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Clin Sci (Lond) (2004) 106 (5): 501–509.
Published: 01 May 2004
..., glycerol, lactate/pyruvate ratio, hydroxyl radicals and neuronal damage score were 42±3 mmHg, 33±3 mmHg, 9±3 mmHg, 109±20 BPU (blood perfusion units), 6±1 mmHg, 51±7 µmol/l, 24±3 µmol/l, 124±32, 694±22% of baseline and 2.25±0.05 respectively. In animals treated with 10% albumin immediately after the onset...
Clin Sci (Lond) (1996) 90 (6): 453–456.
Published: 01 June 1996
...Jaswinder S. Samra; Cate L. Ravell; Sarah L. Giles; Peter Arner; Keith N. Frayn 1. The suggestion that the interstitial glycerol concentration in both adipose tissue and skeletal muscle is around 3 mmol/l (Maggs DG, Jacob R, Rife F, et al. J Clin Invest 1995; 96: 370–7), rather than close to the...
Clin Sci (Lond) (1995) 88 (6): 681–686.
Published: 01 June 1995
... factor I versus insulin; not significant). Plasma palmitate, glycerol and triacylglycerol concentrations had decreased to a similar extent at the end of the infusions of both peptides at either dose. 3. The present results demonstrate that insulin-like growth factor I and insulin infused at doses which...
Clin Sci (Lond) (1994) 86 (2): 177–184.
Published: 01 February 1994
...A. Kurpad; K. Khan; A. G. Calder; S. Coppack; K. Frayn; I. MaCdonald; M. Elia 1. The effect of infusion of noradrenaline (0.42 μmol min −1 kg −1 ) on the exchange of non-esterified fatty acids, glycerol and other metabolites across subcutaneous abdominal adipose tissue was investigated in five...
Clin Sci (Lond) (1993) 84 (1): 99–104.
Published: 01 January 1993
...M. Elia; K. Khan; G. Calder; A. Kurpad 1. Whole-body kinetics and regional exchange of glycerol across forearm muscle were assessed in eight lean subjects by a combination of a tracer method (infusion of [ 2 H 5 ]glycerol) and arteriovenous catheterization. 2. During an apparent steady state, the...
Clin Sci (Lond) (1992) 83 (5): 597–605.
Published: 01 November 1992
... glycerol levels after meals but normal suppression of serum non-esterified fatty acid concentrations. The greatest differences in the profiles of serum lipids and lipid-related metabolites in cirrhotic patients and control subjects occurred at night. Whereas in control subjects, serum non-esterified fatty...
Clin Sci (Lond) (1992) 82 (1): 77–83.
Published: 01 January 1992
.../l throughout both infusions. 4. Compared with during the placebo infusion, the blood glucose concentration decreased ( P < 0.001), the plasma glycerol and free fatty acid concentrations increased by 150 and 225%, respectively (both P < 0.001), and the plasma potassium concentration decreased...
Alan A. Connacher, William M. Bennet, Roland T. Jung, Dennis M. Bier, Christopher C. T. Smith, Charles M. Scrimgeour, Michael J. Rennie
Clin Sci (Lond) (1991) 81 (5): 635–644.
Published: 01 November 1991
...Alan A. Connacher; William M. Bennet; Roland T. Jung; Dennis M. Bier; Christopher C. T. Smith; Charles M. Scrimgeour; Michael J. Rennie 1. Energy expenditure, plasma glucose and palmitate kinetics and leg glycerol release were determined simultaneously both before and during adrenaline infusion in...
Antonio López-Farré, Dulcenombre Gómez-Garre, Fernando Bernabeu, Santiago Ramón Y Cajal, Paloma Perez-Rodrigo, Pierre Braquet, José Miguel López-Novoa
Clin Sci (Lond) (1990) 79 (6): 551–558.
Published: 01 December 1990
... antagonists BN-52021 (1 mg/kg, intraperitoneally) and alprazolam (1 and 5 mg/kg, intraperitoneally) on the evolution of glomerular filtration and renal blood flow, in the experimental model of acute renal failure induced by the intramuscular injection of glycerol in rats. 2. We have also measured...
Clin Sci (Lond) (1990) 79 (2): 131–138.
Published: 01 August 1990
... infusion of adenosine. Arterial levels of glycerol were depressed by more than 50%, but those of glucose and pyruvate were unchanged. 6. In conclusion, exogenous adenosine caused a marked systemic vasodilatation, with different responsiveness in the investigated vascular beds. The vasodilatation occurred...
Clin Sci (Lond) (1990) 79 (1): 81–87.
Published: 01 July 1990
... occlusions. 3. The concentrations of glucose, lactate and glycerol, as well as blood gas variables, in arterial and femoral venous blood did not change during the study or decreased so slightly (pH and lactate) that the arteriovenous difference was not influenced. 4. We conclude that the blood flow of the...
Clin Sci (Lond) (1990) 79 (1): 89–95.
Published: 01 July 1990
... patients with chronic cardiac failure (71.8 ± 7.0 vs 54.1 ± 12.3%, P < 0.0005) and this was mirrored in a lower carbohydrate utilization (24.7 ± 6.5 vs 43.3 ± 12.1%, P < 0.0002). Levels of free fatty acids, glycerol and noradrenaline were greater in patients with chronic cardiac failure. 3. We...
Clin Sci (Lond) (1990) 78 (3): 273–281.
Published: 01 March 1990
...) dextrose (D-glucose) infusion and at the end of days 7 and 8 of each diet, were analysed for urea, glucose, lactate, triacylglycerols, fatty acids, glycerol, 3-hydroxybutyrate, insulin and glucagon. 3. The effect of increasing glucose intake was to increase nitrogen balance by 0.60 ± 0.25 ( sem ) mg/kJ. At...
Clin Sci (Lond) (1989) 77 (6): 663–670.
Published: 01 December 1989
... abdominal wall 2. Eight normal subjects were studied after an overnight fast, and for 120 min during infusion of insulin (mean arterialized plasma insulin 50–55 m-units/l) 3. During the insulin infusion, the arterialized and abdominal venous levels of both non-esterified fatty acids and glycerol fell, and...
Clin Sci (Lond) (1989) 77 (5): 535–539.
Published: 01 November 1989
...Jiann-Liang Chen; Yeou-Chih Wang; Jia-Yi Wang 1. The response of cerebral blood vessels to hyperosmolar agents in vivo remains controversial, and little is known about the effect of glycerol on cerebral vessels. In this study we investigated the cerebrovascular response to intravenous...
Clin Sci (Lond) (1989) 77 (2): 145–147.
Published: 01 August 1989
...Richard J. Barrett; David R. Taylor; Kathryn F. Wright 1. Studies were conducted to test the hypothesis that glycerol-induced acute renal failure in rats may be mediated by 5-hydroxytryptamine. 2. The tryptophan hydroxylase inhibitor, β-chlorophenylalanine, or saline was administered for 4 days...
Clin Sci (Lond) (1989) 76 (5): 509–516.
Published: 01 May 1989
... arterialized blood and in forearm muscle drainage. 3. Non-esterified fatty acid and glycerol concentrations in the abdominal wall drainage were high (three to four times the arterial level) after overnight fast. After glucose ingestion, arterial and abdominal venous levels fell and the arteriovenous...
Clin Sci (Lond) (1986) 70 (1): 23–29.
Published: 01 January 1986
...A. Heaton; M. K. Ward; D. G. Johnston; K. G. M. M. Alberti; D. N. S. Kerr 1. Six patients established on continuous ambulatory peritoneal dialysis entered a trial of treatment with dialysis fluid containing glycerol instead of glucose as the osmotic agent in an attempt to decrease the energy load...
Clin Sci (Lond) (1984) 67 (1): 121–130.
Published: 01 July 1984
...A. Heaton; M. K. Ward; D. G. Johnston; D. V. Nicholson; K. G. M. M. Alberti; D. N. S. Kerr 1. The use of glycerol as an osmotic agent in two different concentrations (92 mmol/l and 272 mmol/l) in peritoneal dialysis fluid was investigated over 3 days in six patients on continuous ambulatory...
Clin Sci (Lond) (1984) 66 (2): 179–186.
Published: 01 February 1984
...% above control level. 6. Plasma glucose and glycerol concentrations remained unchanged, and plasma non-esterified fatty acids, lactate and noradrenaline concentrations increased slightly but significantly. 7. Biopsies taken from the hot interscapular areas did not contain brown adipose tissue. 8. It is...
Clin Sci (Lond) (1983) 65 (3): 247–253.
Published: 01 September 1983
.... There was a small increase in arterial blood glucose concentration, and a decrease in blood alanine concentration during drug infusion. Blood lactate was not affected by phentolamine. The arterial concentrations of free fatty acids and glycerol increased, and the concentration of triglycerides decreased...
Clin Sci (Lond) (1982) 62 (2): 131–136.
Published: 01 February 1982
... substrates lactate and glycerol. 2. To determine whether the effect of non-selective β-adrenoceptor blockade on glucose recovery could be associated with diminished availability of gluconeogenic substrates, lactate and glycerol were infused during hypoglycaemia in four insulin-dependent diabetic patients...
Clin Sci (Lond) (1980) 59 (6): 469–478.
Published: 01 December 1980
... ), stearic acid (C 18:0 ), linoleic acid (C 18:2 ) and palmitoleic acid (C 16:1 ). 4. In contrast to the fall in palmitate turnover the increase in plasma glycerol was greater in heavy exercise (0.054–0.229 mmol/l) than in light exercise (0.053–0.094 mmol/l), suggesting that lipolysis was occurring which did...
Clin Sci (Lond) (1980) 59 (1): 19–27.
Published: 01 July 1980
...H. B. Stoner; K. N. Frayn; R. A. Little; C. J. Threlfall; D. W. Yates; R. N. Barton; D. F. Heath 1. Plasma concentrations of glucose, lactate, amino acids, non-esterified fatty acids, glycerol, ketone bodies, insulin and cortisol were measured in 43 elderly patients with hypothermia. In 15 of these...
Clin Sci (Lond) (1980) 58 (4): 337–340.
Published: 01 April 1980
...Elizabeth Craig; G. J. Cooney; A. G. Dawson 1. The metabolism of glycerol by isolated rat-kidney tubules was investigated. 2. Indomethacin, at a concentration of 0.1 mmol/l, markedly inhibited the utilization of glycerol and its conversion into glucose and CO 2 . 3. The glycerol 3-phosphate...
Clin Sci (Lond) (1979) 56 (6): 563–573.
Published: 01 June 1979
...H. B. Stoner; K. N. Frayn; R. N. Barton; C. J. Threlfall; R. A. Little 1. The plasma concentrations of glucose, lactate, amino acids, non-esterified fatty acids, glycerol, ketone bodies, ethanol, cortisol and insulin were measured in patients within a few hours of injury and before treatment. The...
Clin Sci Mol Med (1978) 55 (5): 505–507.
Published: 01 November 1978
...R. Werb; W. F. Clark; R. M. Lindsay; E. O. P. Jones; D. I. Turnbull; A. L. Linton 1. Acute renal failure was induced in female Sprague—Dawley rats by the subcutaneous injection of glycerol. 2. Four groups of rats were studied; all animals received a glycerol challenge. Group A (control) were sham...
Clin Sci Mol Med (1978) 54 (6): 615–620.
Published: 01 June 1978
... relationship in rats. 2. Endotoxin tolerance was induced by the administration of increasing doses of Escherichia coli 026 lipopolysaccharide. The severity of renal injury was assessed at various times after glycerol administration in endotoxin-tolerant and control animals. At 48 h, endotoxin-tolerant rats had...
Clin Sci Mol Med (1975) 48 (4): 247–257.
Published: 01 April 1975
... between patients and controls with regard to leg uptake of triglyceride or NEFA on either diet. On shifting from a fat-rich to a carbohydrate-rich diet, the control subjects showed reduced values for arterial NEFA and for NEFA turnover, accompanied by a lowered release of NEFA and glycerol from the leg...
Clin Sci Mol Med (1973) 45 (5): 677–690.
Published: 01 November 1973
... glucose there was a variable response. 2-Oxoglutarate, glutamate and glutamine concentrations from blood of fasting subjects, were significantly higher in acute hepatitis patients than controls. 4. There were no significant differences in blood ketones, glycerol and plasma free fatty acid concentrations...
Clin Sci (1972) 42 (5): 591–605.
Published: 01 May 1972
... initial insulin secretion in both hepatitis subjects and controls. 3. Fasting blood ketone bodies, blood glycerol, plasma triglycerides and free fatty acids were all significantly elevated in the patient group. Results were similar to those found in mild diabetes mellitus. 4. In two patients with a more...