...N. I. WEIJL; T. J. ELSENDOORN; R. M. W. MOISON; E. G. W. M. LENTJES; R. BRAND; H. M. BERGER; S. OSANTO Non-protein bound iron (NPBI) is able to catalyse oxidative reactions, causing damage to vital structures. Adverse effects induced by cisplatin seem, in part, to be mediated by free radicals...

... that is capable of catalysing the formation of the potentially harmful hydroxyl free radical. In the present paper, we describe the application of the ethidium-binding assay of DNA damage to the measurement of bleomycin-detectable iron, comparing its performance with the conventional method in the assessment...

... 20 7 1998 The Biochemical Society and the Medical Research Society © 1999 1999 enzyme efflux free radicals muscle damage muscle sulphydryls oxidative stress 105Clinical Science (1999) 96, 105 115 (Printed in Great Britain) Changes in indices of antioxidant status, lipid...

... antioxidants deuterated vitamin E free radicals gas chromatography-mass spectroscopy oxidative stress Clinical Science (1997) 92,87-93 (Printed in Great Britain) 87 Plasma RRR-a-tocopherol concentrations are lower in smokers than in non-smokers after ingestion of a similar oral load of this antioxidant...

...- plantation there is an additional insult of super- imposed reperfusion injury when the transplanted liver is reoxygenated [ S ] . INTRODUCTION Free radicals are produced as a normal conse- quence of aerobic metabolism, phagocytic activity and prostaglandin production. The potentially toxic actions of free...

... minerals, generate free radicals, which, in turn, may contribute to this type of injury. This study examined the characteristics of H 2 O 2 production in a parenteral amino acid solution modelled on a commercially available paediatric parenteral amino acid solution. 2. The solution was exposed to light...

...Rosaire P. Gray; David G. Wickens; David L. H. Patterson; John S. Yudkin 1. Oxygen-derived free radicals have been implicated in reperfusion injury after thrombolytic therapy in acute myocardial infarction. To test the hypothesis that diabetic patients may have increased oxidative stress which may...

... 1993 The Biochemical Society and the Medical Research Society 1993 antioxidant 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonic acid) ferryl myoglobin free radicals premature neonates Trolox Clinical Science (1993) 84, 407-412 (Printed in Great Britain) 407 A novel method for measuring...

.... This effect was abolished by removal of the endothelium or incubation with an inhibitor of NO synthase, N -ω-nitro-L-arginine methyl ester. Catalase alone had a negligible effect on noradrenaline-induced tone. 3. Captopril, an angiotensin-converting enzyme inhibitor and putative free-radical scavenger, did...

...Mary Britton; Christopher Fong; David Wickens; John Yudkin 1. Diene-conjugated fatty acids are one of the products of free-radical attack upon lipids and therefore have been used as markers of such attack. The major diene-conjugated fatty acid in human tissue and serum is an isomer of linoleic acid...

... calcium damage free radicals glutathione skeletal muscle Clinical Science (1991) 80,559-564 559 Glutathione depletion during experimental damage to rat skeletal muscle and its relevance to Duchenne muscular dystrophy M. J. JACKSON, M. H. BROOKE*t, K. KAISER* AND R. H. T. EDWARDS Muscle Research...

... ischaemia. During secondary ischaemia, flaps underwent either total ischaemia (arterial and venous blood supply occluded) or partial ischaemia (vein only occluded). Some of these flaps were treated at the time of reperfusion with the free-radical scavenger superoxide dismutase (EC 1.15.1.1...

... liver disease. 2 4 1986 16 4 1986 © 1986 The Biochemical Society and the Medical Research Society 1986 acetaldehyde alcoholic liver disease free radicals neutrophils Clinical Science ( 1 986) 7 1, 31 3-3 18 313 Superoxide anion production and degranulation of rat neutrophils...

...Clare Selden; Carol A. Seymour; T. J. Peters 1. The activities and subcellular distribution of enzymes implicated in the protection of cells from free-radical mediated damage were determined in liver biopsy specimens from control and iron-overloaded patients. 2. There was a small but insignificant...

... been demonstrated in these patients. 3. The significance of this enzyme deficiency is discussed in relation to the organelle pathology of the syndrome. 29 7 1977 5 12 1977 © 1978 The Biochemical Society and the Medical Research Society 1978 Dubin—Johnson Syndrome free radicals...

... vacuoles, contains a free radical generating NADH-dependent enzyme which plays a primary bactericidal role. The cytosol contains mechanisms which detoxify hydrogen peroxide, superoxide and free radicals and protect the granulocyte from these compounds. 8 6 1976 15 11 1976 © 1977...