... for the cytochrome P450 metabolites, the epoxyeicosatrienoic acids (EETs). However, more recently, this hypothesis has come under severe scrutiny. In this issue of Clinical Science , Passauer et al. demonstrate that an EET cannot be EDHF in the human forearm, and add further to the growing belief that an EET...

...Jens PASSAUER; Eckhart BÜSSEMAKER; Grit LÄSSIG; Frank PISTROSCH; Joachim FAULER; Peter GROSS; Ingrid FLEMING A substantial portion of the vasodilator response elicited by bradykinin in the human forearm is unaffected by the combined inhibition of nitric oxide (NO) synthases and cyclo-oxygenases...

... cortisol and cortisone concentrations in arterial plasma, in saliva and across the forearm at baseline and after administration of GA in normotensive and hypertensive subjects. GA (500mg) or placebo was administered orally to 20 normotensive subjects in a placebo-controlled double-blind fashion. Further...

... (representing local lymph flow per unit distribution volume, V D ), for 99m Tc-labelled human immunoglobulin G in the oedematous proximal forearm, and in the hand (finger web) in women in whom the hand was unaffected. Tracer was injected subcutaneously, and the depot plus the rest of the arm was monitored...

...Gerard A. RONGEN; Jacques W. M. LENDERS; Paul SMITS; John S. FLORAS Although there is as yet no method which measures directly the neuronal release of noradrenaline in humans in vivo , the isotope dilution technique with [ 3 H]noradrenaline has been applied to estimate forearm neuronal...

...Daniel Green; Gerry O'driscoll; Brian Blanksby; Roger Taylor 23 6 1995 23 6 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 antioxidants blood flow cigarette smoking forearm nitric oxide noradrenaline Clinical Science (1995) 89, 343-348...

..., and it is possible that increased production of NO due to induction of NO synthase may be involved in maintaining this vasodilatation. We have examined this possibility by studying the effects of local infusions of N G -monomethyl-l-arginine (an inhibitor of NO synthase) in the forearm arteriolar bed...

...K. N. Cheng; P. J. Pacy; F. Dworzak; G. C. Ford; D. Halliday 1. We have used l -[1- 13 C, 15 N]leucine as the substrate tracer to study leucine and muscle protein metabolism across the forearm of eight normal fasting adults. 2. The rates of protein synthesis and breakdown, de- and re-amination...

...B. F. Robinson; R. J. W. Phillips 1. The effect of a small increase in local plasma calcium concentration on the responsiveness of the forearm resistance vessels to verapamil has been examined in normal subjects, by using a plethysmographic method with infusion of calcium and other agents...

...R. J. W. Phillips; B. F. Robinson 1. The dilator response to local infusion of K + has been assessed in the forearm resistance vessels of 17 men with primary hypertension and 11 controls, by using a standard plethysmographic method. 2. The response to infusion of K + at 0.1 mmol/min was smaller...

...O. J. Hartling; J. Trap-Jensen 1. The pre- and post-junctional α-adrenoceptor blocking agent, phentolamine, was given by intravenous infusion to eight healthy volunteers during rest, forearm exercise and post-exercise. 2. Phentolamine produced a sustained increase in heart rate. The diastolic blood...

...B. F. Robinson; R. J. Dobbs; S. Bayley 1. The response of the forearm resistance vessels to local intra-arterial infusion of verapamil and sodium nitroprusside has been assessed by a plethysmographic method in 23 men with normal arterial pressure and 35 men with primary hypertension. 2. In the 20...

...A. C. Asmal; W. J. H. Butterfield; K. J. Collins; J. D. Few 1. Cortisol metabolism in human forearm tissues has been investigated by measurement of arteriovenous plasma differences. 2. There were no detectable differences in plasma cortisol concentration in fifty-four pairs of arterial and venous...