... patients are also significantly increased in recent years, resulting in increasingly heavy clinical, economic and social burdens. Indeed, in 2014, 44% of new cases of ESRD in the U.S.A. are caused by diabetes. biomarkers diabetes diabetic kidney disease glomerulus GSK-3β inflammation lncRNA...

... ). 4 6 2015 3 9 2015 25 9 2015 © 2015 Authors; published by Portland Press Limited 2015 angiopoietins endothelial cells glomerulus permeability podocytes vascular endothelial growth factor (VEGF) A second vascular growth factor family implicated in glomerular biology...

... and podocytes within the glomerulus. Activation of MRs in these cells appears to lead to glomerular sclerosis. Mechanistically, aldosterone induces excess production of reactive oxygen species (ROS) and oxidative stress in glomerular cells through activation of NADPH oxidase. In mesangial cells, aldosterone...

... regulatory mechanisms of both genes [ 68 – 70 ]. The nephrin and Neph3 genes possess all of the above-mentioned features suggested for bidirectional gene pairs. Correspondence: Dr Sanna Lehtonen (email [email protected] ). 28 5 2013 9 8 2013 21 8 2013 glomerulus...

... amylase charge selectivity glomerulus proteinuria Clinical Science (1994) 87, 421425 (Printed in Great Britain) 42 I Glomerular charge selectivity in primary glomerulopathies J. G. FOX, J. D. QUIN*, D. ST. J. O REILLY? and J. M. BOULTON-JONES Renal Unit, *Diabetes Centre and ?Institute...

.... It precedes the development of renal scarring and may be important in the pathogenesis of this process. 17 2 1993 30 3 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 albuminuria glomerulosclerosis glomerulus leucocyte Clinical Science (1993) 85, V-31...

..., charge selectivity, glomerulus, proteinuria. Abbreviations: C, creatinine clearance; CpAm/C%, ratio of the clearance of pancreatic isoamylase to the clearance of salivary isoamylase; KNb, KPh, km, fractional Clearance of albumin, pancreatic isoamylase and salivary isoamylase relative to creatinine...

... in the clearance of the negatively charged endogenous albumin may be due to a reduction in the glomerular charge barrier. 5 3 1985 19 3 1985 © 1985 The Biochemical Society and the Medical Research Society 1985 albumin dextran glomerulus kidney proteinuria Clinical Science (1985) 69...

... at the glomerulus than their less negatively charged counterparts but were also reabsorbed to a lesser extent by the tubular epithelium. 15 7 1983 24 8 1983 © 1984 The Biochemical Society and the Medical Research Society 1984 albumin charge effects glomerulus kidney proteinuria...

... The Biochemical Society and the Medical Research Society 1981 albuminuria glomerulus proteinuria rat kidney urine Clinical Science (198I) 60,693-702 693 Normal urinary protein composition in the female Wistar rat and its relationship to the proteinuria induced by intraperitoneal bovine albumin...