... saturation point, crystals of uric acid, in the form of monosodium urate, emerge and can predispose an individual to gout, the commonest form of inflammatory arthritis in men aged over 40 years. XOR inhibitors are primarily used in the treatment of gout, reducing the formation of uric acid and thereby...

... tubular net excretion of urate. Key words: familial hyperuricaemic nephropathy, gout, Lesch-Nyhan syndrome, lymphocytes, mono- nuclear cells, purine synthesis de novo, purines, renal failure, urate, uric acid. Abbreviations: APRT, adenine phosphoribosyltrans- ferase; HPRT, hypoxanthine phosphoribosyltrans...

... was measured in lymphocytes obtained on several occasions both from control subjects and from patients with gout, particularly those who tended to overproduce urate as suggested by high values of urinary urate. 4. Lymphocytes obtained from each individual on different occasions showed considerable variations...

... -formyl glycinamide ribonucleotide when the subsequent reactions of the metabolic pathway were completely inhibited by the antibiotic azaserine. 2. Synthesis of 14 C-labelled N -formyl glycinamide ribonucleotide by lymphocytes was measured in healthy control subjects and patients with primary gout...

... pregnancy. Key words : gout, pregnancy, renal clearance, urate. Gout is an uncommon disease in premenopausal women. Mean serum urate concentration is lower than in men of the same age (Mikkelsen, Dodge & Valkenberg, 1965) and this may be due to a higher renal clearance of urate in women (Wolfson, Krevshy...

... fast. 20 6 1973 © 1974 The Biochemical Society and the Medical Research Society 1974 purine synthesis fasting gout Clinical Science and Molecular Medicine (1974) 46, 31-47. THE EFFECT OF FASTING A N D FOOD O N THE RATE OF PURINE BIOSYNTHESIS DE N O V O I N THE RAT SPLEEN P. F...