..., induces the browning of white adipose tissue, but its effects on gluconeogenesis and glycogenesis are unknown. In the present study, we investigated the effects and underlying mechanisms of irisin on gluconeogenesis and glycogenesis in hepatocytes with insulin resistance, and its therapeutic role in type...

...Qian Wang; Ning Wang; Mei Dong; Fang Chen; Zhong Li; Yuanyuan Chen GdCl 3 (gadolinium chloride) has been shown to reduce blood glucose; however, the underlying mechanism remains unclear. Liver gluconeogenesis is an important pathway involved in the maintenance of glucose homoeostasis. The aim...

...Samina KHANI; John A. TAYEK Android obesity is associated with increased cortisol secretion. Direct effects of cortisol on gluconeogenesis and other parameters of insulin resistance were determined in normal subjects. Gluconeogenesis was determined using the reciprocal pool model of Haymond...

...H. J. AGTERESCH; S. LEIJ-HALFWERK; J. W. O. VAN DEN BERG; C. H. HORDIJK-LUIJK; J. H. P. WILSON; P. C. DAGNELIE Cancer cachexia is associated with elevated lipolysis, proteolysis and gluconeogenesis. ATP infusion has been found to significantly inhibit loss of body weight, fat mass and fat-free mass...

...) spectroscopy, reflect elevated whole-body glucose turnover and gluconeogenesis from alanine. Patients with advanced non-small-cell lung cancer without liver metastases ( n = 24; weight loss 0–24%) and healthy control subjects ( n = 13) were studied after an overnight fast. 31 P MR spectra of the liver in vivo...

... human studies that glucocorticoids make an important contribution to the pathophysiology of insulin resistance in the population. adipose tissue glucocorticoid hormones glucocorticoid receptors gluconeogenesis hydroxysteroid dehydrogenases insulin 51398/0388 Clinical Science (1999) 96...

... to consistent changes in the 31 P n.m.r. spectra of the human liver owing to increased concentrations of gluconeogenic intermediates. The ‘n.m.r.-alanine test’ may constitute a useful tool for studies of gluconeogenesis and hepatic biochemical pathology in vivo. 16 4 1992 22 4 1992 © 1992...

...S. Pukrittayakamee; N.J. White; T. M. E. Davis; S. Looareesuwan; W. Supanaranond; V. Desakorn; B. Chaivisuth; D. H. Williamson 1. Hypoglycaemia and lactic acidosis are important manifestations of severe falciparum malaria. To investigate hepatic gluconeogenesis in acute falciparum malaria, liver...

...Jeff Arnold; Marcus J. Hamer; Miles Irving 1. In sepsis various processes of carbohydrate metabolism, such as hepatic gluconeogenesis and glycolysis, are altered. Phosphofructokinase-1, a key glycolytic enzyme, is controlled in the long term via regulation of synthesis and degradation...

...Paulo R.L. De Vasconcelos; Michael G. W. Kettlewell; Dermot H. Williamson 1. The time course (12, 24 and 48 h) of changes in blood metabolites, and in gluconeogenesis and ketogenesis, in isolated hepatocytes from rats made septic by caecal ligation and puncture was measured. 2. Blood glucose...

... exercise gluconeogenesis hepatic lactate metabolism shock © 1981 The Biochemical Society and the Medical Research Society 1981 3 7 1980 3 11 1980 1 12 1980 Clinical Science (1981) 60, 537-542 The effect of combined ischaemia and acidosis on lactate uptake and gluconeogenesis...

...B. Ross; Patricio Silva; Sarah Bullock 1. Experiments were designed to establish the relationship between renal gluconeogenesis and sodium transport. Six inhibitors of gluconeogenesis, with different sites of action, were tested in the isolated perfused rat kidney in which renal function...

... 1980 alanine gluconeogenesis lactate phenformin Clinical Science (1980) 58,153-155 Correlation of plasma phenformin concentration with metabolic effects in normal subjects M. NATTRASS., K A R E N S I Z E R A N D K. G. M. M. ALBERT1 Faculty of Medicine, Chemical Pathologv and Human Metabolism...

.... 2. When the perfusate lactate concentration is above 1.5 mmol/l respiratory acidosis (simulated by high perfusate P co 2 ) inhibits gluconeogenesis from lactate, whereas respiratory alkalosis stimulates gluconeogenesis. 3. In general there were significant positive correlations between intracellular...

...J. D. Tange; B. D. Ross; J. G. G. Ledingham 1. The metabolic effects of p -aminophenol have been compared with those of paracetamol and other analgesics in studies of rat liver and kidney in vitro. 2. p -Aminophenol injected into rats inhibited gluconeogenesis from lactate in renal cortical tubules...

... with the highest concentrations of glucagon in hepatic venous blood. 5. The observed antiketogenic effect of exercise was due to a decreased load of NEFA, mainly caused by a decrease in the hepatic blood flow. Clinical Science and Molecular Medicine (1977) 53, 41 1-418. Regulation of gluconeogenesis...

...B. D. Ross 1. Gluconeogenesis from lactate or from glutamine is inhibited by 90–100% by sodium quinolinate (1 mmol/l) or 3-mercaptopicolinate (150 nmol/l) in the perfused rat kidney. l-Tryptophan is not metabolized and is without effect. 2. Lactate uptake and glucose production are inhibited...

... and the Medical Research Society 1976 acidosis gluconeogenesis kidney lactate Clinical Science and Molecular Medicine (1976) 50, 185-194. The effect of acidosis on lactate removal by the perfused rat kidney J. YUDKIN A N D R. D. COHEN The Metabolic and Endocrine and Medical Units, The London Hospital...