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Clin Sci (Lond) (2016) 130 (23): 2167–2180.
Published: 26 October 2016
... saturation point, crystals of uric acid, in the form of monosodium urate, emerge and can predispose an individual to gout, the commonest form of inflammatory arthritis in men aged over 40 years. XOR inhibitors are primarily used in the treatment of gout, reducing the formation of uric acid and thereby...
Clin Sci (Lond) (1984) 67 (2): 249–258.
Published: 01 August 1984
... gout Lesch-Nyhan syndrome lymphocytes mononuclear cells purine synthesis de novo purines renal failure urate uric acid Clinical Science (1984) 67, 249-258 249 The rate of purine synthesis de nova in blood mononuclear cells in vitro from patients with familial hyperuricaemic nephropathy KAY...
Clin Sci (Lond) (1982) 63 (5): 429–435.
Published: 01 November 1982
... was measured in lymphocytes obtained on several occasions both from control subjects and from patients with gout, particularly those who tended to overproduce urate as suggested by high values of urinary urate. 4. Lymphocytes obtained from each individual on different occasions showed considerable variations...
Clin Sci Mol Med (1978) 54 (6): 595–601.
Published: 01 June 1978
... -formyl glycinamide ribonucleotide when the subsequent reactions of the metabolic pathway were completely inhibited by the antibiotic azaserine. 2. Synthesis of 14 C-labelled N -formyl glycinamide ribonucleotide by lymphocytes was measured in healthy control subjects and patients with primary gout...
Clin Sci Mol Med (1974) 47 (6): 559–565.
Published: 01 December 1974
... was increased only in late pregnancy. 31 5 1974 © 1974 The Biochemical Society and the Medical Research Society 1974 gout pregnancy renal clearance urate Clinical Science and Molecular Medicine (1974) 47, 559-565. SERIAL STUDIES OF THE RENAL CLEARANCE OF URATE A N D INULIN D U R I N G...
Clin Sci Mol Med (1974) 46 (1): 37–47.
Published: 01 January 1974
... : purine synthesis, fasting, gout. At least two mechanisms appear to be operating either singly or in combination in the pro- duction of the hyperuricaemia which characterizes the gouty patient : renal under-excretion of urate and over-production of urate; the latter is consequent on an increased rate...