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Keywords: growth factor
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Clin Sci (Lond) (2014) 127 (8): 539–548.
Published: 02 July 2014
... inhibited platelet-derived growth factor (PDGF)-BB-induced SMC proliferation and migration as determined by bromodeoxyuridine (BrdU) incorporation and a cell counting assay as well as a Boyden chamber assay respectively. DAPK3 siRNA or a pharmacological inhibitor of DAPK3 inhibited PDGF-BB-induced...
Clin Sci (Lond) (2012) 122 (2): 43–52.
Published: 20 September 2011
... of the disease. Numerous studies have shown the key role of the placenta in the pathogenesis of pre-eclampsia. A shift in the sFlt-1 (soluble Fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio is associated with the disease. Although pre-eclampsia seems to be a clearly defined disease, clinical...
Clin Sci (Lond) (2008) 115 (2): 43–55.
Published: 12 June 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 differentiation embryonic stem cell growth factor intracellular signalling self-renewal tyrosine kinase ES cells are pluripotent cell lines derived from the ICM (inner cell mass) of the blastocyst [ 1 , 2 ]. They are maintained...
Clin Sci (Lond) (2008) 114 (7): 467–477.
Published: 29 February 2008
..., increased intra-tumoral pressure and inhibition of the maturation of dendritic cells from haemopoietic progenitors, altering the host immune response [ 19 ]. Other growth factors are also able to stimulate angiogenesis. HGF binds to its tyrosine kinase receptor (met) and stimulates the same signalling...
Clin Sci (Lond) (2006) 111 (6): 401–409.
Published: 14 November 2006
...Rachel E. Wood; Brad E. Sanderson; Christopher D. Askew; Philip J. Walker; Simon Green; Ian B. Stewart Expansion of the capillary network, or angiogenesis, occurs following endurance training. This process, which is reliant on the presence of VEGF (vascular endothelial growth factor...
Clin Sci (Lond) (2006) 110 (2): 217–225.
Published: 17 January 2006
... acetylcholine endothelial function growth factor transgenic mouse vasodilation Acromegaly, characterized by excessive secretion of GH (growth hormone), is associated with cardiovascular disease [ 1 ]. Indeed, cardiovascular events are the most common cause of death in acromegalic patients [ 2 , 3...
Clin Sci (Lond) (2005) 108 (4): 293–308.
Published: 22 March 2005
... function even in the absence of physiological levels of circulating androgen. This review will focus on the role of growth factor signalling in prostate cancer progression to androgen independence and thus outline potential molecular areas of intervention to treat prostate cancer progression. androgen...
Clin Sci (Lond) (2005) 108 (1): 1–11.
Published: 15 December 2004
... androgen cancer therapy epithelial cell differentiation growth factor prostate cancer stem cell The incidence of prostate cancer has increased over the past decade and it is now the most common non-cutaneous malignancy in Europe and North America [ 1 ]. Radical prostatectomy and radiation...
Clin Sci (Lond) (2004) 107 (4): 343–354.
Published: 24 September 2004
... ). 17 3 2004 7 6 2004 1 7 2004 1 7 2004 The Biochemical Society 2004 apoptosis atherogenesis growth factor inflammation oxidative stress plaque rupture signalling pathway The arterial wall is composed of an innermost layer of endothelial cells resting on a thin...
Clin Sci (Lond) (2004) 106 (5): 439–442.
Published: 01 May 2004
...Yoshinori SEKO; Shuichi FUKUDA; Ryozo NAGAI Angiogenesis is controlled by anti-angiogenic factors as well as by angiogenic factors, such as VEGF (vascular endothelial growth factor) and HGF (hepatocyte growth factor). Endostatin, a potent endogenous angiogenesis inhibitor, is known to inhibit...
Clin Sci (Lond) (2003) 104 (3): 223–230.
Published: 30 January 2003
...Rafael SIMÓ; Cristina HERNÁNDEZ; Rosa M. SEGURA; José GARCÍA-ARUMÍ; Laura SARAROLS; Rosa BURGOS; Ana CANTÓN; Jordi MESA The aim of the study was to evaluate the vitreous levels of free insulin-like growth factor 1 (IGF-1) in patients with proliferative diabetic retinopathy (PDR). For this, a total...
Clin Sci (Lond) (2000) 99 (6): 561–567.
Published: 21 November 2000
... specific mRNA transcripts for the recently cloned human LPA-receptors, endothelial differentiation gene (Edg)-2 and Edg-4 (Edg-2 ≫ Edg-4) by reverse transcription-PCR in PT cells. Our data suggest that LPA may behave as a local growth factor in PT cells following tubular injury. Correspondence : Dr C...
Clin Sci (Lond) (1999) 96 (4): 431–436.
Published: 01 April 1999
...Chiyoko N. INOUE; Murray EPSTEIN; Hayley G. FORSTER; Osamu HOTTA; Yoshiaki KONDO; Kazuie IINUMA The last decade has witnessed a phenomenal increase in our understanding of the biological role of lysophosphatidic acid (LPA) and has led to an appreciation of this critical serum-derived growth factor...
Clin Sci (Lond) (1995) 89 (1): 53–57.
Published: 01 July 1995
...ART Ationu; Michael Burch; Donald Singer; Marc De Leval; Bruce Whitehead; Nicholas Carter 1. Insulin-like growth factor I is a major mediator of growth-promoting activities. We studied the ventricular insulin-like growth factor I gene expression at mRNA and peptide levels in 24 heart transplant...