... In this study we have demonstrated that individualized treatment with ADP-receptor blockers might result in an improved efficacy with an equal safety. acute coronary syndrome blood platelet clopidogrel haemorrhage thrombosis • Following a link between high on clopidogrel platelet reactivity...

...Chi-Jen CHU; Shwu-Ling WU; Fa-Yauh LEE; Sun-Sang WANG; Full-Young CHANG; Han-Chieh LIN; Che-Chang CHAN; Shou-Dong LEE Hyposensitivity to vasopressin is a well documented phenomenon in animals with portal hypertension and patients with cirrhosis subject to haemorrhage. Haemorrhage is associated...

... to haemorrhage. Excessive formation of nitric oxide is at least partly responsible for the vascular hyporesponsiveness to vasoconstrictors observed in experimental portal hypertension or in rats with haemorrhagic shock. This study investigated whether addition of aminoguanidine, a preferential inducible nitric...

... with preserved arterial pressure after a bleeding protects cirrhotic rats from ongoing variceal bleeding. 6 5 1997 25 7 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 diazepam ether glomerular filtration rate haemodynamics haemorrhage ketamine liver...

... with 100% portal-systemic shunts was developed in the rat. In this model, we determined the haemodynamic effects of haemorrhage (1.8 ml/100 g body weight) or intravenous infusion of a volume expander (1.8 ml/100 g body weight). Cardiac output and regional blood flows were measured by the radioactive...

..., a somatostatin analogue, was investigated in conscious cirrhotic rats before, during and after experimental bleeding from the portal territory. 3. Before haemorrhage, somatostatin analogue (8 μg h −1 kg −1 body weight, intravenously) produced a significant decrease in portal pressure (17%), whereas a placebo...

...H. R. Bhatt; J. C. Linnell 1. The effects of haemorrhage on vitamin B 12 (cobalamin) homoeostasis have been studied in rats with and without prior administration of 57 Co-labelled cyanocobalamin. 2. Arteriovenous differences in radioactivity and endogenous B 12 were measured across the thigh...

... by intracerebral injection of 6-hydroxydopamine. 2. A marked increase in plasma renin activity and adrenaline concentrations followed haemorrhage (0.5 ml/100 g body weight) in the sham-operated rats. VNAB-lesioned rats showed a similar response to the sham-operated controls, but in DNAB-lesioned animals the rise...

...S. M. Gardiner; T. Bennett 1. The effects of naloxone on blood pressure recovery after either rapid arterial haemorrhage or prolonged venous haemorrhage were studied in rats lacking vasopressin (Brattleboro strain) and in control (Long Evans) rats. 2. To produce similar reductions in blood pressure...

...M. S. Golub; M. E. Berger; N. D. Vlachakis; P. Eggena; M. P. Sambhi 1. Changes in plasma renin activity, plasma noradrenaline and adrenaline, and blood pressure were evaluated after mild haemorrhage (6 ml/kg) and subsequent intravenous captopril in conscious, restrained rabbits. Two protocols were...

...R. A. Banks; L. J. Beilin; J. Soltys; L. Davidson 1. The role of prostaglandins and angiotensin II in blood flow regulation was studied in conscious rabbits subjected to mild haemorrhage. 2. Haemorrhage caused a 13% fall in arterial pressure and a 21% fall in cardiac output, responses which were...

...C. I. Johnston; M. Newman; R. Woods © 1981 The Biochemical Society and the Medical Research Society 1981 antidiuretic hormone haemorrhage orthostasis vasoconstriction vasopressin CIinicalScience (1981) 61, 1 2 9 ~ 1 3 9 s 129s STATE OF THE ART REVIEW Role of vasopressin...

...H. K. Richards; S. A. Grace; A. R. Noble; K. A. Munday 1. Renin activity in rabbit plasma increases after acidification (pH 3·3), probably due to activation of an inactive form of renin. 2. Both active and inactive renin in plasma increase after haemorrhage. This stimulus does not change...

... five-fold caused bradycardia in normal dogs and increase in mean arterial blood pressure in dogs with pharmacological autonomic blockade. 3. A similar degree of elevation of plasma vasopressin concentration was observed after mild non-hypotensive haemorrhage. 4. Renal artery constriction...

... nmol/g). 2. These dogs were studied awake with one of two protocols on each of two separate days. In protocol VH, volume expansion (5% body weight) was followed by haemorrhage of 2% body weight. Fractional sodium excretion fell from 4·7 ± 0·5 to 1·1 ± 0·2% on the denervated side and from 5·6 ± 0·6 to 1...

...G. J. Dusting; Janina Staszewska-Barczak 1. The blood-bathed organ technique was used to study the release of catecholamines, angiotensin II and prostaglandin-like (PL) substances into the circulation during hypercapnia and after haemorrhage in anaesthetized dogs. 2. Elevated blood concentrations...

... increase in plasma renin activity. 3. It is concluded that reduction in blood volume is not a major short-term factor in regulating renin production in humans. 9 7 1975 © 1975 The Biochemical Society and the Medical Research Society 1975 haemodynamics haemorrhage renin Clinical...

...J. L. Imbs; J. Kraetz; M. Schmidt; E. Desaulles; J. Schwartz 1. The effect of propranolol and sotalol on renin secretion was studied in the anaesthetized dog. 2. Beta-adrenergic blockade did not modify basal renin secretion and did not affect the rise of renin secretion induced by haemorrhage...