..., triosephosphate isomerase. ( b ) Threonine catabolism via amino acetone. ( c ) Fragmentation of saccharide moiety of glycated proteins. ( d ) Metabolism of acetone in ketosis. CYP, cytochrome P450. Sources of formation of MG and major routes of metabolism are summarized in Figure 1 . MG is formed...

... in the presence of acrylamide. Albumin thiols and fructosamines, reflecting oxidized and glycation-induced changes in serum albumin respectively, were assessed. Structural changes in albumin were demonstrated by a significant decrease in fluorescence quenching in patients with T2DM, with patients treated with MET...

... protein glycation in diabetes has been linked to the development of diabetic vascular complications. Diabetes is also associated with impaired wound healing. In the present study, we investigated if prolonged exposure of rats to MG (50–75 mg/kg of body weight) induced impairment of wound healing...

.... In the present study, we investigated the effect of glycation and particularly that of human serum albumin on the activity of bile-salt-dependent lipase. In vitro , bile-salt-dependent lipase activity decreased in the presence of human serum albumin; however, this was less pronounced in the presence of glycated...

...E. Lamb; W. R. Cattell; A. Dawnay 1. Chronic use of hyperosmolar glucose solutions in continuous ambulatory peritoneal dialysis may cause glycation of peritoneal structural proteins which could contribute to membrane dysfunction and ultrafiltration failure. To determine whether glycation can occur...