...) and endoplasmic reticulum (ER) stress protein kinase RNA-like ER kinase (PERK)–eukaryotic translation initiation factor 2α (eIF2α)–C/EBP homologous protein (CHOP) pathway. More importantly, folic acid, functioning in the transformation of Hcy, could lower the intracellular Hcy level and further reverse...

...), and Src family kinase, which has recently been approved by FDA to treat idiopathic pulmonary fibrosis. Whether it affects renal fibrosis remains unknown. Here, we demonstrated that administration of nintedanib immediately or 3 days after unilateral ureteral obstruction (UUO) injury and with folic acid (FA...

... randomized clinical trial demonstrates that treatment with high-dose folic acid fails to reduce oxidant stress and albuminuria in human subjects with incipient diabetic nephropathy. Novel treatment options for this condition are urgently needed. circulation complications diabetes mellitus...

...Frank STAM; Yvo M. SMULDERS; Coen van GULDENER; Cornelis JAKOBS; Coen D. A. STEHOUWER; Kees de MEER Folic acid treatment decreases plasma total homocysteine concentrations in healthy subjects, but the effects on homocysteine metabolism are unknown. In the present study, we investigated the effect...

... 2003 4 12 2003 © 2004 The Biochemical Society 2004 atherosclerosis endothelial function folic acid homocysteine Clinical Science (2004) 106, 345 346 (Printed in Great Britain) 345 C O M M E N T Can mild-to-moderate hyperhomocysteinaemia impair endothelial function in the absence...

...G. Kitis; M. L. Lucas; H. Bishop; A. Sargent; R. E. Schneider; J. A. Blair; R. N. Allan 1. Propranolol and folic acid absorption were studied separately in healthy subjects, non-coeliac patients and patients with treated and untreated coeliac disease. 2. The surface pH of jejunal biopsy samples...

... concentrations were normal. 3. When pyridoxine, folic acid and vitamin B 12 , cofactors for homocysteine metabolism, were administered sequentially to 11 arbitrarily selected transplant recipients cysteine—homocysteine decreased from 7.3 ± 2.1 to 4.3 ± 0.8 μmol/l ( P < 0.001) and homocystine became...

... and in normal subjects. 5. These findings suggest that PteGlu malabsorption in coeliac disease is not due to abnormally high pH in the jejunum. 22 3 1976 © 1976 The Biochemical Society and the Medical Research Society 1976 absorption coeliac disease folic acid jejunum pteroylmonoglutamic...

... cells but had no consistent effect in normal cells. 4. Normal and vitamin B 12 -deficient PHA-stimulated lymphocytes took up [ 3 H]folic acid and after 72 h incubation converted this largely into pteroylpolyglutamate forms. 5. The proportion of labelled lymphocyte folate as pteroylpolyglutamate after...

...A. Lavoie; B. A. Cooper 1. [ 3 H]Folic acid infused intravenously into patients with biliary fistulae appeared promptly in bile, coincident with 131 I-labelled Rose Bengal injected simultaneously. The radioactivity was distributed among several fractions of biological folates present in bile...

...R. Corrocher; B. K. Bhuyan; A. V. Hoffbrand 1. The composition of guinea-pig liver folates and the biochemical route of formation of liver folates from injected tritium-labelled pteroylglutamic acid (folic acid) have been studied. 2. Endogenous folate was measured by microbiological assay...