..., confirming a lectin-mediated interaction. 4. 125 I-FF-III exhibited quantitatively similar specific binding to both normal human and coeliac enterocytes. 5. The primary interaction of gliadin peptides with the enterocyte surface membrane is not lectin-mediated and unlikely to be of fundamental importance...

...J. Colyer; M. J. G. Farthing; P. J. Kumar; M. L. Clark; A. D. Ohannesian; N. M. Waldron 1. The agglutinating properties of a crude gluten digest, purified gliadin fractions and established plant lectins were investigated using mammalian erythrocytes, rat enterocytes and normal and coeliac human...

... for putrescine of 0.15 mmol/l. 2. Assay of jejunal transglutaminase activity with a variety of dietary proteins as acceptors showed high activity with gliadin, comparable with that of the standard substrate, dimethylcasein. Deamidation of the gliadin markedly reduced its acceptor activity. Collagen, ovalbumin...

... of unfractionated gliadin and of α-, β-, γ- and ω-gliadin subfractions on the morphology of multiple jejunal biopsies taken from two patients with treated coeliac disease. 2. A dose-response study with increasing quantities of unfractionated gliadin in one coeliac patient showed that 1000 mg produced marked damaged...

...J. J. Phelan; Fiona M. Stevens; B. McNicholl; P. F. Fottrell; C. F. McCarthy 1. Gliadin from which carbohydrate was removed by treatment with carbohydrase from Aspergillus niger was fed to three coeliac patients in remission. 2. Xylose absorption, mucosal morphology and brush-border enzymes were...