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Keywords: glyoxalase
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Clin Sci (Lond) (2016) 130 (19): 1677–1696.
Published: 23 August 2016
... of protein and deoxyguanosine-derived imidazopurinones of DNA. These are formed non-oxidatively. The glyoxalase system provides an efficient and essential basal and stress-response-inducible enzymatic defence against dicarbonyl stress by the reduced glutathione-dependent metabolism of methylglyoxal...
Clin Sci (Lond) (2015) 128 (12): 839–861.
Published: 27 March 2015
.... MGO is mainly formed as a byproduct of glycolysis. Under physiological circumstances, MGO is detoxified by the glyoxalase system into D -lactate, with glyoxalase I (GLO1) as the key enzyme in the anti-glycation defence. New insights indicate that increased levels of MGO and the major MGO-derived AGE...
Clin Sci (Lond) (1996) 91 (5): 575–582.
Published: 01 November 1996
..., erythrocyte glyoxalase I activity correlated positively with methylglyoxal concentration. There was no similar correlation in diabetic patients. In insulin-dependent patients, methylglyoxal concentration correlated positively with duration of diabetes. 5. Glyoxal and methylglyoxal are detoxified...
Clin Sci (Lond) (1994) 87 (1): 21–29.
Published: 01 July 1994
...Antony C. McLellan; Paul J. Thornalley; Jonathan Benn; Peter H. Sonksen 1. The metabolism of methylglyoxal by the glyoxalase system may be linked to the development of diabetic complications. The glyoxalase system was characterized in blood samples from patients with insulin-dependent diabetes...