... may have profound effect on the growth and differentiation of many organ systems, including the heart. Hence, understanding the key molecular players that are synergistically linked in the development of the placenta and heart is critical. This review highlights the key growth factors, angiogenic...

... be leveraged to treat cardiovascular disease. epidermal growth factor receptor growth factors heart failure myocardial remodeling The neuregulin/ErbB pathway has been a source of interest in cardiovascular biology since the disrupted expression of neuregulin 1 (NRG-1), ErbB2, and ErbB4 all...

... nodules and fascial cords which determine debilitating contracture and deformities of fingers and hands. The present study was designed to characterize pro-inflammatory cytokines and growth factors involved in the pathogenesis, progression and recurrence of this disease, in order to find novel targets...

... polypeptide known as gp130 (glycoprotein 130) [2] ; in addition, CT-1 and LIF share a common second receptor component known as LIF receptor subunit b [2]. CT-1 Key words : cytokines, growth factors, heart failure, hypertrophy, immunology. Abbreviations : CT-1, cardiotrophin-1; CTa and CTb, oligopeptides...

... that migration is a highly complex process, which is likely to involve the tightly controlled spatial and temporal interaction of multiple factors: (i) extracellular molecules such as soluble factors (e.g. growth factors, trefoil peptides, cytokines) and matrix components (e.g. collagen, laminin, fibronectin...

... growth factor-1 in arterial blood samples was clearly below presurgical levels in animals receiving vehicle or recombinant human growth hormone, whereas recombinant human insulin-like growth factor-1 infusions more than restored insulin-like growth factor-1 concentrations. These last samples, however...

...Christopher P. Day; Alastair D. Burt; Ashley Stj. M. Brown; Mark K. Bennett; Desmond J. Farrell; Oliver F. W. James; Stephen J. Yeaman 1. Several growth factors important in liver regeneration and fibrosis stimulate phospholipase D in plasma membranes via a receptor/G-protein-coupled mechanism...