ibarrola; Virginia Alvarez; Rafael Sádaba; Amaia Garcia-Peña; Amaya Fernández-Celis; Victoria Cachofeiro; Patrick Rossignol; Natalia López-Andrés Aortic stenosis (AS) is characterized by pressure overload and causes left ventricular (LV) fibrosis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (3): 225–226.
Published: 05 January 2017
... kidney disease cardiovascular disease fibrosis translational science Chronic kidney disease (CKD) is characterized by persisting renal damage and/or loss of renal function. The condition is associated with high morbidity and mortality throughout the continuum from early disease to advanced...
Articles
Clin Sci (Lond) (2016) 130 (24): 2305–2316.
Published: 10 November 2016
.... However, the role of the Ang-(1–7)/Mas receptor on pregnancy-induced cardiac remodelling remains unknown. The objective of the present study was to evaluate the participation of the Mas receptor in the development of the cardiac hypertrophy and fibrosis induced by gestation. Female Wistar rats were...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (23): 2151–2165.
Published: 20 October 2016
...) and total collagen deposition, markers of collagen turnover and AHR compared with that in saline-treated counterparts (all P <0.01 compared with saline-treated controls). RLX or AECs (but not MSCs) alone normalized epithelial thickness and partially diminished the OVA-induced fibrosis and AHR by ∼40–50...
Articles
Clin Sci (Lond) (2016) 130 (5): 365–376.
Published: 26 January 2016
... reduction of SERCA2a (sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase 2a) expression after MI, suggesting less reduction in diastolic Ca 2+ -reuptake into the sarcoplasmic reticulum post-MI. Secondly, male ERβ-OE revealed attenuated cardiac fibrosis in the remote LV tissue and expression of fibrosis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (4): 289–299.
Published: 14 January 2016
..., the underlying mechanism(s) of FasL-related deterioration of heart function remain obscure. The aim of the present study is to determine roles of myocardial FasL in the activation of alternative pathways such as extracellular-signal-regulated kinase 1/2 (ERK1/2), inflammation or fibrosis and to identify...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (12): 1237–1249.
Published: 11 November 2015
... (miR) miR-21 as a key modulator of its prosclerotic actions. In the present study, we demonstrate data indicating that miR-21 up-regulation positively correlates with the severity of fibrosis and rate of decline in renal function in human DN. Furthermore, concomitant analyses of various models...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (12): 1173–1193.
Published: 11 November 2015
..., HGF/Met antagonizes the actions of TGFβ 1 (transforming growth factor β 1 ) and AngII (angiotensin II), thus preventing fibrosis. Moreover, HGF/Met influences the inflammatory response of macrophages and the immune response of dendritic cells, indicating its protective function against atherosclerotic...
Articles
Clin Sci (Lond) (2015) 128 (3): 181–196.
Published: 03 October 2014
..., such as cartilage and bone, in the skeletal system, by manipulating extracellular signalling molecules involved therein by acting as a hub through a web. However, on the other hand, CCN2 occasionally plays profound roles in major human biological disorders, including fibrosis and malignancies in major organs...
Articles
Clin Sci (Lond) (2014) 127 (7): 435–448.
Published: 17 June 2014
...), but the mechanisms involved are not entirely clear. In the present study, we assessed the influences of H2R disruption on left ventricular (LV) dysfunction and the mechanisms involved in mitochondrial dysfunction and calcineurin-mediated myocardial fibrosis. H2R-knockout mice and their wild-type littermates were...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (5): 341–350.
Published: 15 May 2014
...Anke Nijhuis; Paolo Biancheri; Amy Lewis; Cleo L. Bishop; Paolo Giuffrida; Christopher Chan; Roger Feakins; Richard Poulsom; Antonio Di Sabatino; Gino Roberto Corazza; Thomas T. MacDonald; James O. Lindsay; Andrew R. Silver Intestinal fibrosis with stricture formation is a complication of CD...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (12): 845–855.
Published: 26 February 2014
... during chronic liver injury and directly promotes fibrosis. We have reported that Hh signalling enhances viral permissiveness and replication in HCV (hepatitis C virus)-infected cells. Hence we hypothesized that OPN directly promotes HCV replication, and that targeting OPN could be beneficial in HCV...
Articles
Clin Sci (Lond) (2014) 126 (5): 329–337.
Published: 25 October 2013
... (systemic sclerosis). SSc is an autoimmune disorder in which vascular injury occurs and there is a chronic low-grade inflammation followed by excessive ECM (extracellular matrix) deposition and ultimately fibrosis. The fibrosis ultimately leads to organ dysfunction and death. The preceding vascular damage...
Articles
Clin Sci (Lond) (2014) 126 (1): 85–94.
Published: 09 September 2013
...Germán E. González; Nour-Eddine Rhaleb; Pablo Nakagawa; Tang-Dong Liao; Yunhe Liu; Pablo Leung; Xiangguo Dai; Xiao-Ping Yang; Oscar A. Carretero We have reported previously that Ac-SDKP ( N -acetyl-seryl-aspartyl-lysyl-proline) reduces fibrosis and inflammation (in macrophages and mast cells...
Articles
Clin Sci (Lond) (2013) 124 (11): 651–662.
Published: 15 February 2013
... and the pathogenesis of some diseases. Recently, HDACs have come to be considered crucial targets in various diseases, including cancer, interstitial fibrosis, autoimmune and inflammatory diseases, and metabolic disorders. Pharmacological inhibitors of HDACs have been used or tested to treat those diseases...
Articles
Clin Sci (Lond) (2011) 121 (6): 233–251.
Published: 27 May 2011
... regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-β signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-β signal...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2010) 119 (11): 453–463.
Published: 17 August 2010
...Marc Iglarz; Martine Clozel ET (endothelin)-1 was first described as a potent vasoconstrictor. Since then, many other deleterious properties mediated via its two receptors, ET A and ET B , have been described, such as inflammation, fibrosis and hyperplasia. These effects, combined with a wide...
Articles
Clin Sci (Lond) (2010) 118 (12): 691–705.
Published: 30 March 2010
...: Professor Derek A. Mann (email derek.mann@newcastle.ac.uk ). 3 11 2009 6 1 2010 2 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 fibrosis hepatocellular carcinoma ischaemia/reperfusion injury non-alcoholic fatty liver disease (NAFLD) nuclear factor...
Articles
Clin Sci (Lond) (2010) 118 (3): 211–220.
Published: 01 February 2010
..., and interstitial and perivascular fibrosis in the heart of diabetic rats. Diabetes was induced in 55 Sprague–Dawley rats by streptozotocin injection. Control rats ( n =18) underwent only buffer injection. Out of the 55 diabetic rats, 19 were chronically treated with insulin and 13 with the ACEI (ACE inhibitor...
Articles
Clin Sci (Lond) (2010) 118 (6): 411–420.
Published: 14 December 2009
... for the treatment of liver fibrosis. In vitro studies have shown that activation of AMPK (AMP-activated protein kinase), a key player in the regulation of cellular energy homoeostasis, inhibits proliferation of myofibroblasts derived from HSCs. If AMPK is a true regulator of fibrogenesis then defective AMPK...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2009) 116 (1): 71–79.
Published: 28 November 2008
... production and lipid peroxidation, and an increase in antioxidative defence, leading to the prevention of hepatic fibrosis. antioxidant cirrhosis fibrosis intrahepatic resistance portal venous pressure ursodeoxycholic acid (UCDA) An increase in IHR (intrahepatic resistance), due to fibrosis...
Articles
Clin Sci (Lond) (2007) 113 (3): 109–118.
Published: 02 July 2007
...Fiona J. Warner; John S. Lubel; Geoffrey W. McCaughan; Peter W. Angus There is an increasing body of evidence to suggest that the RAS (renin–angiotensin system) contributes to tissue injury and fibrosis in chronic liver disease. A number of studies have shown that components of a local hepatic RAS...
Articles
Clin Sci (Lond) (2007) 112 (5): 265–280.
Published: 01 February 2007
...Neil C. Henderson; John P. Iredale Liver fibrosis represents a major worldwide health care burden. The last 15 years have seen a rapid growth in our understanding of the pathogenesis of this clinically relevant model of inflammation and repair. This work is likely to inform the design of effective...
Articles
Clin Sci (Lond) (2005) 108 (6): 463–477.
Published: 24 May 2005
... and abnormalities in elastin. Genetic influences, as well as fetal and early life exposures, may contribute to structural changes such as subepithelial fibrosis from an early age. Other structural alterations are related to duration of disease and/or long-term uncontrolled inflammation. The increase in smooth...
Articles
Clin Sci (Lond) (1998) 95 (2): 179–186.
Published: 01 August 1998
...C. A. KAWSER; J. P. IREDALE; P. J. WINWOOD; M. J. P. ARTHUR 1. Hepatic stellate cells are key mediators of hepatic fibrosis. We have studied hepatic stellate cell expression of the collagenase and general protease inhibitor α2-macroglobulin after activation in tissue culture and in response...
Articles
Clin Sci (Lond) (1990) 78 (4): 419–422.
Published: 01 April 1990
...Yasuhiro Deguchi; Susumu Kishimoto 1. Scleroderma is a systemic autoimmune disorder characterized by fibrosis affecting the skin, lung, kidney and other organs. The 70 kDa heat-shock protein has been implicated as essential for cell function during cell growth and differentiation. To study...
Articles
Clin Sci (Lond) (1989) 77 (1): 69–76.
Published: 01 July 1989
... inhibitors. As a secondary event the amount of fibrosis in the skin is also reduced, presumably by an increase in collagenase activity from the mononuclear phagocytes. 5. These results support the hypothesis that benzopyrones activate the production of proteinases by mononuclear phagocytes. The resultant...
Articles
Clin Sci (Lond) (1987) 72 (6): 673–678.
Published: 01 June 1987
...%). 3. These results provide evidence that fibrosis of the skin is one of the pathological consequences of exposure to vinyl chloride. 18 12 1986 30 12 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 collagen synthesis collagen cross-links fibrosis...
Articles
Clin Sci (1972) 43 (1): 55–69.
Published: 01 July 1972
...J. M. S. Patton; S. Freedman 1. We have used the rebreathing method to examine the respiratory response to CO 2 in five normal subjects and twelve patients with diffuse pulmonary infiltration or fibrosis. The response to CO 2 was measured in terms of both ventilation and mechanical work rate. 2...