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Keywords: glucocorticoids
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Clin Sci (Lond) (2024) 138 (7): 435–487.
Published: 04 April 2024
... treatment for ALD and sepsis. Glucocorticoids are the most potent anti-inflammatory drugs. MAFLD patients often have a subtle chronic activation of the hypothalamic pituitary adrenal axis leading to a state of subclinical hypercortisolism [ 615 ]. Patients with sAH have higher blood levels of cortisol...
Clin Sci (Lond) (2018) 132 (14): 1529–1543.
Published: 31 July 2018
...Simona Ronchetti; Graziella Migliorati; Stefano Bruscoli; Carlo Riccardi An established body of knowledge and clinical practice has argued in favor of the use of glucocorticoids in various chronic inflammatory and autoimmune diseases. However, the very well-known adverse effects associated...
Clin Sci (Lond) (2017) 131 (12): 1329–1342.
Published: 07 June 2017
... The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 fatty acids glucocorticoids glucose glutamine inflammasomes inflammation insulin lipids macrophages thyroid hormones Figure 2 Glucose, glutamine and palmitic acid metabolism and association...
Clin Sci (Lond) (2015) 129 (5): 405–414.
Published: 11 June 2015
...Camilla Kappe; Liselotte Fransson; Petra Wolbert; Henrik Ortsäter Evidence indicates that subtle abnormalities in GC (glucocorticoid) plasma concentrations and/or in tissue sensitivity to GCs are important in the metabolic syndrome, and it is generally agreed that GCs induce insulin resistance...
Includes: Supplementary data
Clin Sci (Lond) (2004) 107 (2): 111–123.
Published: 27 July 2004
...Mark S. COOPER Glucocorticoids are used widely in a range of medical specialities, but their main limitation is an adverse impact on bone. Although physicians are increasingly aware of these deleterious effects, the marked variation in susceptibility between individuals makes it difficult...
Clin Sci (Lond) (2002) 103 (4): 425–431.
Published: 09 September 2002
...Colin A.J. FARQUHARSON; Allan D. STRUTHERS Experimental studies have suggested a role for aldosterone and glucocorticoids in the pathogenesis of endothelial dysfunction. We therefore set out to characterize the acute effects of these hormones on vascular function in vivo in normal humans...
Clin Sci (Lond) (2001) 100 (4): 451–457.
Published: 20 March 2001
...Anita ZETTERLUND; Paul HJEMDAHL; Kjell LARSSON In vitro studies suggest that glucocorticoids may counteract β-agonist-induced desensitization of β-adrenoceptors by actions at the transcriptional level, but the clinical relevance of such findings is not clear. Oral terbutaline treatment decreases β...
Clin Sci (Lond) (1996) 91 (5): 607–615.
Published: 01 November 1996
... was significant only in male animals. Post-natal growth of male rats exposed to low-protein diets was accelerated, but kidneys were small in relation to body weight. 4. Biochemical indices of glucocorticoid action in liver, hippocampus, hypothalamus and lung were elevated in rats exposed to low-protein diets...
Clin Sci (Lond) (1993) 85 (2): 237–244.
Published: 01 August 1993
... demonstrated in either β 1 - or β 2 -adrenoceptor mRNA levels. 4. Thus, glucocorticoids selectively increase β 2 -adrenoceptor density and function in patients with asthma, studied by using subcutaneous fat cells as an experimental model. 13 4 1993 23 4 1993 © 1993 The Biochemical Society...
Clin Sci (Lond) (1991) 81 (1): 37–42.
Published: 01 July 1991
... that glucocorticoid administration enhances the rates of production of glutamine and alanine from lungs of rats (both in vitro and in vivo ). This may be due to changes in efflux and/or increased intracellular biosynthesis of glutamine and alanine. 19 12 1990 21 1 1991 © 1991 The Biochemical Society...
Clin Sci (Lond) (1990) 79 (2): 139–147.
Published: 01 August 1990
...–34%), but there was no change in that of glutaminase, in muscles of dexamethasone-treated rats. 7. It is concluded that glucocorticoid administration enhances the rates of release of both glutamine and alanine from skeletal muscle of rats (both in vitro and in vivo ). This may be due to changes...
Clin Sci (Lond) (1988) 75 (1): 93–100.
Published: 01 July 1988
...) in intestinal mucosal scrapings of dexamethasone-treated rats, whereas the activity of glutaminase was increased (35%, P < 0.001). 6. It is concluded that glucocorticoid administration decreases the rate of glucose utilization but increases that of glutamine (both in vivo and in vitro ) by the epithelial...
Clin Sci (Lond) (1987) 72 (3): 329–334.
Published: 01 March 1987
...-dihydroxyvitamin D: sensitivity to glucocorticoid treatment S. ADAMI, G. GRAZIANI*, D. TARTAROTTI, R. CAPPELLI, S. CASATI*, A. CANTALUPPI*, V. BRAGA AND V. L o CASCIO Istititto di Semeiotica Medica, University of Verona, Verona, and * Divisione di Nefrologia e Dialisi, Pad. Crofi Ospedale Maggiore, Milano, Italy...
Clin Sci (Lond) (1985) 68 (6): 681–685.
Published: 01 June 1985
... ± 55 ng/day. Collagen-induced platelet thromboxane formation and aggregation were not altered. 3. These results suggest that glucocorticoids do not regulate renal, platelet or total body prostanoid formation in healthy man. 23 11 1984 18 12 1984 © 1985 The Biochemical Society...
Clin Sci (Lond) (1982) 63 (s8): 105s–108s.
Published: 01 October 1982
...R. E. Chatelain; F. M. Bumpus; P. M. Dibello; C. M. Ferrario 1. Changes in plasma glucocorticoid levels and the alterations they imposed upon the lymphoid system and vascular hypertrophy were studied in rats developing either the benign or malignant forms of hypertension during the initial 30 days...
Clin Sci (Lond) (1982) 62 (2): 215–220.
Published: 01 February 1982
...P. Heyma; R. G. Larkins 1. The effect of glucocorticoids on the deiodination of thyroxine (T 4 ) to 3,5,3′-tri-iodothyronine (T 3 ) was studied in rat renal tubules prepared by collagenase digestion. 2. In short-term (6 h) experiments, cortisol and dexamethasone inhibited the conversion of T 4...
Clin Sci (Lond) (1981) 61 (2): 129–133.
Published: 01 August 1981
...D. N. Brindley © 1981 The Biochemical Society and the Medical Research Society 1981 atherosclerosis diabetes diet ethanol fatty liver fructose glucocorticoids insulin lipid metabolism lipoprotein lipase lipoproteins obesity l-α-phosphatidate phosphohydrolase sorbitol stress...
Clin Sci Mol Med (1973) 45 (s1): 295s–299s.
Published: 01 August 1973
...L. R. Krakoff; M. Mendlowitz 1. Plasma renin activity and plasma renin substrate were measured by radioimmunoassay of generated angiotensin I in patients with steroid excess syndromes. Significant increases in substrate were observed in patients with Cushing's syndrome, during glucocorticoid...