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Keyword: genomics
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Articles
Clin Sci (Lond) (2019) 133 (5): 697–708.
Published: 05 March 2019
...Rachel H. Horton; Anneke M. Lucassen Advances in genetic technology are having a major impact in the clinic, and mean that many perceptions of the role and scope of genetic testing are having to change. Genomic testing brings with it a greater opportunity for diagnosis, or predictions of future...
Articles
Clin Sci (Lond) (2017) 131 (24): 2847–2863.
Published: 04 December 2017
... lung function among smokers, suggesting that genetic determinants in COPD susceptibility. During the past decade, genome-wide association studies and exome sequencing have been instrumental to identify the genetic determinants of complex traits, including COPD. Focused studies have revealed mechanisms...
Articles
Clin Sci (Lond) (2017) 131 (6): 439–448.
Published: 06 March 2017
... and their families. The benefits of co-ordinated research in genomics, proteomics, metabolomics, transcriptomics and phenomics along with dietary, lifestyle and social factors have led to novel therapeutic and prognostic applications in other fields such as oncology. Applying such co-ordinated...
Articles
Clin Sci (Lond) (2016) 130 (1): 1–7.
Published: 19 November 2015
...Marianne J. Legato This article is intended to illuminate several important changes in our concept of gender-specific medicine in the genomic era. It reviews the history of gender-specific medicine, pointing out the changes in our perception of the nature of biological sex and our expanding...
Articles
Clin Sci (Lond) (2005) 109 (5): 421–430.
Published: 24 October 2005
...Bernardo C. Vidal, Jr; Joseph V. Bonventre; Stephen I-Hong Hsu Proteomics is widely envisioned as playing a significant role in the translation of genomics to clinically useful applications, especially in the areas of diagnostics and prognostics. In the diagnosis and treatment of kidney disease, a...
Articles
Clin Sci (Lond) (2000) 99 (4): 255–260.
Published: 06 September 2000
... over 100 countries and more than 150 million tablets have been dispensed worldwide. The sildenafil research programme reflects a traditional approach to drug discovery, but pressures to improve productivity have prompted major investments in genome sciences and new technologies. The impact of these...