...Yi-Cheng Wang; Ming-Tsung Wu; Feng-Yao Tang; Der-Yuan Chen; Hsin-An Ko; Barry Shane; Wen-Nan Huang; En-Pei Isabel Chiang Objective: Currently, no guidelines are established for pharmacogenomic testing involving folate metabolic genes in long-term disease-modifying antirheumatic drugs’ (DMARD...

... and the influence of the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene on serum and erythrocyte folate, plasma homocysteine and vascular disease. Diabetic clinic subjects (Type I, n = 354; Type II, n = 392) were recalled for a cross-sectional survey. Standard methods were used...

...]. In patients with chronic hyperhomocyst(e)inaemia, endo- Key words : endothelial function, folate, homocyst(e)ine. Abbreviation: NO, nitric oxide. Correspondence: Dr Hidehiro Matsuoka. thelium-dependent vasodilatation [6,7] and endothelial anticoagulant function [8] are impaired. Thus, exper- imental evidence...

... . 8 8 1994 12 8 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 Brain folate vitamin B 12 hypomethylation methionine synthase methyltransferases methylation ratio nitrous oxide S -adenosylhomocysteine S -adenosylmethionine Clinical Science...

...Michele Matter; Tessa Stittfall; John Graves; Kathryn Myburgh; Brett Adams; Peter Jacobs; Timothy D. Noakes 2 10 1986 24 10 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 blood lactate folate folate therapy iron iron therapy lactate turnpoint...

...D. A. Kelly; J. M. Scott; D. G. Weir 1. Folate deficiency is reported in association with certain malignant tumours, and it has been suggested that this arises from increased folate turnover and catabolism in such circumstances. 2. Using an experimental animal model to determine the rate...

...Berenice Reed; D. Weir; J. Scott 1. It has previously been shown that folate polyglutamates in the rat are catabolized almost exclusively via cleavage of the C-9—N-10 bond, resulting in the formation of pteridines and p -aminobenzoylglutamate. The latter catabolite is rapidly excreted, appearing...

...B. Reed; D. G. Weir; J. M. Scott 1. The recent suggestions that folate polyglutamate biosynthesis demonstrated in vivo with [3′5′9( n )- 3 H]folic acid is due to exchange and cannot be achieved with [2- 14 C]folic acid has been demonstrated to be untrue. 2. The compounds formed with both types...

... cell folate was found in each of the mono-, tetra-, penta- and hexaglutamate peaks after 72 h of incubation. At earlier times, the amounts of labelled folate monoglutamate and lower folate polyglutamates were proportionately greater and the amount of labelled higher folate polyglutamates was lower...

...A. Lavoie; Edith Tripp; K. Parsa; A. V. Hoffbrand 1. Tritiated folic acid (pteroylglutamic acid) was injected into rats whose livers were undergoing regeneration after partial hepatectomy, and into normal control rats. 2. The major form of labelled liver folate was found to be pteroylpentaglutamate...

...A. Lavoie; B. A. Cooper 1. [ 3 H]Folic acid infused intravenously into patients with biliary fistulae appeared promptly in bile, coincident with 131 I-labelled Rose Bengal injected simultaneously. The radioactivity was distributed among several fractions of biological folates present in bile...

...D. G. Weir; J. P. Brown; D. S. Freedman; J. M. Scott 1. The two diastereoisomers of 5-methyltetrahydropteroylglutamate, the form of folate that predominates in food and bile, were prepared chemically. 2. Their intestinal absorption was compared by means of the urinary-excretion method of 3 H...