... -phosphorylated ryanodine receptor 2 were significantly increased in HS-C, and those were suppressed in HS-F and HS-A. Decreased expression of gap junction protein connexin 40 in HS-C was partially restored by treatment with each XO inhibitor. In conclusion, XO inhibitor febuxostat, as well as allopurinol, could...

...Márton Gönczi; Mária Kovács; György Seprényi; Ágnes Végh The present study has examined the role of GJ (gap junctions) in the delayed anti-arrhythmic effect of cardiac pacing, with particular reference to the time-course changes in Cx43 (connexin43) expression both after pacing (4×5 min, at a rate...

...Nicholas S. Peters 1. Ischaemic and hypertrophic heart diseases are associated with ventricular arrhythmias, in which abnormal cellular coupling is implicated as having a causative role. The aim of this series of studies was to characterize gap-junctional organization in normal human ventricular...

...Robert G. Gourdie 1. The heartbeat is co-ordinated by organized propagation of electrical excitation through cardiac muscle. Intercellular conduction and propagation of the cardiac action potential is dependent on electrical connections between myocytes, termed gap junctions. 2. In the last few...