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1-27 of 27
Keywords: gene expression
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (13): 1051–1063.
Published: 23 May 2016
... gene expression methylation muscle metabolism Skeletal muscle is an important tissue for the regulation of whole body metabolic homoeostasis. In most individuals, skeletal muscle constitutes 40–60% of body mass and has a high capacity for substrate oxidation and a relatively high potential...
Articles
Alessandra de Paula A. Sousa, Kelen C. R. Malmegrim, Rodrigo A. Panepucci, Doralina S. Brum, Amilton A. Barreira, Antonio Carlos Dos Santos, Amélia G. Araújo, Dimas Tadeu Covas, Maria C. Oliveira, Daniela A. Moraes, Fabiano Pieroni, George M. Barros, Belinda P. Simões, Richard Nicholas, Richard K. Burt, Júlio C. Voltarelli, Paolo A. Muraro
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (2): 111–120.
Published: 19 September 2014
... system and reconstitute a new adaptive immunity. The aim of our study was to identify, through a robust and unbiased transcriptomic analysis, any changes of gene expression in T-cells potentially underlying the treatment effect in patients who underwent non-myeloablative AHSCT for treatment of MS. We...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (7): 467–478.
Published: 07 December 2012
... exposure of isolated mouse islets to cannabinoid receptor agonists on islet gene expression and function. Quantitative RT–PCR (reverse transcription–PCR) indicated that mRNAs encoding synthesis [NAPE-PLD ( N -acyl-phosphatidyl ethanolamide-hydrolysing phospholipase D)] and degradation [FAAH (fatty acid...
Articles
Valérie Turcot, Luigi Bouchard, Geneviève Faucher, Véronique Garneau, André Tchernof, Yves Deshaies, Louis Pérusse, Simon Marceau, Simon Biron, Odette Lescelleur, Laurent Biertho, Marie-Claude Vohl
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (2): 99–109.
Published: 27 March 2012
... stromal lymphopoietin) gene was less expressed in severely obese men with ( n =7) compared with without ( n =7) the MetS (metabolic syndrome). We hypothesized that TSLP SNPs (single nucleotide polymorphisms) are associated with TSLP gene expression in VAT and with MetS phenotypes. Following validation...
Includes: Supplementary data
Articles
Chiara Taurino, William H. Miller, Martin W. McBride, John D. McClure, Raya Khanin, María U. Moreno, Jane A. Dymott, Christian Delles, Anna F. Dominiczak
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (8): 335–343.
Published: 06 July 2010
...Chiara Taurino; William H. Miller; Martin W. McBride; John D. McClure; Raya Khanin; María U. Moreno; Jane A. Dymott; Christian Delles; Anna F. Dominiczak Owing to the dynamic nature of the transcriptome, gene expression profiling is a promising tool for discovery of disease-related genes...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (5): 447–455.
Published: 24 October 2005
... are unknown. In the present study, the effects of prolonged exposure (24 h) to the amino acid L -alanine on insulin secretory function, gene expression and pro-inflammatory cytokine-induced apoptosis were studied using clonal BRIN-BD11 cells. Expression profiling of BRIN-BD11 cells chronically exposed to L...
Includes: Supplementary data
Articles
Ulrika Hägg, Julia Grönros, Johannes Wikström, Ingibjörg H. Jonsdottir, Göran Bergström, Li-ming Gan
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (3): 325–334.
Published: 24 August 2005
... <0.01). Gene expression of CuZnSOD was up-regulated by 21% in exercised animals compared with controls (1.1±0.16 compared with 0.89±0.09; P <0.01), whereas eNOS expression was unchanged. In conclusion, CFVR in rats can be non-invasively assessed using CDE with high feasibility. Physical exercise...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (3): 185–194.
Published: 18 February 2005
... amino acids apoptosis diabetes gene expression metabolism mitochondria signal transduction Amino acid metabolism, under appropriate conditions, is known to enhance insulin secretion from primary islet cells and β-cell lines [ 1 – 5 ]. In vivo , L -glutamine and L -alanine...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (4): 393–394.
Published: 01 October 2003
.... 17 6 2003 9 7 2003 9 7 2003 © 2003 The Biochemical Society 2003 gene expression hypoxia-inducible factor-1 (HIF-1) mitogen-activated protein kinase (MAP kinase) smooth muscle cell stretch Clinical Science (2003) 105, 393 394 (Printed in Great Britain) 393 C O M M E N T...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (4): 447–456.
Published: 01 October 2003
... in VSMCs after cyclical stretch for 4 h. The phosphorylation of p42/p44 mitogen-activated protein kinase (MAP kinase) increased after stretch and this was inhibited by the MAP kinase kinase inhibitors PD98059 and U0126. PD98059 and U0126 also blocked HIF-1α gene expression induced by cyclical stretch...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 104 (4): 421–428.
Published: 20 March 2003
... 2003 2003 angiopoietin-2 cell culture cyclical stretch gene expression signal transduction Tie receptor 421Clinical Science (2003) 104, 421 428 (Printed in Great Britain) Cyclical mechanical stretch enhances angiopoietin-2 and Tie2 receptor expression in cultured human umbilical vein...
Articles
Richard D. PATTEN, Mark J. ARONOVITZ, Michael EINSTEIN, Matthew LAMBERT, Natesa G. PANDIAN, Michael E. MENDELSOHN, Marvin A. KONSTAM
Journal:
Clinical Science
Clin Sci (Lond) (2003) 104 (2): 109–118.
Published: 09 January 2003
... non-infarct zone collagen content ( P <0.01), ANP ( P <0.01) and collagen type 1 ( P <0.01) gene expression, with a non-significant rise in AT 1a receptor gene expression. Neither losartan or enalapril prevented LV dilation or improved fractional shortening. Both similarly lowered systolic...
Articles
Haruo HANAWA, Satoru ABE, Manabu HAYASHI, Tsuyoshi YOSHIDA, Kaori YOSHIDA, Takaaki SHIONO, Koichi FUSE, Masahiro ITO, Hitoshi TACHIKAWA, Takeshi KASHIMURA, Yuji OKURA, Kiminori KATO, Makoto KODAMA, Seitaro MARUYAMA, Tadashi YAMAMOTO, Yoshifusa AIZAWA
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (6): 623–632.
Published: 19 November 2002
... autoimmune myocarditis (EAM) have not yet been determined. To investigate gene expression in the myocardium of EAM, absolute copy numbers of 44 mRNA species [calcium-handling proteins, contractile proteins, natriuretic peptides (NPs), cytokines, chemokines, growth factors, renin–angiotensin–aldosterone (RAA...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 84S–89S.
Published: 01 September 2002
... contains five exons that span 6kb and shows a duplication on exons 2 and 3, coding for the VIC and VIC-like peptides respectively. Similarities between the genomic organization of the PPVIC/preproET2 and preproendothelin-1 genes suggest that the two are distantly related. PPVIC gene expression was observed...
Articles
Bilal AYACH, John TSANG, Arco Y. JENG, André BLOUIN, Mélanie GOSSELIN, Fu-Hou WANG, Jinshyun R. WU-WONG, Jerry WESSALE, Terry J. OPGENORTH, Bruno BATTISTINI
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 371S–375S.
Published: 01 September 2002
... embolism hypertension blood pressure endothelin ET A receptor gene expression The Seventh International Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr B. Battistini (e-mail [email protected] ). © 2002 The Biochemical Society...
Articles
Tsuyoshi UCHIDE, Yuki FUJIMORI, Takushi SASAKI, Kyosuke TEMMA, Javier ADUR, Yoshinori MASUO, Takaharu KOZAKAI, Yun-Sik LEE, Kaname SAIDA
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 167S–170S.
Published: 01 September 2002
... development, we performed quantitative analysis of ET-1 and VIC gene expression in mouse organs obtained from embryos at days 14 and 17 (E-14 and E-17) of pregnancy, neonates at days 0, 1, 3 and 7 after birth (N-0, -1, -3 and -7), and adult mice (10 weeks old). In intestine, VIC gene expression progressively...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2001) 101 (3): 211–217.
Published: 03 August 2001
... chronically receiving a β 1 -adrenoceptor antagonist and non-treated patients. The results showed no difference in gene expression between the two groups of patients; however, significant positive correlations of gene expression between adenylate cyclase subtypes were found. We conclude that β 1 -adrenoceptor...
Articles
Michael Kaiser, Ole Kahr, Yasuyuki Shimada, Pamela Smith, Martin Kelly, Harin Mahadeva, Matthew Adams, David Lodwick, Christian Aalkjaer, Metin Avkiran, Nilesh J. Samani
Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (4): 359–365.
Published: 01 April 1998
... natriuretic peptide cardiac failure cardiac hypertrophy gene expression rat vasoactive hormones Clinical Science (1998) 94,359-365 (Printed in Great Britain) 359 Differential regulation of ventricular adrenomedullin and atrial natriuretic peptide gene expression in pressure and volume overload...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (5): 455–465.
Published: 01 May 1997
... < 0.05) and between 50 and 100-fold after ACE inhibitor treatment ( P < 0.001). No change in renin gene expression was found in any extra-renal site either following MI or after ACE inhibitor treatment. Hepatic angiotensinogen mRNA level was similar in all groups, but kidney angiotensinogen mRNA level...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1996) 91 (2): 213–218.
Published: 01 August 1996
... mice, whereas parenteral iron overload increased pancreatitis-associated protein mRNA levels. 6. The data presented suggest regulation of pancreatitis-associated protein gene expression by both oxygen tension and iron status. 15 3 1996 10 4 1996 © 1996 The Biochemical Society...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1996) 90 (3): 197–204.
Published: 01 March 1996
...Hideo Kawakami; Hideki Okayama; Mareomi Hamada; Kunio Hiwada 1. We assessed the changes of atrial natriuretic peptide and brain natriuretic peptide gene expression associated with progression and regression of cardiac hypertrophy in renovascular hypertensive rats (RHR). 2. Two-kidney, one-clip...
Articles
Allan D. Cumming, Timothy Walsh, Davina Wojtacha, Stewart Fleming, David Thomson, David A. S. Jenkins
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (1): 5–11.
Published: 01 July 1994
... gene expression was seen in the carcinoma nephrectomy specimens. Positive expression was seen in the trauma nephrectomy tissue, and in four of five nephrotic syndrome biopsies. In all kidneys, expression was confined to the renal cortex. The dominant site of gene expression was the distal tubule. Apart...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (1): 1–4.
Published: 01 July 1994
...- cation of the method of Auffray and Rougeon [7] as Key words: gene expression, hypertension, S, gene, spontaneously hypertensive rat. Abbreviations: HGPT. hypxanthine-guanine phorphoribosyltransferae; SHR, spontaneously hypertensive rat; WKY, Wistar-Kyoto. Correspondence: Dr N. J. Samani, Department...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (4): 417–424.
Published: 01 October 1993
.... Endothelin-1 gene expression is increased in placental villous tissue of pre-eclamptic gestations, possibly contributing to placental vasoconstriction/vascular insufficiency and hence fetal growth retardation in this disease. Clinical Science (1993) 85, 417-424 (Printed in Great Britain) Expression...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (4): 461–468.
Published: 01 April 1992
...Tsukasa Nakamura; Isao Ebihara; Shiori Osada; Ko Okumura; Yasuhiko Tomino; Hikaru Koide 1. We studied perforin gene expression in T lymphocytes obtained from 26 patients with IgA nephropathy and from 15 healthy age-matched control subjects. 2. The majority of patients with IgA nephropathy (96%) had...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1991) 80 (4): 339–344.
Published: 01 April 1991
... groups compared with their respective controls, in most of the extrarenal tissue studied minimal, if any, difference was seen in renin mRNA levels between the hypertensive and control rats. 3. The findings suggest that in these extra-renal tissues renin gene expression is differently regulated from...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 60 (6): 689–692.
Published: 01 June 1981
... rate in men. 6. It is concluded that the rate of sweat rate in men is caused by androgen-induced gene expression at puberty and not by androgen modulation in adult life. 27 1 1981 2 2 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 androgen gene...