...Maria E. Muñoz; Alejandro Esteller; Javier González 1. The effect of high bilirubin loads (60 μmol/kg twice daily for 2 days) on glucuronosyltransferase activity and biliary excretion of bilirubin was studied in Wistar rats. 2. The concentration of bilirubin in serum increased from 1.1 μmol/l...

... rats. As similar changes have been observed in Gilbert's syndrome, heterozygous Gunn rats can be used as a model for this disorder. 2. Treatment for 2 weeks with phenobarbitone or glutethimide produced a 2.6- and a 1.3-fold increase in hepatic glucuronosyltransferase activity in Wistar and heterozygous...