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Keywords: gene expression
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Clin Sci (Lond) (2016) 130 (13): 1051–1063.
Published: 23 May 2016
... gene expression methylation muscle metabolism Skeletal muscle is an important tissue for the regulation of whole body metabolic homoeostasis. In most individuals, skeletal muscle constitutes 40–60% of body mass and has a high capacity for substrate oxidation and a relatively high potential...
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Clin Sci (Lond) (2013) 124 (7): 467–478.
Published: 07 December 2012
... exposure of isolated mouse islets to cannabinoid receptor agonists on islet gene expression and function. Quantitative RT–PCR (reverse transcription–PCR) indicated that mRNAs encoding synthesis [NAPE-PLD ( N -acyl-phosphatidyl ethanolamide-hydrolysing phospholipase D)] and degradation [FAAH (fatty acid...
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Clin Sci (Lond) (2005) 108 (3): 185–194.
Published: 18 February 2005
... amino acids apoptosis diabetes gene expression metabolism mitochondria signal transduction Amino acid metabolism, under appropriate conditions, is known to enhance insulin secretion from primary islet cells and β-cell lines [ 1 – 5 ]. In vivo , L -glutamine and L -alanine...
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Clin Sci (Lond) (2003) 105 (4): 393–394.
Published: 01 October 2003
.... 17 6 2003 9 7 2003 9 7 2003 © 2003 The Biochemical Society 2003 gene expression hypoxia-inducible factor-1 (HIF-1) mitogen-activated protein kinase (MAP kinase) smooth muscle cell stretch Clinical Science (2003) 105, 393 394 (Printed in Great Britain) 393 C O M M E N T...
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Clin Sci (Lond) (2003) 105 (4): 447–456.
Published: 01 October 2003
... in VSMCs after cyclical stretch for 4 h. The phosphorylation of p42/p44 mitogen-activated protein kinase (MAP kinase) increased after stretch and this was inhibited by the MAP kinase kinase inhibitors PD98059 and U0126. PD98059 and U0126 also blocked HIF-1α gene expression induced by cyclical stretch...
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Clin Sci (Lond) (2003) 104 (4): 421–428.
Published: 20 March 2003
... 2003 2003 angiopoietin-2 cell culture cyclical stretch gene expression signal transduction Tie receptor 421Clinical Science (2003) 104, 421 428 (Printed in Great Britain) Cyclical mechanical stretch enhances angiopoietin-2 and Tie2 receptor expression in cultured human umbilical vein...
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Clin Sci (Lond) (2002) 103 (s2002): 167S–170S.
Published: 01 September 2002
... development, we performed quantitative analysis of ET-1 and VIC gene expression in mouse organs obtained from embryos at days 14 and 17 (E-14 and E-17) of pregnancy, neonates at days 0, 1, 3 and 7 after birth (N-0, -1, -3 and -7), and adult mice (10 weeks old). In intestine, VIC gene expression progressively...
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Clin Sci (Lond) (1996) 91 (2): 213–218.
Published: 01 August 1996
... mice, whereas parenteral iron overload increased pancreatitis-associated protein mRNA levels. 6. The data presented suggest regulation of pancreatitis-associated protein gene expression by both oxygen tension and iron status. 15 3 1996 10 4 1996 © 1996 The Biochemical Society...
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Clin Sci (Lond) (1994) 87 (1): 5–11.
Published: 01 July 1994
... gene expression was seen in the carcinoma nephrectomy specimens. Positive expression was seen in the trauma nephrectomy tissue, and in four of five nephrotic syndrome biopsies. In all kidneys, expression was confined to the renal cortex. The dominant site of gene expression was the distal tubule. Apart...
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Clin Sci (Lond) (1994) 87 (1): 1–4.
Published: 01 July 1994
...- cation of the method of Auffray and Rougeon [7] as Key words: gene expression, hypertension, S, gene, spontaneously hypertensive rat. Abbreviations: HGPT. hypxanthine-guanine phorphoribosyltransferae; SHR, spontaneously hypertensive rat; WKY, Wistar-Kyoto. Correspondence: Dr N. J. Samani, Department...
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Clin Sci (Lond) (1993) 85 (4): 417–424.
Published: 01 October 1993
.... Endothelin-1 gene expression is increased in placental villous tissue of pre-eclamptic gestations, possibly contributing to placental vasoconstriction/vascular insufficiency and hence fetal growth retardation in this disease. Clinical Science (1993) 85, 417-424 (Printed in Great Britain) Expression...
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Clin Sci (Lond) (1991) 80 (4): 339–344.
Published: 01 April 1991
... groups compared with their respective controls, in most of the extrarenal tissue studied minimal, if any, difference was seen in renin mRNA levels between the hypertensive and control rats. 3. The findings suggest that in these extra-renal tissues renin gene expression is differently regulated from...
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Clin Sci (Lond) (1981) 60 (6): 689–692.
Published: 01 June 1981
... rate in men. 6. It is concluded that the rate of sweat rate in men is caused by androgen-induced gene expression at puberty and not by androgen modulation in adult life. 27 1 1981 2 2 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 androgen gene...