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Keywords: glutathione
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Clin Sci (Lond) (2018) 132 (12): 1257–1280.
Published: 29 June 2018
...Percíllia V.S. Oliveira; Francisco R.M. Laurindo Thiol groups are crucially involved in signaling/homeostasis through oxidation, reduction, and disulphide exchange. The overall thiol pool is the resultant of several individual pools of small compounds (e.g. cysteine), peptides (e.g. glutathione...
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Clin Sci (Lond) (2012) 122 (12): 591–597.
Published: 05 March 2012
.... In addition to glutamine, glutathione may be a limiting factor in ICU patients with MOF (multiple organ failure). To study the prevalence of glutamine and glutathione depletion an observational study was performed. The results were analysed in relation to mortality and the conventional predictors of mortality...
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Clin Sci (Lond) (2009) 117 (9): 313–319.
Published: 01 September 2009
...Urban B. Fläring; Christina Hebert; Jan Wernerman; Folke Hammarqvist; Olav E. Rooyackers Patients with septic shock have high plasma glutathione concentrations, whereas intracellular concentrations in erythrocytes and muscle are low. In the present study, we investigated the temporal pattern...
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Clin Sci (Lond) (2007) 113 (7): 313–318.
Published: 03 September 2007
...Bo Westman; Lars Weidenhielm; Olav Rooyackers; Katarina Fredriksson; Jan Wernerman; Folke Hammarqvist The temporal pattern of metabolic alterations in muscle tissue during total ischaemia and reperfusion are not well-characterized in humans with respect to glutathione, amino acids and energy-rich...
Includes: Supplementary data
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Clin Sci (Lond) (2004) 106 (3): 235–237.
Published: 01 March 2004
... for disease progression from stable steatosis to steatohepatitis. Correspondence: Dr Isabelle Leclercq ( isabelle_leclercq@wmi.usyd.edu.au ). 7 11 2003 7 11 2003 7 11 2003 © 2004 The Biochemical Society 2004 antioxidant pathway glutathione non-alcoholic fatty liver disease...
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Clin Sci (Lond) (2003) 104 (3): 275–282.
Published: 14 February 2003
...U.B. FLÄRING; O.E. ROOYACKERS; J. WERNERMAN; F. HAMMARQVIST Glutathione is quantitatively the most important endogenous scavenger system. Glutathione depletion in skeletal muscle is pronounced following major trauma and sepsis in intensive care unit patients. Also, following elective surgery...
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Clin Sci (Lond) (2002) 103 (1): 53–57.
Published: 11 June 2002
...) were incubated with serum from 18 pre-eclamptic, 18 healthy pregnant and 18 healthy non-pregnant women for 24h. The levels of reduced glutathione (GSH) and lipid peroxides (LPOs) were measured in endothelial cell lysates. Measurement of malondialdehyde in combination with 4-hydroxyalkenals has been...
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Clin Sci (Lond) (2000) 99 (4): 315–320.
Published: 01 September 2000
... of glutathione, one of the antioxidant systems that plays a critical role in defence against oxidative stress. On the other hand, α-tocopherol may be decreased in liver diseases, and treatment with this vitamin reduces liver injury in CCl 4 -treated rats. Since there is a close relationship among the different...
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Clin Sci (Lond) (1996) 91 (2): 121–130.
Published: 01 August 1996
..., released from muscle, glucose derived from increased hepatic gluconeo- genesis of amino acids and oleic acid from lipolysis, are major nutrients for cells of the system [l2, 131. ~~ Key words: amino acids, antioxidants, cytokines. fats, glutathione, inflammation, interleukin, nutrition, tumour necrosis...
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Clin Sci (Lond) (1996) 90 (6): 517–523.
Published: 01 June 1996
...Takeshi Ishizaki; Youichi Kishi; Fumihiko Sasaki; Shingo Ameshima; Tsuguhiko Nakai; Susumu Miyabo 1. We hypothesized that probucol, an oral hypocholesterolaemic agent, can suppress the oxidant stress induced by acute tobacco smoke inhalation in rats. We determined lung tissue glutathione (reduced...
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Clin Sci (Lond) (1994) 87 (1): 21–29.
Published: 01 July 1994
... (21). The reduced glutathione concentrations in blood samples from the insulin-dependent and non-insulin-dependent diabetic patient groups were not different from the control group values ( P >0.05). 3. The activities of glyoxalase enzymes in erythrocytes were increased: glyoxalase I activity [mean...
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Clin Sci (Lond) (1992) 82 (6): 709–716.
Published: 01 June 1992
...M. Salleh; M. Ardawi 1. The hepatic metabolism of glutamine, alanine, ammonia, urea, glutathione and glucose was studied in rats made septic by caecal ligation and puncture and was compared with that in rats that had undergone sham operation (laparotomy). 2. Sepsis resulted in increases...
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Clin Sci (Lond) (1985) 69 (4): 383–393.
Published: 01 October 1985
... endoperoxides but not arachidonic acid into prostacyclin, and most probably is due to high concentrations of peroxides: it can be accelerated by H 2 O 2 or by interrupting the glutathione cycle, while it is delayed by reduced glutathione. 2. Incubation of exhausted rings in human plasma or in a plasma filtrate...
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Clin Sci (Lond) (1982) 62 (3): 279–283.
Published: 01 March 1982
...E. C. P. Shi; R. Fisher; Maeve McEvoy; Rebecca Vantol; Margaret Rose; J. M. Ham 1. Hepatic total glutathione (reduced plus oxidized) and oxidized glutathione levels were measured in operative wedge liver biopsy specimens obtained from 70 patients. 2. The effects on hepatic reduced glutathione (GSH...
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Clin Sci Mol Med (1975) 49 (5): 495–502.
Published: 01 November 1975
... into the liver and excretion into the bile. Impaired hepatic uptake of bromosulphthalein could also be demonstrated in man at doses of the drug within the therapeutic range. 3. In patients studied a smaller proportion of bromosulphthalein was retained in the plasma as the glutathione conjugate after an overdose...