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Keywords: glomerular filtration rate
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Articles
Clin Sci (Lond) (2018) 132 (13): 1453–1470.
Published: 18 July 2018
... the contribution of neuronal UCHL1 to this is unclear. Immunofluorescence revealed significant neuronal UCHL1 expression in mouse kidney, including periglomerular axons. Glomerular filtration rate trended higher in 6-week-old Uchl1 -/- mice, and by 12 weeks of age, these displayed significant glomerular...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (12): 1215–1242.
Published: 21 June 2018
... in the pathophysiology of three maternal manifestations of severe PE (hypertension, decreased renal glomerular filtration rate (GFR), and pulmonary edema) and one fetal complication of PE-associated prematurity (cerebral intraventricular hemorrhage (IVH)) are explored. Based on these considerations, a model is proposed...
Articles
Clin Sci (Lond) (2008) 114 (2): 109–118.
Published: 11 December 2007
... on intrarenal NO metabolism and the control of single-nephron GFR (glomerular filtration rate) in rodent models of DN are also presented. Characterization of valid experimental models of DN should include a careful delineation of the absence or presence of early hyperfiltration, with special efforts made...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 39S–43S.
Published: 01 September 2002
... 20–21, 10098 Berlin, Germany (e-mail berthold.hocher@charite.de ). © 2002 The Biochemical Society and the Medical Research Society 2002 blood pressure glomerular filtration rate human ET-1 transgenic mice interstitial fibrosis laminin matrix proteins ...
Articles
Clin Sci (Lond) (2002) 102 (1): 91–98.
Published: 10 December 2001
...Giovanni SANSOÈ; Alberto FERRARI; Carmen Nives CASTELLANA; Lorenzo BONARDI; Erica VILLA; Federico MANENTI Cimetidine inhibits the tubular secretion of creatinine, without altering the glomerular filtration rate (GFR). During cimetidine administration the creatinine/inulin clearance ratio approaches...
Articles
Clin Sci (Lond) (2000) 98 (4): 439–444.
Published: 17 March 2000
...A. M. PETERS; B. L. HENDERSON; D. LUI The conventional way in which to scale or index a measurement of glomerular filtration rate (GFR) is to express it in relation to body surface area (BSA). However, BSA may not be appropriate for infants and children because, as individuals increase in size...
Articles
Clin Sci (Lond) (1999) 97 (2): 149–156.
Published: 16 June 1999
... in a cross-sectional design. We measured basal and glucagon-stimulated plasma C-peptide, abdominal sagittal diameter, skinfold thickness, glomerular filtration rate, albumin excretion rate and standard clinical characteristics. Mean HbA1c was 6.4% in Type I and 6.3% in Type II diabetes. Patients...
Articles
Clin Sci (Lond) (1998) 96 (1): 5–15.
Published: 01 January 1999
... : -0.8%) than in control subjects (DFR Na : -3.7%). Baseline values for glomerular filtration rate and renal plasma flow were reduced in congestive heart failure, but brain natriuretic peptide induced no significant changes between congestive heart failure and control subjects. Brain natriuretic peptide...
Articles
Clin Sci (Lond) (1997) 93 (6): 549–556.
Published: 01 December 1997
.... In cirrhotic rats with and without ascites, glomerular filtration rate tends to be higher ( P = 0.12), renal plasma flow is elevated ( P = 0.001) and nitration fraction is lower ( P = 0.002) than in healthy rats. 4. In conclusion, haemodynamic experiments in the cirrhotic rat should be performed in the awake...
Articles
Clin Sci (Lond) (1996) 91 (4): 489–496.
Published: 01 October 1996
...Jesper Melchior Hansen; Niels Vidiendal Olsen; Paul Peter Leyssac 1. The nephrotoxic effects of cyclosporin A may diminish the ability of the transplanted kidney to increase the glomerular filtration rate and effective renal plasma flow during infusion of dopamine or amino acids. 2. The present...
Articles
Clin Sci (Lond) (1995) 88 (2): 197–201.
Published: 01 February 1995
... in the group pretreated with parathyroid hormone. 4. Parathyroid hormone produced only a small increase in mean plasma calcium concentration, and glomerular filtration rate was not altered by either hormone. 5. These results demonstrate that high physiological concentrations of parathyroid hormone do have...
Articles
Clin Sci (Lond) (1994) 87 (5): 519–523.
Published: 01 November 1994
...Anne-Lise Kamper; Niels-Henrik Holstein-Rathlou; Svend Strandgaard; Paul Peter Leyssac; Ole Munck 1. Glomerular filtration rate and sequential tubular function were investigated in 18 adult renal transplant recipients and in their matched, adult living-related kidney donors before and 5 days after...
Articles
Clin Sci (Lond) (1994) 87 (1): 13–20.
Published: 01 July 1994
..., and a final 1 h period with lower body negative pressure. 4. During noradrenaline infusion the relative decrease in effective renal plasma flow, glomerular filtration rate and clearance of lithium and sodium was significantly more pronounced in the long-term transplanted patients than in the control subjects...
Articles
Clin Sci (Lond) (1994) 86 (3): 251–255.
Published: 01 March 1994
... albuminuria glomerular filtration rate pre-eclampsia hypertension pregnancy Clinical Science (1994) 86, 251-255 (Printed in Great Britain) 251 Albumin excretory rate in normal and hypertensive pregnancy Mark A. BROWN Min-Xia WANG Megan L. BUDDLE', Mark A. CARLTON', Gregory M. CARIO', Vivienne C. ZAMMIT...
Articles
Clin Sci (Lond) (1993) 85 (6): 713–716.
Published: 01 December 1993
...A. Golik; J. Weissgarten; D. Cotariu; N. Cohen; R. Zaidenstein; Y. Ramot; Z. Averbukh; D. Modai 1. Hypouricaemia is prevalent in diabetic patients. In most of the studies, the diabetic patients had some degree of diabetic nephropathy as evidenced by a decreased glomerular filtration rate...
Articles
Clin Sci (Lond) (1992) 82 (2): 119–126.
Published: 01 February 1992
... to infusion of atrial natriuretic factor, the packed cell volume rose by 4.2% ( P < 0.001) and the filtration fraction by 5% (from 22 to 27%, P <0.05), but there was no significant change in renal plasma flow, glomerular filtration rate or mean arterial blood pressure. Likewise, the plasma catecholamine...
Articles
Clin Sci (Lond) (1991) 81 (s25): 457–464.
Published: 01 October 1991
...T. Hannedouche; M. Lazaro; A. G. Delgado; C. Boitard; B. Lacour; J.-P. Grünfeld 1. A sustained high glomerular filtration rate in diabetes mellitus is associated with increased proximal reabsorption, suggesting alterations in the tubulo-glomerular feedback system. To test this hypothesis, renal...
Articles
Clin Sci (Lond) (1991) 81 (3): 367–372.
Published: 01 September 1991
..., no further improvement was seen during the combination therapy. 5. The changes in proteinuria were associated with changes in glomerular filtration rate, which showed a pronounced fall with combination therapy. The renal haemodynamic profiles during the different therapies suggest a post-glomerular...
Articles
Clin Sci (Lond) (1991) 80 (2): 131–136.
Published: 01 February 1991
... monophosphate; dopamine glomerular filtration rate renal blood flow Clincial Science (1991) 80,131-136 131 Differential effects of atrial natriuretic peptide and dopamine on urinary protein excretion in chronic glomerulonephritis YASUNOBU HIRATA, MASAO ISHII, KAZUSHIGE FUKUI, HIROSHI HAYAKAWA, ETSU SUZUKI...
Articles
Clin Sci (Lond) (1991) 80 (2): 167–176.
Published: 01 February 1991
.... Urine collection and fluid loading are not required for the single injection technique, and it is more reproducible and less demanding than the constant infusion method. With simple precautions, the single injection method with inulin is suitable for routine estimation of the glomerular filtration rate...
Articles
Clin Sci (Lond) (1990) 79 (6): 551–558.
Published: 01 December 1990
... and the Medical Research Society 1990 acute renal failure glomerular filtration rate glomeruli glycerol platelet-activating factor renal blood flow Clinical Science (1990) 79, 551-558 551 Platelet-activating factor mediates glycerol-induced acute renal failure in rats ANTONIO LOPEZ-FA-, DULCENOMBRE...
Articles
Clin Sci (Lond) (1990) 79 (4): 299–305.
Published: 01 October 1990
... filtration rate and a higher serum concentration of urea were seen in 50-day-old essential fatty acid-deficient rats compared with age-matched controls. Later, the glomerular filtration rate progressively deteriorated in parallel with a decline in effective renal plasma flow and with a concomittant rise...
Articles
Clin Sci (Lond) (1990) 79 (4): 381–386.
Published: 01 October 1990
... with a mixed amino acid solution by using the isolated rat kidney perfused with a physiological saline solution containing 6.7% (w/v) albumin and a basal level of 2 mmol/l mixed amino acids. 2. In a control series, the renal perfusate flow was stable but the glomerular filtration rate, as measured by [ 14 C...
Articles
Clin Sci (Lond) (1990) 78 (6): 585–590.
Published: 01 June 1990
...Enrico Valvo; Patrizia Casagrande; Valeria Bedogna; Francesca Dal Santo; Daniele Alberti; Cristina Fontanarosa; Paolo Braggio; Giuseppe Maschio 1. Urinary albumin excretion and the effect of an acute oral protein load (a meat meal) on glomerular filtration rate ('renal functional reserve') were...
Articles
Clin Sci (Lond) (1990) 78 (5): 481–485.
Published: 01 May 1990
...S. C. Tam; L. S. Tang; C. K. Lai; M. G. Nicholls; R. Swaminathan 1. The increase in glomerular filtration rate after a protein meal is believed to be mediated by hormonal factors. Since natriuresis is often observed after a protein meal, it was postulated that the increase in glomerular filtration...
Articles
Clin Sci (Lond) (1989) 77 (6): 643–650.
Published: 01 December 1989
... the transglomerular permeability to plasma protein in damaged glomeruli, most likely affecting the steric hindrance. 30 5 1989 12 6 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 glomerular filtration rate α-human atrial natriuretic peptide primary glomerular...
Articles
Clin Sci (Lond) (1989) 77 (3): 311–318.
Published: 01 September 1989
... rate, and there was no suggestion of distal tubular reabsorption of lithium or influence of osmotic diuresis. 3. Fractional reabsorption of lithium was reduced in most patients with glomerular filtration rates below 25 ml/min. 4. Calculated fractional distal reabsorption of sodium was reduced in most...
Articles
Clin Sci (Lond) (1989) 77 (1): 105–111.
Published: 01 July 1989
...M. G. Koopman; G. C. M. Koomen; R. T. Krediet; E. A. M. de Moor; F. J. Hoek; L. Arisz 1. In a group of 11 normal individuals we measured glomerular filtration rate (GFR) by inulin clearances and effective renal plasma flow (ERPF) by p -aminohippurate clearances during a period of 24 h and a regimen...
Articles
Clin Sci (Lond) (1989) 76 (1): 81–86.
Published: 01 January 1989
.... The serum concentration of 1,25-dihydroxyvitamin D was found to be significantly and positively correlated with the serum concentrations of 25-hydroxyvitamin D ( P < 0.001) and parathyroid hormone ( P < 0.003), and with the glomerular filtration rate ( P < 0.03), and negatively correlated...
Articles
Clin Sci (Lond) (1988) 75 (6): 655–659.
Published: 01 December 1988
..., β 2 -microglobulin, albumin and immunoglobulin G. 2. The glomerular filtration rate (GFR) of the kidney that remained in the donor rose from 45 ± 10 (mean ± sd ) to 59 ± 10 ml/min ( P < 0.01) 5 days after contralateral nephrectomy and remained at this level through the observation period. 3...
Articles
Clin Sci (Lond) (1988) 75 (6): 621–628.
Published: 01 December 1988
... + -depleted animals, values for total glomerular filtration rate and single-nephron filtration rate were significantly lower than in controls. Urine osmolality was also reduced; this was associated with reductions in the osmolality, Na + concentration and K + concentration of papillary interstitial fluid...
Articles
Clin Sci (Lond) (1988) 75 (5): 495–498.
Published: 01 November 1988
...) infusions have similar effects on glomerular filtration rate, natriuresis and kaliuresis, we decided to investigate the possibility that a protein meal could stimulate ANF activity. 2. We studied 10 normal volunteers who had a fixed protein and sodium intake for 7 days before the experiments. The subjects...
Articles
Clin Sci (Lond) (1988) 74 (5): 519–525.
Published: 01 May 1988
... nerve activity may modify the effects of ANP on renal haemodynamics and sodium excretion. 7 9 1987 26 10 1987 © 1988 The Biochemical Society and the Medical Research Society 1988 atrial natriuretic peptide glomerular filtration rate potassium excretion renal nerve sodium...
Articles
Clin Sci (Lond) (1988) 74 (1): 63–69.
Published: 01 January 1988
...S. B. Harrap; A. E. Doyle 1. To determine the relevance of renal circulatory abnormalities found in the immature spontaneously hypertensive rat (SHR) to the genetic hypertensive process, glomerular filtration rate and renal blood flow were measured in conscious F 2 rats, derived from crossbreeding...
Articles
Clin Sci (Lond) (1987) 73 (1): 105–108.
Published: 01 July 1987
... of patients with renal disease (3.6–52.6 nmol/ml), in proportion to the serum level of creatinine ( n = 50, r = 0.726, P < 0.001), β 2 -microglobulin ( n = 34, r = 0.551, P < 0.005), and to glomerular filtration rate ( n = 39, r = 0.556, P < 0.001). ageing d -amino acid d -amino acid oxidase...
Articles
Clin Sci (Lond) (1987) 72 (6): 657–667.
Published: 01 June 1987
... for non-clipped kidneys increased from 5.9 ± 0.4 to 6.5 ± 0.3 ml/min, indicating a 30% reduction of renal vascular resistance ( P values 0.01; n = 9). Glomerular filtration rate (GFR) for non-clipped kidneys ( n = 24) increased from 0.91 ± 0.09 to 1.47 ± 0.14 ml/min and filtration fraction increased from...
Articles
Clin Sci (Lond) (1987) 72 (5): 611–620.
Published: 01 May 1987
... without signs of autonomic or somatic neuropathy. Six age-matched clinically healthy patients in remission from the minimal change nephrotic syndrome served as controls. 2. The diabetic patients had a higher glomerular filtration rate and effective renal plasma flow and a lower venous plasma noradrenaline...
Articles
Clin Sci (Lond) (1987) 72 (4): 429–436.
Published: 01 April 1987
...Margrethe E. Olsen; John E. Hall; Jean-Pierre Montani; John E. Cornell 9 7 1986 24 10 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 angiotensin II autoregulation glomerular filtration rate prostaglandins renal blood flow tubuloglomerular...
Articles
Clin Sci (Lond) (1987) 72 (3): 289–296.
Published: 01 March 1987
... patients the relation between the fractional clearances of neutral and anionic macromolecules was dependent on glomerular filtration rate. 4. It seems likely that the altered glomerular permeability in diabetic nephropathy is associated with a decrease of charge as renal function deteriorates...
Articles
Clin Sci (Lond) (1987) 72 (3): 305–312.
Published: 01 March 1987
... and the Medical Research Society 1970 aldosterone atrial natriuretic peptide blood pressure blood pressure glomerular filtration rate natriuresis natriuretic factor renin-angiotensin system CIinicalScience(l987) 7 2 , 305-312 305 Atrial natriuretic peptide: evidence of action as a natriuretic...
Articles
Clin Sci (Lond) (1986) 71 (3): 277–282.
Published: 01 September 1986
... 1986 diuresis glomerular filtration rate human atrial natriuretic polypeptide papillary function Clinical Science( 1986) 71, 277-282 277 Renal response to atrial natriuretic factor in rats without intact papillae SHOZO TORIKAI Department of Pharmacology, National Cardiovascular Center...
Articles
Clin Sci (Lond) (1986) 70 (5): 453–460.
Published: 01 May 1986
... hypertensive and control rats. Addition of captopril further reduced arterial pressure in hypertensive rats only. 3. There were significant increases in glomerular filtration rate (GFR), urine flow and absolute and fractional excretory rates of sodium and potassium in the non-clipped kidney. In contrast...
Articles
Clin Sci (Lond) (1986) 70 (3): 243–247.
Published: 01 March 1986
... taking sulindac for 28 days. 3. Effective renal plasma flow was reduced in all subjects after 28 days but the glomerular filtration rate did not change. 4. Plasma renin activity, potassium and aldosterone concentrations and urinary sodium excretion did not change but urinary prostaglandin E 2 excretion...
Articles
Clin Sci (Lond) (1984) 67 (2): 243–248.
Published: 01 August 1984
...Boothur J. Z. Danesh; Joyce Brunton; David J. Sumner 1. The effect of 4-6 weeks’ treatment with propranolol and nadolol on effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) was studied, in 14 patients with essential hypertension, in single blind, random and cross-over design...
Articles
Clin Sci (Lond) (1984) 66 (5): 591–597.
Published: 01 May 1984
... clearance [ 99m Tc]diethylenetriaminepenta-acetate distribution volume extracellular fluid volume glomerular filtration rate oxalate oxalosis primary hyperoxaluria renal failure Clinical Science (1984) 66, 591-597 59 1 Oxalate dynamics and removal rates during haemodialysis and peritoneal...
Articles
Clin Sci (Lond) (1983) 65 (6): 627–633.
Published: 01 December 1983
... with primary hyperoxaluria. The renal clearance and distribution volumes of [ 99m Tc]DTPA (diethylenetriaminepenta-acetate) were measured simultaneously to provide estimates of glomerular filtration rate (GFR) and extracellular fluid volume (ECF). The same measurements were made on each of five normal...
Articles
Clin Sci (Lond) (1983) 65 (5): 449–455.
Published: 01 November 1983
..., and discuss how these are changed during pregnancy; comments on the possible mechanisms involved in these changes are presented where appropriate. © 1983 The Biochemical Society and the Medical Research Society 1983 glomerular filtration rate glucose reabsorption kidney pregnancy sodium...
Articles
Clin Sci (Lond) (1983) 65 (4): 399–406.
Published: 01 October 1983
... greater glomerular filtration rates when the experiment ended after 7 months. 4. We conclude that dietary protein influences favourably the development of glomerular scarring and renal failure after subtotal nephrectomy in rats. glomerular filtration rate glomerular sclerosis low protein diet...
Articles
Clin Sci (Lond) (1983) 65 (1): 47–55.
Published: 01 July 1983
...- and water-deprived rats. 3. Glomerular filtration rate and renal blood flow were not affected by atrial extract, indicating that the atrial natriuretic factor (ANF) directly inhibited sodium reabsorption at the tubular level. 4. Distal tubular blockade with a combination of frusemide and amiloride...
Articles
Clin Sci (Lond) (1982) 63 (s8): 61s–64s.
Published: 01 October 1982
... close to those in conscious unmanipulated animals, the glomerular filtration rate (GFR) per g kidney weight was higher and the kidney weight/body weight ratio lower in MHS than in MNS rats ( P < 0.001). This suggests that there is increased transtubular ion transport in MHS animals. 3. The MHS rats...