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Keywords: glucose metabolism
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Articles

Maternal voluntary wheel running modulates glucose homeostasis, the gut microbiota and its derived fecal metabolites in offspring

In Collection
Reproductive Physiology and Disease
Ling Zhang, Wenyu Zou, Yongyan Hu, Honghua Wu, Ying Gao, Junqing Zhang, Jia Zheng
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1151–1166.
https://doi.org/10.1042/CS20230372
Published: 09 August 2023
...Ling Zhang; Wenyu Zou; Yongyan Hu; Honghua Wu; Ying Gao; Junqing Zhang; Jia Zheng Maternal overnutrition can dramatically increase the susceptibility of offspring to metabolic diseases, whereas maternal exercise may improve glucose metabolism in offspring. However, the underlying mechanism...
View article titled, Maternal voluntary wheel running modulates glucose homeostasis, the gut microbiota and its derived fecal metabolites in offspring
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Includes: Supplementary data
Articles

AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle

Miao Chen, Caoyu Ji, Qingchen Yang, Shuya Gao, Yue Peng, Zhe Li, Xingyu Gao, Yaoting Li, Nan Jiang, Yubin Zhang, Xiaohong Bian, Caiping Chen, Kaidi Zhang, Daniel Sanchis, Fangrong Yan, Junmei Ye
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2381–2398.
https://doi.org/10.1042/CS20191320
Published: 16 September 2020
... to insulin stimulation compared with WT mice. Our study establishes a new and important function of AKT2 in regulating skeletal muscle development and glucose metabolism via AMPK-dependent signaling. The embedded muscle tissue was sectioned and stained with uranium lead double staining (2% uranyl...
View article titled, AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle
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Includes: Supplementary data
Articles

Lactate kinetics and mitochondrial respiration in skeletal muscle of healthy humans under influence of adrenaline

Jonathan Grip, Towe Jakobsson, Christina Hebert, Maria Klaude, Gustaf Sandström, Jan Wernerman, Olav Rooyackers
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (4): 375–384.
https://doi.org/10.1042/CS20140448
Published: 27 May 2015
... of the study were (1) to evaluate the three-compartment model for muscle lactate turnover in humans, and (2) to study the effects of adrenaline on human muscle lactate turnover in relation to substrate metabolism. For the second aim, measures of glucose metabolism and mitochondrial function were also included...
View article titled, Lactate kinetics and mitochondrial respiration in skeletal muscle of healthy humans under influence of adrenaline
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Articles

Diabetes mellitus at the time of diagnosis ofcirrhosis is associated with higher incidence of spontaneous bacterial peritonitis, but not with increased mortality

Nick Wlazlo, Marleen M. van Greevenbroek, Joyce Curvers, Erik J. Schoon, Pieter Friederich, Jos W. R. Twisk, Bert Bravenboer, Coen D. A. Stehouwer
Journal: Clinical Science
Clin Sci (Lond) (2013) 125 (7): 341–348.
https://doi.org/10.1042/CS20120596
Published: 07 June 2013
... risk factors for DM, such as age, obesity, or a family history of DM [ 3 ]. chronic liver disease diabetes glucose metabolism infections prognosis survival The prognostic impact of DM in patients with cirrhosis is currently unclear, although some studies have suggested that DM may...
View article titled, Diabetes mellitus at the time of diagnosis ofcirrhosis is associated with higher incidence of spontaneous bacterial peritonitis, but not with increased mortality
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Articles

Protein restriction during gestation and/or lactation causes adverse transgenerational effects on biometry and glucose metabolism in F1 and F2 progenies of rats

Alessandra R. Pinheiro, Isadora D. M. Salvucci, Marcia B. Aguila, Carlos A. Mandarim-de-Lacerda
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (5): 381–392.
https://doi.org/10.1042/CS20070302
Published: 01 February 2008
... born with low birthweight, but afterwards they had catch-up growth, reaching the weight of the CC1 offspring. The increased glycaemia in RC1 offspring was associated with insulin resistance. CR1 and RR1 offspring had impaired growth with no changes in glucose metabolism. RC2 offspring had high BM (body...
View article titled, Protein restriction during gestation and&#x2F;or lactation causes adverse transgenerational effects on biometry and <span class="search-highlight">glucose</span> <span class="search-highlight">metabolism</span> in F1 and F2 progenies of rats
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Articles

Life and death decisions of the pancreatic β-cell: the role of fatty acids

Philip Newsholme, Deirdre Keane, Hannah J. Welters, Noel G. Morgan
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (1): 27–42.
https://doi.org/10.1042/CS20060115
Published: 01 December 2006
... The Biochemical Society 2007 acetyl-CoA apoptosis fatty acid toxicity glucose metabolism insulin secretion non-esterified fatty acid (NEFA) pancreatic β-cell In writing this review, we are fully aware that most of the studies cited have utilized rat-, mouse- or hamster-derived insulinoma β...
View article titled, Life and death decisions of the pancreatic β-cell: the role of fatty acids
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Articles

Intravenous hydration with a 2.5% glucose solution in Type II diabetes

Fredrik Sjöstrand, Thomas Nyström, Robert G. Hahn
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (2): 127–134.
https://doi.org/10.1042/CS20050361
Published: 13 July 2006
[email protected] ). glucose metabolism haemodilution hydration pharmacokinetics Type II diabetes volume kinetics As many as 30–40% of geriatric patients are undernourished and probably also dehydrated when admitted to hospital, and approx. 50% of the residents in nursing homes suffer from the same...
View article titled, Intravenous hydration with a 2.5% glucose solution in Type II diabetes
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Articles

Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle

Luc J. C. VAN LOON, Robyn MURPHY, Audrey M. OOSTERLAAR, David CAMERON-SMITH, Mark HARGREAVES, Anton J. M. WAGENMAKERS, Rodney SNOW
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (1): 99–106.
https://doi.org/10.1042/CS20030116
Published: 01 January 2004
...Luc J. C. VAN LOON; Robyn MURPHY; Audrey M. OOSTERLAAR; David CAMERON-SMITH; Mark HARGREAVES; Anton J. M. WAGENMAKERS; Rodney SNOW It has been speculated that creatine supplementation affects muscle glucose metabolism in humans by increasing muscle glycogen storage and up-regulating GLUT-4 protein...
View article titled, Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle
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Articles

Aspects of organ protein, amino acid and glucose metabolism in a porcine model of hypermetabolic sepsis

Maaike J. BRUINS, Nicolaas E.P. DEUTZ, Peter B. SOETERS
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (2): 127–141.
https://doi.org/10.1042/cs1040127
Published: 10 January 2003
... acid and glucose metabolism in a porcine model of compensated hyperdynamic sepsis. Fasting catheterized pigs received endotoxin ( Escherichia coli lipopolysaccharide; 3 µ g·h -1 ·kg -1 ; intravenous) or saline (controls) and volume resuscitation over 24h to reproduce hyperdynamic sepsis. Primed...
View article titled, Aspects of organ protein, amino acid and <span class="search-highlight">glucose</span> <span class="search-highlight">metabolism</span> in a porcine model of hypermetabolic sepsis
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Articles

Endothelin-stimulated glucose uptake: effects of intracellular Ca 2+ , cAMP and glucosamine

Jinshyun R. WU-WONG, Cathleen E. BERG, Brian D. DAYTON
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 418S–423S.
https://doi.org/10.1042/CS103S418S
Published: 01 September 2002
.... INTRODUCTION Glucose metabolism plays a pivotal role in maintaining the normal function of various cells and tissues [1]. Glucose transport into cells is the rate-limiting step in glucose metabolism. Among the six known facilitative glucose transporters (GLUT1 5 and GLUT7) [2], GLUT1 and GLUT4 are expressed...
View article titled, Endothelin-stimulated glucose uptake: effects of intracellular Ca 2+ , cAMP and glucosamine
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Articles

Glucose flux is normalized by compensatory hyperinsulinaemia in growth hormone-induced insulin resistance in healthy subjects, while skeletal muscle protein synthesis remains unchanged

Jonas NYGREN, Anders THORELL, Kerstin BRISMAR, Pia ESSÉN, Jan WERNERMAN, Margaret A. MCNURLAN, Peter J. GARLICK, Olle LJUNGQVIST
Journal: Clinical Science
Clin Sci (Lond) (2002) 102 (4): 457–464.
https://doi.org/10.1042/cs1020457
Published: 18 March 2002
... remained unchanged. The nitrogen retention accompanying GH treatment seems to be due largely to improved nitrogen balance in non-muscle tissue. Key words: glucose clamp technique, glucose metabolism, growth hormone, insulin resistance, protein metabolism. Abbreviations: GH, growth hormone; IGF, insulin...
View article titled, Glucose flux is normalized by compensatory hyperinsulinaemia in growth hormone-induced insulin resistance in healthy subjects, while skeletal muscle protein synthesis remains unchanged
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Articles

The hyperinsulinaemic–euglycaemic glucose clamp: reproducibility and metabolic effects of prolonged insulin infusion in healthy subjects

Mattias SOOP, Jonas NYGREN, Kerstin BRISMAR, Anders THORELL, Olle LJUNGQVIST
Journal: Clinical Science
Clin Sci (Lond) (2000) 98 (4): 367–374.
https://doi.org/10.1042/cs0980367
Published: 24 February 2000
... Society © 2000 2000 glucose clamp technique glucose metabolism glucose tracers reproducibility 367Clinical Science (2000) 98, 367 374 (Printed in Great Britain) The hyperinsulinaemic euglycaemic glucose clamp: reproducibility and metabolic effects of prolonged insulin infusion in healthy...
View article titled, The hyperinsulinaemic–euglycaemic glucose clamp: reproducibility and metabolic effects of prolonged insulin infusion in healthy subjects
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Articles

Increased phosphoglycerate kinase in the brains of patients with Down's syndrome but not with Alzheimer's disease

Olga LABUDOVA, Erwin KITZMUELLER, Hermann RINK, Nigel CAIRNS, Gert LUBEC
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (3): 279–285.
https://doi.org/10.1042/cs0960279
Published: 01 March 1999
...Olga LABUDOVA; Erwin KITZMUELLER; Hermann RINK; Nigel CAIRNS; Gert LUBEC Impaired glucose metabolism in Down's syndrome (DS) has been well-documented in vivo , although information on the underlying biochemical defect is limited and no biochemical studies on glucose handling enzymes have been...
View article titled, Increased phosphoglycerate kinase in the brains of patients with Down's syndrome but not with Alzheimer's disease
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Articles

Lipolysis and Lactate Production in Human Skeletal Muscle and Adipose Tissue following Glucose Ingestion

Daniëlle A. J. M. Kerckhoffs, Peter Arner, Jan Bolinder
Journal: Clinical Science
Clin Sci (Lond) (1998) 94 (1): 71–77.
https://doi.org/10.1042/cs0940071
Published: 01 January 1998
... muscle: development and a p p l i i of the m i c d i s ethand technique. Ph.D. Thesis. Stockholm: Repro Print AB, 1995: pp 1-67. 3 9 1997 22 9 1997 blood flow glucose metabolism insulin lipid mobilization microdialysis ...
View article titled, Lipolysis and Lactate Production in Human Skeletal Muscle and Adipose Tissue following Glucose Ingestion
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Articles

Site of Insulin Resistance after Surgery: The Contribution of Hypocaloric Nutrition and Bed Rest

Jonas Nygren, Anders Thorell, Suad Efendic, K. Sree Nair, Olle Ljungqvist
Journal: Clinical Science
Clin Sci (Lond) (1997) 93 (2): 137–146.
https://doi.org/10.1042/cs0930137
Published: 01 August 1997
... on endogenous glucose production. 7 3 1997 27 3 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 fasting glucose clamp technique glucose metabolism insulin resistance stable isotopes Clinical Science (1997) 93, 137-146 (Printed in Great Britain) Site...
View article titled, Site of Insulin Resistance after Surgery: The Contribution of Hypocaloric Nutrition and Bed Rest
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Articles

Acute Effects of Central Neuropeptide Y Injection on Glucose Metabolism in Fasted Rats

J. P. H. Wilding, Y. T. Kruszynska, P. D. Lambert, S. R. Bloom
Journal: Clinical Science
Clin Sci (Lond) (1995) 89 (5): 543–548.
https://doi.org/10.1042/cs0890543
Published: 01 November 1995
...J. P. H. Wilding; Y. T. Kruszynska; P. D. Lambert; S. R. Bloom 1. Neuropeptide Y is a potent appetite stimulant and has been found to modulate glucose metabolism when given chronically. The acute effects of neuropeptide on peripheral glucose handling have not been studied in detail. We have studied...
View article titled, Acute Effects of Central Neuropeptide Y Injection on <span class="search-highlight">Glucose</span> <span class="search-highlight">Metabolism</span> in Fasted Rats
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Articles

Comparison of Intraperitoneal and Subcutaneous Insulin Administration on Insulin Sensitivity and Serum Lipids in Type I Diabetic Patients on Continuous Ambulatory Peritoneal Dialysis Treatment

Jorma T. Lahtela, Jukka Mustonen, Amos Pasternack
Journal: Clinical Science
Clin Sci (Lond) (1995) 88 (4): 427–432.
https://doi.org/10.1042/cs0880427
Published: 01 April 1995
... 11 1994 5 1 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 continuous ambulatory peritoneal dialysis diabetes mellitus glucose metabolism intraperitoneal insulin insulin action insulin sensitivity serum lipids subcutaneous insulin Clinical...
View article titled, Comparison of Intraperitoneal and Subcutaneous Insulin Administration on Insulin Sensitivity and Serum Lipids in Type I Diabetic Patients on Continuous Ambulatory Peritoneal Dialysis Treatment
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Articles

Indomethacin Stimulates Basal Glucose Production in Humans without Changes in Concentrations of Glucoregulatory Hormones

E. P. M. Corssmit, J. A. Romijn, E. Endert, H. P. Sauerwein
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (6): 679–685.
https://doi.org/10.1042/cs0850679
Published: 01 December 1993
... and the Medical Research Society 1993 cytokines glucose metabolism prostaglandins Clinical Science (1993) 85, 679-685 (Printed in Great Britain) lndomethacin stimulates basal glucose production in humans without changes in concentrations of glucoregulatory hormones E. P. M. CORSSMIT', J. A. ROMIJN's* E...
View article titled, Indomethacin Stimulates Basal Glucose Production in Humans without Changes in Concentrations of Glucoregulatory Hormones
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Articles

Non-insulin-mediated glucose uptake in human immunodeficiency virus-infected men

R. Heyligenberg, J. A. Romijn, M. J. T. Hommes, E. Endert, J. K. M. Eeftinck Schattenkerk, H. P. Sauerwein
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (2): 209–216.
https://doi.org/10.1042/cs0840209
Published: 01 February 1993
... by a real increase in insulin sensitivity and not by augmented non-insulin-mediated glucose uptake. 4 9 1992 18 9 1992 © 1993 The Biochemical Society and the Medical Research Society 1993 acquired immunodeficiency syndrome glucose metabolism insulin sensitivity isotope dilution...
View article titled, Non-insulin-mediated glucose uptake in human immunodeficiency virus-infected men
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Articles

Dose-response relationships for the effects of insulin on glucose and fat metabolism in injured patients and control subjects

Alistair A. Henderson, Keith N. Frayn, Charles S. B. Galasko, Roderick A. Little
Journal: Clinical Science
Clin Sci (Lond) (1991) 80 (1): 25–32.
https://doi.org/10.1042/cs0800025
Published: 01 January 1991
...-regulatory’ hormones. 13 7 1990 20 7 1990 © 1991 The Biochemical Society and the Medical Research Society 1991 carbohydrate oxidation energy production fat oxidation forearm glucose uptake glucose metabolism injury insulin Clinical Science (1991) 80,25-32 25 Dose-response...
View article titled, Dose-response relationships for the effects of insulin on glucose and fat metabolism in injured patients and control subjects
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Articles

Hepatic and Peripheral Insulin Action in Chronic Renal Failure before and during Continuous Ambulatory Peritoneal Dialysis

A. Heaton, R. Taylor, D. G. Johnston, M. K. Ward, R. Wilkinson, K. G. M. M. Alberti
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (4): 383–388.
https://doi.org/10.1042/cs0770383
Published: 01 October 1989
... during continuous ambulatory peritoneal dialysis, but hepatic insulin action was unchanged. 6 3 1989 20 3 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 chronic renal failure continuous ambulatory peritoneal dialysis glucose metabolism insulin action...
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Articles

Effects of Insulin on Glucose Metabolism in Skeletal Muscle from Septic and Endotoxaemic Rats

Brendan Leighton, George D. Dimitriadis, Mark Parry-Billings, Jane Bond, Paulo R. L. de Vasconcelos, Eric A. Newsholme
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (1): 61–67.
https://doi.org/10.1042/cs0770061
Published: 01 July 1989
...Brendan Leighton; George D. Dimitriadis; Mark Parry-Billings; Jane Bond; Paulo R. L. de Vasconcelos; Eric A. Newsholme 1. The effects of non-lethal bacteraemia or endotoxaemia on insulin-stimulated glucose metabolism were studied in isolated, incubated soleus muscle of rats after 24 and 48 h. 2...
View article titled, Effects of Insulin on <span class="search-highlight">Glucose</span> <span class="search-highlight">Metabolism</span> in Skeletal Muscle from Septic and Endotoxaemic Rats
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Articles

Assessment of Glucose Turnover in Normal Man with the Use of a Non-Radioactive Isotopically Labelled Preparation, [6,6- 2 H]Glucose, as Tracer

J. W. Haigh, D. G. Johnston, A. J. McCulloch, M. F. Laker, J. Welby, S. Evans
Journal: Clinical Science
Clin Sci (Lond) (1982) 63 (5): 437–440.
https://doi.org/10.1042/cs0630437
Published: 01 November 1982
... Research Society 1982 glucose kinetics glucose metabolism glucose turnover mass spectrometry stable isotopes tracer methodology Clinical Science (1982) 63,431440 437 Assessment of glucose turnover in normal man with the use of a non-radioactive isotopically labelled preparation, [6,6-2H...
View article titled, Assessment of Glucose Turnover in Normal Man with the Use of a Non-Radioactive Isotopically Labelled Preparation, [6,6- 2 H]Glucose, as Tracer
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Articles

Metabolic Effect and Uptake of [ 3 H]Digoxin in the Forearm of Man

R. I. Ogilvie, G. A. Klassen
Journal: Clinical Science
Clin Sci (1972) 42 (5): 567–577.
https://doi.org/10.1042/cs0420567
Published: 01 May 1972
...+ by forearm tissues. 4. This is the first demonstration of the stimulatory effects of digoxin on glucose metabolism, the antilipolytic effects of this drug and its effect on Ca 2+ fluxes in vivo in man. 27 9 1971 © 1972 The Biochemical Society and the Medical Research Society 1972 forearm...
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Articles

Effects of Uraemic Serum, Urea, Creatinine and Methylguanidine on Glucose Metabolism

P. L. Balestri, P. Rindi, M. Biagini, S. Giovannetti
Journal: Clinical Science
Clin Sci (1972) 42 (4): 395–404.
https://doi.org/10.1042/cs0420395
Published: 01 April 1972
... creatinine methylguanidine glucose metabolism Clinical Science (1972) 42, 395401. EFFECTS O F URAEMIC S E R U M , U R E A , CREATININE A N D M E T H Y L G U A N I D I N E O N GLUCOSE METABOLISM P. L. BALESTRI, P. RINDI , M. BIAGINI AND S. GIOVANNETTI Divisione Nefrologica, Ospedali S. Chiara, Pisa...
View article titled, Effects of Uraemic Serum, Urea, Creatinine and Methylguanidine on <span class="search-highlight">Glucose</span> <span class="search-highlight">Metabolism</span>
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