... inhibited platelet-derived growth factor (PDGF)-BB-induced SMC proliferation and migration as determined by bromodeoxyuridine (BrdU) incorporation and a cell counting assay as well as a Boyden chamber assay respectively. DAPK3 siRNA or a pharmacological inhibitor of DAPK3 inhibited PDGF-BB-induced...

... of the disease. Numerous studies have shown the key role of the placenta in the pathogenesis of pre-eclampsia. A shift in the sFlt-1 (soluble Fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio is associated with the disease. Although pre-eclampsia seems to be a clearly defined disease, clinical...

... The Authors Journal compilation © 2008 Biochemical Society 2008 differentiation embryonic stem cell growth factor intracellular signalling self-renewal tyrosine kinase ES cells are pluripotent cell lines derived from the ICM (inner cell mass) of the blastocyst [ 1 , 2 ]. They are maintained...

... importance of inhibitors of angiogenesis in HCC therapy. © The Authors Journal compilation © 2008 Biochemical Society 2008 angiogenesis growth factor hepatocellular carcinoma (HCC) inflammation liver vascular endothelial growth factor (VEGF) COX-2 (cyclo-oxygenase-2) expression...

...Rachel E. Wood; Brad E. Sanderson; Christopher D. Askew; Philip J. Walker; Simon Green; Ian B. Stewart Expansion of the capillary network, or angiogenesis, occurs following endurance training. This process, which is reliant on the presence of VEGF (vascular endothelial growth factor...

... acetylcholine endothelial function growth factor transgenic mouse vasodilation Acromegaly, characterized by excessive secretion of GH (growth hormone), is associated with cardiovascular disease [ 1 ]. Indeed, cardiovascular events are the most common cause of death in acromegalic patients [ 2 , 3...

... function even in the absence of physiological levels of circulating androgen. This review will focus on the role of growth factor signalling in prostate cancer progression to androgen independence and thus outline potential molecular areas of intervention to treat prostate cancer progression. androgen...

... androgen cancer therapy epithelial cell differentiation growth factor prostate cancer stem cell The incidence of prostate cancer has increased over the past decade and it is now the most common non-cutaneous malignancy in Europe and North America [ 1 ]. Radical prostatectomy and radiation...

... ). 17 3 2004 7 6 2004 1 7 2004 1 7 2004 The Biochemical Society 2004 apoptosis atherogenesis growth factor inflammation oxidative stress plaque rupture signalling pathway The arterial wall is composed of an innermost layer of endothelial cells resting on a thin...

...Yoshinori SEKO; Shuichi FUKUDA; Ryozo NAGAI Angiogenesis is controlled by anti-angiogenic factors as well as by angiogenic factors, such as VEGF (vascular endothelial growth factor) and HGF (hepatocyte growth factor). Endostatin, a potent endogenous angiogenesis inhibitor, is known to inhibit...

...Rafael SIMÓ; Cristina HERNÁNDEZ; Rosa M. SEGURA; José GARCÍA-ARUMÍ; Laura SARAROLS; Rosa BURGOS; Ana CANTÓN; Jordi MESA The aim of the study was to evaluate the vitreous levels of free insulin-like growth factor 1 (IGF-1) in patients with proliferative diabetic retinopathy (PDR). For this, a total...

... specific mRNA transcripts for the recently cloned human LPA-receptors, endothelial differentiation gene (Edg)-2 and Edg-4 (Edg-2 ≫ Edg-4) by reverse transcription-PCR in PT cells. Our data suggest that LPA may behave as a local growth factor in PT cells following tubular injury. Correspondence : Dr C...

...Chiyoko N. INOUE; Murray EPSTEIN; Hayley G. FORSTER; Osamu HOTTA; Yoshiaki KONDO; Kazuie IINUMA The last decade has witnessed a phenomenal increase in our understanding of the biological role of lysophosphatidic acid (LPA) and has led to an appreciation of this critical serum-derived growth factor...

...ART Ationu; Michael Burch; Donald Singer; Marc De Leval; Bruce Whitehead; Nicholas Carter 1. Insulin-like growth factor I is a major mediator of growth-promoting activities. We studied the ventricular insulin-like growth factor I gene expression at mRNA and peptide levels in 24 heart transplant...