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Aliye Uc, Alicia K. Olivier, Michelle A. Griffin, David K. Meyerholz, Jianrong Yao, Maisam Abu-El-Haija, Katherine M. Buchanan, Oriana G. Vanegas Calderón, Marwa Abu-El-Haija, Alejandro A. Pezzulo, Leah R. Reznikov, Mark J. Hoegger, Michael V. Rector, Lynda S. Ostedgaard, Peter J. Taft, Nick D. Gansemer, Paula S. Ludwig, Emma E. Hornick, David A. Stoltz, Katie L. Ode, Michael J. Welsh, John F. Engelhardt, Andrew W. Norris
Clin Sci (Lond) (2015) 128 (2): 131–142.
Published: 19 September 2014
... pancreas function by intravenous glucose tolerance test (IV-GTT). In fetal pigs, pancreatic insulin and glucagon density was similar between CF and non-CF. In newborn and older pigs, the insulin and glucagon density was unchanged between CF and non-CF per total pancreatic area, but increased per remnant...
Includes: Supplementary data
Clin Sci (Lond) (2008) 115 (5): 167–174.
Published: 01 August 2008
... Sandostatin® (somatostatin) infusion to decrease the inappropriate secretion of glucagon during the meal. During the 210 min of somatostatin infusion, the glucagon response was suppressed and IGFBP-1 levels were increased concomitantly with the peak in insulin levels, without any significant decrease after...
Clin Sci (Lond) (2008) 114 (9): 589–590.
Published: 02 April 2008
...Philip E. Cryer Glucagon, in the setting of absolute or relative insulin deficiency, is thought to contribute to the pathogenesis of hyperglycaemia in diabetes, but much of the evidence is extrapolated from short-term studies to the long-term condition. In the present issue of Clinical Science , Li...
Clin Sci (Lond) (2008) 114 (9): 591–601.
Published: 02 April 2008
...Xiao C. Li; Tang-dong Liao; Jia L. Zhuo Clinical studies have shown that patients with early Type 2 diabetes often have elevated serum glucagon rather than insulin deficiency. Imbalance of insulin and glucagon in favouring the latter may contribute to impaired glucose tolerance, persistent...
Clin Sci (Lond) (2007) 113 (4): 183–193.
Published: 13 July 2007
...Xiao C. Li; Jia L. Zhuo Pancreatic bi-hormones insulin and glucagon are the Yin and Yang in the regulation of glucose metabolism and homoeostasis. Insulin is synthesized primarily by pancreatic β-cells and is released in response to an increase in blood glucose levels (hyperglycaemia). By contrast...
Clin Sci (Lond) (1999) 96 (2): 179–184.
Published: 01 February 1999
...D. R. PARKER; A. BARGIOTA; G. D. BRAATVEDT; M. HALLIWELL; R. J. M. CORRALL Superior mesenteric artery blood flow increases significantly after hypoglycaemia in healthy humans. Glucagon has vasoactive properties but its role in hypoglycaemic hyperaemia is unclear. To assess this role, we studied...
Clin Sci (Lond) (1993) 84 (2): 193–199.
Published: 01 February 1993
...G. D. Braatvedt; A. Stanners; P. G. Newrick; M. Halliwell; R. J. M. Corrall 1. Previous studies have suggested that glucagon in supraphysiological doses may mediate postprandial and hypoglycaemia-induced splanchnic vasodilatation in man and experimental animals. There are no reported studies...
Raymond Bruce, Ian Godsland, John Stevenson, Maxeen Devenport, Fiona Borth, David Crook, Mohammed Ghatei, Malcolm Whitehead, Victor Wynn
Clin Sci (Lond) (1992) 82 (2): 211–217.
Published: 01 February 1992
...Raymond Bruce; Ian Godsland; John Stevenson; Maxeen Devenport; Fiona Borth; David Crook; Mohammed Ghatei; Malcolm Whitehead; Victor Wynn 1. Danazol elevates plasma insulin, plasma glucagon and serum low-density lipoprotein concentrations and reduces the serum high-density lipoprotein concentration...
Clin Sci (Lond) (1991) 80 (1): 71–76.
Published: 01 January 1991
... fed the low phosphate diet. 3. Using the acute response to the glucoregulatory hormones, glucagon and insulin, administered exogenously, we found that the regulation of plasma glucose concentration did not differ between Hyp/Y and +/ Y mice. 4. The significantly lower plasma glucose concentration...
Clin Sci (Lond) (1990) 78 (3): 273–281.
Published: 01 March 1990
...) dextrose (D-glucose) infusion and at the end of days 7 and 8 of each diet, were analysed for urea, glucose, lactate, triacylglycerols, fatty acids, glycerol, 3-hydroxybutyrate, insulin and glucagon. 3. The effect of increasing glucose intake was to increase nitrogen balance by 0.60 ± 0.25 ( sem ) mg/kJ...
Jan Wernerman, Danielle Botta, Folke Hammarqvist, Stig Thunell, Alexandra von der Decken, Erik Vinnars
Clin Sci (Lond) (1989) 77 (6): 611–616.
Published: 01 December 1989
... skeletal muscle was investigated. Healthy volunteers were given a 6 h infusion of adrenaline ( n = 8), Cortisol ( n = 8), a triple-hormone combination of adrenaline, Cortisol and glucagon ( n = 8), or saline ( n = 8) 2. The total ribosome concentration declined by 30.4 ± 7.2% in the triple-hormone group...
Clin Sci (Lond) (1988) 74 (5): 539–545.
Published: 01 May 1988
... 5.1 ± 0.5 mmol/l, P < 0.05, paired t -test). The post-operative urea synthesis rate exceeded the amino nitrogen infusion by 20%. 4. Post-operatively, the insulin response to the amino acid infusion more than doubled, and the glucagon response increased by 54 %. Fasting Cortisol doubled...
Clin Sci (Lond) (1985) 68 (s10): 137s–139s.
Published: 01 January 1985
...- to three-fold increase in plasma glucagon and a similar reduction in plasma insulin. Only the latter was antagonized by idazoxan. No consistent changes in plasma ACTH were observed after either idazoxan or guanfacine. 5. Idazoxan itself elevated plasma noradrenaline up to twice baseline values, but did...
Clin Sci (Lond) (1984) 66 (5): 557–559.
Published: 01 May 1984
... plasma levels of adenosine 3′:5′-cyclic monophosphate (cyclic AMP) after an intravenous injection of glucagon in eight patients receiving long term lithium treatment and in six control subjects. Urinary cyclic AMP levels after an intravenous injection of bovine parathyroid hormone (PTH) were also...
Clin Sci (Lond) (1980) 59 (s6): 469s–472s.
Published: 01 December 1980
...B. N. Garrett; P. Raskin; N. M. Kaplan 1. In eight hypertensive diabetic subjects receiving hydrochlorothiazide, glucose homeostasis as measured by the changes in plasma glucose, insulin and glucagon after an oral glucose load was not significantly affected by 8 weeks of therapy with metoprolol. 2...
K. J. Foster, K. G. M. M. Alberti, C. Binder, Leslie Hinks, S. Karran, Patricia Smythe, S. Talbot, D. Turnell, H. Ørskov
Clin Sci (Lond) (1980) 58 (6): 507–515.
Published: 01 June 1980
... glucose by approximately 1 mmol/l. Total nitrogen excretion during glucose/insulin infusion was significantly less than during saline infusion. 4. Infusion of amino acids, compared with saline infusion, resulted in raised blood glucose, alanine, serum insulin and plasma glucagon concentrations but lower...
Clin Sci (Lond) (1980) 58 (5): 393–401.
Published: 01 May 1980
...M. A. Kirschenbaum; E. T. Zawada 1. Three groups of anaesthetized dogs were studied to determine the role of renal prostaglandins in glucagon-induced natriuresis. 2. Urine flow, sodium and prostaglandin E excretion rates increased significantly in the experimental kidney with glucagon infusion...
Clin Sci Mol Med (1978) 55 (s4): 323s–324s.
Published: 01 December 1978
... with small, but significant, increases in plasma triglyceride concentrations and suppression of fasting immuno-reactive glucagon concentrations. © 1978 The Biochemical Society and the Medical Research Society 1978 β-adrenoreceptor antagonists atenolol glucagon metoprolol pindolol propranolol...
Clin Sci Mol Med (1978) 55 (5): 499–504.
Published: 01 November 1978
... in blood ketones without much change in plasma FFA. 3. An infusion of glucagon given together with Intralipid did not alter the reduction in blood ketones produced by oral glucose in normal subjects. 4. Oral glucose given 60 min after the start of the Intralipid infusion in three insulin-requiring diabetic...
L. Sestoft, J. Trap-Jensen, J. Lyngsøe, J. P. Clausen, J. J. Holst, S. L. Nielsen, J. F. Rehfeld, O. Schaffalitzky De Muckadell
Clin Sci Mol Med (1977) 53 (5): 411–418.
Published: 01 November 1977
... was highly sensitive to load, but was also regulated by the concentration of hepatic venous glucagon. The uptake of pyruvate was high in exercising diabetic subjects, who had a high lactate/pyruvate concentration ratio in hepatic venous blood. 3. The rate of uptake of the total measured gluconeogenic...
Clin Sci Mol Med (1976) 51 (3): 281–285.
Published: 01 September 1976
...A. Caniggia; C. Gennari; A. Vattimo; P. Nardi; R. Nuti 1. The effect of calcitonin, a large amount of calcium given orally, pentagastrin and glucagon on plasma 47 Ca radioactivity curves in subjects pretreated with 47 Ca was examined. 2. A sudden increase of plasma radioactivity after intravenous...
Clin Sci Mol Med (1976) 50 (6): 487–491.
Published: 01 June 1976
...K. Siddle; C. J. Davies; K. J. Shetty; R. S. Elkeles 1. The action of insulin on plasma cyclic nucleotide concentrations in normal human subjects has been studied after intravenous injection, alone and in combination with glucagon. 2. After injection of insulin alone there was an initial small...
Clin Sci Mol Med (1975) 48 (s2): 31s–32s.
Published: 01 January 1975
... isoprenaline-induced and glucagon-induced stimulation of renin secretion. © 1975 The Biochemical Society and the Medical Research Society 1975 calcium flux glucagon isoprenaline kidney lanthanum noradrenaline renin Clinical Science and Molecular Medicine (1975) 48, 31 s-32s. Blockade of renin...
Clin Sci Mol Med (1975) 48 (1): 27–31.
Published: 01 January 1975
...R. S. Elkeles; J. H. Lazarus; K. Siddle; A. K. Campbell 1. The plasma adenosine 3′:5′-cyclic monophosphate (cyclic AMP) response to intravenously administered glucagon has been studied in nine hyperthyroid, five hypothyroid and ten euthyroid patients. 2. Concentrations of the nucleotide rose...
Clin Sci Mol Med (1974) 46 (1): 125–129.
Published: 01 January 1974
...W. M. O. Moore; B. S. Ward; C. Gordon 1. The permeability of human chorion laeve in vitro to 125 I-labelled glucagon was investigated. The problem caused by degradation of 125 I-labelled glucagon in the preparation and a means to prevent this are described. 2. The human chorion laeve was found...